| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J McGrath, J W Stewart, F M Quitkin, S Wager, S W Jenkins, D G Archibald, J C Stringfellow, D S Robinso. Gepirone treatment of atypical depression: preliminary evidence of serotonergic involvement. Journal of clinical psychopharmacology. vol 14. issue 5. 1995-02-01. PMID:7806692. |
gepirone is a novel antidepressant that holds promise for the treatment of atypical depression and that may be of heuristic value because of its relatively specific actions on the serotonergic system. |
1995-02-01 |
2023-08-12 |
Not clear |
| C D Kilt. Recent pharmacologic advances in antidepressant therapy. The American journal of medicine. vol 97. issue 6A. 1995-01-11. PMID:7992824. |
the serotonergic properties of newer generation antidepressants underscore the role of 5-hydroxytryptamine (5-ht, serotonin) in both the pathophysiology and the pharmacotherapy of major depression. |
1995-01-11 |
2023-08-12 |
Not clear |
| G Spurlock, P Buckland, M O'Donovan, P McGuffi. Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984281. |
serotonergic transmission is thought to be central to the aetiology of depression and the therapeutic actions of antidepressant drugs, and the latters' delayed effect has given rise to the hypothesis that an adaptive change may be involved, possibly at the level of gene expression. |
1994-12-30 |
2023-08-12 |
rat |
| C B Nemeroff, D L Knight, J Franks, W E Craighead, K R Krishna. Further studies on platelet serotonin transporter binding in depression. The American journal of psychiatry. vol 151. issue 11. 1994-11-15. PMID:7943450. |
there is an impressive literature implicating abnormalities in serotonergic neural systems in depression. |
1994-11-15 |
2023-08-12 |
human |
| L Kubin, C Reignier, H Tojima, O Taguchi, A I Pack, R O Davie. Changes in serotonin level in the hypoglossal nucleus region during carbachol-induced atonia. Brain research. vol 645. issue 1-2. 1994-09-21. PMID:7520343. |
the levels of 5ht and its metabolite, 5-hydroxyindoleacetic acid (5hiaa), were determined using hplc and electrochemical detection in dialysate samples collected over successive 20 min periods under four successive experimental conditions: control (at least 2 h after probe insertion); during the postural atonia and respiratory depression produced by pontine microinjection of carbachol; recovery from the effects of carbachol produced by pontine microinjection of atropine; and, to verify that the presence of 5ht in the dialysate was related to the activity of serotonergic cells of the brainstem, following administration of 8-oh-dpat, a 5ht 1a receptor agonist known to suppress activity in the serotonergic cells of the raphe system. |
1994-09-21 |
2023-08-12 |
Not clear |
| U Lepol. Alcohol and depression in panic disorder. Acta psychiatrica Scandinavica. Supplementum. vol 377. 1994-09-06. PMID:7914395. |
serotonergic medications are effective in treating pd and depression. |
1994-09-06 |
2023-08-12 |
Not clear |
| M A Menza, M H Mar. Parkinson's disease and depression: the relationship to disability and personality. The Journal of neuropsychiatry and clinical neurosciences. vol 6. issue 2. 1994-08-31. PMID:8044039. |
harm avoidance, a trait related to central serotonergic systems, was, however, correlated with depression (p < 0.001) and explained 31% of the variance in depression scores. |
1994-08-31 |
2023-08-12 |
human |
| M A Menza, M H Mar. Parkinson's disease and depression: the relationship to disability and personality. The Journal of neuropsychiatry and clinical neurosciences. vol 6. issue 2. 1994-08-31. PMID:8044039. |
results support the hypotheses that both physiologic and psychologic factors contribute to depression seen in these patients and that serotonergic function plays a more critical role than dopaminergic function. |
1994-08-31 |
2023-08-12 |
human |
| Y Okamoto, N Motohashi, H Hayakawa, O Kikumoto, K Kawai, A J Tanra, A Nishida, S Yamawak. [Studies on lithium potentiation of antidepressant treatment]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 14. issue 1. 1994-08-26. PMID:8048278. |
it is speculated that the therapeutic action of li when added to tricyclic antidepressants in the treatment of refractory depression may partly have its basis in potentiation of effects on the activation of presynaptic serotonergic system. |
1994-08-26 |
2023-08-12 |
rat |
