| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Gallinat, R Bottlender, G Juckel, A Munke-Puchner, G Stotz, H J Kuss, P Mavrogiorgou, U Heger. The loudness dependency of the auditory evoked N1/P2-component as a predictor of the acute SSRI response in depression. Psychopharmacology. vol 148. issue 4. 2000-12-12. PMID:10928314. |
thus, an indicator of central serotonergic activity could lead to a more specific pharmacological treatment of depression. |
2000-12-12 |
2023-08-12 |
human |
| M Fujita, D S Charney, R B Inni. Imaging serotonergic neurotransmission in depression: hippocampal pathophysiology may mirror global brain alterations. Biological psychiatry. vol 48. issue 8. 2000-12-07. PMID:11063976. |
imaging serotonergic neurotransmission in depression: hippocampal pathophysiology may mirror global brain alterations. |
2000-12-07 |
2023-08-12 |
human |
| E Eriksso. Antidepressant drugs: does it matter if they inhibit the reuptake of noradrenaline or serotonin? Acta psychiatrica Scandinavica. Supplementum. vol 402. 2000-11-16. PMID:10901154. |
it has been suggested that nris influence depression by indirectly facilitating serotonergic transmission, or that ssris act by facilitating noradrenaline; however, the marked differences between ssris and nris with respect to effects and side-effect profile do not support any of these assumptions, but rather suggest that ssris and nris influence depression by parallel, independent pathways. |
2000-11-16 |
2023-08-12 |
Not clear |
| H M Prakash, K Suman. The biology of depression. Journal of the Indian Medical Association. vol 98. issue 5. 2000-10-27. PMID:11203058. |
abnormalities in serotonergic activity in depression can occur in one or more levels. |
2000-10-27 |
2023-08-12 |
Not clear |
| L Franke, H J Schewe, B Müller, V Campman, W Kitzrow, R Uebelhack, A Berghöfer, B Müller-Oerlinghause. Serotonergic platelet variables in unmedicated patients suffering from major depression and healthy subjects: relationship between 5HT content and 5HT uptake. Life sciences. vol 67. issue 3. 2000-09-19. PMID:10983874. |
serotonergic platelet variables in unmedicated patients suffering from major depression and healthy subjects: relationship between 5ht content and 5ht uptake. |
2000-09-19 |
2023-08-12 |
human |
| B L Jacobs, H van Praag, F H Gag. Adult brain neurogenesis and psychiatry: a novel theory of depression. Molecular psychiatry. vol 5. issue 3. 2000-09-12. PMID:10889528. |
reciprocally, therapeutic interventions for depression that increase serotonergic neurotransmission act at least in part by augmenting dentate gyrus neurogenesis and thereby promoting recovery from depression. |
2000-09-12 |
2023-08-12 |
Not clear |
| M Fava, R D Vuolo, E C Wright, A A Nierenberg, J E Alpert, J F Rosenbau. Fenfluramine challenge in unipolar depression with and without anger attacks. Psychiatry research. vol 94. issue 1. 2000-08-07. PMID:10788673. |
we have previously hypothesized that patients with major depression and anger attacks may have a greater central serotonergic dysregulation than depressed patients without such attacks. |
2000-08-07 |
2023-08-12 |
human |
| M E Thas. Treatment issues related to sleep and depression. The Journal of clinical psychiatry. vol 61 Suppl 11. 2000-08-04. PMID:10926055. |
serotonergic neurons play a critical role in modulating the onset and maintenance of sleep, and it is thought that insomnia in depression is caused by dysfunction of serotonergic systems. |
2000-08-04 |
2023-08-12 |
Not clear |
| R T Khisti, C T Chopd. Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice. Brain research. vol 865. issue 2. 2000-07-24. PMID:10821935. |
the present study demonstrated the antidepressant-like effect of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha, 5alpha thp) in mouse forced swim test of depression and its modulation by different serotonergic agents. |
2000-07-24 |
2023-08-12 |
mouse |
| L Sevinçok, A Ero. The prolactin response to buspirone in poststroke depression: a preliminary report. Journal of affective disorders. vol 59. issue 2. 2000-07-19. PMID:10837886. |
the issue of whether a serotonergic abnormality is involved in poststroke depression (psd) was investigated in a sample of poststroke patients. |
2000-07-19 |
2023-08-12 |
Not clear |
| W Bligh-Glover, T N Kolli, L Shapiro-Kulnane, G E Dilley, L Friedman, E Balraj, G Rajkowska, C A Stockmeie. The serotonin transporter in the midbrain of suicide victims with major depression. Biological psychiatry. vol 47. issue 12. 2000-07-12. PMID:10862800. |
