| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Mongeau, P Blier, C de Montign. The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments. Brain research. Brain research reviews. vol 23. issue 3. 1997-07-16. PMID:9164669. |
this review focuses on the effects of distinct classes of antidepressant treatments on the serotonergic and the noradrenergic systems of the hippocampus, which is one of the brain limbic areas thought to be relevant in depression: it illustrates the complexity of action of these treatments in a single brain area. |
1997-07-16 |
2023-08-12 |
Not clear |
| S Kaspe. Efficacy of antidepressants in the treatment of severe depression: the place of mirtazapine. Journal of clinical psychopharmacology. vol 17 Suppl 1. 1997-06-19. PMID:9090574. |
mirtazapine, a noradrenergic and specific serotonergic antidepressant, displays comparable antidepressant efficacy to clomipramine and amitriptyline in severe depression and seems to be a useful option in this patient population. |
1997-06-19 |
2023-08-12 |
Not clear |
| P D Hrdina, D Bakish, A Ravindran, J Chudzik, P Cavazzoni, Y D Lapierr. Platelet serotonergic indices in major depression: up-regulation of 5-HT2A receptors unchanged by antidepressant treatment. Psychiatry research. vol 66. issue 2-3. 1997-06-12. PMID:9075272. |
platelet serotonergic indices in major depression: up-regulation of 5-ht2a receptors unchanged by antidepressant treatment. |
1997-06-12 |
2023-08-12 |
human |
| P D Hrdina, D Bakish, A Ravindran, J Chudzik, P Cavazzoni, Y D Lapierr. Platelet serotonergic indices in major depression: up-regulation of 5-HT2A receptors unchanged by antidepressant treatment. Psychiatry research. vol 66. issue 2-3. 1997-06-12. PMID:9075272. |
this study examined, in the largest sample of major depressives reported so far, platelet serotonergic parameters (5-ht uptake, [3h]paroxetine binding and 5-ht2a receptors measured by [3h]lsd binding) in 60 antidepressant-free depressed patients and 40 age- and gender-matched control subjects before treatment, and in 45 major depression patients during treatment with antidepressants. |
1997-06-12 |
2023-08-12 |
human |
| W Kuhn, T Müller, M Gerlach, E Sofic, G Fuchs, N Heye, R Prautsch, H Przunte. Depression in Parkinson's disease: biogenic amines in CSF of "de novo" patients. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 12. 1997-05-15. PMID:9029411. |
etiology of depression in parkinson's disease (pd) is associated with serotonergic dysfunction. |
1997-05-15 |
2023-08-12 |
Not clear |
| M Wielos. [The role of serotonergic system in the mechanism of action of antidepressant agents]. Psychiatria polska. vol 30. issue 6. 1997-04-29. PMID:9132770. |
thirty eight years after the successful clinical introduction of antidepressant agents, there has been an important progress in the knowledge and changes in thinking about the role of central serotonergic system in depression and in the mechanism of their therapeutic efficacy. |
1997-04-29 |
2023-08-12 |
Not clear |
| J J Mann, K M Malon. Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biological psychiatry. vol 41. issue 2. 1997-04-02. PMID:9018386. |
previous studies have found that not all suicide attempters with major depression have reduced serotonergic activity based on low cerebrospinal fluid 5-hydroxyindoleacetic acid (csf- 5-hiaa) levels. |
1997-04-02 |
2023-08-12 |
Not clear |
| J J Mann, K M Malon. Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biological psychiatry. vol 41. issue 2. 1997-04-02. PMID:9018386. |
low serotonergic activity may correlate with a predisposition to more lethal suicide attempts in major depression. |
1997-04-02 |
2023-08-12 |
Not clear |
| T A Slotkin, E C McCook, J C Ritchie, B J Carroll, F J Seidle. Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects. Biological psychiatry. vol 41. issue 2. 1997-04-02. PMID:9018387. |
hyperactivity of the hypothalamus-pituitary-adrenal axis is more common in elderly depression than in younger cohorts and glucocorticoids are known to influence serotonergic systems. |
1997-04-02 |
2023-08-12 |
rat |
| J F Neumaier, D C Root, M W Hambli. Chronic fluoxetine reduces serotonin transporter mRNA and 5-HT1B mRNA in a sequential manner in the rat dorsal raphe nucleus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 5. 1997-03-14. PMID:8914125. |
in major depression in humans and in animal models of depression, there is a defect in serotonergic neurotransmission that can be relieved by chronic antidepressant treatment. |