| T J Riedlinger, J E Riedlinge. Psychedelic and entactogenic drugs in the treatment of depression. Journal of psychoactive drugs. vol 26. issue 1. 1994-08-09. PMID:7913128. |
existing drug modalities for treating depression include some with serotonergic effects. |
1994-08-09 |
2023-08-12 |
Not clear |
| G S Waterman, R E Dahl, B Birmaher, P Ambrosini, H Rabinovich, D Williamson, H Novacenko, B Nelson, J Puig-Antich, N D Rya. The 24-hour pattern of prolactin secretion in depressed and normal adolescents. Biological psychiatry. vol 35. issue 7. 1994-08-04. PMID:8018794. |
these findings are discussed in the context of changes in prolactin in childhood depression using a serotonergic challenge study, as well as in relation to baseline prolactin studies in adult depression. |
1994-08-04 |
2023-08-12 |
Not clear |
| S J Weiner, T N Ward, C L Ravari. Headache and electroconvulsive therapy. Headache. vol 34. issue 3. 1994-07-07. PMID:8200790. |
studies of the mechanisms of ect as a treatment for depression indicate that alterations in serotonergic neurotransmission appear to be related to its efficacy. |
1994-07-07 |
2023-08-12 |
Not clear |
| A Eckert, H Gann, D Riemann, J Aldenhoff, W E Mülle. Platelet and lymphocyte free intracellular calcium in affective disorders. European archives of psychiatry and clinical neuroscience. vol 243. issue 5. 1994-06-09. PMID:8172937. |
1991b) about elevated [ca2+]i after serotonin stimulation in platelets of depressed patients was interpreted as further evidence for enhanced serotonergic sensitivity in depression. |
1994-06-09 |
2023-08-12 |
Not clear |
| A Eckert, H Gann, D Riemann, J Aldenhoff, W E Mülle. Platelet and lymphocyte free intracellular calcium in affective disorders. European archives of psychiatry and clinical neuroscience. vol 243. issue 5. 1994-06-09. PMID:8172937. |
together with the observations of an enhanced ca2+ response in platelets after thrombin stimulation, we speculate that the findings rather suggest alterations of [ca2+]i regulation in depression than specific changes of serotonergic sensitivity. |
1994-06-09 |
2023-08-12 |
Not clear |
| B Shapira, M Newman, B Lere. Serotonergic mechanisms in depression: clinical insights and biological correlates. Israel journal of medical sciences. vol 30. issue 2. 1994-05-10. PMID:8150605. |
serotonergic mechanisms in depression: clinical insights and biological correlates. |
1994-05-10 |
2023-08-12 |
Not clear |
| D J Hellerstein, P Yanowitch, J Rosenthal, C Hemlock, K Kasch, L W Samstag, A Winsto. Long-term treatment of double depression: a preliminary study with serotonergic antidepressants. Progress in neuro-psychopharmacology & biological psychiatry. vol 18. issue 1. 1994-03-31. PMID:8115668. |
long-term treatment of double depression: a preliminary study with serotonergic antidepressants. |
1994-03-31 |
2023-08-12 |
Not clear |
| M D Johnso. Synaptic glutamate release by postnatal rat serotonergic neurons in microculture. Neuron. vol 12. issue 2. 1994-03-29. PMID:7906530. |
serotonergic neurons are thought to play a role in depression and obsessive compulsive disorder. |
1994-03-29 |
2023-08-12 |
rat |
| M J Owens, C B Nemerof. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clinical chemistry. vol 40. issue 2. 1994-03-24. PMID:7508830. |
considerable evidence has accrued in the last two decades to support the hypothesis that alterations in serotonergic neuronal function in the central nervous system occur in patients with major depression. |
1994-03-24 |
2023-08-12 |
Not clear |
| J E Myers, D J Buysse, M E Thase, J Perel, J M Miewald, T B Cooper, D J Kupfer, J J Man. The effects of fenfluramine on sleep and prolactin in depressed inpatients: a comparison of potential indices of brain serotonergic responsivity. Biological psychiatry. vol 34. issue 11. 1994-03-03. PMID:8292678. |
these effects on sleep electroencephalogram (eeg) did not correlate significantly with another measure of serotonergic responsivity, namely peak prolactin level following fenfluramine, nor with the severity of depression. |
1994-03-03 |
2023-08-12 |
Not clear |
| J R Cornelius, I M Salloum, M D Cornelius, J M Perel, M E Thase, J G Ehler, J J Man. Fluoxetine trial in suicidal depressed alcoholics. Psychopharmacology bulletin. vol 29. issue 2. 1994-02-23. PMID:8290665. |
the selective serotonergic agonist fluoxetine has demonstrated efficacy in the treatment of depression and has suggested efficacy in the treatment of alcoholism. |
1994-02-23 |
2023-08-12 |
Not clear |