| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvie Lemonde, Gustavo Turecki, David Bakish, Lisheng Du, Pavel D Hrdina, Christopher D Bown, Adolfo Sequeira, Neena Kushwaha, Stephen J Morris, Ajoy Basak, Xiao-Ming Ou, Paul R Alber. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 25. 2003-10-14. PMID:14507979. |
we suggest a novel transcriptional model in which the g(-1019) allele derepresses 5-ht1a autoreceptor expression to reduce serotonergic neurotransmission, predisposing to depression and suicide. |
2003-10-14 |
2023-08-12 |
drosophila_melanogaster |
| Karin C Weiss, Dennis Y Kim, Catherine T Pawson, Sabine P Corde. A genetic screen for mouse mutations with defects in serotonin responsiveness. Brain research. Molecular brain research. vol 115. issue 2. 2003-10-01. PMID:12877987. |
deficits in serotonergic neurotransmission have been implicated in psychiatric disorders, such as schizophrenia and depression. |
2003-10-01 |
2023-08-12 |
mouse |
| William M McDonald, Irene H Richard, Mahlon R DeLon. Prevalence, etiology, and treatment of depression in Parkinson's disease. Biological psychiatry. vol 54. issue 3. 2003-09-26. PMID:12893111. |
the incidence of depression is correlated with changes in central serotonergic function and neurodegeneration of specific cortical and subcortical pathways. |
2003-09-26 |
2023-08-12 |
Not clear |
| Catharine A Winstanley, Yogita Chudasama, Jeffrey W Dalley, David E H Theobald, Jeffrey C Glennon, Trevor W Robbin. Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats. Psychopharmacology. vol 167. issue 3. 2003-09-24. PMID:12677356. |
the central serotonergic systems are a major target for drugs used to treat neuropsychiatric disorders such as depression and schizophrenia in which disruption of frontal cortex function has been implicated. |
2003-09-24 |
2023-08-12 |
rat |
| Eric A Stone, Yan Lin, Helen Rosengarten, H Kenneth Kramer, David Quartermai. Emerging evidence for a central epinephrine-innervated alpha 1-adrenergic system that regulates behavioral activation and is impaired in depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 8. 2003-09-12. PMID:12813473. |
currently, most basic and clinical research on depression is focused on either central serotonergic, noradrenergic, or dopaminergic neurotransmission as affected by various etiological and predisposing factors. |
2003-09-12 |
2023-08-12 |
Not clear |
| Jolanta Rajewska, Janusz K Rybakowsk. Depression in premenopausal women: gonadal hormones and serotonergic system assessed by D-fenfluramine challenge test. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 4. 2003-08-29. PMID:12787860. |
depression in premenopausal women: gonadal hormones and serotonergic system assessed by d-fenfluramine challenge test. |
2003-08-29 |
2023-08-12 |
Not clear |
| Jolanta Rajewska, Janusz K Rybakowsk. Depression in premenopausal women: gonadal hormones and serotonergic system assessed by D-fenfluramine challenge test. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 4. 2003-08-29. PMID:12787860. |
the aim of the study was to compare the activity of gonadal hormones and serotonergic system in premenopausal women with or without depression in relation to clinical and hormonal indices of menopause. |
2003-08-29 |
2023-08-12 |
Not clear |
| Rivka Ofir, Snait Tamir, Soliman Khatib, Jacob Vay. Inhibition of serotonin re-uptake by licorice constituents. Journal of molecular neuroscience : MN. vol 20. issue 2. 2003-08-18. PMID:12794307. |
in conclusion, this study showed that several isoflavans are unique phytoestrogens, which like estradiol, affects the serotonergic system and inhibits serotonin re-uptake and, thus, potentially may be beneficial for mild to moderate depression in pre- and postmenopausal women. |
2003-08-18 |
2023-08-12 |
human |
| V L Bush, D N Middlemiss, C A Marsden, K C F Fon. Implantation of a slow release corticosterone pellet induces long-term alterations in serotonergic neurochemistry in the rat brain. Journal of neuroendocrinology. vol 15. issue 6. 2003-08-13. PMID:12716412. |
many studies point to an involvement of deficits in the serotonergic nervous system and hyperactivity of the hypothalamic-pituitary-adrenal (hpa) axis function with depression. |
2003-08-13 |
2023-08-12 |
rat |
| Tracy L Bale, Wylie W Val. Increased depression-like behaviors in corticotropin-releasing factor receptor-2-deficient mice: sexually dichotomous responses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832554. |
because differences in behaviors in the forced swim test are good indicators of serotonergic and catecholaminergic involvement, our results may reveal an interaction of crf pathways with other known antidepressant systems and may also support an involvement of crf receptors in the development of depression such that elevated crfr1 activity, in the absence of crfr2, increases depression-like behaviors. |
