| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul R Albert, Brice Le François, Anne M Milla. Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness. Molecular brain. vol 4. 2011-11-30. PMID:21619616. |
over-expression of the 5-ht1a autoreceptor has been implicated in reducing serotonergic neurotransmission, and is associated with major depression and suicide. |
2011-11-30 |
2023-08-12 |
Not clear |
| Michael R Bruchas, Abigail G Schindler, Haripriya Shankar, Daniel I Messinger, Mayumi Miyatake, Benjamin B Land, Julia C Lemos, Catherine E Hagan, John F Neumaier, Albert Quintana, Richard D Palmiter, Charles Chavki. Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron. vol 71. issue 3. 2011-10-18. PMID:21835346. |
selective p38α mapk deletion in serotonergic neurons produces stress resilience in models of depression and addiction. |
2011-10-18 |
2023-08-12 |
mouse |
| Lydia Günther, Julia Rothe, André Rex, Jörg-Peter Voigt, Mark J Millan, Heidrun Fink, Bettina Ber. 5-HT(1A)-receptor over-expressing mice: genotype and sex dependent responses to antidepressants in the forced swim-test. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21419787. |
deficiencies in serotonergic neurotransmission are involved in the pathophysiology of depression. |
2011-10-14 |
2023-08-12 |
mouse |
| Hendrika J Luijendijk, Julia F van den Berg, Albert Hofman, Henning Tiemeier, Bruno H Ch Stricke. β-blockers and the risk of incident depression in the elderly. Journal of clinical psychopharmacology. vol 31. issue 1. 2011-10-13. PMID:21192142. |
the aim of this cohort study was to examine whether β-blockers, in general, highly lipid-soluble, nonselective, or serotonergic receptor-binding β-blockers, are associated with incident depression. |
2011-10-13 |
2023-08-12 |
Not clear |
| Thibault Renoir, Michelle S Zajac, Xin Du, Terence Y Pang, Leah Leang, Caroline Chevarin, Laurence Lanfumey, Anthony J Hanna. Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression. PloS one. vol 6. issue 7. 2011-10-13. PMID:21760962. |
sexually dimorphic serotonergic dysfunction in a mouse model of huntington's disease and depression. |
2011-10-13 |
2023-08-12 |
mouse |
| Thibault Renoir, Michelle S Zajac, Xin Du, Terence Y Pang, Leah Leang, Caroline Chevarin, Laurence Lanfumey, Anthony J Hanna. Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression. PloS one. vol 6. issue 7. 2011-10-13. PMID:21760962. |
in the general population, women are more prone to develop depression and such susceptibility might be related to serotonergic dysregulation. |
2011-10-13 |
2023-08-12 |
mouse |
| Deepali Gupta, Thangaraj Devadoss, Shvetank Bhatt, Baldev Gautam, Ankur Jindal, Dilip Pandey, Radhakrishnan Mahes. Anti-depressant-like activity of a novel serotonin type-3 (5-HT3) receptor antagonist in rodent models of depression. Indian journal of experimental biology. vol 49. issue 8. 2011-09-29. PMID:21870430. |
further, reversal of parthenolide induced depression in mice and reserpine induced hypothermia in rat models indicate the serotonergic influence of qcm-13 for anti-depressant potential. |
2011-09-29 |
2023-08-12 |
mouse |
| Whorra P Chander, Navdeep Singh, Gulshan K Mukhiy. Serotonin syndrome in maintenance haemodialysis patients following sertraline treatment for depression. Journal of the Indian Medical Association. vol 109. issue 1. 2011-09-22. PMID:21888157. |
in our experience the use of ssri, sertraline for depression in esrd patients on maintenance haemodalysis was associated with a high incidence of serotonergic side-effects and toxic serotonin syndrome. |
2011-09-22 |
2023-08-12 |
Not clear |
| P C McHugh, P R Joyce, X Deng, M A Kenned. A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants. The pharmacogenomics journal. vol 11. issue 3. 2011-09-14. PMID:20351752. |
given the pivotal role of the serotonergic system in mood disorders and selective serotonin reuptake inhibitors (ssris) antidepressant function, we tested the hypothesis that gfrp gene (gchfr) variants would modify response to antidepressants in subjects with major depression. |
2011-09-14 |
2023-08-12 |
human |
| T Hochstrasser, C Ullrich, B Sperner-Unterweger, C Humpe. Inflammatory stimuli reduce survival of serotonergic neurons and induce neuronal expression of indoleamine 2,3-dioxygenase in rat dorsal raphe nucleus organotypic brain slices. Neuroscience. vol 184. 2011-09-13. PMID:21501664. |
neuroinflammation results in dysregulation of serotonergic neurons in the dorsal raphe nucleus (dor) and is considered to play an important role in the pathophysiology of depression. |
2011-09-13 |
2023-08-12 |
rat |
| Lynette Hui-Wen Lee, Guanghou Shui, Akhlaq A Farooqui, Markus R Wenk, Chay-Hoon Tan, Wei-Yi On. Lipidomic analyses of the mouse brain after antidepressant treatment: evidence for endogenous release of long-chain fatty acids? The international journal of neuropsychopharmacology. vol 12. issue 7. 2011-09-06. PMID:19203412. |
