| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Suwalska, J Rybakowsk. [Biological mechanisms of drug-resistant depression]. Psychiatria polska. vol 30. issue 5. 1997-01-08. PMID:8984513. |
treatment-resistant depression may result from the inability of antidepressants to normalize serotonergic transmission. |
1997-01-08 |
2023-08-12 |
Not clear |
| A Suwalska, J Rybakowsk. [Biological mechanisms of drug-resistant depression]. Psychiatria polska. vol 30. issue 5. 1997-01-08. PMID:8984513. |
efficacy of therapeutic strategies enhancing serotonergic function such as potentiation of tricyclic antidepressants with lithium or fluoxetine as well as effectiveness of selective serotonin reuptake inhibitors in drug-resistant depression may support this hypothesis. |
1997-01-08 |
2023-08-12 |
Not clear |
| K Twardowska, J Rybakowsk. [Limbic-hypothalamic-pituitary-adrenal axis in depression: literature review]. Psychiatria polska. vol 30. issue 5. 1997-01-08. PMID:8984515. |
disturbances of serotonergic and noradrenergic neurotransmission in depression may also partially result from lhpa axis dysfunction. |
1997-01-08 |
2023-08-12 |
Not clear |
| B Lerer, D Gillon, P Lichtenberg, M Gorfine, Y Gelfin, B Shapir. Interrelationship of age, depression, and central serotonergic function: evidence from fenfluramine challenge studies. International psychogeriatrics. vol 8. issue 1. 1996-12-27. PMID:8805090. |
the purpose of this study was to examine the relationship between age-associated changes in central serotonergic function and abnormalities associated with major depression. |
1996-12-27 |
2023-08-12 |
human |
| B Lerer, D Gillon, P Lichtenberg, M Gorfine, Y Gelfin, B Shapir. Interrelationship of age, depression, and central serotonergic function: evidence from fenfluramine challenge studies. International psychogeriatrics. vol 8. issue 1. 1996-12-27. PMID:8805090. |
age-related decline in central serotonergic function may make older individuals more vulnerable to depression and possibly render depressive episodes more frequent, more severe, and less amenable to treatment. |
1996-12-27 |
2023-08-12 |
human |
| J M Gorman, J D Copla. Comorbidity of depression and panic disorder. The Journal of clinical psychiatry. vol 57 Suppl 10. 1996-12-18. PMID:8917130. |
panic disorder and depression share well-defined disturbances in hypothalamic-pituitary-adrenal axis function, serotonergic neurotransmission, and growth hormone response to pharmacologic challenge. |
1996-12-18 |
2023-08-12 |
Not clear |
| Y Okamoto, N Motohasi, H Hayakawa, M Muraoka, S Yamawak. Addition of lithium to chronic antidepressant treatment potentiates presynaptic serotonergic function without changes in serotonergic receptors in the rat cerebral cortex. Neuropsychobiology. vol 33. issue 1. 1996-10-29. PMID:8821370. |
it is speculated that the therapeutic action of li when added to antidepressants in the treatment of refractory depression may partly have its basis in the further activation of the presynaptic serotonergic system. |
1996-10-29 |
2023-08-12 |
rat |
| M Hamo. [New perspectives in the serotoninergic treatment for depression]. Therapie. vol 50. issue 6. 1996-10-24. PMID:8745948. |
a great deal of data support the view that depression is frequently associated with a decrease in central serotonergic neurotransmission. |
1996-10-24 |
2023-08-12 |
Not clear |
| T G Dina. Serotonin: current understanding and the way forward. International clinical psychopharmacology. vol 11 Suppl 1. 1996-10-09. PMID:8732440. |
neuroendocrine studies suggest decreased serotonergic responsivity in patients with major depression. |
1996-10-09 |
2023-08-12 |
Not clear |
| H M Pappiu. Cortical hypometabolism in injured brain: new correlations with the noradrenergic and serotonergic systems and with behavioral deficits. Neurochemical research. vol 20. issue 11. 1996-09-25. PMID:8786817. |
this supports the hypothesis that post-injury cortical hypometabolism is a reflection of cortical functional depression in which both the serotonergic and noradrenergic neurotransmitter systems play a role, compatible with their inhibitory effects in the cortex and their postulated involvement in cortical information processing. |
1996-09-25 |
2023-08-12 |
rat |