the midbrain dorsal raphe nucleus (dr) has been implicated as a site for diminished serotonergic activity in that suicide victims with major depression have a significant increase in serotonin-1a autoreceptors in the dr. |
2000-07-12 |
2023-08-12 |
Not clear |
| J D Matthews, M Fav. Risk of suicidality in depression with serotonergic antidepressants. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 12. issue 1. 2000-07-06. PMID:10798825. |
risk of suicidality in depression with serotonergic antidepressants. |
2000-07-06 |
2023-08-12 |
Not clear |
| Y Charnay, I Cusin, P G Vallet, P Muzzin, F Rohner-Jeanrenaud, C Boura. Intracerebroventricular infusion of leptin decreases serotonin transporter binding sites in the frontal cortex of the rat. Neuroscience letters. vol 283. issue 2. 2000-05-12. PMID:10739882. |
although the cellular and molecular mechanisms underlying such an effect of leptin need further investigation, our observations support the notion of a possible interaction between leptin and the serotonergic system of potential interest in the pathophysiology of depression. |
2000-05-12 |
2023-08-12 |
rat |
| C M Helgason, J L Frank, D R Johnson, M G Frank, S E Hendrick. The effects of St. John's Wort (Hypericum perforatum) on NK cell activity in vitro. Immunopharmacology. vol 46. issue 3. 2000-05-11. PMID:10741904. |
serotonergic pharmacotherapy is associated with amelioration of depression as well as increases in natural killer (nk) cell activity (nkca). |
2000-05-11 |
2023-08-12 |
Not clear |
| G Huethe. Acute regulation and long-term modulation of presynaptic serotonin output. Advances in experimental medicine and biology. vol 467. 2000-05-09. PMID:10721032. |
examples of such long-term alterations of the 5-ht-output pattern in distant projection fields of the raphe-neurons are the downregulation of cortical serotonin-transporters after long-term food restriction, the loss of serotonergic nerve terminals caused by substituted amphetamines, the serotonergic hyperinnervation of the frontal cortex seen after olfactory bulbectomy in rats, or the long lasting changes in the levels of tryptophanhydroxylase, of serotonin-transporter depression or in the density of serotonergic nerve terminals in distant projection fields caused by long-term antidepressant treatments. |
2000-05-09 |
2023-08-12 |
rat |
| M Hansenne, M Anssea. P300 event-related potential and serotonin-1A activity in depression. European psychiatry : the journal of the Association of European Psychiatrists. vol 14. issue 3. 2000-05-02. PMID:10572339. |
since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the p300 event-related brain potential and serotonergic activity in depression. |
2000-05-02 |
2023-08-12 |
Not clear |
| R M Hirschfel. History and evolution of the monoamine hypothesis of depression. The Journal of clinical psychiatry. vol 61 Suppl 6. 2000-04-26. PMID:10775017. |
this finding led to the adoption of the monoamine hypothesis of depression, first put forward over 30 years ago, which proposes that the underlying biological or neuroanatomical basis for depression is a deficiency of central noradrenergic and/or serotonergic systems and that targeting this neuronal lesion with an antidepressant would tend to restore normal function in depressed patients. |
2000-04-26 |
2023-08-12 |
Not clear |
| R M Hirschfel. History and evolution of the monoamine hypothesis of depression. The Journal of clinical psychiatry. vol 61 Suppl 6. 2000-04-26. PMID:10775017. |
still, the monoamine hypothesis does not address key issues such as why antidepressants are also effective in other disorders such as panic disorder, obsessive-compulsive disorder, and bulimia, or why all drugs that enhance serotonergic or noradrenergic transmission are not necessarily effective in depression. |
2000-04-26 |
2023-08-12 |
Not clear |
| B E Leonar. Evidence for a biochemical lesion in depression. The Journal of clinical psychiatry. vol 61 Suppl 6. 2000-04-26. PMID:10775019. |
there is therefore substantial clinical and experimental evidence that lesions in the serotonergic and noradrenergic systems are responsible for depression and that antidepressant treatment can reverse these alterations. |
2000-04-26 |
2023-08-12 |
Not clear |
| L Matzen, C van Amsterdam, W Rautenberg, H E Greiner, J Harting, C A Seyfried, H Böttche. 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants. Journal of medicinal chemistry. vol 43. issue 6. 2000-04-13. PMID:10737747. |
this dual pharmacological profile should in theory lead to a pronounced enhancement in serotonergic neurotransmission and consequently to a more efficient treatment of depression. |
2000-04-13 |
2023-08-12 |
rat |