| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J Haleem, A Yasmeen, M A Haleem, A Zafa. 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. Life sciences. vol 57. issue 19. 1995-12-15. PMID:7475912. |
the findings are discussed as repeated caffeine administration producing adaptive changes in the serotonergic neurons to decrease the conversion of tryptophan to 5-ht and this may precipitate depression particularly in conditions of caffeine withdrawal. |
1995-12-15 |
2023-08-12 |
rat |
| J J López-Ibor Aliño, J Saiz Ruiz, M I López-Ibor Alcocer, R Viñas Pifarr. [Obsessive-compulsive disorder and depression]. Actas luso-espanolas de neurologia, psiquiatria y ciencias afines. vol 23. issue 3. 1995-09-20. PMID:7544059. |
ocd patients not fulfilling diagnostic criteria for depression have an exaggerated response to a serotonergic challenge, measured by the increase in prl, cor and gh plasma concentrations when compared to controls. |
1995-09-20 |
2023-08-12 |
Not clear |
| D Baldwin, S Rudg. The role of serotonin in depression and anxiety. International clinical psychopharmacology. vol 9 Suppl 4. 1995-08-31. PMID:7622823. |
recent research has identified that various abnormalities in serotonergic function are involved in the pathogenesis of depression and anxiety, and has facilitated the development of new pharmacological agents with great therapeutic potential, for example the selective serotonin reuptake inhibitors (ssris). |
1995-08-31 |
2023-08-12 |
Not clear |
| D Baldwin, S Rudg. The role of serotonin in depression and anxiety. International clinical psychopharmacology. vol 9 Suppl 4. 1995-08-31. PMID:7622823. |
as the central serotonergic system continues to be "mapped", newer and more selective drugs are likely to be introduced, thereby possibly improving the overall successful management of depression and anxiety disorders. |
1995-08-31 |
2023-08-12 |
Not clear |
| M Bijak, M Pap. The effect of chronic treatment with imipramine on the responsiveness of hippocampal CA1 neurons to phenylephrine and serotonin in a chronic mild stress model of depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 5. issue 1. 1995-08-24. PMID:7613100. |
these results suggest that the imipramine-induced functional changes in alpha 1-noradrenergic and serotonergic receptors in the hippocampus are not involved in the anti-anhedonic effect of chronic imipramine administration in the cms model of depression. |
1995-08-24 |
2023-08-12 |
rat |
| L Rampello, G Nicoletti, R Raffaele, F Drag. Comparative effects of amitriptyline and amineptine in patients affected by anxious depression. Neuropsychobiology. vol 31. issue 3. 1995-08-17. PMID:7609861. |
the present results suggest that alterations in serotonergic rather than dopaminergic transmission contribute to the pathophysiology of anxious depression. |
1995-08-17 |
2023-08-12 |
Not clear |
| U Scheffel, R F Dannals, M Suehiro, G A Ricaurte, F I Carroll, M J Kuhar, H N Wagne. Development of PET/SPECT ligands for the serotonin transporter. NIDA research monograph. vol 138. 1995-08-10. PMID:7603538. |
moreover, these radioligands would allow the study of serotonergic function in the normal living human brain, and they also would be useful in the examination of altered serotonergic neurotransmission in diseases such as depression and obsessive-compulsive and other neuropsychiatric disorders. |
1995-08-10 |
2023-08-12 |
human |
| Y I Sheline, M E Bardgett, J L Jackson, J W Newcomer, J G Csernansk. Platelet serotonin markers and depressive symptomatology. Biological psychiatry. vol 37. issue 7. 1995-07-27. PMID:7786957. |
dysfunction of brain serotonergic symptoms may be a factor in the mood and behavioral disturbances associated with depression. |
1995-07-27 |
2023-08-12 |
Not clear |
| E Le Poul, L Lima, A M Laporte, C Even, E Doucet, C M Fattaccini, N Laaris, M Hamon, L Lanfume. [Central serotonin receptors and chronic treatment with selective serotonin reuptake inhibitors in the rat: comparative effects of fluoxetine and paroxetine]. L'Encephale. vol 21. issue 2. 1995-07-20. PMID:7781583. |
the hypothesis that a dysfunction of serotonergic neurotransmission is implicated in depression is supported by the clinical efficiency of selective serotonin (5-hydroxytryptamine, 5-ht) reuptake inhibitors (ssris) in the treatment of depressive disorders. |
1995-07-20 |
2023-08-12 |
rat |
| J H Thakore, T G Dina. Cortisol synthesis inhibition: a new treatment strategy for the clinical and endocrine manifestations of depression. Biological psychiatry. vol 37. issue 6. 1995-07-07. PMID:7772644. |
this implies that hypercortisolemia may be responsible for the clinical features and serotonergic subsensitivity observed in depression. |
