| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniele Consoli, Gian Marco Leggio, Carmen Mazzola, Vincenzo Micale, Filippo Drag. Behavioral effects of the beta3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs? European journal of pharmacology. vol 573. issue 1-3. 2008-03-13. PMID:17669397. |
a large body of evidence corroborates the notion that deficiencies of serotonergic system are likely involved in the pathogenesis of both depression and anxiety. |
2008-03-13 |
2023-08-12 |
mouse |
| R Mahesh, R Rajkumar, B Minasri, R Venkatesha Peruma. Potential antidepressants: pharmacology of 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in rodent behavioural models. Die Pharmazie. vol 62. issue 12. 2008-03-04. PMID:18214343. |
this preliminary study points to a serotonergic mechanism behind the antidepressant-like effects of na-2 and invigorates further investigation of analogous compounds in various other models of depression. |
2008-03-04 |
2023-08-12 |
mouse |
| Cara M Hildreth, James R Padley, Paul M Pilowsky, Ann K Goodchil. Impaired serotonergic regulation of heart rate may underlie reduced baroreflex sensitivity in an animal model of depression. American journal of physiology. Heart and circulatory physiology. vol 294. issue 1. 2008-02-28. PMID:17993598. |
impaired serotonergic regulation of heart rate may underlie reduced baroreflex sensitivity in an animal model of depression. |
2008-02-28 |
2023-08-12 |
rat |
| Cara M Hildreth, James R Padley, Paul M Pilowsky, Ann K Goodchil. Impaired serotonergic regulation of heart rate may underlie reduced baroreflex sensitivity in an animal model of depression. American journal of physiology. Heart and circulatory physiology. vol 294. issue 1. 2008-02-28. PMID:17993598. |
these data suggest that impaired serotonergic control of cardiac reflex function could be one mechanism linking reduced sbrs to increased cardiac risk in depression. |
2008-02-28 |
2023-08-12 |
rat |
| Henrik Dam, Erling T Mellerup, Per Plenge, Rosa Winther, Gitta Wörtwei. The serotonin transporter and 5HT2A receptor in rat brain after localized lesions. Neurological research. vol 29. issue 7. 2008-02-19. PMID:17711618. |
the development of depression may include the serotonergic system because selective serotonin reuptake inhibitors (ssris) can be used to treat the depression. |
2008-02-19 |
2023-08-12 |
rat |
| Dorota Łojko, Janusz K Rybakowsk. L-thyroxine augmentation of serotonergic antidepressants in female patients with refractory depression. Journal of affective disorders. vol 103. issue 1-3. 2008-02-07. PMID:17289154. |
l-thyroxine augmentation of serotonergic antidepressants in female patients with refractory depression. |
2008-02-07 |
2023-08-12 |
Not clear |
| Dorota Łojko, Janusz K Rybakowsk. L-thyroxine augmentation of serotonergic antidepressants in female patients with refractory depression. Journal of affective disorders. vol 103. issue 1-3. 2008-02-07. PMID:17289154. |
in this paper, the efficacy of addition of moderate dose of l-thyroxine (t4) to serotonergic antidepressants in refractory depression was evaluated. |
2008-02-07 |
2023-08-12 |
Not clear |
| Brian E Leonar. Psychopathology of depression. Drugs of today (Barcelona, Spain : 1998). vol 43. issue 10. 2008-01-31. PMID:17987223. |
while the monoamine theory, that postulates dysfunctional noradrenergic and serotonergic systems as the underlying cause of depression, has been valuable in the development of conventional antidepressants that are thought to act by reversing these dysfunctional states, recent clinical and experimental studies have questioned this reductionist view of depression. |
2008-01-31 |
2023-08-12 |
Not clear |
| N Müller, M J Schwar. [Immunological aspects of depressive disorders]. Der Nervenarzt. vol 78. issue 11. 2008-01-15. PMID:17928982. |
by this mechanism, the dysbalance of the immune response and the astrocyte:microglia dysbalance may contribute to serotonergic deficiency and glutamatergic overproduction in depression. |
2008-01-15 |
2023-08-12 |
Not clear |
| E Hame. Serotonin and migraine: biology and clinical implications. Cephalalgia : an international journal of headache. vol 27. issue 11. 2008-01-10. PMID:17970989. |
although the exact cascade of events that link abnormal serotonergic neurotransmission to the manifestation of head pain and the accompanying symptoms has yet to be fully understood, recent evidence suggests that a low 5-ht state facilitates activation of the trigeminovascular nociceptive pathway, as induced by cortical spreading depression. |
2008-01-10 |
2023-08-12 |
Not clear |
| N Müller, M J Schwar. The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Molecular psychiatry. vol 12. issue 11. 2008-01-09. PMID:17457312. |
