| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jordanna E Bermack, Guy Debonne. The role of sigma receptors in depression. Journal of pharmacological sciences. vol 97. issue 3. 2005-08-29. PMID:15750289. |
in addition to the behavioral data, we discuss electrophysiological and biochemical models demonstrating sigma receptors' ability to modulate important factors in the pathophysiology of depression and/or the mechanisms of action of antidepressants such as the serotonergic neurotransmission in the dorsal raphe nucleus (drn) and the glutamatergic transmission in the hippocampus. |
2005-08-29 |
2023-08-12 |
Not clear |
| Justin E Aldridge, Edward D Levin, Frederic J Seidler, Theodore A Slotki. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environmental health perspectives. vol 113. issue 5. 2005-08-16. PMID:15866758. |
developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. |
2005-08-16 |
2023-08-12 |
rat |
| David H Overstreet, Elliot Friedman, Aleksander A Mathé, Gal Yadi. The Flinders Sensitive Line rat: a selectively bred putative animal model of depression. Neuroscience and biobehavioral reviews. vol 29. issue 4-5. 2005-08-16. PMID:15925699. |
neurochemical and/or pharmacological evidence suggests that the fsl rat exhibits changes consistent with the cholinergic, serotonergic, dopaminergic, npy, and circadian rhythm models but not the noradrenergic, hpa axis or gabaergic models of depression. |
2005-08-16 |
2023-08-12 |
rat |
| C Mizrahi, A Stojanovic, M Urbina, I Carreira, L Lim. Differential cAMP levels and serotonin effects in blood peripheral mononuclear cells and lymphocytes from major depression patients. International immunopharmacology. vol 4. issue 8. 2005-07-11. PMID:15270025. |
the present report indicates: (1) differential responses of immune cells from control individuals and depressed patients, with lower apparent adenylate cyclase activity in patient's cells; (2) variation in the population of cells, with responses to serotonergic agonists being lower in mononuclear cells and higher in lymphocytes from major depression patients; (3) increases of camp levels by serotonin and 5ht1a agonist in the patient's cells; and (4) evidence of impairment in serotonergic transduction systems in immune cells during depression. |
2005-07-11 |
2023-08-12 |
human |
| Moonkyu Kang, Kwang-Ho Pyun, Choon-Gon Jang, Hyuntaek Kim, Hyunsu Bae, Insop Shi. Nelumbinis Semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats. The Journal of pharmacy and pharmacology. vol 57. issue 5. 2005-06-28. PMID:15901354. |
these results suggest that ns increases the serotonin levels normally decreased in depression, resulting in an enhancement of central serotonergic transmission and possible therapeutic action in depression. |
2005-06-28 |
2023-08-12 |
rat |
| Moussa B H Youdim, Mati Fridkin, Hailin Zhen. Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases. Mechanisms of ageing and development. vol 126. issue 2. 2005-06-13. PMID:15621213. |
many pd and dlb subjects have dementia and depression resulting from possible degeneration of cholinergic and noradrenergic and serotonergic neurons. |
2005-06-13 |
2023-08-12 |
mouse |
| Olaf Moeller, Guenter Hetzel, Nikolaus Michael, Matthias Rothermundt, Volker Arolt, Andreas Erfurt. Basal prolactin values correlate with response to reboxetine treatment in major depression, but not with response to citalopram. Neuropsychobiology. vol 51. issue 2. 2005-04-29. PMID:15741746. |
in order to examine whether bpv predict response to selective mono-aminergic therapy, 24 in-patients with major depression were treated in a single-masked, randomised study using the most selective noradrenergic or serotonergic reuptake inhibitors available for antidepressant treatment, i.e. |
2005-04-29 |
2023-08-12 |
Not clear |
| Martin E Keck, Simone B Sartori, Tobias Welt, Marianne B Müller, Frauke Ohl, Florian Holsboer, Rainer Landgraf, Nicolas Singewal. Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715667. |
disturbances in serotonergic neurotransmission have been suggested to be closely interlinked with hyperactivity of the hypothalamic-pituitary-adrenocortical (hpa) system, and are likely to be involved in the pathophysiology of anxiety disorders and major depression. |
2005-04-28 |
2023-08-12 |
rat |
| Jolanta Rabe-Jabłońska, Adam Mille. [Links between pain and depression]. Psychiatria polska. vol 39. issue 1. 2005-04-21. PMID:15771150. |
presently we know at least five kinds of links between depression and pain: 1) depression appeared prior to the start of pain, 2) depression is a consequence of chronic pain and stress, 3) depressive episodes cause an increase of risk of next affective episodes in patients with chronic pain, 4) psychologic factors play an important role in the development of depressive symptoms, 5) altered balance between noradrenergic and serotonergic pathways and disregulation of other neurotransmitter systems (cholinergic, gaba-ergic, dopaminergic) and neuropeptides may cause chronic pain and depressive disorder. |
2005-04-21 |
2023-08-12 |
Not clear |
