| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Hamish McAllister-Williams, Eleanor Smith, Ian M Anderson, Jane Barnes, Peter Gallagher, Heinz C R Grunze, Peter M Haddad, Allan O House, Tom Hughes, Adrian J Lloyd, Elaine M M McColl, Simon H S Pearce, Najma Siddiqi, Baxi Sinha, Chris Speed, I Nick Steen, June Wainright, Stuart Watson, Fiona H Winter, I Nicol Ferrie. Study protocol for the randomised controlled trial: antiglucocorticoid augmentation of anti-Depressants in Depression (The ADD Study). BMC psychiatry. vol 13. 2015-01-06. PMID:23914988. |
the antiglucocorticoid augmentation of anti-depressants in depression (the add study) is a multicentre randomised placebo controlled trial of metyrapone augmentation of serotonergic antidepressants in a large population of patients with trd in the uk national health service. |
2015-01-06 |
2023-08-12 |
Not clear |
| Rani K Vasudeva, Barry D Waterhous. Cellular profile of the dorsal raphe lateral wing sub-region: relationship to the lateral dorsal tegmental nucleus. Journal of chemical neuroanatomy. vol 57-58. 2015-01-05. PMID:24704911. |
as one of the main serotonergic (5ht) projections to the forebrain, the dorsal raphe nucleus (drn) has been implicated in disorders of anxiety and depression. |
2015-01-05 |
2023-08-13 |
human |
| Jaanus Harro, Margus Kanarik, Tanel Kaart, Denis Matrov, Kadri Kõiv, Tanel Mällo, Joaquin Del Río, Rosa M Tordera, Maria J Ramire. Revealing the cerebral regions and networks mediating vulnerability to depression: oxidative metabolism mapping of rat brain. Behavioural brain research. vol 267. 2014-12-11. PMID:24662150. |
rats were rendered vulnerable to depression either by partial serotonergic lesion or by maternal deprivation, or selected for a vulnerable phenotype (low positive affect, low novelty-related activity or high hedonic response). |
2014-12-11 |
2023-08-12 |
human |
| Ofelia Limón-Morales, Cesar Soria-Fregozo, Marcela Arteaga-Silva, Gonzalo Vázquez-Palacios, Herlinda Bonilla-Jaim. Altered expression of 5-HT1A receptors in adult rats induced by neonatal treatment with clomipramine. Physiology & behavior. vol 124. 2014-12-10. PMID:24211235. |
dysfunctions in the activity of the central nervous system's serotonergic function are important in understanding the pathophysiology of depression. |
2014-12-10 |
2023-08-12 |
rat |
| Lauren Wright, William Simpson, Ryan J Van Lieshout, Meir Steine. Depression and cardiovascular disease in women: is there a common immunological basis? A theoretical synthesis. Therapeutic advances in cardiovascular disease. vol 8. issue 2. 2014-12-01. PMID:24510936. |
this review takes the standpoint that depression and cvd are both inflammatory disorders, and that their co-occurrence may be related to how the hypothalamic-pituitary-adrenal axis, serotonergic transmission and circulation, and the renin-angiotensin-aldosterone system via angiotensin ii are affected by the excess secretion of proinflammatory cytokines. |
2014-12-01 |
2023-08-12 |
human |
| Mei Shi, Jian Hu, Xuesong Dong, Yue Gao, Ganghui An, Wei Liu, Li Chen, Xueying Su. Association of unipolar depression with gene polymorphisms in the serotonergic pathways in Han Chinese. Acta neuropsychiatrica. vol 20. issue 3. 2014-11-13. PMID:25385523. |
association of unipolar depression with gene polymorphisms in the serotonergic pathways in han chinese. |
2014-11-13 |
2023-08-13 |
Not clear |
| Mei Shi, Jian Hu, Xuesong Dong, Yue Gao, Ganghui An, Wei Liu, Li Chen, Xueying Su. Association of unipolar depression with gene polymorphisms in the serotonergic pathways in Han Chinese. Acta neuropsychiatrica. vol 20. issue 3. 2014-11-13. PMID:25385523. |
the present study aims to investigate the association of unipolar depression (upd) with six serotonergic gene polymorphisms in han chinese. |
2014-11-13 |
2023-08-13 |
Not clear |
| Julian Macovean. Serotonergic modulation of reward and punishment: evidence from pharmacological fMRI studies. Brain research. vol 1556. 2014-11-06. PMID:24508910. |
the new findings may have implications in understanding psychiatric disorders such as major depression which is characterized by abnormal serotonergic function and reward-related processing and may also provide a neural correlated for the emotional blunting observed in the clinical treatment of psychiatric disorders with selective serotonin reuptake inhibitors. |
2014-11-06 |
2023-08-12 |
human |
| Alvaro L Garcia-Garcia, Adrian Newman-Tancredi, E David Leonard. 5-HT(1A) [corrected] receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function. Psychopharmacology. vol 231. issue 4. 2014-10-10. PMID:24337875. |
serotonin (5-ht) neurotransmission is intimately linked to anxiety and depression and a diverse body of evidence supports the involvement of the main inhibitory serotonergic receptor, the serotonin-1a (5-ht(1a)) subtype, in both disorders. |
2014-10-10 |
2023-08-12 |
Not clear |