beside the well-known deficiency in serotonergic neurotransmission as pathophysiological correlate of major depression (md), recent evidence points to a pivotal role of increased glutamate receptor activation as well. |
2008-01-09 |
2023-08-12 |
Not clear |
| Christine Winter, Anke von Rumohr, Adrian Mundt, Dominique Petrus, Julia Klein, Thomas Lee, Rudolf Morgenstern, Andreas Kupsch, Georg Jucke. Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats. Behavioural brain research. vol 184. issue 2. 2008-01-09. PMID:17698212. |
the effects of citalopram administration on depressive behavior induced by lesions of dopaminergic brain regions furthermore suggest an involvement of serotonergic pathways in dopaminergic cell loss-induced depression. |
2008-01-09 |
2023-08-12 |
rat |
| Akira Sakurai, Robert J Calin-Jageman, Paul S Kat. Potentiation phase of spike timing-dependent neuromodulation by a serotonergic interneuron involves an increase in the fraction of transmitter release. Journal of neurophysiology. vol 98. issue 4. 2008-01-08. PMID:17686912. |
in the mollusk, tritonia diomedea, the serotonergic dorsal swim interneuron (dsi) produces spike timing-dependent neuromodulation (stdn) of the synaptic output of ventral swim interneuron b (vsi) resulting in a biphasic, bidirectional change of synaptic strength characterized by a rapid heterosynaptic potentiation followed by a more prolonged heterosynaptic depression. |
2008-01-08 |
2023-08-12 |
Not clear |
| Kjell Fuxe, Annica Dahlström, Malin Höistad, Daniel Marcellino, Anders Jansson, Alicia Rivera, Zaida Diaz-Cabiale, Kirsten Jacobsen, Barbro Tinner-Staines, Beth Hagman, Giuseppina Leo, William Staines, Diego Guidolin, Jan Kehr, Susanna Genedani, Natale Belluardo, Luigi F Agnat. From the Golgi-Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: wiring and volume transmission. Brain research reviews. vol 55. issue 1. 2008-01-04. PMID:17433836. |
furthermore, the ascending raphe serotonin neuron systems were found to globally innervate the forebrain with few synapses, and where deficits in serotonergic function appeared to play a major role in depression. |
2008-01-04 |
2023-08-12 |
Not clear |
| Bruno P Guiard, Jean-Philippe Guilloux, Christelle Reperant, Stephen P Hunt, Miklos Toth, Alain M Gardie. Substance P neurokinin 1 receptor activation within the dorsal raphe nucleus controls serotonin release in the mouse frontal cortex. Molecular pharmacology. vol 72. issue 6. 2008-01-04. PMID:17890358. |
a better knowledge of the complex relationship between tachykininergic, serotonergic, and glutamatergic systems within the drn might help better understand the pathophysiology and subsequent treatment of depression. |
2008-01-04 |
2023-08-12 |
mouse |
| Alexander Sartorius, Fritz A Hen. Deep brain stimulation of the lateral habenula in treatment resistant major depression. Medical hypotheses. vol 69. issue 6. 2008-01-03. PMID:17498883. |
modern theories about the pathophysiology of depression are derived from studies examining the mechanism of antidepressants influencing the serotonergic (5-ht) and noradrenergic (ne) systems. |
2008-01-03 |
2023-08-12 |
human |
| Cavit Boz, Sibel Gazioglu, Vildan Altunayoglu, Cicek Hocaogl. Effect of serotonergic antidepressant therapy on temperament and character scales in patients with chronic tension-type headache. Psychiatry and clinical neurosciences. vol 61. issue 5. 2007-12-21. PMID:17875033. |
forty-five patients with ctth filled out the tci and beck depression inventory (bdi) before and after 4-month prophylactic therapy with serotonergic antidepressants. |
2007-12-21 |
2023-08-12 |
human |
| Raffaella Zanardi, Lorenzo Magri, David Rossini, Alessia Malaguti, Silvia Giordani, Cristina Lorenzi, Adele Pirovano, Enrico Smeraldi, Adelio Lucc. Role of serotonergic gene polymorphisms on response to transcranial magnetic stimulation in depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 17. issue 10. 2007-12-06. PMID:17466494. |
role of serotonergic gene polymorphisms on response to transcranial magnetic stimulation in depression. |
2007-12-06 |
2023-08-12 |
human |
| U Dannlowski, P Ohrmann, J Bauer, H Kugel, B T Baune, C Hohoff, A Kersting, V Arolt, W Heindel, J Deckert, T Suslo. Serotonergic genes modulate amygdala activity in major depression. Genes, brain, and behavior. vol 6. issue 7. 2007-11-20. PMID:17284168. |
serotonergic genes modulate amygdala activity in major depression. |
2007-11-20 |
2023-08-12 |
Not clear |
| U Dannlowski, P Ohrmann, J Bauer, H Kugel, B T Baune, C Hohoff, A Kersting, V Arolt, W Heindel, J Deckert, T Suslo. Serotonergic genes modulate amygdala activity in major depression. Genes, brain, and behavior. vol 6. issue 7. 2007-11-20. PMID:17284168. |
serotonergic genes have been implicated in the pathogenesis of depression probably via their influence on neural activity during emotion processing. |
2007-11-20 |
2023-08-12 |
Not clear |