| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Hiemke, S Härtte. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacology & therapeutics. vol 85. issue 1. 2000-03-23. PMID:10674711. |
these different pharmacokinetic properties of the five ssris, especially their drug-drug interaction potential, should be considered when selecting a distinct ssri for treatment of depression or other disorders with a suggested dysfunction of the serotonergic system in the brain. |
2000-03-23 |
2023-08-12 |
Not clear |
| P L Delgado, F A Moren. Role of norepinephrine in depression. The Journal of clinical psychiatry. vol 61 Suppl 1. 2000-03-09. PMID:10703757. |
the data reviewed suggest that both noradrenergic and serotonergic systems are involved in antidepressant action, but the specific impairment that underlies depression is unclear and is likely to vary among patients. |
2000-03-09 |
2023-08-12 |
human |
| M S Cousins, G Vosmer, D H Overstreet, L S Seide. Rats selectively bred for responsiveness to 5-hydroxytryptamine(1A) receptor stimulation: differences in differential reinforcement of low rate 72-second performance and response to serotonergic drugs. The Journal of pharmacology and experimental therapeutics. vol 292. issue 1. 2000-01-27. PMID:10604936. |
because the lds and hds rats have different responses to 5-ht-acting drugs, these rats may be useful for studying the role of the serotonergic system in depression. |
2000-01-27 |
2023-08-12 |
rat |
| J C Alvarez, N Gluck, I Arnulf, P Quintin, M Leboyer, R Pecquery, J M Launay, F Perez-Diaz, O Spreux-Varoquau. Decreased platelet serotonin transporter sites and increased platelet inositol triphosphate levels in patients with unipolar depression: effects of clomipramine and fluoxetine. Clinical pharmacology and therapeutics. vol 66. issue 6. 2000-01-04. PMID:10613618. |
the central serotonergic system has been implicated in the pathophysiology of depression and in the mechanism of the action of antidepressant drugs. |
2000-01-04 |
2023-08-12 |
human |
| J C Nelso. A review of the efficacy of serotonergic and noradrenergic reuptake inhibitors for treatment of major depression. Biological psychiatry. vol 46. issue 9. 1999-12-15. PMID:10560035. |
a review of the efficacy of serotonergic and noradrenergic reuptake inhibitors for treatment of major depression. |
1999-12-15 |
2023-08-12 |
Not clear |
| S M Southwick, S Paige, C A Morgan, J D Bremner, J H Krystal, D S Charne. Neurotransmitter alterations in PTSD: catecholamines and serotonin. Seminars in clinical neuropsychiatry. vol 4. issue 4. 1999-12-13. PMID:10553029. |
evidence of serotonergic dysregulation in ptsd includes frequent symptoms of aggression, impulsivity, depression and suicidality, decreased platelet paroxetine binding, blunted prolactin response to fenfluramine, exaggerated reactivity to m-chloro-phenyl-piperazine, and clinical efficacy of serotonin reuptake inhibitors. |
1999-12-13 |
2023-08-12 |
Not clear |
| Mirtazapine--another new class of antidepressant. Drug and therapeutics bulletin. vol 37. issue 1. 1999-11-22. PMID:10562767. |
the manufacturer claims that mirtazapine is "effective in all types of depression", with "minimal serotonergic, anticholinergic and antiadrenergic side-effects", "low propensity for interactions", and lower likelihood of relapse during maintenance treatment than with amitriptyline. |
1999-11-22 |
2023-08-12 |
Not clear |
| J Wingrove, A J Bond, A J Cleare, R Sherwoo. Plasma tryptophan and trait aggression. Journal of psychopharmacology (Oxford, England). vol 13. issue 3. 1999-11-19. PMID:10512077. |
in conclusion, there is evidence for an association between high concentrations of plasma tryptophan and aggressive behaviour in men, presumably mediated by some aspect of central serotonergic function, which seems unlikely to be explained by high trait anxiety or depression. |
1999-11-19 |
2023-08-12 |
human |
| V E Dyakonova, F Schürmann, D A Sakharo. Effects of serotonergic and opioidergic drugs on escape behaviors and social status of male crickets. Die Naturwissenschaften. vol 86. issue 9. 1999-11-17. PMID:10501691. |
we suggest that serotonergic and opioid systems are involved in the dominance induced depression of escape behavior. |
1999-11-17 |
2023-08-12 |
cricket |
| A Hein. [Serotonergic dysfunction caused by social isolation. Implications for the development of aggressiveness and alcoholism]. Der Nervenarzt. vol 70. issue 9. 1999-11-15. PMID:10522245. |