| M Elizabeth Sublette, Hanga C Galfalvy, Joseph R Hibbeln, John G Keilp, Kevin M Malone, Maria A Oquendo, J John Man. Polyunsaturated fatty acid associations with dopaminergic indices in major depressive disorder. The international journal of neuropsychopharmacology. vol 17. issue 3. 2014-09-17. PMID:24300434. |
the robust relationship of omega-3 pufas with dopaminergic but not serotonergic indices suggests that omega-6:omega-3 balance may impact depression pathophysiology through effects on the dopaminergic system. |
2014-09-17 |
2023-08-12 |
Not clear |
| Orna Issler, Sharon Haramati, Evan D Paul, Hiroshi Maeno, Inbal Navon, Rayya Zwang, Shosh Gil, Helen S Mayberg, Boadie W Dunlop, Andreas Menke, Rajeshwar Awatramani, Elisabeth B Binder, Evan S Deneris, Christopher A Lowry, Alon Che. MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity. Neuron. vol 83. issue 2. 2014-09-12. PMID:24952960. |
the link between dysregulated serotonergic activity and depression and anxiety disorders is well established, yet the molecular mechanisms underlying these psychopathologies are not fully understood. |
2014-09-12 |
2023-08-13 |
mouse |
| Jens D Bukh, Camilla Bock, Lars V Kessin. Association between genetic polymorphisms in the serotonergic system and comorbid personality disorders among patients with first-episode depression. Journal of personality disorders. vol 28. issue 3. 2014-09-08. PMID:24344840. |
association between genetic polymorphisms in the serotonergic system and comorbid personality disorders among patients with first-episode depression. |
2014-09-08 |
2023-08-12 |
human |
| Jens D Bukh, Camilla Bock, Lars V Kessin. Association between genetic polymorphisms in the serotonergic system and comorbid personality disorders among patients with first-episode depression. Journal of personality disorders. vol 28. issue 3. 2014-09-08. PMID:24344840. |
using the "enriched sample method," the authors of the present study aimed to assess the association between polymorphisms in the serotonergic transmitter system and comorbid personality disorders in patients recently diagnosed with first-episode depression. |
2014-09-08 |
2023-08-12 |
human |
| Dan A Kim, Willie G McClure, Jordan B Neighoff, Dhananjay Vaidya, Marlene S William. Platelet response to serotonin in patients with stable coronary heart disease. The American journal of cardiology. vol 114. issue 2. 2014-08-26. PMID:24952926. |
given that the pathophysiology of depression is considered to involve disruption in brain serotonergic signaling, we investigated platelet response to serotonin stimulation in patients with stable coronary artery disease (cad). |
2014-08-26 |
2023-08-13 |
Not clear |
| Claudio N Soare. Depression in peri- and postmenopausal women: prevalence, pathophysiology and pharmacological management. Drugs & aging. vol 30. issue 9. 2014-08-13. PMID:23801148. |
transdermal estradiol, as well as serotonergic and noradrenergic antidepressants, have shown efficacy in the management of depression in this population. |
2014-08-13 |
2023-08-12 |
Not clear |
| Ian Mahar, Francis Rodriguez Bambico, Naguib Mechawar, José N Nobreg. Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neuroscience and biobehavioral reviews. vol 38. 2014-08-08. PMID:24300695. |
the goal of this review is to link the serotonergic and neurogenic hypotheses of depression and antidepressant effects in the context of stress. |
2014-08-08 |
2023-08-12 |
Not clear |
| Chris Baeken, Axel Bossuyt, Rudi De Raed. Dorsal prefrontal cortical serotonin 2A receptor binding indices are differentially related to individual scores on harm avoidance. Psychiatry research. vol 221. issue 2. 2014-07-28. PMID:24412555. |
ha is a personality feature closely related to stress, anxiety and depression proneness, and it is thought to be mediated by the serotonergic system. |
2014-07-28 |
2023-08-12 |
Not clear |
| Yan Li, Kasper F Raaby, Connie Sánchez, Maria Gulinell. Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats. Behavioural brain research. vol 256. 2014-06-26. PMID:24016840. |
serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats. |
2014-06-26 |
2023-08-12 |
rat |
| Andreas Menk. Gene expression: biomarker of antidepressant therapy? International review of psychiatry (Abingdon, England). vol 25. issue 5. 2014-06-26. PMID:24151803. |
antidepressants as currently available usually enhance serotonergic, noradrenergic and dopaminergic neurotransmission and may contribute to the inadequate remission rates for major depression. |
2014-06-26 |
2023-08-12 |
Not clear |
| J G Rahol. Antidepressants: pharmacological profile and clinical consequences. International journal of psychiatry in clinical practice. vol 5. issue 1. 2014-06-19. PMID:24936991. |
three neurotransmitter systems are implicated in the biological basis of depression: the serotonergic system is thought to be a major component in the development of depression and in the efficacy of antidepressant drugs, while the noradrenergic and dopaminergic systems play lesser roles, but are important in the development of antidepressant side-effects. |
2014-06-19 |
2023-08-13 |
Not clear |