| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuya Kanemaru, Kyoko Nishi, Mirko Diksi. AGN-2979, an inhibitor of tryptophan hydroxylase activation, does not affect serotonin synthesis in Flinders Sensitive Line rats, a rat model of depression, but produces a significant effect in Flinders Resistant Line rats. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19463878. |
alterations in any of the normal parameters of serotonergic neurotransmission can produce several different psychiatric disorders, including major depression. |
2009-11-17 |
2023-08-12 |
human |
| Marat G Uzbeko. Antidepressant action of tianeptine is connected with acceleration of serotonin turnover in the synapse: a hypothesis. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 11. issue 2. 2009-11-04. PMID:19827315. |
based on the results of our investigation of patients with anxious depression under the treatment with serotonergic antidepressants with different mechanism of action on serotonin reuptake we, the first time in the literature, propose the hypothesis about neurochemical mechanism of tianeptine action. |
2009-11-04 |
2023-08-12 |
Not clear |
| Nadja Osterberg, Eleni Rouss. Characterization of primary neurospheres generated from mouse ventral rostral hindbrain. Cell and tissue research. vol 336. issue 1. 2009-11-03. PMID:19224248. |
serotonergic (5-ht) neurons of the reticular formation play a key role in the modulation of behavior, and their dysfunction is associated with severe neurological and psychiatric disorders, such as depression and schizophrenia. |
2009-11-03 |
2023-08-12 |
mouse |
| Thomas Linka, Gudrun Sartory, Markus Gastpar, Norbert Scherbaum, Bernhard W Mülle. Clinical symptoms of major depression are associated with the intensity dependence of auditory event-related potential components. Psychiatry research. vol 169. issue 2. 2009-10-29. PMID:19700202. |
the purpose of the present study is to evaluate associations between clinical symptoms of major depression and the idap as an indirect indicator of cortical serotonergic function. |
2009-10-29 |
2023-08-12 |
Not clear |
| Thomas Linka, Gudrun Sartory, Jens Wiltfang, Bernhard W Mülle. Treatment effects of serotonergic and noradrenergic antidepressants on the intensity dependence of auditory ERP components in major depression. Neuroscience letters. vol 463. issue 1. 2009-10-23. PMID:19616062. |
treatment effects of serotonergic and noradrenergic antidepressants on the intensity dependence of auditory erp components in major depression. |
2009-10-23 |
2023-08-12 |
human |
| Marishka K Brown, Yuan Lu. Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans. BMC neuroscience. vol 10. 2009-08-17. PMID:19545409. |
dysfunctions in the serotonergic system have been implicated in several neurological disorders such as depression. |
2009-08-17 |
2023-08-12 |
caenorhabditis_elegans |
| Jeffrey M Miller, Erin L Kinnally, R Todd Ogden, Maria A Oquendo, J John Mann, Ramin V Parse. Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder. Synapse (New York, N.Y.). vol 63. issue 7. 2009-08-13. PMID:19288578. |
physical or psychological adversity in childhood is associated with a higher risk for depression in adulthood, and with persistent serotonergic abnormalities in humans and in animal models. |
2009-08-13 |
2023-08-12 |
human |
| Katherine F Croom, Caroline M Perry, Greg L Ploske. Mirtazapine: a review of its use in major depression and other psychiatric disorders. CNS drugs. vol 23. issue 5. 2009-08-12. PMID:19453203. |
mirtazapine (remeron, zispin) is a noradrenergic and specific serotonergic antidepressant (nassa) that is approved in many counties for use in the treatment of major depression. |
2009-08-12 |
2023-08-12 |
Not clear |
| Stefan Wüst, Robert Kumsta, Jens Treutlein, Josef Frank, Sonja Entringer, Thomas G Schulze, Marcella Rietsche. Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion. Psychoneuroendocrinology. vol 34. issue 7. 2009-08-11. PMID:19249159. |
a key regulator of serotonergic neurotransmission is the serotonin transporter (5-htt) and a common 5htt gene promoter polymorphism, termed 5httlpr, is associated with phenotypes related to anxiety and depression. |
2009-08-11 |
2023-08-12 |
Not clear |
| Hsin Chun Tsai, Tzung Lieh Yeh, Ming Hong Hsieh, I Hui Lee, Kao Ching Chen, Po See Chen, Yen Kuang Yang, Wei Jen Ya. Association between serotonin transporter availability and overall rating scores of quality of life in healthy volunteers. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 4. 2009-08-10. PMID:19332100. |
however, it is unclear whether the correlation between the qol scores and the central serotonergic tone is only mediated by the severity of either the depression symptoms or the physical illness itself. |
2009-08-10 |
2023-08-12 |
human |
| Khanh Q Nguyen, Yoshihiro Tohyama, Arata Watanabe, Shu Hasegawa, Ivan Skelin, Mirko Diksi. Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats. Neurochemistry international. vol 54. issue 3-4. 2009-07-28. PMID:19073228. |
