| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charles B Nemerof. Recent advances in the neurobiology of depression. Psychopharmacology bulletin. vol 36 Suppl 2. 2007-05-03. PMID:12490820. |
substantial evidence has accrued, including changes in neurotransmitter and neurotransmitter metabolite concentrations, reuptake sites, and receptors, to support the hypothesis that alteration in neuronal serotonergic and noradrenergic function occurs in the central nervous system of patients with major depression. |
2007-05-03 |
2023-08-12 |
Not clear |
| Ingeborg Winge, Jeffrey A McKinney, Per M Knappskog, Jan Haavi. Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. Journal of neurochemistry. vol 100. issue 6. 2007-05-01. PMID:17181551. |
these findings provide potential molecular explanations for disorders related to the central serotonergic system, such as depression or suicidal behaviour. |
2007-05-01 |
2023-08-12 |
mouse |
| Linda Booij, A J Willem Van der Doe. Cognitive and serotonergic vulnerability to depression: convergent findings. Journal of abnormal psychology. vol 116. issue 1. 2007-04-20. PMID:17324019. |
cognitive and serotonergic vulnerability to depression: convergent findings. |
2007-04-20 |
2023-08-12 |
Not clear |
| Maria A Oquendo, Ramin S Hastings, Yung-Yu Huang, Norman Simpson, R Todd Ogden, Xian-Zhang Hu, David Goldman, Victoria Arango, Ronald L Van Heertum, J John Mann, Ramin V Parse. Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Archives of general psychiatry. vol 64. issue 2. 2007-04-16. PMID:17283287. |
associations of serotonin transporter promoter polymorphisms and bipolarity have been reported; however, research on alterations in serotonergic neurotransmission in bipolar depression remains scant. |
2007-04-16 |
2023-08-12 |
Not clear |
| Mikael Landén, Michael E Thas. A model to explain the therapeutic effects of serotonin reuptake inhibitors: the role of 5-HT2 receptors. Psychopharmacology bulletin. vol 39. issue 1. 2007-04-03. PMID:17065978. |
consequently, these conditions can be assumed to benefit from the acute increase of serotonergic neurotransmission following ingestion of an sri rather than the secondary receptor changes, which would explain why there is a therapeutic lag time when sris are used to treat depression but not premenstrual dysphoric disorder. |
2007-04-03 |
2023-08-12 |
Not clear |
| Lene Christiansen, Qihua Tan, Maria Iachina, Lise Bathum, Torben A Kruse, Matthew McGue, Kaare Christense. Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Biological psychiatry. vol 61. issue 2. 2007-03-15. PMID:16806099. |
candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. |
2007-03-15 |
2023-08-12 |
Not clear |
| Ender Taner, Esra Yancar Demir, Behcet Cosa. Comparison of the effectiveness of reboxetine versus fluoxetine in patients with atypical depression: a single-blind, randomized clinical trial. Advances in therapy. vol 23. issue 6. 2007-03-14. PMID:17276965. |
thus it can be speculated that noradrenergic antidepressants might be superior to serotonergic antidepressants in reducing symptoms of atypical depression. |
2007-03-14 |
2023-08-12 |
Not clear |
| David H Overstreet, Amir H Rezvani, Elvan Djouma, Abbas Parsian, Andrew J Lawrenc. Depressive-like behavior and high alcohol drinking co-occur in the FH/WJD rat but appear to be under independent genetic control. Neuroscience and biobehavioral reviews. vol 31. issue 1. 2007-03-01. PMID:16982094. |
other literature in addition to the high swim test immobility suggests that the fh/wjd rat may also be an animal model of depression (high basal corticosterone levels, blunted hormonal responses to serotonergic agonists). |
2007-03-01 |
2023-08-12 |
human |
| Natalia Alenina, Saleh Bashammakh, Michael Bade. Specification and differentiation of serotonergic neurons. Stem cell reviews. vol 2. issue 1. 2007-02-27. PMID:17142880. |
because serotonin is a relevant pathophysiological factor in several neurological diseases such as bipolar disorder and depression tools to generate or maintain serotonergic neurons might be of therapeutic value. |
2007-02-27 |
2023-08-12 |
mouse |
| Thomas C Baghai, Hans-Peter Volz, Hans-Jürgen Mölle. Drug treatment of depression in the 2000s: An overview of achievements in the last 10 years and future possibilities. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 7. issue 4. 2007-02-23. PMID:17071541. |
future pharmacological treatments of depression will not only enhance serotonergic and noradrenergic neurotransmission: other systems, such as the melatonergic receptor system and the hypothalamus-pituitary-adrenal axis, are also the targets of newly developed and upcoming substances with putative antidepressant effects. |
2007-02-23 |
2023-08-12 |
Not clear |
