| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jayne E Clarkson, J Matthew Lacy, Corinne L Fligner, Norman Thiersch, John Howard, Richard C Harruff, Barry K Loga. Tramadol (Ultram) concentrations in death investigation and impaired driving cases and their significance. Journal of forensic sciences. vol 49. issue 5. 2005-01-24. PMID:15461118. |
however, tramadol may be a significant contributor to lethal intoxication when taken in excess with other drugs, via the potential interaction with serotonergic antidepressant medications, as well as the potential for increased cns depression. |
2005-01-24 |
2023-08-12 |
human |
| S R De Vriese, A B Christophe, M Mae. In humans, the seasonal variation in poly-unsaturated fatty acids is related to the seasonal variation in violent suicide and serotonergic markers of violent suicide. Prostaglandins, leukotrienes, and essential fatty acids. vol 71. issue 1. 2005-01-13. PMID:15172679. |
both depression and suicide show a seasonal variation and are related to disorders in the serotonergic system. |
2005-01-13 |
2023-08-12 |
Not clear |
| Stephen Stahl, Mike Brile. Understanding pain in depression. Human psychopharmacology. vol 19 Suppl 1. 2005-01-12. PMID:15378669. |
a dysfunction of the serotonergic and noradrenergic pathways is commonly accepted as playing a major role in the aetiology of depression. |
2005-01-12 |
2023-08-12 |
Not clear |
| Stephen Stahl, Mike Brile. Understanding pain in depression. Human psychopharmacology. vol 19 Suppl 1. 2005-01-12. PMID:15378669. |
a dysfunction at the level of the serotonergic and noradrenergic neurons can thus affect both the ascending and descending pathways resulting in the psychological and somatic symptoms of depression but also in physical painful symptoms. |
2005-01-12 |
2023-08-12 |
Not clear |
| Gregor Hasler, Wayne C Drevets, Husseini K Manji, Dennis S Charne. Discovering endophenotypes for major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15213704. |
second, the most consistent heritable biological markers of major depression are proposed as biological endophenotypes for genetic studies: rem sleep abnormalities, functional and structural brain abnormalities, dysfunctions in serotonergic, catecholaminergic, hypothalamic-pituitary-adrenocortical axis, and crh systems, and intracellular signal transduction endophenotypes. |
2004-11-22 |
2023-08-12 |
Not clear |
| G Hetzel, O Moeller, A Erfurth, N Michael, M Rothermundt, V Arolt, S Ever. The impact of the selective monoamine reuptake inhibitors reboxetine and citalopram on visually-evoked event-related potentials in depressed patients. Pharmacopsychiatry. vol 37. issue 5. 2004-11-02. PMID:15470798. |
the aim of our study was to assess the possible relationship between event-related potentials (erp) and serotonergic or noradrenergic activity in depression. |
2004-11-02 |
2023-08-12 |
Not clear |
| V Fenik, R O Davies, L Kubi. Combined antagonism of aminergic excitatory and amino acid inhibitory receptors in the XII nucleus abolishes REM sleep-like depression of hypoglossal motoneuronal activity. Archives italiennes de biologie. vol 142. issue 3. 2004-09-24. PMID:15260378. |
we used this model to determine whether microinjections of a combination of antagonists of serotonergic, adrenergic, gaba(a) and glycinergic receptors (methysergide, prazosin, bicuculline and strychnine) into the xii nucleus can abolish the carbachol-induced depression of xii motoneuronal activity. |
2004-09-24 |
2023-08-12 |
rat |
| Andrew H Kemp, Marcus A Gray, Richard B Silberstein, Stuart M Armstrong, Pradeep J Natha. Augmentation of serotonin enhances pleasant and suppresses unpleasant cortical electrophysiological responses to visual emotional stimuli in humans. NeuroImage. vol 22. issue 3. 2004-09-16. PMID:15219580. |
the serotonergic system is one of the major systems targeted in the pharmacological treatment of a wide range of mood disorders including depression; however, little is known about the neurophysiological mechanisms underlying the effects of serotonin (5-ht) on affective phenomena including emotional behaviours, mood and emotional processing. |
2004-09-16 |
2023-08-12 |
human |
| C Dalla, K Antoniou, Z Papadopoulou-Daifoti, J Balthazart, J Bakke. Oestrogen-deficient female aromatase knockout (ArKO) mice exhibit depressive-like symptomatology. The European journal of neuroscience. vol 20. issue 1. 2004-09-07. PMID:15245494. |
the possible organizational role of oestradiol on the hippocampal serotonergic system and the 'depressive-like' profile of arko females provide new insights into the pathophysiology of depression and the increased vulnerability of women to depression. |
2004-09-07 |
2023-08-12 |
mouse |
| Paul H Soloff, Thomas M Kelly, Stephen J Strotmeyer, Kevin M Malone, J John Man. Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. Psychiatry research. vol 119. issue 1-2. 2004-08-24. PMID:12860356. |
