| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria Arango, Mark D Underwood, J John Man. Serotonin brain circuits involved in major depression and suicide. Progress in brain research. vol 136. 2002-09-19. PMID:12143401. |
a diffuse reduction of sert binding throughout the dorsoventral extent of the pfc in major depression may reflect a widespread impairment of serotonergic function consistent with the range of psychopathology in major depression. |
2002-09-19 |
2023-08-12 |
Not clear |
| Kevin C F Fone, Ian A Topha. Alteration in 5-hydroxytryptamine agonist-induced behaviour following a corticosterone implant in adult rats. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888572. |
hypercortisolism and altered serotonergic function may account for the pathological symptoms seen in depression. |
2002-09-11 |
2023-08-12 |
rat |
| Kevin C F Fone, Ian A Topha. Alteration in 5-hydroxytryptamine agonist-induced behaviour following a corticosterone implant in adult rats. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888572. |
a comparison of the brain region-dependent alteration in serotonergic function produced by hypercorticosterone in the rat with that seen in depression is discussed. |
2002-09-11 |
2023-08-12 |
rat |
| Michael Camilleri, Elena Atanasova, Paula J Carlson, Umraan Ahmad, H Jae Kim, Blanca E Viramontes, Sanna McKinzie, Raul Urruti. Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. Gastroenterology. vol 123. issue 2. 2002-08-16. PMID:12145795. |
polymorphisms in the promoter for synthesis of sert (sert-p) influence response to serotonergic medications in depression. |
2002-08-16 |
2023-08-12 |
Not clear |
| H Dhaene. Imaging the serotonergic system in depression. European archives of psychiatry and clinical neuroscience. vol 251 Suppl 2. 2002-07-17. PMID:11824843. |
imaging the serotonergic system in depression. |
2002-07-17 |
2023-08-12 |
Not clear |
| E Sibille, R He. Combining genetic and genomic approaches to study mood disorders. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 11. issue 6. 2002-07-03. PMID:11704418. |
the serotonin system, and the serotonin(1a) (5-ht(1a)) receptor in particular, have been under intense investigation, mostly due to the fact that serotonergic drugs that directly or indirectly affect the 5-ht(1a) receptor, are effective therapeutic agents in treating patients with various neuropsychiatric disorders, including anxiety and depression. |
2002-07-03 |
2023-08-12 |
mouse |
| Stephen M Stah. Does depression hurt? The Journal of clinical psychiatry. vol 63. issue 4. 2002-05-31. PMID:12000200. |
ascending serotonergic and noradrenergic pathways may mediate the emotional and vegetative symptoms of depression and can potentially be targets of serotonin and norepinephrine reuptake inhibitors to obtain relief of these symptoms. |
2002-05-31 |
2023-08-12 |
Not clear |
| Cornelius Gross, Xiaoxi Zhuang, Kimberly Stark, Sylvie Ramboz, Ronald Oosting, Lynn Kirby, Luca Santarelli, Sheryl Beck, René He. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature. vol 416. issue 6879. 2002-05-14. PMID:11919622. |
serotonin is implicated in mood regulation, and drugs acting via the serotonergic system are effective in treating anxiety and depression. |
2002-05-14 |
2023-08-12 |
mouse |
| Robert N Golden, Amy Durr Heine, R David Ekstrom, Joseph M Bebchuk, Martha E Leatherman, James C Garbut. A longitudinal study of serotonergic function in depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 5. 2002-05-07. PMID:11927190. |
a longitudinal study of serotonergic function in depression. |
2002-05-07 |
2023-08-12 |
human |
| R G Peñalva, C Flachskamm, S Zimmermann, W Wurst, F Holsboer, J M H M Reul, A C E Linthors. Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice. Neuroscience. vol 109. issue 2. 2002-04-12. PMID:11801362. |
previous research has implicated both corticotropin-releasing hormone and the serotonergic system as causative factors in the development and course of stress-related psychiatric disorders such as major depression. |
2002-04-12 |
2023-08-12 |
mouse |
