| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T A Klempan, A Sequeira, L Canetti, A Lalovic, C Ernst, J ffrench-Mullen, G Tureck. Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. Molecular psychiatry. vol 14. issue 2. 2009-04-08. PMID:17938633. |
the prefrontal cortex is believed to play a major role in depression and suicidal behavior through regulation of cognition, memory, recognition of emotion, and anxiety-like states, with numerous post-mortem studies documenting a prefrontal serotonergic dysregulation considered to be characteristic of depressive psychopathology. |
2009-04-08 |
2023-08-12 |
human |
| T Frodl, N Koutsouleris, R Bottlender, C Born, M Jäger, M Mörgenthaler, J Scheuerecker, P Zill, T Baghai, C Schüle, R Rupprecht, B Bondy, M Reiser, H-J Möller, E M Meisenzah. Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression. Molecular psychiatry. vol 13. issue 12. 2009-04-08. PMID:19008895. |
the serotonergic system is involved in the pathophysiology of major depression as well as in the early central nervous system development and adult neuroplasticity. |
2009-04-08 |
2023-08-12 |
human |
| Pasquale G Frisina, Vahram Haroutunian, Leslie S Libo. The neuropathological basis for depression in Parkinson's disease. Parkinsonism & related disorders. vol 15. issue 2. 2009-03-26. PMID:18571456. |
our evidence suggests that depression in pd is related more to catecholaminergic than serotonergic system dysfunction. |
2009-03-26 |
2023-08-12 |
Not clear |
| Patrycja Stein, Markus Savli, Wolfgang Wadsak, Markus Mitterhauser, Martin Fink, Christoph Spindelegger, Leonhard-Key Mien, Ulrike Moser, Robert Dudczak, Kurt Kletter, Siegfried Kasper, Rupert Lanzenberge. The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635. European journal of nuclear medicine and molecular imaging. vol 35. issue 12. 2009-03-09. PMID:18542956. |
the higher prevalence rates of depression and anxiety disorders in women compared to men have been associated with sexual dimorphisms in the serotonergic system. |
2009-03-09 |
2023-08-12 |
Not clear |
| Marian J Bakermans-Kranenburg, Marinus H van Ijzendoor. Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social cognitive and affective neuroscience. vol 3. issue 2. 2009-03-04. PMID:19015103. |
controlling for differences in maternal education, depression and marital discord, parents with the possibly less efficient variants of the serotonergic (5-htt ss) and oxytonergic (aa/ag) system genes showed lower levels of sensitive responsiveness to their toddlers. |
2009-03-04 |
2023-08-12 |
human |
| Terence Y C Pang, Xin Du, Michelle S Zajac, Monique L Howard, Anthony J Hanna. Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease. Human molecular genetics. vol 18. issue 4. 2009-02-27. PMID:19008301. |
our findings implicate altered serotonergic signaling as the basis for the development of depression during the preclinical stages of hd. |
2009-02-27 |
2023-08-12 |
mouse |
| Christoph Czermak, Richard Hauger, Wayne C Drevets, David A Luckenbaugh, Marilla Geraci, Dennis S Charney, Alexander Neumeiste. Plasma NPY concentrations during tryptophan and sham depletion in medication-free patients with remitted depression. Journal of affective disorders. vol 110. issue 3. 2009-02-17. PMID:18281099. |
neuropeptide y (npy) and serotonergic systems have been implicated in the pathophysiology of depression but have not yet been linked together. |
2009-02-17 |
2023-08-12 |
Not clear |
| Linda A W Jans, Arjan Bloklan. Influence of chronic mild stress on the behavioural effects of acute tryptophan depletion induced by a gelatin-based mixture. Behavioural pharmacology. vol 19. issue 7. 2009-01-23. PMID:18797247. |
this depression may be caused by the effects of stress on the serotonergic system, which may make the system more vulnerable. |
2009-01-23 |
2023-08-12 |
rat |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
the mechanisms underlying these changes are uncertain, but increased tph2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression. |
2009-01-23 |
2023-08-12 |
Not clear |
| Martyn D Wood, Paul B Wre. Serotonin-dopamine interactions: implications for the design of novel therapeutic agents for psychiatric disorders. Progress in brain research. vol 172. 2009-01-15. PMID:18772035. |
since the discovery that reserpine and amphetamine induce symptoms in man that resemble those associated with depression and schizophrenia respectively, much attention has focussed on the development of drugs which affect the serotonergic and dopaminergic systems in psychiatric disorders. |
2009-01-15 |
2023-08-12 |
Not clear |
| Gal Yadid, Alexander Friedma. Dynamics of the dopaminergic system as a key component to the understanding of depression. Progress in brain research. vol 172. 2009-01-15. PMID:18772037. |
for decades, clinical treatment of depression has usually involved antidepressants that target noradrenergic and serotonergic neurotransmission. |
