| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J K Staley, R T Malison, R B Inni. Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression. Biological psychiatry. vol 44. issue 7. 1999-01-06. PMID:9787877. |
with the rapid development of novel pet and spect radiotracers, future studies of the serotonergic system that evaluate presynaptic (5-ht transporter) and postsynaptic (5-ht1a and 5-ht2a receptors) markers and the interaction of synaptic levels of 5-ht with these sites will make profound contributions to the understanding of the role of the serotonergic synapse in the pathophysiology of depression. |
1999-01-06 |
2023-08-12 |
human |
| A J Cleare, R M Murray, V O'Kean. Assessment of serotonergic function in major depression using d-fenfluramine: relation to clinical variables and antidepressant response. Biological psychiatry. vol 44. issue 7. 1999-01-06. PMID:9787879. |
assessment of serotonergic function in major depression using d-fenfluramine: relation to clinical variables and antidepressant response. |
1999-01-06 |
2023-08-12 |
human |
| A J Cleare, R M Murray, V O'Kean. Assessment of serotonergic function in major depression using d-fenfluramine: relation to clinical variables and antidepressant response. Biological psychiatry. vol 44. issue 7. 1999-01-06. PMID:9787879. |
d-fenfluramine, a specific serotonin (5-ht)-releasing agent without the catecholamine effects of d,l-fenfluramine, was used as a serotonergic neuroendocrine challenge in subjects with unipolar major depression. |
1999-01-06 |
2023-08-12 |
human |
| M H Baumann, R B Rothma. Alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to major depression in humans. Biological psychiatry. vol 44. issue 7. 1999-01-06. PMID:9787882. |
alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to major depression in humans. |
1999-01-06 |
2023-08-12 |
rat |
| K Neiswanger, G S Zubenko, D E Giles, E Frank, D J Kupfer, B B Kapla. Linkage and association analysis of chromosomal regions containing genes related to neuroendocrine or serotonin function in families with early-onset, recurrent major depression. American journal of medical genetics. vol 81. issue 5. 1998-12-15. PMID:9754632. |
we genotyped the members of 16 families identified by probands with early onset (< or = 25 years), recurrent unipolar, major depression for 38 simple sequence tandem repeat polymorphisms (sstrps) from chromosomal regions containing 12 genes involved in neuroendocrine or serotonergic functioning. |
1998-12-15 |
2023-08-12 |
Not clear |
| D S Charne. Monoamine dysfunction and the pathophysiology and treatment of depression. The Journal of clinical psychiatry. vol 59 Suppl 14. 1998-12-02. PMID:9818625. |
alterations in noradrenergic and serotonergic function in the central nervous system (cns) have been implicated in the pathophysiology of depression and the mechanism of action of antidepressant drugs. |
1998-12-02 |
2023-08-12 |
Not clear |
| C Lestra, T d'Amato, C Ghaemmaghami, A Perret-Liaudet, M Broyer, B Renaud, J Dalery, G Chamb. Biological parameters in major depression: effects of paroxetine, viloxazine, moclobemide, and electroconvulsive therapy. Relation to early clinical outcome. Biological psychiatry. vol 44. issue 4. 1998-11-12. PMID:9715359. |
clinical and pharmacologic studies report a relative or absolute serotonergic deficiency in major depression; however, the variability of clinical characteristics of illness has led to controversial results. |
1998-11-12 |
2023-08-12 |
Not clear |
| S Ruhrmann, S Kasper, B Hawellek, B Martinez, G Höflich, T Nickelsen, H J Mölle. Effects of fluoxetine versus bright light in the treatment of seasonal affective disorder. Psychological medicine. vol 28. issue 4. 1998-11-02. PMID:9723147. |
disturbances of serotonergic neurotransmission appear to be particularly important for the pathophysiology of winter depression. |
1998-11-02 |
2023-08-12 |
Not clear |
| M J Espey, H J Du, J W Downi. Serotonergic modulation of spinal ascending activity and sacral reflex activity evoked by pelvic nerve stimulation in cats. Brain research. vol 798. issue 1-2. 1998-09-11. PMID:9666094. |
a potential mechanism of action for serotonergic inhibition of bladder function is a depression of the ascending limb of the supraspinal reflex mediating micturition. |
1998-09-11 |
2023-08-12 |
Not clear |
| E Seifritz, J C Gillin, M H Rapaport, J R Kelsoe, T Bhatti, S M Stah. Sleep electroencephalographic response to muscarinic and serotonin1A receptor probes in patients with major depression and in normal controls. Biological psychiatry. vol 44. issue 1. 1998-09-02. PMID:9646880. |