| Stefania Bonaccorso, Valentina Marino, Antonella Puzella, Massimo Pasquini, Massimo Biondi, Marco Artini, Cristiana Almerighi, Robert Verkerk, Herbert Meltzer, Michael Mae. Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system. Journal of clinical psychopharmacology. vol 22. issue 1. 2002-03-25. PMID:11799348. |
there is also evidence that induction of the cytokine network modulates the serotonergic system and that major depression is related to activation of the cytokine network and disturbances in the serotonergic metabolism. |
2002-03-25 |
2023-08-12 |
Not clear |
| Derek N Middlemiss, Gary W Price, Jeannette M Watso. Serotonergic targets in depression. Current opinion in pharmacology. vol 2. issue 1. 2002-03-20. PMID:11786304. |
serotonergic targets in depression. |
2002-03-20 |
2023-08-12 |
Not clear |
| A Parsian, C R Cloninge. Serotonergic pathway genes and subtypes of alcoholism: association studies. Psychiatric genetics. vol 11. issue 2. 2002-03-07. PMID:11525423. |
disturbances of the serotonergic pathway have been implicated in many psychiatric disorders, including alcoholism, aggression, schizophrenia and depression. |
2002-03-07 |
2023-08-12 |
Not clear |
| F Benedetti, E Campori, B Barbini, M C Fulgosi, C Colomb. Dopaminergic augmentation of sleep deprivation effects in bipolar depression. Psychiatry research. vol 104. issue 3. 2002-02-26. PMID:11728613. |
total sleep deprivation (tsd) has been used in association with lithium salts and with serotonergic and noradrenergic antidepressants, leading to sustained improvements in patients affected by major depression. |
2002-02-26 |
2023-08-12 |
Not clear |
| G N Pandey, X Ren, S C Pandey, Y Dwivedi, R Sharma, P G Janica. Hyperactive phosphoinositide signaling pathway in platelets of depressed patients: effect of desipramine treatment. Psychiatry research. vol 105. issue 1-2. 2002-02-26. PMID:11740972. |
there is some evidence to suggest that certain neurotransmitter receptors, such as adrenergic and serotonergic receptors and receptor-linked signaling systems, may be altered in depression. |
2002-02-26 |
2023-08-12 |
human |
| V Arango, M D Underwood, M Boldrini, H Tamir, S A Kassir, S Hsiung, J J Chen, J J Man. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 6. 2002-01-28. PMID:11750182. |
suicide and depression are associated with reduced serotonergic neurotransmission. |
2002-01-28 |
2023-08-12 |
Not clear |
| D A Axelson, B Birmahe. Relation between anxiety and depressive disorders in childhood and adolescence. Depression and anxiety. vol 14. issue 2. 2001-12-05. PMID:11668659. |
integrating the treatment literature with studies of phenomenology, biology and genetics indicates that pediatric anxiety disorders and depression may share a genetically determined neurobiological component that could involve neural circuits that include or are modulated by serotonergic neurons. |
2001-12-05 |
2023-08-12 |
Not clear |
| F Pillman. [Social rank and depression--an example of "evolutionary psychopathology"]. Fortschritte der Neurologie-Psychiatrie. vol 69. issue 6. 2001-12-04. PMID:11455909. |
common biochemical and pharmacological features of subordination and depression include an activation of the stress axis, diminished serotonergic neurotransmission and modification by antidepressants. |
2001-12-04 |
2023-08-12 |
Not clear |
| b' E G\\xc3\\xb3mez, R Catal\\xc3\\xa1n, R Navin\\xc3\\xa9s, C Gast\\xc3\\xb. [Serotonin receptor changes in depression: evidences and limitations]. Actas espanolas de psiquiatria. vol 29. issue 3. 2001-11-01. PMID:11412493.' |
in the following, research data supporting the general hypothesis of adaptatives changes in density and functioning of serotonergic receptors in depression are review. |
2001-11-01 |
2023-08-12 |
Not clear |
| B E Leonar. The immune system, depression and the action of antidepressants. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 4. 2001-10-25. PMID:11383977. |
evidence is provided that the consequences of the hypersecretion of glucocorticoids and pro-inflammatory cytokines result in the malfunctioning of noradrenergic and serotonergic neurotransmission in the brain, changes which are reflected in the major symptoms of depression. |
2001-10-25 |
2023-08-12 |
Not clear |