| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helen Bould, Nicola Wiles, John Potokar, Philip Cowen, David J Nutt, Tim J Peters, Glyn Lewi. Does baseline fatigue influence treatment response to reboxetine or citalopram in depression? An open label randomized controlled trial. Journal of psychopharmacology (Oxford, England). vol 26. issue 5. 2013-01-21. PMID:22223618. |
it has been suggested that antidepressants that increase noradrenergic transmission should be better than serotonergic antidepressants at treating fatigue in depression. |
2013-01-21 |
2023-08-12 |
Not clear |
| Peter A Fasching, Florian Faschingbauer, Tamme W Goecke, Anne Engel, Lothar Häberle, Anna Seifert, Franziska Voigt, Manuela Amann, Dirk Rebhan, Pascal Burger, Johannes Kornhuber, Arif B Ekici, Matthias W Beckmann, Elisabeth B Binde. Genetic variants in the tryptophan hydroxylase 2 gene (TPH2) and depression during and after pregnancy. Journal of psychiatric research. vol 46. issue 9. 2013-01-09. PMID:22721547. |
a number of studies indicate that altered serotonergic transmission may be a risk factor for depression in the peripartum period. |
2013-01-09 |
2023-08-12 |
Not clear |
| Daphna Sourani, Renana Eitan, Noam Gordon, Gadi Goelma. The habenula couples the dopaminergic and the serotonergic systems: application to depression in Parkinson's disease. The European journal of neuroscience. vol 36. issue 6. 2013-01-09. PMID:22774942. |
the habenula couples the dopaminergic and the serotonergic systems: application to depression in parkinson's disease. |
2013-01-09 |
2023-08-12 |
rat |
| Steven Wishart, Graeme J A Macphe. Evaluation and management of the non-motor features of Parkinson's disease. Therapeutic advances in chronic disease. vol 2. issue 2. 2012-12-20. PMID:23251743. |
other nms such as dementia and severe depression may be unresponsive to dopaminergic treatment and may reflect perturbations in cholinergic, serotonergic or noradrenergic neurotransmitter function. |
2012-12-20 |
2023-08-12 |
Not clear |
| F Göthe, D Enache, L O Wahlund, B Winblad, M Crisby, J Lökk, D Aarslan. Cerebrovascular diseases and depression: epidemiology, mechanisms and treatment. Panminerva medica. vol 54. issue 3. 2012-12-06. PMID:22801433. |
potential mechanisms mediating the association between depression and cvd are neuroinflammation and hpa-axis activation, fronto-subcortical circuit lesions, and serotonergic dysfunction. |
2012-12-06 |
2023-08-12 |
Not clear |
| Martina M Hughes, Angela Carballedo, Declan M McLoughlin, Francesco Amico, Andrew Harkin, Thomas Frodl, Thomas J Conno. Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. Brain, behavior, and immunity. vol 26. issue 6. 2012-11-20. PMID:22683764. |
ido expression is driven by inflammatory cytokines, and has been suggested as the link between inflammation and a serotonergic deficit in depression. |
2012-11-20 |
2023-08-12 |
Not clear |
| Martina M Hughes, Angela Carballedo, Declan M McLoughlin, Francesco Amico, Andrew Harkin, Thomas Frodl, Thomas J Conno. Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. Brain, behavior, and immunity. vol 26. issue 6. 2012-11-20. PMID:22683764. |
taken together these data question the ability of the mild inflammatory phenotype observed in depression to induce molecules such as ido and sert that could negatively impact upon serotonergic functioning. |
2012-11-20 |
2023-08-12 |
Not clear |
| Agnes J Jasinska, Christopher A Lowry, Margit Burmeiste. Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression. Trends in neurosciences. vol 35. issue 7. 2012-11-12. PMID:22301434. |
the controversy persists in part because a mechanistic account of this gxe on serotonergic neurotransmission and risk of depression has been lacking. |
2012-11-12 |
2023-08-12 |
Not clear |
| Agnes J Jasinska, Christopher A Lowry, Margit Burmeiste. Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression. Trends in neurosciences. vol 35. issue 7. 2012-11-12. PMID:22301434. |
in particular, the recently characterized stressor-responsive serotonergic interneurons originating from the dorsolateral dr may hold a key to unlocking the gxe mechanism of depression. |
2012-11-12 |
2023-08-12 |
Not clear |
| Raquel Tonello, Jardel Gomes Villarinho, Gabriela da Silva Sant'Anna, Lídia Tamiozzo, Pablo Machado, Gabriela Trevisan, Marcos Antônio Pinto Martins, Juliano Ferreira, Maribel Antonello Rubi. The potential antidepressant-like effect of imidazoline I2 ligand 2-BFI in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 37. issue 1. 2012-11-08. PMID:22122878. |
in conclusion, these results suggest that the antidepressant-like effect of 2-bfi might involve serotonergic, dopaminergic and imidazoline systems, and then the imidazoline site could represent a new pharmacological target for the treatment of depression. |
2012-11-08 |
2023-08-12 |
mouse |
