| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Lykouras, M Markianos, Y Hatzimanoli. Prolactin and cortisol responses to acute intravenous clomipramine challenge in patients with mania, depression and healthy controls: evidence for reduced serotonergic responsivity. Neuropsychobiology. vol 63. issue 2. 2011-05-25. PMID:21178381. |
serotonergic dysregulation has been shown to be involved in the pathophysiology of unipolar and bipolar depression. |
2011-05-25 |
2023-08-12 |
human |
| L Lykouras, M Markianos, Y Hatzimanoli. Prolactin and cortisol responses to acute intravenous clomipramine challenge in patients with mania, depression and healthy controls: evidence for reduced serotonergic responsivity. Neuropsychobiology. vol 63. issue 2. 2011-05-25. PMID:21178381. |
we assessed serotonergic neuroendocrine responsivity in patients with depression (n = 22), mania (n = 11) and 15 healthy controls by measuring the prolactin (prl) and cortisol responses to i.v. |
2011-05-25 |
2023-08-12 |
human |
| L Lykouras, M Markianos, Y Hatzimanoli. Prolactin and cortisol responses to acute intravenous clomipramine challenge in patients with mania, depression and healthy controls: evidence for reduced serotonergic responsivity. Neuropsychobiology. vol 63. issue 2. 2011-05-25. PMID:21178381. |
the blunted prl responses to cmi in patients with mania and depression suggest that serotonergic functioning in mania and depression is similarly impaired, at least at the level of hypothalamus-hypophysis. |
2011-05-25 |
2023-08-12 |
human |
| Gregory V Carr, Lee E Schechter, Irwin Luck. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacology. vol 213. issue 2-3. 2011-05-24. PMID:20217056. |
although selective serotonin reuptake inhibitors (ssris) produce clinical therapeutic effects on depression and anxiety through augmentation of serotonergic neurotransmission, there is little known about the potential contributions of the 5-ht(6) receptor in the treatment of mood disorders. |
2011-05-24 |
2023-08-12 |
rat |
| Caroline A Browne, Gerard Clarke, Timothy G Dinan, John F Crya. Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains. Neuropharmacology. vol 60. issue 4. 2011-05-12. PMID:21130784. |
chronic stress and alterations in the serotonergic system are key predisposing factors to the development of major depression. |
2011-05-12 |
2023-08-12 |
mouse |
| Patricia Lagos, Jessika Urbanavicius, María Cecilia Scorza, Rodrigo Miraballes, Pablo Torterol. Depressive-like profile induced by MCH microinjections into the dorsal raphe nucleus evaluated in the forced swim test. Behavioural brain research. vol 218. issue 2. 2011-05-06. PMID:21056060. |
in the present study we confirmed the presence of mchergic fibers within the dorsal raphe nucleus (drn), a serotonergic nucleus involved in the physiopathology of major depression. |
2011-05-06 |
2023-08-12 |
rat |
| Albert Adel. Lu-AA21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety. IDrugs : the investigational drugs journal. vol 13. issue 12. 2011-05-02. PMID:21154150. |
lu-aa21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety. |
2011-05-02 |
2023-08-12 |
rat |
| Albert Adel. Lu-AA21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety. IDrugs : the investigational drugs journal. vol 13. issue 12. 2011-05-02. PMID:21154150. |
lu-aa21004, an oral, multimodal serotonergic agent, is currently under development by h lundbeck and takeda pharmaceutical, for the potential treatment of depression and anxiety. |
2011-05-02 |
2023-08-12 |
rat |
| Brecht Geeraerts, Lukas Van Oudenhove, Werend Boesmans, Rita Vos, Pieter Vanden Berghe, Jan Tac. Influence of acute tryptophan depletion on gastric sensorimotor function in humans. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 2. 2011-03-15. PMID:20884888. |
a dysfunctional serotonergic system may provide a plausible link between functional dyspepsia symptoms and its high psychosocial comorbidity such as anxiety and depression. |
2011-03-15 |
2023-08-12 |
human |
| Iu O Fedotov. [Behavioral effects of m-CPP and ketanserine during ovarian cycle in female rats]. Eksperimental'naia i klinicheskaia farmakologiia. vol 73. issue 11. 2011-02-17. PMID:21254590. |
the data obtained are indicative of a close interaction between the ovarian hormonal and serotonergic systems of the brain in the mechanisms of anxiety and depression. |
2011-02-17 |
2023-08-12 |
rat |
| C M Middeldorp, M C T Slof-Op 't Landt, S E Medland, C E M van Beijsterveldt, M Bartels, G Willemsen, J-J Hottenga, E J C de Geus, H E D Suchiman, C V Dolan, M C Neale, P E Slagboom, D I Boomsm. Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes? Genes, brain, and behavior. vol 9. issue 7. 2011-02-08. PMID:20633049. |
anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes? |
2011-02-08 |
2023-08-12 |
human |
