| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Caroline Bell, Sue Wilson, Ann Rich, Jayne Bailey, David Nut. Effects on sleep architecture of pindolol, paroxetine and their combination in healthy volunteers. Psychopharmacology. vol 166. issue 2. 2003-04-02. PMID:12536263. |
the combination of pindolol with a serotonergic antidepressant has been used to speed up the antidepressant response and to augment in cases of resistant depression. |
2003-04-02 |
2023-08-12 |
human |
| Rui Tao, Sidney B Auerbac. Influence of inhibitory and excitatory inputs on serotonin efflux differs in the dorsal and median raphe nuclei. Brain research. vol 961. issue 1. 2003-04-01. PMID:12535783. |
the dorsal (drn) and median raphe nuclei (mrn) are two major sources of serotonergic projections to forebrain that are involved in regulation of behavioral state and motor activity, and implicated in affective disorders such as depression and schizophrenia. |
2003-04-01 |
2023-08-12 |
rat |
| Eliyahu Dremencov, Eitan Gur, Bernard Lerer, Michael E Newma. Effects of chronic antidepressants and electroconvulsive shock on serotonergic neurotransmission in the rat hypothalamus. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 6. 2003-03-26. PMID:12452522. |
there are two main lines of evidence for this: firstly, many of its functions correspond to those altered in depression; and secondly, many hypothalamic functions are regulated by the serotonergic system, which is a common target of antidepressant treatments. |
2003-03-26 |
2023-08-12 |
rat |
| Eliyahu Dremencov, Eitan Gur, Bernard Lerer, Michael E Newma. Effects of chronic antidepressants and electroconvulsive shock on serotonergic neurotransmission in the rat hypothalamus. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 6. 2003-03-26. PMID:12452522. |
we postulate that presynaptic autoregulation of serotonergic neurotransmission in the hypothalamus may play a critical role in the pathophysiology and treatment of depression. |
2003-03-26 |
2023-08-12 |
rat |
| b' Nela Pivac, Dorotea M\\xc3\\xbcck-Seler, Marina Sagud, Miro Jakovljevi\\xc4\\x8. Platelet serotonergic markers in posttraumatic stress disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 6. 2003-03-26. PMID:12452545.' |
these findings suggest that platelet 5-ht concentration and platelet mao activity are not altered in three drug-free groups--war veterans who did or did not develop ptsd, or in prisoners of war with ptsd--and that these platelet serotonergic markers are not associated with symptoms of ptsd or comorbid depression. |
2003-03-26 |
2023-08-12 |
human |
| Esther Gómez-Gil, Cristóbal Gastó, Maribel Díaz-Ricart, Marta Carretero, Manel Salamero, Rosa Catalán, Ginés Escola. Platelet 5-HT2A-receptor-mediated induction of aggregation is not altered in major depression. Human psychopharmacology. vol 17. issue 8. 2003-03-17. PMID:12457378. |
studies of the 5-ht(2a) receptor subtype in major depression have focused on the density of these receptors in neuronal cells and platelets, showing an up-regulation secondary to a deficit in serotonergic activity in major depression. |
2003-03-17 |
2023-08-12 |
Not clear |
| Nicoletta Sonino, Giovanni A Fav. Residual symptoms in depression an emerging therapeutic concept. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 4. 2003-03-12. PMID:12188108. |
the use of serotonergic drugs in cushing's disease may yield important insights in the understanding of serotonergic regulation both in cushing's disease and in the hpa axis in nonendocrine major depression. |
2003-03-12 |
2023-08-12 |
Not clear |
| A Heinz, D W Jones, G Bissette, D Hommer, P Ragan, M Knable, S Wellek, M Linnoila, D R Weinberge. Relationship between cortisol and serotonin metabolites and transporters in alcoholism [correction of alcolholism]. Pharmacopsychiatry. vol 35. issue 4. 2003-02-27. PMID:12163982. |
stress hormone activation may induce clinical depression via an interference with central serotonergic neurotransmission. |
2003-02-27 |
2023-08-12 |
human |
| Daisuke Mochizuki, Ryuichi Tsujita, Shinji Yamada, Koh Kawasaki, Yuji Otsuka, Shinji Hashimoto, Tsuyoshi Hattori, Yoshihisa Kitamura, Naomasa Mik. Neurochemical and behavioural characterization of milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats. Psychopharmacology. vol 162. issue 3. 2003-02-26. PMID:12122491. |
reduced function of the serotonergic and noradrenergic systems is another feature of depression. |
2003-02-26 |
2023-08-12 |
rat |
| Manolis Markianos, John Hatzimanolis, Lefteris Lykoura. Serotonergic and dopaminergic neuroendocrine responses of male depressive patients before and after a therapeutic ECT course. European archives of psychiatry and clinical neuroscience. vol 252. issue 4. 2003-02-24. PMID:12242578. |