recently, there has been considerable interest in a possible link between changes in brain polyunsaturated fatty acids, neural membrane phospholipid degradation, serotonergic neurotransmission, and depression. |
2011-09-06 |
2023-08-12 |
mouse |
| Cristina Miguelez, Laura Grandoso, Luisa Uged. Locus coeruleus and dorsal raphe neuron activity and response to acute antidepressant administration in a rat model of Parkinson's disease. The international journal of neuropsychopharmacology. vol 14. issue 2. 2011-09-02. PMID:20426885. |
in addition to noradrenergic and serotonergic systems, dopaminergic neurotransmission seems to play an important role in the aetiopathogenesis of, and recovery from, depression. |
2011-09-02 |
2023-08-12 |
rat |
| Oguz Mutlu, Guner Ulak, Ipek Komsuoglu Celikyurt, Firuzan Yildiz Akar, Faruk Erde. Effects of citalopram on cognitive performance in passive avoidance, elevated plus-maze and three-panel runway tasks in naïve rats. The Chinese journal of physiology. vol 54. issue 1. 2011-08-18. PMID:21786537. |
citalopram, a selective serotonin reuptake inhibitor (ssri), is one of the most widely used drugs for the treatment of disorders related to serotonergic dysfunction like depression and anxiety. |
2011-08-18 |
2023-08-12 |
rat |
| Sâmia Regiane L Joca, Cláudia Maria Padovan, Francisco Silveira Guimarãe. [Stress, depression and the hippocampus]. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 25 Suppl 2. 2011-08-15. PMID:14978587. |
antidepressive drugs attenuate these effects, probably by increasing the expression of neurotrophic factors; 2. facilitation of serotonergic neurotransmission in the hippocampus attenuates behavioral consequences of stress and produce antidepressive-like effects in several animal models; 3. antagonism of glutamate, the main excitatory neurotransmitter of the hippocampus, also induce antidepressive-like effects; 4. increased hippocampal activity has been described in genetically selected rats that are more sensitive to depression models. |
2011-08-15 |
2023-08-12 |
rat |
| César Augusto Brüning, Ana Cristina Guerra Souza, Bibiana Mozzaquatro Gai, Gilson Zeni, Cristina Wayne Nogueir. Antidepressant-like effect of m-trifluoromethyl-diphenyl diselenide in the mouse forced swimming test involves opioid and serotonergic systems. European journal of pharmacology. vol 658. issue 2-3. 2011-07-25. PMID:21371464. |
serotonergic and opioid systems have been implicated in major depression and in the action mechanism of antidepressants. |
2011-07-25 |
2023-08-12 |
mouse |
| Ian M Anderson, Gabriella Juhasz, Emma Thomas, Darragh Downey, Shane McKie, J F William Deakin, Rebecca Elliot. The effect of acute citalopram on face emotion processing in remitted depression: a pharmacoMRI study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:20599362. |
both reduced serotonergic (5-ht) function and negative emotional biases have been associated with vulnerability to depression. |
2011-07-20 |
2023-08-12 |
human |
| Krisztina Mekli, Antony Payton, Fabio Miyajima, Hazel Platt, Emma Thomas, Darragh Downey, Kathryn Lloyd-Williams, Diana Chase, Zoltan G Toth, Rebecca Elliott, William E Ollier, Ian M Anderson, J F William Deakin, Gyorgy Bagdy, Gabriella Juhas. The HTR1A and HTR1B receptor genes influence stress-related information processing. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:20638825. |
the serotonergic system has been widely implicated in stress related psychiatric disorders such as depression and anxiety. |
2011-07-20 |
2023-08-12 |
human |
| L Lykouras, R Gournelli. [Behavioral and psychological symptoms of dementia and their management]. Psychiatrike = Psychiatriki. vol 22. issue 1. 2011-07-08. PMID:21688522. |
patients with depression present greater loss of noradrenergic cells in the locus coeruleus and loss of serotonergic nuclei of dorsal raphe. |
2011-07-08 |
2023-08-12 |
Not clear |
| Thomas Mueggler, Florence Razoux, Holger Russig, Anna Buehler, Tamara B Franklin, Christof Baltes, Isabelle M Mansuy, Markus Rudi. Mapping of CBV changes in 5-HT(1A) terminal fields by functional MRI in the mouse brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 4. 2011-06-15. PMID:20656461. |
the method opens novel perspectives for investigating 5-ht(1a) receptor functions in mouse models of human pathologies resulting from a dysfunction of the 5-ht(1a) receptor or the serotonergic system, including depression and anxiety. |
2011-06-15 |
2023-08-12 |
mouse |
| L Lykouras, M Markianos, Y Hatzimanoli. Prolactin and cortisol responses to acute intravenous clomipramine challenge in patients with mania, depression and healthy controls: evidence for reduced serotonergic responsivity. Neuropsychobiology. vol 63. issue 2. 2011-05-25. PMID:21178381. |
prolactin and cortisol responses to acute intravenous clomipramine challenge in patients with mania, depression and healthy controls: evidence for reduced serotonergic responsivity. |
2011-05-25 |
2023-08-12 |
human |