dysfunction of serotonergic neurotransmission has been associated with two different psychopathological syndromes--impulsive aggressivity resulting form a lack of stimulation of the "behavior inhibition system" on the one hand and the manifestation of clinical depression and compulsive syndromes on the other. |
1999-11-15 |
2023-08-12 |
Not clear |
| R M Bagby, R D Levitan, S H Kennedy, A J Levitt, R T Joff. Selective alteration of personality in response to noradrenergic and serotonergic antidepressant medication in depressed sample: evidence of non-specificity. Psychiatry research. vol 86. issue 3. 1999-10-21. PMID:10482340. |
thus, while antidepressants may have a direct effect on neurochemical pathways relevant to personality, independent of changes in depression severity, these effects cannot be directly or specifically attributed to a serotonergic mechanism. |
1999-10-21 |
2023-08-12 |
Not clear |
| G Juckel, A Mendlin, B L Jacob. Electrical stimulation of rat medial prefrontal cortex enhances forebrain serotonin output: implications for electroconvulsive therapy and transcranial magnetic stimulation in depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 3. 1999-10-19. PMID:10457536. |
decreased activity of the prefrontal cortex (pfc), as well as reduced serotonergic neurotransmission, is considered as a characteristic feature of major depression. |
1999-10-19 |
2023-08-12 |
rat |
| A Degl'Innocenti, H Agren, O Zachrisson, L Bäckma. The influence of prolactin response to d-fenfluramine on executive functioning in major depression. Biological psychiatry. vol 46. issue 4. 1999-10-14. PMID:10459401. |
the main purpose of this study was to assess the influence of serotonergic activity, as measured by prolactin response to d-fenfluramine, on executive functioning in major depression. |
1999-10-14 |
2023-08-12 |
Not clear |
| R Ramasubbu, A Flint, G Brown, G Awad, S Kenned. A neuroendocrine study of serotonin function in depressed stroke patients compared to non depressed stroke patients and healthy controls. Journal of affective disorders. vol 52. issue 1-3. 1999-09-17. PMID:10357025. |
we employed a neuroendocrine challenge paradigm to study serotonergic abnormalities associated with poststroke depression. |
1999-09-17 |
2023-08-12 |
Not clear |
| P Rosel, B Arranz, J Vallejo, P Alvarez, J M Menchon, T Palencia, M A Navarr. Altered [3H]imipramine and 5-HT2 but not [3H]paroxetine binding sites in platelets from depressed patients. Journal of affective disorders. vol 52. issue 1-3. 1999-09-17. PMID:10357037. |
serotonergic system alterations were studied in 51 depressed patients classified according to dsm-iii-r criteria for major depression with melancholia compared to 31 healthy controls. |
1999-09-17 |
2023-08-12 |
Not clear |
| J J Man. Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432495. |
role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. |
1999-09-17 |
2023-08-12 |
Not clear |
| C Scorza, R Silveira, D E Nichols, M Reyes-Parad. Effects of 5-HT-releasing agents on the extracellullar hippocampal 5-HT of rats. Implications for the development of novel antidepressants with a short onset of action. Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428424. |
based on evidence showing that an acute enhancement of 5-ht neurotransmission might result in the rapid appearance of therapeutic effects of serotonergic antidepressants, we suggest that mta and mmai might serve as leads for a novel family of compounds with a short onset of action useful for treating depression. |
1999-09-03 |
2023-08-12 |
rat |
| B H Zorn, H Montgomery, K Pieper, M Gray, W D Steer. Urinary incontinence and depression. The Journal of urology. vol 162. issue 1. 1999-07-19. PMID:10379745. |
serotonergic neuronal systems have been implicated in anxiety and depression. |
1999-07-19 |
2023-08-12 |
Not clear |
| S Romano, R Judge, J Dillon, C Shuler, K Sundel. The role of fluoxetine in the treatment of premenstrual dysphoric disorder. Clinical therapeutics. vol 21. issue 4. 1999-07-13. PMID:10363729. |
although the etiology of pmdd is unknown, symptoms of dysphoria, including depression and anxiety, predominate and indicate a link to serotonergic neurotransmission. |
1999-07-13 |
2023-08-12 |
Not clear |
| J Deltito, D Beye. The scientific, quasi-scientific and popular literature on the use of St. John's Wort in the treatment of depression. Journal of affective disorders. vol 51. issue 3. 1999-06-28. PMID:10333988. |
actually, little is known about the putative mechanism of action of hypericum in depression; if indeed it does involve serotonergic mechanisms or monoamine-oxidase inhibition, it invites caution with concurrent use with an ssri and, of course, with a maoi. |
1999-06-28 |
2023-08-12 |
Not clear |