1997-03-14 |
2023-08-12 |
rat |
| A González-Pinto, J J López Ibor, J Sáiz, M Gutiérrez, J L Figuerido, M J García Godo. [The clomipramine test and subtypes of depression]. Actas luso-espanolas de neurologia, psiquiatria y ciencias afines. vol 24. issue 6. 1997-03-12. PMID:9054201. |
neuroendocrine challenge paradigms have been used to assess serotonergic system in depression but limitations in the specificity of many of these tests have been noted. |
1997-03-12 |
2023-08-12 |
human |
| T A Slotkin, E C McCook, J C Ritchie, F J Seidle. Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model. Biological psychiatry. vol 40. issue 7. 1997-02-21. PMID:8886290. |
adrenocorticosteroids and serotonergic neurons exert reciprocal regulatory actions, and both are abnormal in depression. |
1997-02-21 |
2023-08-12 |
rat |
| b' V S Kosti\\xc4\\x87, D Leci\\xc4\\x87, M Doder, J Marinkovi\\xc4\\x87, S Filipovi\\xc4\\x8. Prolactin and cortisol responses to fenfluramine in Parkinson\'s disease. Biological psychiatry. vol 40. issue 8. 1997-02-21. PMID:8894070.' |
dysfunction of the central serotonergic system has been associated with depression in parkinson's disease. |
1997-02-21 |
2023-08-12 |
Not clear |
| b' V S Kosti\\xc4\\x87, D Leci\\xc4\\x87, M Doder, J Marinkovi\\xc4\\x87, S Filipovi\\xc4\\x8. Prolactin and cortisol responses to fenfluramine in Parkinson\'s disease. Biological psychiatry. vol 40. issue 8. 1997-02-21. PMID:8894070.' |
to evaluate central serotonergic function in parkinson's disease in relation to depression, we examined prolactin and cortisol responses to a single-dose challenge with fenfluramine (60 mg orally), a serotonin releasing/uptake-inhibiting agent, in the course of 5 hours in 11 patients with parkinson's disease associated with major depression (sads-rdc), 22 nondepressed parkinsonians, and 20 age- and gender-matched healthy controls. |
1997-02-21 |
2023-08-12 |
Not clear |
| b' V S Kosti\\xc4\\x87, D Leci\\xc4\\x87, M Doder, J Marinkovi\\xc4\\x87, S Filipovi\\xc4\\x8. Prolactin and cortisol responses to fenfluramine in Parkinson\'s disease. Biological psychiatry. vol 40. issue 8. 1997-02-21. PMID:8894070.' |
these findings indicate that there is a diminished serotonergic responsivity in depression associated with parkinson's disease. |
1997-02-21 |
2023-08-12 |
Not clear |
| F Fumagalli, S R Jones, M G Caron, F J Seidler, T A Slotki. Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids. Brain research. vol 719. issue 1-2. 1997-02-04. PMID:8782886. |
adrenocortical dysregulation is common in elderly depression; our results suggest that glucocorticoids interact with aging to exacerbate abnormalities of serotonergic function, contributing to reduced antidepressant effectiveness. |
1997-02-04 |
2023-08-12 |
rat |
| D F Papolos, Y M Yu, E Rosenbaum, H M Lachma. Modulation of learned helplessness by 5-hydroxytryptamine2A receptor antisense oligodeoxynucleotides. Psychiatry research. vol 63. issue 2-3. 1997-01-16. PMID:8878316. |
serotonergic systems have been implicated in the pathogenesis of major depression in humans as well as in learned helplessness (lh), an animal model of depression. |
1997-01-16 |
2023-08-12 |
rat |
| D F Papolos, Y M Yu, E Rosenbaum, H M Lachma. Modulation of learned helplessness by 5-hydroxytryptamine2A receptor antisense oligodeoxynucleotides. Psychiatry research. vol 63. issue 2-3. 1997-01-16. PMID:8878316. |
these data support the view that central 5ht, mediated by the 5ht2a receptor, participates in regulating behaviors that are affected by inescapable stress, and that the induction of behavioral depression may be specifically regulated via serotonergic pathways that terminate in this hippocampal subfield. |
1997-01-16 |
2023-08-12 |
rat |
| H H Berendsen, R C Kester, B W Peeters, C L Broekkam. Modulation of 5-HT receptor subtype-mediated behaviours by corticosterone. European journal of pharmacology. vol 308. issue 2. 1997-01-15. PMID:8840120. |
malfunction of the serotonergic system and dysregulation of the hypothalamo-pituitary-adrenocortical axis have been implicated in the pathophysiology of depression. |
1997-01-15 |
2023-08-12 |
rat |
| G E Ruof. Depression in the patient with chronic pain. The Journal of family practice. vol 43. issue 6 Suppl. 1997-01-15. PMID:8969710. |
regardless of their etiology, evidence exists to suggest that depression and chronic pain share common biologic pathways, namely, the serotonergic (5-ht) and noradrenergic systems. |
1997-01-15 |
2023-08-12 |
Not clear |