pindolol acceleration and augmentation of ssri antidepressant therapy for human depression may be mediated by attenuation of 5-ht(1a/b) autoreceptor feedback, permitting unhindered ssri effects on serotonergic terminals. |
2009-07-28 |
2023-08-12 |
human |
| Kyoko Nishi, Kazuya Kanemaru, Mirko Diksi. A genetic rat model of depression, Flinders sensitive line, has a lower density of 5-HT(1A) receptors, but a higher density of 5-HT(1B) receptors, compared to control rats. Neurochemistry international. vol 54. issue 5-6. 2009-07-28. PMID:19121358. |
deficiencies in brain serotonergic neurotransmission, which is in part associated with the alteration of brain serotonin (5-ht) receptors, have been proposed as part of a neurochemical imbalance in affective disorders, including depression. |
2009-07-28 |
2023-08-12 |
human |
| John F Grede. Treating depression and pain. The Journal of clinical psychiatry. vol 70. issue 6. 2009-07-20. PMID:19573472. |
depression and pain have overlapping neurobiologic mechanisms, and a comprehensive treatment plan for patients with depression and painful physical symptoms should include pharmacotherapy to target serotonergic and noradrenergic neurotransmitters, along with cognitive-behavioral therapy, exercise, and patient education. |
2009-07-20 |
2023-08-12 |
Not clear |
| Alja Videtic, Tomaz Zupanc, Peter Pregelj, Joze Balazic, Martina Tomori, Radovan Kome. Suicide, stress and serotonin receptor 1A promoter polymorphism -1019C>G in Slovenian suicide victims. European archives of psychiatry and clinical neuroscience. vol 259. issue 4. 2009-07-15. PMID:19224112. |
the suggestion that the g allele depresses htr1a autoreceptor expression, and therefore reduces serotonergic neurotransmission that might predispose to depression and suicide, made the promoter polymorphism -1019c>g a very promising candidate gene. |
2009-07-15 |
2023-08-12 |
Not clear |
| Viktorija Trajkovska, Lisbeth Kirkegaard, Gesa Krey, Anders B Marcussen, Morten S Thomsen, Sabine Chourbaji, Christiane Brandwein, Stephanie Ridder, Christer Halldin, Peter Gass, Gitte M Knudsen, Susana Azna. Activation of glucocorticoid receptors increases 5-HT2A receptor levels. Experimental neurology. vol 218. issue 1. 2009-07-07. PMID:19379741. |
major depression is associated with both dysregulation of the hypothalamic pituitary adrenal axis and serotonergic deficiency, not the least of the 5-ht2a receptor. |
2009-07-07 |
2023-08-12 |
mouse |
| Michael Maes, Raz Yirmyia, Jens Noraberg, Stefan Brene, Joe Hibbeln, Giulia Perini, Marta Kubera, Petr Bob, Bernard Lerer, Mario Ma. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metabolic brain disease. vol 24. issue 1. 2009-07-06. PMID:19085093. |
despite extensive research, the current theories on serotonergic dysfunctions and cortisol hypersecretion do not provide sufficient explanations for the nature of depression. |
2009-07-06 |
2023-08-12 |
mouse |
| Yu-Cheng Li, Fu-Meng Wang, Ying Pan, Li-Qin Qiang, Guang Cheng, Wei-Yun Zhang, Ling-Dong Kon. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 3. 2009-06-16. PMID:19302828. |
our findings provided a basis for examining the interaction of serotonergic receptors and ac-camp pathway in depression and curcumin treatment. |
2009-06-16 |
2023-08-12 |
rat |
| Aleksandra Rajewska-Rager, Monika Dmitrzak-Weglarz, Paweł Kapelski, Maria Skibińska, Magdalena Kaczmarkiewicz-Fass, Joanna Hause. [Association between polymorphisms of ins/del in the 5-HTT gene and T102C in the 5HTR2A gene and the drug response for escitalopram and nortriptyline in depressed patients]. Psychiatria polska. vol 42. issue 6. 2009-06-04. PMID:19441667. |
the role of the serotonin receptor 5ht2a and serotonin transporter 5httlpr polymorphisms was suggested in the pathogenesis of depression and the therapeutic response to serotonergic drugs. |
2009-06-04 |
2023-08-12 |
Not clear |
| Antoine Pelissol. [Depression and pain: prevalence and clinical implication]. Presse medicale (Paris, France : 1983). vol 38. issue 3. 2009-04-27. PMID:18977630. |
aetiological hypothesis to explain the coexistence of physical pains and depression are based on the well-known dysfunction of the serotonergic and noradrenergic pathways in depression, which explains mood symptoms but also a lack of inhibitory control of ascending pain messages, normally controlled in spinal cord by descending serotonergic and noradrenergic projections. |
2009-04-27 |
2023-08-12 |
Not clear |
| b' Ricard Navin\\xc3\\xa9s, Roc\\xc3\\xado Mart\\xc3\\xadn-Santos, Esther G\\xc3\\xb3mez-Gil, Mar\\xc3\\xada J Mart\\xc3\\xadnez de Osaba, Crist\\xc3\\xb2bal Gast\\xc3\\xb. Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 8. 2009-04-15. PMID:18725263.' |
interactions between serotonergic and the endogenous opioid systems have been suggested to be involved in the etiopathogenesis of depression and in the mechanism of action of antidepressants. |
2009-04-15 |
2023-08-12 |
Not clear |