2009-01-15 |
2023-08-12 |
human |
| P Feng, D Vurbic, Z Wu, Y Hu, K P Stroh. Changes in brain orexin levels in a rat model of depression induced by neonatal administration of clomipramine. Journal of psychopharmacology (Oxford, England). vol 22. issue 7. 2009-01-06. PMID:18753273. |
depression is associated with a deficiency of serotonergic neurons that have been found to suppress orexinergic neurons, which in turn activate these neurons in a feedback loop. |
2009-01-06 |
2023-08-12 |
rat |
| Leo Sher, Barbara H Stanley, Thomas B Cooper, Kevin M Malone, J John Mann, Maria A Oquend. Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 9. 2008-12-18. PMID:18590952. |
dysfunction of serotonergic neurotransmission has been implicated in the etiopathogenesis of major depression (mdd) and alcohol use disorders (aud). |
2008-12-18 |
2023-08-12 |
human |
| Christine Firk, C Rob Marku. Effects of acute tryptophan depletion on affective processing in first-degree relatives of depressive patients and controls after exposure to uncontrollable stress. Psychopharmacology. vol 199. issue 2. 2008-12-16. PMID:18551283. |
individuals with a family history of depression may be more likely to develop depression due to an innate vulnerability of their serotonergic system. |
2008-12-16 |
2023-08-12 |
Not clear |
| Charles S Carver, Sheri L Johnson, Jutta Joorman. Serotonergic function, two-mode models of self-regulation, and vulnerability to depression: what depression has in common with impulsive aggression. Psychological bulletin. vol 134. issue 6. 2008-12-04. PMID:18954161. |
serotonergic function, two-mode models of self-regulation, and vulnerability to depression: what depression has in common with impulsive aggression. |
2008-12-04 |
2023-08-12 |
Not clear |
| Charles S Carver, Sheri L Johnson, Jutta Joorman. Serotonergic function, two-mode models of self-regulation, and vulnerability to depression: what depression has in common with impulsive aggression. Psychological bulletin. vol 134. issue 6. 2008-12-04. PMID:18954161. |
evidence from diverse literatures supports the viewpoint that two modes of self-regulation exist, a lower-order system that responds quickly to associative cues of the moment and a higher-order system that responds more reflectively and planfully; that low serotonergic function is linked to relative dominance of the lower-order system; that how dominance of the lower-order system is manifested depends on additional variables; and that low serotonergic function therefore can promote behavioral patterns as divergent as impulsive aggression and lethargic depression. |
2008-12-04 |
2023-08-12 |
Not clear |
| Charles S Carver, Sheri L Johnson, Jutta Joorman. Serotonergic function, two-mode models of self-regulation, and vulnerability to depression: what depression has in common with impulsive aggression. Psychological bulletin. vol 134. issue 6. 2008-12-04. PMID:18954161. |
literatures reviewed include work on two-mode models; studies of brain function supporting the biological plausibility of the two-mode view and the involvement of serotonergic pathways in functions pertaining to it; and studies relating low serotonergic function to impulsiveness, aggression (including extreme violence), aspects of personality, and depression vulnerability. |
2008-12-04 |
2023-08-12 |
Not clear |
| Charles S Carver, Sheri L Johnson, Jutta Joorman. Serotonergic function, two-mode models of self-regulation, and vulnerability to depression: what depression has in common with impulsive aggression. Psychological bulletin. vol 134. issue 6. 2008-12-04. PMID:18954161. |
substantial differences between depression and other phenomena reviewed are interpreted by proposing that depression reflects both low serotonergic function and low reward sensitivity. |
2008-12-04 |
2023-08-12 |
Not clear |
| András Sümeg. [Domino principle--monoamines in bottom-view]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 10. issue 3. 2008-12-03. PMID:18956617. |
it is clearly held that most, if not all, antidepressant pharmacotherapies treatments produce their therapeutic antidepressant effects, at least in part, by modulating monoamine systems (noradrenergic, serotonergic, and dopaminergic) by a selective or a multi-acting way; however, much less is known about the neurobiological pathology of these monoamine systems in depression. |
2008-12-03 |
2023-08-12 |
Not clear |
| Benicio N Frey, Catherine Lord, Claudio N Soare. Depression during menopausal transition: a review of treatment strategies and pathophysiological correlates. Menopause international. vol 14. issue 3. 2008-11-18. PMID:18714078. |
transdermal estradiol and serotonergic and noradrenergic antidepressants are efficacious in the treatment of depression and vasomotor symptoms in symptomatic, midlife women. |
2008-11-18 |
2023-08-12 |
Not clear |