2003-08-05 |
2023-08-12 |
mouse |
| B Eggers, W Hermann, H Barthel, O Sabri, A Wagner, S Hess. The degree of depression in Hamilton rating scale is correlated with the density of presynaptic serotonin transporters in 23 patients with Wilson's disease. Journal of neurology. vol 250. issue 5. 2003-07-25. PMID:12736737. |
it has been suggested that depression is associated with deficits in serotonergic neurotransmission, but, hitherto, no measurements have been performed in wd. |
2003-07-25 |
2023-08-12 |
Not clear |
| Roger T Mulder, Richard J Porter, Peter R Joyc. The prolactin response to fenfluramine in depression: effects of melancholia and baseline cortisol. Journal of psychopharmacology (Oxford, England). vol 17. issue 1. 2003-07-22. PMID:12680745. |
depression may be associated with a hypofunction of central serotonergic systems. |
2003-07-22 |
2023-08-12 |
Not clear |
| Chantal Moret, Brigitt Grimaldi, Olivier Massot, Gille Fillio. The role and therapeutic potential of 5-HT-moduline in psychiatry. Seminars in clinical neuropsychiatry. vol 8. issue 2. 2003-07-01. PMID:12728412. |
because the serotonergic activity is known to play a key role in psychiatric disorders such as depression and anxiety, compounds capable of mimicking or inhibiting the activity of 5-ht-moduline can represent novel antidepressants or anxiolytics. |
2003-07-01 |
2023-08-12 |
mouse |
| Benjamin N Greenwood, Teresa E Foley, Heidi E W Day, Jay Campisi, Sayamwong H Hammack, Serge Campeau, Steven F Maier, Monika Fleshne. Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684476. |
freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. |
2003-05-30 |
2023-08-12 |
rat |
| David C Purselle, Charles B Nemerof. Serotonin transporter: a potential substrate in the biology of suicide. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 4. 2003-05-29. PMID:12655305. |
suicide is highly correlated with depressive symptoms, and considerable evidence suggests that depression is associated with a relative deficiency in serotonergic neurotransmission. |
2003-05-29 |
2023-08-12 |
Not clear |
| Y Pollak, E Orion, I Goshen, H Ovadia, R Yirmiy. Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of 'depression due to multiple sclerosis'. Brain, behavior, and immunity. vol 16. issue 5. 2003-05-28. PMID:12401467. |
in particular, we show that: (1) eae and depression are associated not only with similar behavioral symptomatology, but also with common physiological alterations, including impaired serotonergic neurotransmission, and activation of neuroendocrine (e.g., adrenocortical) and inflammatory cytokine systems; (2) the ebs precedes any neurological deficit during the initial eae attack, as well as further exacerbations, and remits during recovery and between relapses. |
2003-05-28 |
2023-08-12 |
mouse |
| Anthony J Rothschil. Challenges in the treatment of depression with psychotic features. Biological psychiatry. vol 53. issue 8. 2003-05-15. PMID:12706954. |
patients with mdpsy demonstrate distinct biological abnormalities in studies of the hypothalamic-pituitary-adrenal (hpa) axis, dopaminergic activity, enzyme studies, brain imaging, electroencephalogram sleep profiles, and measures of serotonergic function when compared with nonpsychotic depression. |
2003-05-15 |
2023-08-12 |
Not clear |
| Baojian Yu, Jie Liu, David H Overstreet, Joel P Gallaghe. Serotonin produces an enhanced outward current recorded at rat dorsal lateral septal neurons from the Flinders Sensitive Line of rats, a genetically-selected animal model of depression. Neuroscience letters. vol 339. issue 3. 2003-05-05. PMID:12633896. |
abnormalities in serotonin (5-ht), serotonin receptors, and serotonergic neurons have been reported in studies of brains from patients diagnosed clinically with depression. |
2003-05-05 |
2023-08-12 |
rat |
| Dante D C Wan, Divya Kundhur, Kevin Solomons, Lakshmi N Yatham, Raymond W La. Mirtazapine for treatment-resistant depression: a preliminary report. Journal of psychiatry & neuroscience : JPN. vol 28. issue 1. 2003-04-17. PMID:12587851. |
to describe the effectiveness and tolerability of mirtazapine, a noradrenergic and specific serotonergic antidepressant, in the open-label treatment of patients with depression who were resistant to other antidepressant agents. |
2003-04-17 |
2023-08-12 |
Not clear |
| Stephen M Stahl, Richard Entsuah, Richard L Rudolp. Comparative efficacy between venlafaxine and SSRIs: a pooled analysis of patients with depression. Biological psychiatry. vol 52. issue 12. 2003-04-10. PMID:12488062. |
serotonergic and adrenergic enhancement may be synergistic and more effective than serotonergic enhancement alone in treating depression. |
2003-04-10 |
2023-08-12 |
Not clear |