| S Lam, Y Shen, T Nguyen, T L Messier, M Brann, D Comings, S R George, B F O'Dow. A serotonin receptor gene (5HT1A) variant found in a Tourette's syndrome patient. Biochemical and biophysical research communications. vol 219. issue 3. 1996-07-15. PMID:8645269. |
serotonergic pathway disturbances have been implicated in neuropsychiatric disorders such as tourette's syndrome (ts), substance abuse, and depression. |
1996-07-15 |
2023-08-12 |
human |
| T G Dina. Noradrenergic and serotonergic abnormalities in depression: stress-induced dysfunction? The Journal of clinical psychiatry. vol 57 Suppl 4. 1996-07-09. PMID:8636061. |
noradrenergic and serotonergic abnormalities in depression: stress-induced dysfunction? |
1996-07-09 |
2023-08-12 |
Not clear |
| T G Dina. Noradrenergic and serotonergic abnormalities in depression: stress-induced dysfunction? The Journal of clinical psychiatry. vol 57 Suppl 4. 1996-07-09. PMID:8636061. |
noradrenergic and serotonergic abnormalities have long been suspected in patients with major depression. |
1996-07-09 |
2023-08-12 |
Not clear |
| C P Chen, J T Alder, D M Bowen, M M Esiri, B McDonald, T Hope, K A Jobst, P T Franci. Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication. Journal of neurochemistry. vol 66. issue 4. 1996-06-25. PMID:8627315. |
presynaptic serotonergic markers in community-acquired cases of alzheimer's disease: correlations with depression and neuroleptic medication. |
1996-06-25 |
2023-08-12 |
human |
| G Gerra, G Fertonani, P Tagliavini, A Zaimovic, R Delsignore, D Maestri, P Avanzini, R Caccavari, F Brambill. Serotonin function in detoxified heroin abusers: prolactin and cortisol responses to fenfluramine challenge. Psychiatry research. vol 58. issue 2. 1996-03-01. PMID:8570767. |
our data suggest that the function of the serotonergic system is impaired in heroin addicts with comorbid depression but not in heroin addicts who are not clinically depressed. |
1996-03-01 |
2023-08-12 |
human |
| D A Gorard, P A Dewsnap, S H Medbak, L A Perry, G W Libby, M J Farthin. Central 5-hydroxytryptaminergic function in irritable bowel syndrome. Scandinavian journal of gastroenterology. vol 30. issue 10. 1996-02-09. PMID:8545621. |
hormonal responses after a serotonergic challenge assess the functional integrity of central 5-hydroxytryptaminergic pathways and are diminished in depression. |
1996-02-09 |
2023-08-12 |
Not clear |
| R W Lam, A P Zis, A Grewal, P L Delgado, D S Charney, J H Krysta. Effects of rapid tryptophan depletion in patients with seasonal affective disorder in remission after light therapy. Archives of general psychiatry. vol 53. issue 1. 1996-02-08. PMID:8540776. |
previous studies show that rapid tryptophan depletion reverses the effects of therapy with serotonergic, but not noradrenergic, antidepressant drugs in patients with remitted nonseasonal depression. |
1996-02-08 |
2023-08-12 |
Not clear |
| Y Gelfin, B Lerer, K P Lesch, M Gorfine, B Alloli. Complex effects of age and gender on hypothermic, adrenocorticotrophic hormone and cortisol responses to ipsapirone challenge in normal subjects. Psychopharmacology. vol 120. issue 3. 1996-01-19. PMID:8524984. |
these findings should be taken into consideration in the use of ipsapirone and other 5-ht1a agonists as challenge procedures for studying central serotonergic function in depression and other disorders. |
1996-01-19 |
2023-08-12 |
human |
| J R Cornelius, I M Salloum, M D Cornelius, J M Perel, J G Ehler, P J Jarrett, R L Levin, A Black, J J Man. Preliminary report: double-blind, placebo-controlled study of fluoxetine in depressed alcoholics. Psychopharmacology bulletin. vol 31. issue 2. 1996-01-04. PMID:7491382. |
the selective serotonergic agonist fluoxetine has demonstrated efficacy in the treatment of depression and has possible efficacy in the treatment of nondepressed and depressed alcoholics. |
1996-01-04 |
2023-08-12 |
Not clear |
| J R Cornelius, I M Salloum, M D Cornelius, J M Perel, J G Ehler, P J Jarrett, R L Levin, A Black, J J Man. Preliminary report: double-blind, placebo-controlled study of fluoxetine in depressed alcoholics. Psychopharmacology bulletin. vol 31. issue 2. 1996-01-04. PMID:7491382. |
however, no double-blind, placebo-controlled trials with any selective serotonergic medication have been reported in patients who have both major depression and alcoholism. |
1996-01-04 |
2023-08-12 |
Not clear |