behavioral impulsivity in borderline personality disorder (bpd) is associated with indices of diminished central serotonergic function, independent of suicidal behavior, depression or alcohol use disorder. |
2004-08-24 |
2023-08-12 |
human |
| Motoko Honda, Mitsuo Tanabe, Hideki On. Serotonergic depression of spinal monosynaptic transmission is mediated by 5-HT1B receptors. European journal of pharmacology. vol 482. issue 1-3. 2004-08-16. PMID:14660017. |
serotonergic depression of spinal monosynaptic transmission is mediated by 5-ht1b receptors. |
2004-08-16 |
2023-08-12 |
rat |
| Motoko Honda, Mitsuo Tanabe, Hideki On. Serotonergic depression of spinal monosynaptic transmission is mediated by 5-HT1B receptors. European journal of pharmacology. vol 482. issue 1-3. 2004-08-16. PMID:14660017. |
these results suggest that serotonergic depression of monosynaptic reflex transmission is mediated by 5-ht(1b) receptors. |
2004-08-16 |
2023-08-12 |
rat |
| Carlos A Zarate, Jennifer L Payne, Jaskaran Singh, Jorge A Quiroz, David A Luckenbaugh, Kirk D Denicoff, Dennis S Charney, Husseini K Manj. Pramipexole for bipolar II depression: a placebo-controlled proof of concept study. Biological psychiatry. vol 56. issue 1. 2004-08-05. PMID:15219473. |
the original serotonergic and noradrenergic hypotheses do not fully account for the neurobiology of depression or mechanism of action of effective antidepressants. |
2004-08-05 |
2023-08-12 |
Not clear |
| Shiro Ohyama, Masahiro Kuniyoshi, Syogoro Nishi, Kazutoyo Inanag. [Postherpetic neuralgia alleviated by an SSRI fluvoxamine: two cases of PHN accompanied with depression were treated with fluvoxamine]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 2. 2004-07-30. PMID:15164615. |
the long latency of fluvoxamine action, its shortening by tandospirone and the parallel changes of phn and depression are all indicative of that the same mechanism, namely renormalization of the dysfunctioned central serotonergic transmission would be underlying both the anti-phn and antidepressant actions. |
2004-07-30 |
2023-08-12 |
Not clear |
| I Hindmarc. Beyond the monoamine hypothesis: mechanisms, molecules and methods. European psychiatry : the journal of the Association of European Psychiatrists. vol 17 Suppl 3. 2004-07-29. PMID:15177084. |
it could be argued that the blinkered view of depression as a solely serotonergic phenomenon has not only restrained and limited research into other potential systems, but has also slowed down the discovery of putative antidepressant drugs. |
2004-07-29 |
2023-08-12 |
Not clear |
| Carol A Shively, Cynthia L Bethe. Cognition, mood disorders, and sex hormones. ILAR journal. vol 45. issue 2. 2004-07-16. PMID:15111738. |
understanding the effects of ovarian steroids on the neural serotonergic system is necessary to understand depression in women. |
2004-07-16 |
2023-08-12 |
monkey |
| Seung-Ho Ryu, Seung-Hwan Lee, Heon-Jeong Lee, Ji-Hyun Cha, Byung-Joo Ham, Chang-Su Han, Myoung-Jin Choi, Min-Soo Le. Association between norepinephrine transporter gene polymorphism and major depression. Neuropsychobiology. vol 49. issue 4. 2004-07-06. PMID:15118352. |
noradrenergic and serotonergic abnormalities have long been implicated in patients with major depression. |
2004-07-06 |
2023-08-12 |
Not clear |
| Weidong Yang, Qingde Wang, Stephen J Kanes, John M Murray, Kazuko Nishikur. Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy. Brain research. Molecular brain research. vol 124. issue 1. 2004-06-28. PMID:15093687. |
it has been speculated that rna editing may play a role in several pharmacological and behavioral processes where the serotonergic plasticity is mediated through 5-ht(2c)r. interferon-alpha (ifn-alpha) often causes severe depression in patients treated for chronic viral hepatitis and certain malignancies. |
2004-06-28 |
2023-08-12 |
human |
| Michelle Hendricksen, Alan J Thomas, I Nicol Ferrier, Paul Ince, John T O'Brie. Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression. The American journal of psychiatry. vol 161. issue 6. 2004-06-24. PMID:15169699. |
few studies have examined pathological changes in serotonergic neurons in depression, particularly in elderly patients and in elderly patients in which depression occurs in dementia. |
2004-06-24 |
2023-08-12 |
human |
| Michelle Hendricksen, Alan J Thomas, I Nicol Ferrier, Paul Ince, John T O'Brie. Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression. The American journal of psychiatry. vol 161. issue 6. 2004-06-24. PMID:15169699. |
the authors hypothesized that greater neurofibrillary pathology and fewer serotonergic neurons would be found in the dorsal raphe nuclei in depressed elderly subjects, compared with nondepressed elderly subjects, and in alzheimer's disease patients with depression, compared to alzheimer's disease patients without depression. |
2004-06-24 |
2023-08-12 |
human |