1995-07-07 |
2023-08-12 |
Not clear |
| C R McKittrick, D C Blanchard, R J Blanchard, B S McEwen, R R Saka. Serotonin receptor binding in a colony model of chronic social stress. Biological psychiatry. vol 37. issue 6. 1995-07-07. PMID:7772647. |
these results are discussed in the context of regulation of the serotonergic system by stress and glucocorticoids and possible relevance to the pathophysiology of depression. |
1995-07-07 |
2023-08-12 |
rat |
| M Steiner, S Steinberg, D Stewart, D Carter, C Berger, R Reid, D Grover, D Streine. Fluoxetine in the treatment of premenstrual dysphoria. Canadian Fluoxetine/Premenstrual Dysphoria Collaborative Study Group. The New England journal of medicine. vol 332. issue 23. 1995-06-08. PMID:7739706. |
premenstrual dysphoria shares certain features with depression and anxiety states, which have been linked to serotonergic dysregulation. |
1995-06-08 |
2023-08-12 |
Not clear |
| I R Bell, D Amend, A W Kaszniak, G E Schwartz, J M Peterson, W A Stini, J W Miller, J Selhu. Trait shyness in the elderly: evidence for an association with Parkinson's disease in family members and biochemical correlates. Journal of geriatric psychiatry and neurology. vol 8. issue 1. 1995-05-18. PMID:7710641. |
in parallel, (a) depression in pd patients is associated with increased harm avoidance (a possible serotonergic function), and (b) pd patients have premorbid and comorbid decreases in novelty-seeking (a possible dopaminergic function). |
1995-05-18 |
2023-08-12 |
Not clear |
| P D Hrdina, D Bakish, J Chudzik, A Ravindran, Y D Lapierr. Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors. Journal of psychiatry & neuroscience : JPN. vol 20. issue 1. 1995-03-27. PMID:7865496. |
serotonergic markers in platelets of patients with major depression: upregulation of 5-ht2 receptors. |
1995-03-27 |
2023-08-12 |
human |
| C S Aulakh, J L Hill, D L Murph. Enhanced anorexic responses to m-chlorophenylpiperazine during lithium administration to fawn-hooded rats. Pharmacology, biochemistry, and behavior. vol 49. issue 3. 1995-03-22. PMID:7862734. |
in the present study, we investigated whether functional adaptational changes in the serotonergic neurotransmitter mechanisms regulating food intake following long-term lithium treatment in fawn-hooded rats (a rat strain suggested to represent a genetic model of depression) were different or similar to those previously observed in wistar rats. |
1995-03-22 |
2023-08-12 |
rat |
| C S Aulakh, J L Hill, D L Murph. Enhanced anorexic responses to m-chlorophenylpiperazine during lithium administration to fawn-hooded rats. Pharmacology, biochemistry, and behavior. vol 49. issue 3. 1995-03-22. PMID:7862734. |
this finding contrasts with our previous report demonstrating attenuation of m-cpp-induced anorexia in wistar rats following similar long-term lithium treatment, and therefore suggests a differential adaptation in the serotonergic neurotransmitter mechanisms regulating food intake in a genetic animal model of depression. |
1995-03-22 |
2023-08-12 |
rat |
| M M Katz, J W Maas, A Frazer, S H Koslow, C L Bowden, N Berman, A C Swann, P E Stoke. Drug-induced actions on brain neurotransmitter systems and changes in the behaviors and emotions of depressed patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 11. issue 2. 1995-03-07. PMID:7530963. |
despite cumulative evidence that the tricyclic drugs result in significant changes in the functioning of brain serotonergic (5-ht) and nordrenergic (ne) systems, such changes have not been found to be associated with recovery from depression. |
1995-03-07 |
2023-08-12 |
Not clear |
| M Papp, V Klimek, P Willne. Effects of imipramine on serotonergic and beta-adrenergic receptor binding in a realistic animal model of depression. Psychopharmacology. vol 114. issue 2. 1995-02-27. PMID:7838924. |
effects of imipramine on serotonergic and beta-adrenergic receptor binding in a realistic animal model of depression. |
1995-02-27 |
2023-08-12 |
Not clear |
| M E Newman, B Lerer, P Lichtenberg, B Shapir. Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function. Psychopharmacology. vol 109. issue 1-2. 1995-02-23. PMID:1365662. |
platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function. |
1995-02-23 |
2023-08-11 |
human |
| P J McGrath, J W Stewart, F M Quitkin, S Wager, S W Jenkins, D G Archibald, J C Stringfellow, D S Robinso. Gepirone treatment of atypical depression: preliminary evidence of serotonergic involvement. Journal of clinical psychopharmacology. vol 14. issue 5. 1995-02-01. PMID:7806692. |
gepirone treatment of atypical depression: preliminary evidence of serotonergic involvement. |
1995-02-01 |
2023-08-12 |
Not clear |