to test the hypothesis that depression is associated with an increased ratio of cholinergic to serotonergic neurotransmission, we compared the effects of pilocarpine, a muscarinic agonist, and ipsapirone, a serotonin (5-ht)1a agonist, on electroencephalographic (eeg) sleep in depressed and healthy subjects. |
1998-09-02 |
2023-08-12 |
human |
| D H Overstreet, L C Daws, G D Schiller, J Orbach, D S Janowsk. Cholinergic/serotonergic interactions in hypothermia: implications for rat models of depression. Pharmacology, biochemistry, and behavior. vol 59. issue 4. 1998-06-26. PMID:9586831. |
the flinders sensitive line (fsl) rat, a genetic animal model of depression derived for cholinergic supersensitivity, is more sensitive to both cholinergic and serotonergic agonists, and exhibits exaggerated immobility in the forced swim test relative to the control, flinders resistant line (frl), rat. |
1998-06-26 |
2023-08-12 |
rat |
| C A Stockmeie. Neurobiology of serotonin in depression and suicide. Annals of the New York Academy of Sciences. vol 836. 1998-06-24. PMID:9616801. |
however, a clear picture of serotonergic abnormalities has not emerged from postmortem studies of depression and suicide. |
1998-06-24 |
2023-08-12 |
human |
| C A Stockmeie. Neurobiology of serotonin in depression and suicide. Annals of the New York Academy of Sciences. vol 836. 1998-06-24. PMID:9616801. |
in suicide victims with major depression and psychiatrically normal control subjects, we have examined various indices of serotonergic neurotransmission in axonal projection areas such as prefrontal cortex and hippocampus, and cell bodies of origin within the dorsal raphe nucleus (dr). |
1998-06-24 |
2023-08-12 |
human |
| C C Meltzer, G Smith, S T DeKosky, B G Pollock, C A Mathis, R Y Moore, D J Kupfer, C F Reynold. Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 6. 1998-06-23. PMID:9571651. |
extensive evidence implicates a deficit in serotonergic neurotransmission in the development of major depression. |
1998-06-23 |
2023-08-12 |
human |
| L E Rueter, C De Montigny, P Blie. Electrophysiological characterization of the effect of long-term duloxetine administration on the rat serotonergic and noradrenergic systems. The Journal of pharmacology and experimental therapeutics. vol 285. issue 2. 1998-06-08. PMID:9580577. |
therefore, this study demonstrates that duloxetine increases serotonergic tone in a limbic forebrain structure and may therefore be effective in the treatment of depression. |
1998-06-08 |
2023-08-12 |
rat |
| J D Flory, J J Mann, S B Manuck, M F Muldoo. Recovery from major depression is not associated with normalization of serotonergic function. Biological psychiatry. vol 43. issue 5. 1998-05-05. PMID:9513746. |
recovery from major depression is not associated with normalization of serotonergic function. |
1998-05-05 |
2023-08-12 |
Not clear |
| A J Cleare, R M Murray, V O'Kean. Do noradrenergic reuptake inhibitors affect serotonergic function in depression? Psychopharmacology. vol 134. issue 4. 1998-03-17. PMID:9452184. |
do noradrenergic reuptake inhibitors affect serotonergic function in depression? |
1998-03-17 |
2023-08-12 |
human |
| A J Cleare, R M Murray, V O'Kean. Do noradrenergic reuptake inhibitors affect serotonergic function in depression? Psychopharmacology. vol 134. issue 4. 1998-03-17. PMID:9452184. |
d-fenfluramine, a specific 5-ht releasing agent without the catecholamine effects of d,l-fenfluramine, was used as a serotonergic neuroendocrine challenge in subjects with unipolar major depression. |
1998-03-17 |
2023-08-12 |
human |
| A Dubini, M Bosc, V Poli. Noradrenaline-selective versus serotonin-selective antidepressant therapy: differential effects on social functioning. Journal of psychopharmacology (Oxford, England). vol 11. issue 4 Suppl. 1998-02-26. PMID:9438229. |
in conclusion, while social motivation and behaviour in depression are significantly affected by both noradrenergic and serotonergic antidepressant treatment, noradrenergic therapy seems particularly effective in improving negative self-perception and motivation towards action, resulting in a better quality of remission in terms of social functioning. |
1998-02-26 |
2023-08-12 |
Not clear |
| T D Geracioti, P T Loosen, N N Ekhator, D Schmidt, B Chambliss, D G Baker, J W Kasckow, N M Richtand, P E Keck, M H Eber. Uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling. Depression and anxiety. vol 6. issue 3. 1998-02-24. PMID:9442982. |
uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling. |
1998-02-24 |
2023-08-12 |
human |