| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akira Toyofuk. Efficacy of milnacipran for glossodynia patients. International journal of psychiatry in clinical practice. vol 7 Suppl 1. 2014-06-19. PMID:24937416. |
pain and depression are thought to arise from a common neurochemical dysfunction at the level of noradrenergic and serotonergic neurons, and antidepressants are used to treat chronic pain. |
2014-06-19 |
2023-08-13 |
Not clear |
| A R Brunoni, A H Kemp, P Shiozawa, Q Cordeiro, L C L Valiengo, A C Goulart, B Coprerski, P A Lotufo, D Brunoni, A B A Perez, F Fregni, I M Benseño. Impact of 5-HTTLPR and BDNF polymorphisms on response to sertraline versus transcranial direct current stimulation: implications for the serotonergic system. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 11. 2014-06-17. PMID:23615118. |
therefore, we hypothesize that tdcs is a neuromodulation technique that acts over depression through the modulation of serotonergic system and that tdcs "top-down" antidepressant effects might not be optimal in brain networks with a hyperactive amygdala inducing bottom-up effects, such as occurs in short-carriers. |
2014-06-17 |
2023-08-12 |
human |
| J Q Bostic, T E Wilens, T Spencer, J Biederma. Antidepressant treatment of juvenile depression. International journal of psychiatry in clinical practice. vol 3. issue 3. 2014-06-17. PMID:24927202. |
emerging research suggests that juvenile depression may respond better to serotonergic and atypical pharmacologic agents, so guidelines for selection and administration of these agents are provided. |
2014-06-17 |
2023-08-13 |
Not clear |
| Ozgür Oztürk, Defne Eraslan, Bülent Kayaha. Paroxetine augmentation to tianeptine treatment causes exacerbation of depressive symptoms: presentation of two cases. International journal of psychiatry in clinical practice. vol 8. issue 4. 2014-06-17. PMID:24930557. |
thus, efficacy of tianeptine as an antidepressant agent caused a challenge to the concept of serotonergic deficit theory in depression. |
2014-06-17 |
2023-08-13 |
Not clear |
| David S Baldwi. Serotonin noradrenaline reuptake inhibitors: A new generation of treatment for anxiety disorders. International journal of psychiatry in clinical practice. vol 10 Suppl 2. 2014-06-14. PMID:24921677. |
there is clear evidence for decreased serotonergic function in anxiety as well as in depression. |
2014-06-14 |
2023-08-13 |
Not clear |
| Pedro L Delgad. Serotonin noradrenaline reuptake inhibitors: New hope for the treatment of chronic pain. International journal of psychiatry in clinical practice. vol 10 Suppl 2. 2014-06-14. PMID:24921678. |
a dysfunction of the serotonergic and noradrenergic neurons can thus affect both the ascending and descending pathways resulting in the psychological symptoms of depression and somatic pain symptoms such as chronic pain, fibromyalgia, non-cardiac chest pain, or irritable bowel syndrome. |
2014-06-14 |
2023-08-13 |
Not clear |
| Hsin Chun Tsai, Shih-Hsien Lin, I Hui Lee, Po See Chen, Kao Chin Chen, Tzung Lieh Yeh, Wei Jen Yao, Nan-Tsing Chiu, Ru-Band Lu, Yen Kuang Yan. Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder--a small-sample SPECT study with [¹²³I]ADAM. Psychoneuroendocrinology. vol 38. issue 11. 2014-06-13. PMID:23816429. |
the association between hypothalamo-pituitary-adrenal (hpa) axis function and the serotonergic system could be involved in the mechanism of depression. |
2014-06-13 |
2023-08-12 |
human |
| Alan L Pehrson, Connie Sanche. Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. CNS spectrums. vol 19. issue 2. 2014-06-03. PMID:23903233. |
serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. |
2014-06-03 |
2023-08-12 |
Not clear |
| Alan L Pehrson, Connie Sanche. Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. CNS spectrums. vol 19. issue 2. 2014-06-03. PMID:23903233. |
the multimodal compounds vortioxetine and vilazodone are examples of this approach with diverse mechanisms, and their different clinical effects will provide valuable insights into serotonergic modulation of glutamate transmission for the potential treatment of depression and associated cognitive dysfunction. |
2014-06-03 |
2023-08-12 |
Not clear |
| Jonathon A Nye, David Purselle, Christophe Plisson, Ronald J Voll, Jeffrey S Stehouwer, John R Votaw, Clinton D Kilts, Mark M Goodman, Charles B Nemerof. Decreased brainstem and putamen SERT binding potential in depressed suicide attempters using [11C]-zient PET imaging. Depression and anxiety. vol 30. issue 10. 2014-05-30. PMID:23526784. |
deficits in serotonergic neurotransmission have been implicated in the pathogenesis of depression and suicidality. |
2014-05-30 |
2023-08-12 |
human |