| Brian Alexander, Jennifer Warner-Schmidt, Therese Eriksson, Carol Tamminga, Margarita Arango-Lievano, Margarita Arango-Llievano, Subroto Ghose, Mary Vernov, Mihaela Stavarache, Mihaela Stavarche, Sergei Musatov, Marc Flajolet, Per Svenningsson, Paul Greengard, Michael G Kaplit. Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Science translational medicine. vol 2. issue 54. 2011-02-01. PMID:20962330. |
the etiology of major depression remains unknown, but dysfunction of serotonergic signaling has long been implicated in the pathophysiology of this disorder. |
2011-02-01 |
2023-08-12 |
mouse |
| M Politis, K Wu, C Loane, F E Turkheimer, S Molloy, D J Brooks, P Piccin. Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures. Neurology. vol 75. issue 21. 2011-01-04. PMID:21098407. |
the etiology of depression in pd remains uncertain though abnormal serotonergic neurotransmission could play a role. |
2011-01-04 |
2023-08-12 |
Not clear |
| Krista L Lanctôt, Mark J Rapoport, Florance Chan, Ryan D Rajaram, John Strauss, Tricia Sicard, Scott McCullagh, Anthony Feinstein, Alex Kiss, James L Kennedy, Anne S Bassett, Nathan Herrman. Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury. Brain injury. vol 24. issue 7-8. 2010-12-23. PMID:20515362. |
to determine which serotonergic system-related single nucleotide polymorphisms (snps) predicted variation in treatment response to citalopram in depression following a traumatic brain injury (tbi). |
2010-12-23 |
2023-08-12 |
Not clear |
| Jan C Beucke, Idun Uhl, Michail Plotkin, Christine Winter, Hans-Jörg Assion, Tanja Endrass, Holger Amthauer, Andreas Kupsch, Georg Jucke. Serotonergic neurotransmission in early Parkinson's disease: a pilot study to assess implications for depression in this disorder. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 11. issue 6. 2010-12-06. PMID:20586535. |
serotonergic neurotransmission in early parkinson's disease: a pilot study to assess implications for depression in this disorder. |
2010-12-06 |
2023-08-12 |
Not clear |
| J Brezo, A Bureau, C Mérette, V Jomphe, E D Barker, F Vitaro, M Hébert, R Carbonneau, R E Tremblay, G Tureck. Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study. Molecular psychiatry. vol 15. issue 8. 2010-12-03. PMID:19381154. |
main outcome measures included (1) mood disorders (bipolar disorder and major depression) and suicide attempts by early adulthood; (2) odds ratios and probabilities associated with 143 single nucleotide polymorphisms in 11 serotonergic genes, acting directly or as moderators in gene-environment interactions with childhood sexual or childhood physical abuse (cpa), and in gene-gene interactions; (3) regression coefficients for putative endophenotypes for mood disorders (childhood anxiousness) and suicide attempts (childhood disruptiveness). |
2010-12-03 |
2023-08-12 |
Not clear |
| Gerd Wagner, Kathrin Koch, Claudia Schachtzabel, Thomas Sobanski, Jürgen R Reichenbach, Heinrich Sauer, Ralf G M Schlösse. Differential effects of serotonergic and noradrenergic antidepressants on brain activity during a cognitive control task and neurofunctional prediction of treatment outcome in patients with depression. Journal of psychiatry & neuroscience : JPN. vol 35. issue 4. 2010-10-28. PMID:20598238. |
differential effects of serotonergic and noradrenergic antidepressants on brain activity during a cognitive control task and neurofunctional prediction of treatment outcome in patients with depression. |
2010-10-28 |
2023-08-12 |
Not clear |
| Sladana Strkalj Ivezić, Marija Kusan Jukić, Ana Tikvica, Dinka Pavicić Baldan. [Diagnostic and therapeutic algorithm for the treatment of premenstrual dysphoric disorder]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti. vol 64. issue 3. 2010-10-28. PMID:20922861. |
although the etiology of premenstrual dysphoric disorder is unknown, the symptoms of dysphoria, including depression and anxiety, have been associated with serotonergic dysregulation. |
2010-10-28 |
2023-08-12 |
Not clear |
| Leith C R Meyer, Robyn S Hetem, Linda G Fick, Duncan Mitchell, Andrea Fulle. Effects of serotonin agonists and doxapram on respiratory depression and hypoxemia in etorphine-immobilized impala (Aepyceros melampus). Journal of wildlife diseases. vol 46. issue 2. 2010-10-22. PMID:20688644. |
serotonergic ligands have the potential to reverse opioid-induced respiratory depression. |
2010-10-22 |
2023-08-12 |
Not clear |
| Leith C R Meyer, Robyn S Hetem, Linda G Fick, Duncan Mitchell, Andrea Fulle. Effects of serotonin agonists and doxapram on respiratory depression and hypoxemia in etorphine-immobilized impala (Aepyceros melampus). Journal of wildlife diseases. vol 46. issue 2. 2010-10-22. PMID:20688644. |
we examined whether any of three serotonergic ligands could reverse this depression in etorphine-immobilized (0.07 mg/kg) impala (aepyceros melampus). |
2010-10-22 |
2023-08-12 |
Not clear |