to test such hypotheses, we studied possible changes in the serotonergic and in dopaminergic systems' responsivity in 11 male patients with major depression by performing neuroendocrine challenge tests before and after a therapeutic ect course. |
2003-02-24 |
2023-08-12 |
Not clear |
| Nicoletta Sonino, Giovanni A Fav. Erratum to "CNS drugs in Cushing's disease: pathophysiological and therapeutic implications for mood disorders" [Prog. Neuro-Psycol. Biol. Psychiatry, 26, 763 (2002)]. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 5. 2003-02-11. PMID:12369251. |
the use of serotonergic drugs in cushing's disease may yield important insights in the understanding of serotonergic regulation both in cushing's disease and in the hpa axis in nonendocrine major depression. |
2003-02-11 |
2023-08-12 |
Not clear |
| Lawrence S Kegeles, Kevin M Malone, Mark Slifstein, Steven P Ellis, Eric Xanthopoulos, John G Keilp, Carl Campbell, Maria Oquendo, Ronald L Van Heertum, J John Man. Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders. The American journal of psychiatry. vol 160. issue 1. 2003-01-30. PMID:12505804. |
the authors applied a dl-fenfluramine challenge method to study metabolic response in this region to serotonergic challenge in familial major depression. |
2003-01-30 |
2023-08-12 |
human |
| Dorotea Mück-Seler, Nela Pivac, Marina Sagud, Miro Jakovljević, Alma Mihaljević-Pele. The effects of paroxetine and tianeptine on peripheral biochemical markers in major depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502009. |
depression is related to the alterations of the central serotonergic system and some antidepressants achieve their therapeutic effects through alteration of serotonin (5-ht) (re)uptake. |
2003-01-27 |
2023-08-12 |
Not clear |
| Maria A Oquendo, Giovanni P A Placidi, Kevin M Malone, Carl Campbell, John Keilp, Beth Brodsky, Lawrence S Kegeles, Thomas B Cooper, Ramin V Parsey, Ronald L van Heertum, J John Man. Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Archives of general psychiatry. vol 60. issue 1. 2003-01-23. PMID:12511168. |
positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. |
2003-01-23 |
2023-08-12 |
Not clear |
| Maria A Oquendo, Giovanni P A Placidi, Kevin M Malone, Carl Campbell, John Keilp, Beth Brodsky, Lawrence S Kegeles, Thomas B Cooper, Ramin V Parsey, Ronald L van Heertum, J John Man. Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Archives of general psychiatry. vol 60. issue 1. 2003-01-23. PMID:12511168. |
lower serotonergic activity correlates with high-lethality suicide attempts in major depression. |
2003-01-23 |
2023-08-12 |
Not clear |
| Yechiel Levkovitz, Ruth Caftori, Avi Avital, Gal Richter-Levi. The SSRIs drug Fluoxetine, but not the noradrenergic tricyclic drug Desipramine, improves memory performance during acute major depression. Brain research bulletin. vol 58. issue 4. 2002-11-15. PMID:12183009. |
accumulating evidence suggests that noradrenergic and serotonergic drugs are equally effective in ameliorating the depressive symptoms of major depression. |
2002-11-15 |
2023-08-12 |
Not clear |
| Teri Pearlstei. Selective serotonin reuptake inhibitors for premenstrual dysphoric disorder: the emerging gold standard? Drugs. vol 62. issue 13. 2002-10-30. PMID:12215058. |
treatments that enhance serotonergic action improve premenstrual irritability and dysphoria with a rapid onset of action, suggesting a different mechanism of action than in the treatment of depression. |
2002-10-30 |
2023-08-12 |
Not clear |
| Rosa M Tordera, Antonio Monge, Joaquín Del Río, Berta Lashera. Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. European journal of pharmacology. vol 442. issue 1-2. 2002-10-08. PMID:12020683. |
consequently, vn2222 is a new compound with a dual effect on the serotonergic system, as 5-ht uptake blocker and 5-ht1a receptor partial agonist, and with a remarkable activity in an animal model of depression with high predictive validity. |
2002-10-08 |
2023-08-12 |
mouse |
| Gurpreet Kaur, Shrinivas K Kulkarn. Evidence for serotonergic modulation of progesterone-induced hyperphagia, depression and algesia in female mice. Brain research. vol 943. issue 2. 2002-09-27. PMID:12101043. |
evidence for serotonergic modulation of progesterone-induced hyperphagia, depression and algesia in female mice. |
2002-09-27 |
2023-08-12 |
mouse |
| Victoria Arango, Mark D Underwood, J John Man. Serotonin brain circuits involved in major depression and suicide. Progress in brain research. vol 136. 2002-09-19. PMID:12143401. |
over the past 25 years, major depression and suicide have come to be recognized as associated with alteration in serotonergic neurons and their target receptors. |
2002-09-19 |
2023-08-12 |
Not clear |