| Carmen Frías-Domínguez, Julieta Garduño, Salvador Hernández, René Drucker-Colin, Stefan Mihailesc. Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats. Brain research bulletin. vol 98. 2014-05-30. PMID:23872451. |
major depression is characterized by a diminished activity of the brain serotonergic system as well as by the flattening of plasma cortisol levels. |
2014-05-30 |
2023-08-12 |
rat |
| Javier A Bravo, Timothy G Dinan, John F Crya. Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain. Frontiers in molecular neuroscience. vol 7. 2014-04-30. PMID:24782706. |
neonatal maternal separation (ms) is an animal model of depression with an altered serotonergic response. |
2014-04-30 |
2023-08-13 |
rat |
| Begoña Fernández-Pastor, Jorge E Ortega, J Javier Mean. Involvement of serotonin 5-HT3 receptors in the modulation of noradrenergic transmission by serotonin reuptake inhibitors: a microdialysis study in rat brain. Psychopharmacology. vol 229. issue 2. 2014-03-31. PMID:23636303. |
selective serotonin reuptake inhibitors (ssris), in addition to being able to enhance serotonergic neurotransmission, are able to modulate other brain systems involved in depression. |
2014-03-31 |
2023-08-12 |
rat |
| Jennifer M Spaethling, David Piel, Hannah Dueck, Peter T Buckley, Jacqueline F Morris, Stephen A Fisher, Jaehee Lee, Jai-Yoon Sul, Junhyong Kim, Tamas Bartfai, Sheryl G Beck, James H Eberwin. Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 2. 2014-03-27. PMID:24192459. |
despite the recognized importance of the dorsal raphe (dr) serotonergic (5-ht) nuclei in the pathophysiology of depression and anxiety, the molecular components/putative drug targets expressed by these neurons are poorly characterized. |
2014-03-27 |
2023-08-12 |
Not clear |
| J Dyavanapalli, P Byrne, D Mendelowit. Activation of D2-like dopamine receptors inhibits GABA and glycinergic neurotransmission to pre-motor cardiac vagal neurons in the nucleus ambiguus. Neuroscience. vol 247. 2014-03-18. PMID:23727508. |
in addition, the dopamine mediated depression of inhibitory synaptic responses were prevented by the d2-like receptor antagonist sulpiride, but not by d1-like or adrenergic or serotonergic receptor antagonists, suggesting that these responses were d2-like receptor mediated and not d1-like or adrenergic or 5-ht receptor mediated. |
2014-03-18 |
2023-08-12 |
rat |
| Qiang-Song Wang, Shi-Lan Ding, Hao-Ping Mao, Yuan-Lu Cui, Xue-Jie Q. Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice. Journal of ethnopharmacology. vol 148. issue 2. 2014-03-05. PMID:23702040. |
furthermore, the alkaloids from the two herbs in zjp may provide a protective effect for depression in individuals with a low expressing 5-htt allele by increasing receptor concentration in serotonergic neurons. |
2014-03-05 |
2023-08-12 |
mouse |
| Baldev Kumar Gautam, Ankur Jindal, Arghya Kusum Dhar, Radhakrishnan Mahes. Antidepressant-like activity of 2-(4-phenylpiperazin-1-yl)-1, 8-naphthyridine-3-carboxylic acid (7a), a 5-HT₃ receptor antagonist in behaviour based rodent models: evidence for the involvement of serotonergic system. Pharmacology, biochemistry, and behavior. vol 109. 2014-01-07. PMID:23680574. |
these results suggest that the antidepressant-like action of 7a may be mediated by an interaction with the serotonergic system and this molecule should be further investigated as an alternative therapeutic approach for the treatment of depression. |
2014-01-07 |
2023-08-12 |
mouse |
| Oliver J Robinson, Cassie Overstreet, Philip S Allen, Alison Letkiewicz, Katherine Vytal, Daniel S Pine, Christian Grillo. The role of serotonin in the neurocircuitry of negative affective bias: serotonergic modulation of the dorsal medial prefrontal-amygdala 'aversive amplification' circuit. NeuroImage. vol 78. 2014-01-06. PMID:23583742. |
serotonergic medications can mitigate the negative affective biases in disorders such as depression or anxiety, but the neural mechanism by which this occurs is largely unknown. |
2014-01-06 |
2023-08-12 |
human |
| H Suzuki, R P A Barros, N Sugiyama, V Krishnan, B C Yaden, H-J Kim, M Warner, J-Å Gustafsso. Involvement of estrogen receptor β in maintenance of serotonergic neurons of the dorsal raphe. Molecular psychiatry. vol 18. issue 6. 2014-01-03. PMID:22665260. |
the serotonergic neurons of the dorsal raphe (dr) nucleus in the cns are involved in fear, anxiety and depression. |
2014-01-03 |
2023-08-12 |
mouse |
| Parichehr Yaghmaei, Shahrbanoo Oryan, Khadijeh Mohammadi, Jalal Solat. Role of serotonergic system on modulation of depressogenic-like effects of silymarine. Iranian journal of pharmaceutical research : IJPR. vol 11. issue 1. 2013-11-19. PMID:24250456. |
in the present study, we have investigated the effects of silymarine on depression and the possible role of serotonergic system in these effects. |
2013-11-19 |
2023-08-12 |
rat |