| Gustavo E Tafet, Jaime Smolovic. Psychoneuroendocrinological studies on chronic stress and depression. Annals of the New York Academy of Sciences. vol 1032. 2005-04-19. PMID:15677427. |
therefore, we investigated the potential link between alterations of the limbic-hpa system with the serotonergic hypothesis of depression at both the molecular and clinical levels. |
2005-04-19 |
2023-08-12 |
human |
| David A Slattery, Sandrine Desrayaud, John F Crya. GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependent. The Journal of pharmacology and experimental therapeutics. vol 312. issue 1. 2005-04-13. PMID:15333677. |
together, these data demonstrate that gaba(b) receptor antagonists via an interaction with the serotonergic system display antidepressant-like properties and therefore represent a novel approach for the treatment of depression. |
2005-04-13 |
2023-08-12 |
rat |
| M Garcia-Alloza, F J Gil-Bea, M Diez-Ariza, C P L-H Chen, P T Francis, B Lasheras, M J Ramire. Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease. Neuropsychologia. vol 43. issue 3. 2005-04-12. PMID:15707619. |
cholinergic and serotonergic functions were assessed in post-mortem frontal and temporal cortex from 22 ad patients who had been prospectively assessed with the mini-mental state examination (mmse) for cognitive impairment and with the present behavioral examination (pbe) for bpsd including aggressive behavior, overactivity, depression and psychosis. |
2005-04-12 |
2023-08-12 |
Not clear |
| Matthias R Lemke, Gerd Fuchs, Irene Gemende, Birgit Herting, Christian Oehlwein, Heinz Reichmann, Jürgen Rieke, Jens Volkman. Depression and Parkinson's disease. Journal of neurology. vol 251 Suppl 6. 2005-04-08. PMID:15675721. |
serotonergic, noradrenergic and dopaminergic mechanisms play key roles in the etiology of depression in pd. |
2005-04-08 |
2023-08-12 |
Not clear |
| Orli Kampf-Sherf, Zoli Zlotogorski, Asaf Gilboa, Lynn Speedie, Jossef Lereya, Paula Rosca, Yehuda Shavi. Neuropsychological functioning in major depression and responsiveness to selective serotonin reuptake inhibitors antidepressants. Journal of affective disorders. vol 82. issue 3. 2005-04-04. PMID:15555698. |
cumulative evidence linking serotonergic depletion and cognition led us to hypothesize that the neuropsychological functioning of major depression patients may predict their responsiveness to ssri antidepressants. |
2005-04-04 |
2023-08-12 |
Not clear |
| D F Avgustinovich, O V Alekseenko, I V Bakshtanovskaia, L A Koriakina, T V Lipina, M V Tenditnik, N P Bondar', I L Kovalenko, N N Kudriavtsev. [Dynamic changes of brain serotonergic and dopaminergic activities during development of anxious depression: experimental study]. Uspekhi fiziologicheskikh nauk. vol 35. issue 4. 2005-03-31. PMID:15573884. |
[dynamic changes of brain serotonergic and dopaminergic activities during development of anxious depression: experimental study]. |
2005-03-31 |
2023-08-12 |
mouse |
| D F Avgustinovich, O V Alekseenko, I V Bakshtanovskaia, L A Koriakina, T V Lipina, M V Tenditnik, N P Bondar', I L Kovalenko, N N Kudriavtsev. [Dynamic changes of brain serotonergic and dopaminergic activities during development of anxious depression: experimental study]. Uspekhi fiziologicheskikh nauk. vol 35. issue 4. 2005-03-31. PMID:15573884. |
hypofunction of serotonergic system is suggested at the stage of pronounced depression state in animals. |
2005-03-31 |
2023-08-12 |
mouse |
| Anne Herva, Jari Jokelainen, Anneli Pouta, Juha Veijola, Markku Timonen, Juha T Karvonen, Matti Joukama. Age at menarche and depression at the age of 31 years: findings from the Northern Finland 1966 Birth Cohort Study. Journal of psychosomatic research. vol 57. issue 4. 2005-02-23. PMID:15518670. |
the role of oestrogen in depression is not clear, although it affects serotonergic functions in the central nervous system (cns). |
2005-02-23 |
2023-08-12 |
Not clear |
| Gonzalo Vázquez-Palacios, Herlinda Bonilla-Jaime, Javier Velázquez-Moctezum. Antidepressant effects of nicotine and fluoxetine in an animal model of depression induced by neonatal treatment with clomipramine. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 1. 2005-02-15. PMID:15610943. |
to examine the suggested antidepressant effect of nicotine and its possible interaction with the serotonergic system, we assessed the effect of nicotine and fluoxetine (flx) in an animal model of depression induced by neonatal treatment with clomipramine (cli) and submitted to the forced swim test (fst). |
2005-02-15 |
2023-08-12 |
rat |
| Boris B Quednow, Kai-Uwe Kühn, Richard Stelzenmuelle, Klaus Hoenig, Wolfgang Maier, Michael Wagne. Effects of serotonergic and noradrenergic antidepressants on auditory startle response in patients with major depression. Psychopharmacology. vol 175. issue 4. 2005-01-26. PMID:15042278. |
effects of serotonergic and noradrenergic antidepressants on auditory startle response in patients with major depression. |
2005-01-26 |
2023-08-12 |
Not clear |
| Theodore A Slotkin, Mandy M Cousins, Charlotte A Tate, Frederic J Seidle. Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 1. 2005-01-26. PMID:15367926. |
serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats. |
2005-01-26 |
2023-08-12 |
rat |