| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Taro Kato, Yuji Matsumoto, Masanori Yamamoto, Kenji Matsumoto, Satoko Baba, Keiko Nakamichi, Harumi Matsuda, Haruka Nishimuta, Kazuki Yabuuch. DSP-1053, a novel serotonin reuptake inhibitor with 5-HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats. Pharmacology research & perspectives. vol 3. issue 3. 2015-07-14. PMID:26171224. |
enhancement of serotonergic neurotransmission has been the main stream of treatment for patients with depression. |
2015-07-14 |
2023-08-13 |
human |
| Elyse C Dankoski, Kara L Agster, Megan E Fox, Sheryl S Moy, R Mark Wightma. Facilitation of serotonin signaling by SSRIs is attenuated by social isolation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:24981046. |
hypofunction of the serotonergic system is often associated with major depression and obsessive compulsive disorder (ocd). |
2015-07-07 |
2023-08-13 |
mouse |
| P C Hsieh, K C Chen, T L Yeh, I H Lee, P S Chen, W J Yao, N-T Chiu, C-C Chen, M-H Liao, Y K Yan. Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand SPECT study. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24439516. |
in addition, a family history of depression is a potent risk factor for developing depression, and inherited vulnerability to serotonergic and dopaminergic dysfunction is suspected in this. |
2015-05-15 |
2023-08-12 |
human |
| Amy C Bilderbeck, Judi Wakeley, Beata R Godlewska, Francis McGlone, Tirril Harris, Phillip J Cowen, Robert D Roger. Preliminary evidence that sub-chronic citalopram triggers the re-evaluation of value in intimate partnerships. Social cognitive and affective neuroscience. vol 9. issue 9. 2015-05-14. PMID:23996287. |
depression frequently involves disrupted inter-personal relationships, while treatment with serotonergic anti-depressants can interfere with libido and sexual function. |
2015-05-14 |
2023-08-12 |
human |
| Shvetank Bhatt, Radhakrishnan Mahesh, Ankur Jindal, Thangaraj Devados. Neuropharmacological effect of novel 5-HT3 receptor antagonist, N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n) on chronic unpredictable mild stress-induced molecular and cellular response: Behavioural and biochemical evidences. Pharmacological reports : PR. vol 66. issue 5. 2015-05-13. PMID:25149984. |
the 5-ht3 receptor antagonists modulate serotonergic pathways and show antidepressant-like effect in various animal models of depression. |
2015-05-13 |
2023-08-13 |
human |
| Amanda P Borrow, Nicole M Camero. Estrogenic mediation of serotonergic and neurotrophic systems: implications for female mood disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 54. 2015-05-12. PMID:24865152. |
this review argues two major mechanisms by which estrogens influence depression and depressive-like behavior: through interactions with neurotrophic factors and through an influence on the serotonergic system. |
2015-05-12 |
2023-08-13 |
Not clear |
| Ajeet Bhagat Singh, Chad A Bousman, Chee Hong Ng, Keith Byron, Michael Ber. Effects of persisting emotional impact from child abuse and norepinephrine transporter genetic variation on antidepressant efficacy in major depression: a pilot study. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 13. issue 1. 2015-04-27. PMID:25912538. |
previous studies suggest child abuse and serotonergic polymorphism influence depression susceptibility and antidepressant efficacy. |
2015-04-27 |
2023-08-13 |
Not clear |
| J Macoveanu, U Knorr, A Skimminge, M G Søndergaard, A Jørgensen, M Fauerholdt-Jepsen, O B Paulson, G M Knudsen, H R Siebner, L V Kessin. Altered reward processing in the orbitofrontal cortex and hippocampus in healthy first-degree relatives of patients with depression. Psychological medicine. vol 44. issue 6. 2015-03-31. PMID:23866315. |
healthy first-degree relatives of patients with major depression (rmd+) show brain structure and functional response anomalies and have elevated risk for developing depression, a disorder linked to abnormal serotonergic neurotransmission and reward processing. |
2015-03-31 |
2023-08-12 |
Not clear |
| Enrica Olivola, Mariangela Pierantozzi, Paola Imbriani, Claudio Liguori, Mario Stampanoni Bassi, Marco Conti, Vincenza D'Angelo, Nicola Biagio Mercuri, Alessandro Stefan. Serotonin impairment in CSF of PD patients, without an apparent clinical counterpart. PloS one. vol 9. issue 7. 2015-03-30. PMID:25036938. |
given these findings, an add-on therapy with serotonergic agents seems questionable in pd patients, or should be individually tailored, unless severe depression is present. |
2015-03-30 |
2023-08-13 |
human |
| Bartłomiej Pochwat, Agnieszka Pałucha-Poniewiera, Bernadeta Szewczyk, Andrzej Pilc, Gabriel Nowa. NMDA antagonists under investigation for the treatment of major depressive disorder. Expert opinion on investigational drugs. vol 23. issue 9. 2015-03-05. PMID:24818801. |
furthermore, treatment of depression therapeutics, mainly influencing the serotonergic and adrenergic systems, is considered insufficient. |
2015-03-05 |
2023-08-13 |
Not clear |