| Derick E Vergne, Charles B Nemerof. The interaction of serotonin transporter gene polymorphisms and early adverse life events on vulnerability for major depression. Current psychiatry reports. vol 8. issue 6. 2007-02-22. PMID:17094925. |
considerable literature supports the hypothesis of dysfunction in central nervous system serotonergic circuits in the pathophysiology of mood disorders, specifically major depression. |
2007-02-22 |
2023-08-12 |
Not clear |
| Derick E Vergne, Charles B Nemerof. The interaction of serotonin transporter gene polymorphisms and early adverse life events on vulnerability for major depression. Current psychiatry reports. vol 8. issue 6. 2007-02-22. PMID:17094925. |
the discovery of a functional sert polymorphism has provided a novel tool to further scrutinize the role of serotonergic neurons in depression. |
2007-02-22 |
2023-08-12 |
Not clear |
| Bonnie Spring, Brian Hitsman, Regina Pingitore, Dennis E McChargue, Dianna Gunnarsdottir, Joyce Corsica, Michele Pergadia, Neal Doran, John W Crayton, Sankar Baruah, Donald Hedeke. Effect of tryptophan depletion on smokers and nonsmokers with and without history of major depression. Biological psychiatry. vol 61. issue 1. 2007-02-20. PMID:16893526. |
serotonergic dysregulation is posited to contribute to comorbidity between nicotine dependence and depression. |
2007-02-20 |
2023-08-12 |
Not clear |
| Roland W Freudenmann, Carlos Schönfeldt-Lecuona, Manfred Spitzer, Leopold Hermle, Georg Grö. Electroconvulsive therapy in the treatment of depression in a former ecstasy user. Journal of psychopharmacology (Oxford, England). vol 20. issue 6. 2007-01-26. PMID:16891342. |
depression in former ecstasy users may not respond to selective serotonin reuptake inhibitors (ssris) possibly due to damaged serotonergic synapses following long-term heavy ecstasy use. |
2007-01-26 |
2023-08-12 |
Not clear |
| Anette Schra. Quality of life and depression in Parkinson's disease. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16797028. |
imaging studies have demonstrated abnormalities of dopaminergic, noradrenergic and serotonergic functioning with some correlation with severity of depression. |
2007-01-23 |
2023-08-12 |
Not clear |
| Rainer Hellweg, Maha Zueger, Katharina Fink, Heide Hörtnagl, Peter Gas. Olfactory bulbectomy in mice leads to increased BDNF levels and decreased serotonin turnover in depression-related brain areas. Neurobiology of disease. vol 25. issue 1. 2007-01-23. PMID:16990008. |
thus, olfactory bulbectomy seems to be a valid animal model also in mice related to serotonergic dysfunctions resembling bulbectomized rats that are a well-known model of hyposerotoninergic agitated depression. |
2007-01-23 |
2023-08-12 |
mouse |
| S Totterdel. The anatomy of co-morbid neuropsychiatric disorders based on cortico-limbic synaptic interactions. Neurotoxicity research. vol 10. issue 2. 2007-01-03. PMID:17062369. |
alterations in dopamine activity may underpin both schizophrenia and the establishment and maintenance of drug dependence while disruption of serotonergic signalling may be crucial in both depression and schizophrenia. |
2007-01-03 |
2023-08-12 |
Not clear |
| David R Thomas, Ellen M Soffin, Claire Roberts, James N C Kew, Raul M de la Flor, Lee A Dawson, Victoria A Fry, Sara A Coggon, Stefania Faedo, Philip D Hayes, David F Corbett, Ceri H Davies, Jim J Haga. SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain. Neuropharmacology. vol 51. issue 3. 2006-12-14. PMID:16846620. |
in guinea pig dorsal raphe slices, sb-699551-a (1 microm) did not alter neuronal firing per se but attenuated the 5-ct-induced depression in serotonergic neuronal firing in a subpopulation of cells insensitive to the 5-ht1a receptor-selective antagonist way-100635 (100 nm). |
2006-12-14 |
2023-08-12 |
human |
| Gregory M Sullivan, Maria A Oquendo, Yung-yu Huang, J John Man. Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid levels in women with comorbid depression and panic disorder. The international journal of neuropsychopharmacology. vol 9. issue 5. 2006-12-11. PMID:16259647. |
therefore, we hypothesized that central serotonergic function in the patients with comorbid panic disorder would be more disturbed than in major depression alone. |
2006-12-11 |
2023-08-12 |
human |
| Soili Lehto, Tommi Tolmunen, Mikko Joensuu, Pirjo Irmeli Saarinen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Jyrki Kuikka, Johannes Lehtone. Midbrain binding of [123I]nor-beta-CIT in atypical depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 7. 2006-10-31. PMID:16644083. |
atypical depression (atd) has been suggested to be connected to decreased serotonergic transmission, but no studies have been published on the association between brain serotonin transporter density and atd. |
2006-10-31 |
2023-08-12 |
Not clear |