| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wojciech Kostowski, Paweł Krzaści. Neonatal 5-hydroxytryptamine depletion induces depressive-like behavior in adult rats. Polish journal of pharmacology. vol 55. issue 6. 2004-06-15. PMID:14730089. |
the influence of neonatal serotonergic lesion on adult behavior in locomotor and depression models was studied in male wistar rats. |
2004-06-15 |
2023-08-12 |
rat |
| O Fajardo, J Galeno, M Urbina, I Carreira, L Lim. Serotonin, serotonin 5-HT(1A) receptors and dopamine in blood peripheral lymphocytes of major depression patients. International immunopharmacology. vol 3. issue 9. 2004-05-10. PMID:12890432. |
thus, there is a serotonergic dysfunction in immune circulating cells of major depression patients, without changes in the number of 5-ht(1a) receptors, although the coupling of these receptors to transduction mechanisms could be affected and may be related to the alteration of 5-ht turnover rate. |
2004-05-10 |
2023-08-12 |
human |
| Kelly A Gendall, Peter R Joyce, Roger T Mulder, Sue E Lut. Thyroid indices and response to fluoxetine and nortriptyline in major depression. Journal of psychopharmacology (Oxford, England). vol 17. issue 4. 2004-05-07. PMID:14870956. |
it is suggested that a blunted dmaxtsh may reflect a predominantly serotonergic disturbance in this group of patients with major depression. |
2004-05-07 |
2023-08-12 |
Not clear |
| Joel Paris, Hallie Zweig-Frank, N M K Ng Ying Kin, George Schwartz, Howard Steiger, N P V Nai. Neurobiological correlates of diagnosis and underlying traits in patients with borderline personality disorder compared with normal controls. Psychiatry research. vol 121. issue 3. 2004-05-06. PMID:14675743. |
subjects were 30 women with bpd and 22 normal controls, assessed using the diagnostic interview for borderlines, revised, the hamilton depression scale (ham-a) and the hamilton anxiety scale (ham-a), the diagnostic assessment of personality pathology, the buss-durkee guilt-hostility inventory, the barratt impulsivity scale (bis), and challenge tests to measure serotonergic, cholinergic and noradrenergic activity. |
2004-05-06 |
2023-08-12 |
human |
| Maggie Nellissery, Richard S Feinn, Jonathan Covault, Joel Gelernter, Raymond F Anton, Helen Pettinati, Darlene Moak, Timothy Mueller, Henry R Kranzle. Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics. Alcoholism, clinical and experimental research. vol 27. issue 9. 2004-05-04. PMID:14506400. |
serotonergic neurotransmission has been implicated in the pathogenesis of both alcohol dependence and mood disorders and may therefore be important in understanding the pathophysiology of comorbid alcohol dependence and major depression. |
2004-05-04 |
2023-08-12 |
Not clear |
| Andrew C Leo. Are two antidepressant mechanisms better than one? Issues in clinical trial design and analysis. The Journal of clinical psychiatry. vol 65 Suppl 4. 2004-04-27. PMID:15046539. |
the introduction of newer antidepressants that affect both serotonergic and noradrenergic neurotransmission has prompted the question of whether two antidepressant mechanisms of action are better than one for the treatment of depression. |
2004-04-27 |
2023-08-12 |
Not clear |
| Winfried Rief, Florian Pilger, Daniel Ihle, Robert Verkerk, Simon Scharpe, Michael Mae. Psychobiological aspects of somatoform disorders: contributions of monoaminergic transmitter systems. Neuropsychobiology. vol 49. issue 1. 2004-03-08. PMID:14730197. |
to evaluate the possible biological aspects of 'unexplained physical symptoms', this study examined serotonergic and noradrenergic monoamino acids in somatoform disorders and/or depression. |
2004-03-08 |
2023-08-12 |
Not clear |
| Paresh D Patel, Crystal Pontrello, Sharon Burk. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biological psychiatry. vol 55. issue 4. 2004-03-08. PMID:14960297. |
regulation of raphe serotonergic cells is fundamental to the prevailing hypothesis of major depression pathophysiology. |
2004-03-08 |
2023-08-12 |
rat |
| T Bschor, U Lewitzka, J Sasse, M Adli, U Köberle, M Baue. Lithium augmentation in treatment-resistant depression: clinical evidence, serotonergic and endocrine mechanisms. Pharmacopsychiatry. vol 36 Suppl 3. 2004-02-27. PMID:14677084. |
lithium augmentation in treatment-resistant depression: clinical evidence, serotonergic and endocrine mechanisms. |
2004-02-27 |
2023-08-12 |
Not clear |
| Peter Zill, Thomas C Baghai, Rolf Engel, Peter Zwanzger, Cornelius Schüle, Christo Minov, Stefanie Behrens, Ronald Bottlender, Markus Jäger, Rainer Rupprecht, Hans-Jürgen Möller, Manfred Ackenheil, Brigitta Bond. Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 120B. issue 1. 2004-02-19. PMID:12815745. |