| Irene Lopez-Vilchez, Montserrat Serra-Millas, Victor Navarro, M Rosa Hernandez, Jaume Villalta, Maribel Diaz-Ricart, Cristobal Gasto, Gines Escolar, Ana M Gala. Prothrombotic platelet phenotype in major depression: downregulation by antidepressant treatment. Journal of affective disorders. vol 159. 2015-02-26. PMID:24679387. |
serotonergic mechanisms have been suggested as a link between major depression and cardiovascular risk. |
2015-02-26 |
2023-08-12 |
Not clear |
| C Bruzos-Cidón, C Miguelez, J J Rodríguez, R Gutiérrez-Lanza, L Ugedo, M Torrecill. Altered neuronal activity and differential sensitivity to acute antidepressants of locus coeruleus and dorsal raphe nucleus in Wistar Kyoto rats: a comparative study with Sprague Dawley and Wistar rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 7. 2015-02-12. PMID:24582527. |
overall, these results point out important electrophysiological differences regarding noradrenergic and serotonergic systems between wis and wky rats, supporting the utility of the wky rat as an important tool in the research of cellular basis of depression. |
2015-02-12 |
2023-08-12 |
rat |
| William R Lovallo, Mary-Anne Enoch, Eldad Yechiam, David C Glahn, Ashley Acheson, Kristen H Sorocco, Colin A Hodgkinson, Bojeong Kim, Andrew J Cohoon, Andrea S Vincent, David Goldma. Differential impact of serotonin transporter activity on temperament and behavior in persons with a family history of alcoholism in the Oklahoma Family Health Patterns Project. Alcoholism, clinical and experimental research. vol 38. issue 6. 2015-02-12. PMID:24796636. |
central serotonergic (5-ht) function is implicated in pathways to alcohol dependence, including dysphoria manifested by symptoms of anxiety and depression. |
2015-02-12 |
2023-08-13 |
Not clear |
| Shiny John, Kavitarati Dharwadkar, Manjunath V Motag. Study on association between lipid profile values and psychiatric disorders. Journal of clinical and diagnostic research : JCDR. vol 8. issue 12. 2015-02-05. PMID:25654015. |
several studies showed that there may be a link between depression and low cholesterol because of altered central serotonergic functions. |
2015-02-05 |
2023-08-13 |
Not clear |
| Jae Yong Choi, Sora Shin, Minkyung Lee, Tae Joo Jeon, Youngbeom Seo, Chul Hoon Kim, Dong Goo Kim, Chi Hoon Yi, Kyochul Lee, Tae Hyun Choi, Jee Hae Kang, Young Hoon Ry. Acute physical stress induces the alteration of the serotonin 1A receptor density in the hippocampus. Synapse (New York, N.Y.). vol 68. issue 8. 2015-02-02. PMID:24771590. |
stress affects the serotonergic system, which is associated with depression. |
2015-02-02 |
2023-08-13 |
rat |
| Paul R Albert, Laura M Fior. Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity. Current pharmaceutical design. vol 20. issue 23. 2015-01-30. PMID:24180393. |
we present evidence that by targeting specific transcription factors it may be possible to oppositely regulate 5-ht1a auto- and heteroreceptor expression, synergistically increasing serotonergic neurotransmission for the treatment of depression. |
2015-01-30 |
2023-08-12 |
Not clear |
| Evan D Paul, Christopher A Lowr. Functional topography of serotonergic systems supports the Deakin/Graeff hypothesis of anxiety and affective disorders. Journal of psychopharmacology (Oxford, England). vol 27. issue 12. 2015-01-27. PMID:23704363. |
finally, serotonergic neurons in the median raphe nucleus, and the developmentally and functionally-related interfascicular part of the dorsal raphe nucleus, give rise to forebrain limbic projections that are involved in tolerance and coping with aversive stimuli, which could be important for affective disorders like depression. |
2015-01-27 |
2023-08-12 |
Not clear |
| Antonio Rodríguez-Gaztelumendi, María Luisa Rojo, Angel Pazos, Alvaro Día. An altered spinal serotonergic system contributes to increased thermal nociception in an animal model of depression. Experimental brain research. vol 232. issue 6. 2015-01-26. PMID:24584836. |
an altered spinal serotonergic system contributes to increased thermal nociception in an animal model of depression. |
2015-01-26 |
2023-08-12 |
rat |
| Antonio Rodríguez-Gaztelumendi, María Luisa Rojo, Angel Pazos, Alvaro Día. An altered spinal serotonergic system contributes to increased thermal nociception in an animal model of depression. Experimental brain research. vol 232. issue 6. 2015-01-26. PMID:24584836. |
the olfactory bulbectomized (ob) rat, an animal model of chronic depression with comorbid anxiety, exhibits a profound dysregulation of the brain serotonergic signalling, a neurotransmission system involved in pain transmission and modulation. |
2015-01-26 |
2023-08-12 |
rat |
| Antonio Rodríguez-Gaztelumendi, María Luisa Rojo, Angel Pazos, Alvaro Día. An altered spinal serotonergic system contributes to increased thermal nociception in an animal model of depression. Experimental brain research. vol 232. issue 6. 2015-01-26. PMID:24584836. |
our findings demonstrate the participation of the spinal serotonergic system in the increased thermal nociception exhibited by the ob rat and the antinociceptive effect of chronic fluoxetine in this animal model of depression. |
2015-01-26 |
2023-08-12 |
rat |