| Lin Xia, Claudine Deloménie, Indira David, Quentin Rainer, Myriam Marouard, Hervé Delacroix, Denis J David, Alain M Gardier, Jean-Philippe Guillou. Ventral hippocampal molecular pathways and impaired neurogenesis associated with 5-HT₁A and 5-HT₁B receptors disruption in mice. Neuroscience letters. vol 521. issue 1. 2012-10-15. PMID:22622174. |
the serotonergic system has been widely implicated in stress related psychiatric disorders such as depression and anxiety. |
2012-10-15 |
2023-08-12 |
mouse |
| Madhuchhanda Banerjee, Shabana Siddique, Anindita Dutta, Bidisha Mukherjee, Manas Ranjan Ra. Cooking with biomass increases the risk of depression in pre-menopausal women in India. Social science & medicine (1982). vol 75. issue 3. 2012-10-11. PMID:22580071. |
compared with the control group, women who cooked with biomass had a higher prevalence of depression and depleted platelet serotonin, suggesting altered serotonergic activity in the brain. |
2012-10-11 |
2023-08-12 |
Not clear |
| Jae-Min Kim, Robert Stewart, Kyung-Yeol Bae, Sung-Wan Kim, Hee-Ju Kang, Il-Seon Shin, Joon-Tae Kim, Man-Seok Park, Myung-Kyu Kim, Sung-Woo Park, Young-Hoon Kim, Jong-Keun Kim, Ki-Hyun Cho, Jin-Sang Yoo. Serotonergic and BDNF genes and risk of depression after stroke. Journal of affective disorders. vol 136. issue 3. 2012-10-09. PMID:22014446. |
serotonergic and bdnf genes and risk of depression after stroke. |
2012-10-09 |
2023-08-12 |
Not clear |
| Stephanie L Willard, Carol A Shivel. Modeling depression in adult female cynomolgus monkeys (Macaca fascicularis). American journal of primatology. vol 74. issue 6. 2012-09-20. PMID:22076882. |
social stress-associated behavioral depression in adult female cynomolgus macaques closely resembles human depression in physiological, neurobiological, and behavioral characteristics, including reduced body mass, hypothalamic-pituitary-adrenal axis perturbations, autonomic dysfunction, increased cardiovascular disease risk, reduced hippocampal volume, altered serotonergic function, decreased activity levels, and increased mortality. |
2012-09-20 |
2023-08-12 |
human |
| Anne Lesemann, Claudia Reinel, Petra Hühnchen, Maximilian Pilhatsch, Rainer Hellweg, Philipp Klaissle, Christine Winter, Barbara Steine. MPTP-induced hippocampal effects on serotonin, dopamine, neurotrophins, adult neurogenesis and depression-like behavior are partially influenced by fluoxetine in adult mice. Brain research. vol 1457. 2012-09-13. PMID:22520437. |
deficits in the generation and maturation of new neurons in the adult hippocampus seem to be key mechanisms of major depression and cognitive decline and are robustly influenced by serotonergic pharmacotherapy. |
2012-09-13 |
2023-08-12 |
mouse |
| F Duval, M C Mokrani, P Bailey, H Corrêa, M A Crocq, T Son Diep, J P Mache. Serotonergic and noradrenergic function in depression: clinical correlates. Dialogues in clinical neuroscience. vol 2. issue 3. 2012-09-10. PMID:22033550. |
serotonergic and noradrenergic function in depression: clinical correlates. |
2012-09-10 |
2023-08-12 |
Not clear |
| Fabrice Duval, Marie-Claude Mokrani, Jose Monreal, Thomas Weiss, Said Fattah, Beatrice Hamel, Jean-Paul Mache. Interaction between the serotonergic system and HPA and HPT axes in patients with major depression: implications for pathogenesis of suicidal behavior. Dialogues in clinical neuroscience. vol 4. issue 4. 2012-09-10. PMID:22033833. |
interaction between the serotonergic system and hpa and hpt axes in patients with major depression: implications for pathogenesis of suicidal behavior. |
2012-09-10 |
2023-08-12 |
Not clear |
| Thibault Renoir, Terence Y C Pang, Michelle S Zajac, Grace Chan, Xin Du, Leah Leang, Caroline Chevarin, Laurence Lanfumey, Anthony J Hanna. Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise. British journal of pharmacology. vol 165. issue 5. 2012-09-07. PMID:21718306. |
women are more prone to develop depression and such susceptibility might be related to 5-hydroxytryptaminergic (serotonergic) dysregulation. |
2012-09-07 |
2023-08-12 |
mouse |
| Aravind Mittu. Trazodone: properties and utility in multiple disorders. Expert review of clinical pharmacology. vol 4. issue 2. 2012-09-04. PMID:22115401. |
owing to its atypical mixed serotonergic and adrenolytic pharmacology, trazodone has been investigated in a number of disorders besides depression and insomnia, including anxiety disorders, chronic pain, frontal cognitive dysfunctions, erectile dysfunction and others. |
2012-09-04 |
2023-08-12 |
human |
| Michael Browning, Maud Grol, Verena Ly, Guy M Goodwin, Emily A Holmes, Catherine J Harme. Using an experimental medicine model to explore combination effects of pharmacological and cognitive interventions for depression and anxiety. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 13. 2012-08-14. PMID:21832988. |
selective serotonergic reuptake inhibitors (ssris) and cognitive therapies are effective in the treatment of anxiety and depression. |
2012-08-14 |
2023-08-12 |
human |