although we could not detect an association between the beta(1)ar polymorphism and major depression we found a tendency for a relation between cc homozygosity and a better and even faster response to antidepressant treatment in those patients, which were treated with antidepressants affecting directly or indirectly the beta(1)ar system (tricyclic antidepressants, noradrenergic and serotonergic specific agents, selective noradrenaline reuptake inhibitors) determined by the hamd and cgi score (p = 0.05). |
2004-02-19 |
2023-08-12 |
Not clear |
| S Hesse, H Barthel, W Hermann, T Murai, R Kluge, A Wagner, O Sabri, B Egger. Regional serotonin transporter availability and depression are correlated in Wilson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 8. 2004-02-19. PMID:12898347. |
in vivo neuroimaging studies suggest that depression and other neuropsychiatric disorders are associated with central serotonergic deficits. |
2004-02-19 |
2023-08-12 |
Not clear |
| Justin W C Leung, Hong Xu. GABAergic functions and depression: from classical therapies to herbal medicine. Current drug targets. CNS and neurological disorders. vol 2. issue 6. 2004-01-30. PMID:14683464. |
classical medications employed to treat depression comprise mostly tricyclic antidepressants (tcas), specific serotonin reuptake inhibitors (ssris) and monoamine oxidase inhibitors (maois), in accord with the recognized involvement of serotonergic and adrenergic systems in depression. |
2004-01-30 |
2023-08-12 |
Not clear |
| Klaus Fabel, Konstanze Fabel, Betty Tam, Daniela Kaufer, Armin Baiker, Natalie Simmons, Calvin J Kuo, Theo D Palme. VEGF is necessary for exercise-induced adult hippocampal neurogenesis. The European journal of neuroscience. vol 18. issue 10. 2004-01-26. PMID:14656329. |
as in humans, chronic stress or depression in animals is accompanied by hippocampal dysfunction, and neurogenesis is correspondingly down regulated, in part, by the activity of the hypothalamic-pituitary-adrenal axis as well as glutamatergic and serotonergic networks. |
2004-01-26 |
2023-08-12 |
mouse |
| Violetta Klimek, Gary Roberson, Craig A Stockmeier, Gregory A Ordwa. Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression. Journal of psychiatric research. vol 37. issue 5. 2004-01-22. PMID:12849931. |
these findings imply that serotonergic innervation of the lc is intact in major depression. |
2004-01-22 |
2023-08-12 |
human |
| Maurizio Fav. The role of the serotonergic and noradrenergic neurotransmitter systems in the treatment of psychological and physical symptoms of depression. The Journal of clinical psychiatry. vol 64 Suppl 13. 2004-01-20. PMID:14552653. |
the role of the serotonergic and noradrenergic neurotransmitter systems in the treatment of psychological and physical symptoms of depression. |
2004-01-20 |
2023-08-12 |
Not clear |
| Carolyn W Harle. Norepinephrine and serotonin axonal dynamics and clinical depression: a commentary on the interaction between serotonergic and noradrenergic axons during axonal regeneration. Experimental neurology. vol 184. issue 1. 2004-01-05. PMID:14637074. |
norepinephrine and serotonin axonal dynamics and clinical depression: a commentary on the interaction between serotonergic and noradrenergic axons during axonal regeneration. |
2004-01-05 |
2023-08-12 |
Not clear |
| Sophie Grigoriadis, Sidney H Kennedy, R Michael Bagb. A comparison of antidepressant response in younger and older women. Journal of clinical psychopharmacology. vol 23. issue 4. 2003-11-20. PMID:12920418. |
younger women with depression are more responsive to serotonergic antidepressants. |
2003-11-20 |
2023-08-12 |
Not clear |
| A Heinz, C Denke, G Erns. [Drug-induced headache--pathomechanisms of addiction]. Schmerz (Berlin, Germany). vol 13. issue 5. 2003-11-04. PMID:12799918. |
several drugs that ameliorate acute headache interact with central serotonergic neurotransmission and may affect anxiety and depression in patients with chronic daily headache. |
2003-11-04 |
2023-08-12 |
human |
| Nela Pivac, Dorotea Mück-Seler, Marina Sagud, Miro Jakovljević, Maja Mustapić, Alma Mihaljević-Pele. Long-term sertraline treatment and peripheral biochemical markers in female depressed patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 5. 2003-10-23. PMID:12921906. |
serotonergic system is implicated in the pathogenesis of depression. |
2003-10-23 |
2023-08-12 |
human |
| Dorotea Mück-Seler, Nela Pivac, Miro Jakovljević, Marina Sagud, Alma Mihaljević-Pele. Platelet 5-HT concentration and comorbid depression in war veterans with and without posttraumatic stress disorder. Journal of affective disorders. vol 75. issue 2. 2003-10-17. PMID:12798257. |
the serotonergic system is implicated in the pathophysiology of posttraumatic stress disorder (ptsd) and depression. |
2003-10-17 |
2023-08-12 |
Not clear |