| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yilong Cui, Qing-Hua Li, Hisao Yamada, Yasuyoshi Watanabe, Yosky Kataok. Chronic degeneration of dorsal raphe serotonergic neurons modulates cortical spreading depression: a possible pathophysiology of migraine. Journal of neuroscience research. vol 91. issue 6. 2013-10-30. PMID:23456883. |
chronic degeneration of dorsal raphe serotonergic neurons modulates cortical spreading depression: a possible pathophysiology of migraine. |
2013-10-30 |
2023-08-12 |
rat |
| Yilong Cui, Qing-Hua Li, Hisao Yamada, Yasuyoshi Watanabe, Yosky Kataok. Chronic degeneration of dorsal raphe serotonergic neurons modulates cortical spreading depression: a possible pathophysiology of migraine. Journal of neuroscience research. vol 91. issue 6. 2013-10-30. PMID:23456883. |
to investigate whether the brain parenchymal serotonergic nervous system is involved in the etiology of migraine, we prepared an experimental model of migraine by generation of cortical spreading depression (sd), characterized by spreading of neuronal/glial membrane depolarization accompanied by temporal elevation of the cerebral blood flow (cbf) throughout the cerebral cortical hemisphere in rats, which underwent pharmacological treatment for degeneration of serotonergic neurons in the dorsal raphe nucleus. |
2013-10-30 |
2023-08-12 |
rat |
| Yilong Cui, Qing-Hua Li, Hisao Yamada, Yasuyoshi Watanabe, Yosky Kataok. Chronic degeneration of dorsal raphe serotonergic neurons modulates cortical spreading depression: a possible pathophysiology of migraine. Journal of neuroscience research. vol 91. issue 6. 2013-10-30. PMID:23456883. |
these results indicate that the dorsal raphe serotonergic neurons modulate cortical spreading depression and might be involved in migraine pathology via a similar mechanism. |
2013-10-30 |
2023-08-12 |
rat |
| Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. |
serotonergic drugs for depression and beyond. |
2013-10-29 |
2023-08-12 |
Not clear |
| Chiara Fabbri, Agnese Marsano, Alessandro Serrett. Genetics of serotonin receptors and depression: state of the art. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23547754. |
given the high heritability of md (estimated between 31% and 42% for unipolar depression), genes coding for key regulators of the serotonergic neurotransmission have been considered as optimal candidates. |
2013-10-29 |
2023-08-12 |
Not clear |
| Esther Berrocoso, Kazutaka Ikeda, Ichiro Sora, George R Uhl, Pilar Sánchez-Blázquez, Juan Antonio Mic. Active behaviours produced by antidepressants and opioids in the mouse tail suspension test. The international journal of neuropsychopharmacology. vol 16. issue 1. 2013-10-17. PMID:22217458. |
most classical preclinical tests to predict antidepressant activity were initially developed to detect compounds that influenced noradrenergic and/or serotonergic activity, in accordance with the monoaminergic hypothesis of depression. |
2013-10-17 |
2023-08-12 |
mouse |
| Satoko Kimura, Yoshiaki Ohi, Akira Haj. Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats. European journal of pharmacology. vol 703. issue 1-3. 2013-09-23. PMID:23438874. |
the present study suggests that activation of cholinergic or serotonergic (5-ht1a) mechanisms may be a useful therapeutic approach for morphine-induced ventilatory depression without loss of its analgesic action. |
2013-09-23 |
2023-08-12 |
rat |
| Faisal Shabbir, Akash Patel, Charles Mattison, Sumit Bose, Raathathulaksi Krishnamohan, Emily Sweeney, Sarina Sandhu, Wynand Nel, Afsha Rais, Ranbir Sandhu, Nguasaah Ngu, Sushil Sharm. Effect of diet on serotonergic neurotransmission in depression. Neurochemistry international. vol 62. issue 3. 2013-08-29. PMID:23306210. |
effect of diet on serotonergic neurotransmission in depression. |
2013-08-29 |
2023-08-12 |
Not clear |
| Faisal Shabbir, Akash Patel, Charles Mattison, Sumit Bose, Raathathulaksi Krishnamohan, Emily Sweeney, Sarina Sandhu, Wynand Nel, Afsha Rais, Ranbir Sandhu, Nguasaah Ngu, Sushil Sharm. Effect of diet on serotonergic neurotransmission in depression. Neurochemistry international. vol 62. issue 3. 2013-08-29. PMID:23306210. |
this report highlights the clinical significance of tryptophan-rich diet and vitamin b(6) to boost serotonergic neurotransmission in depression observed in various neurodegenerative diseases. |
2013-08-29 |
2023-08-12 |
Not clear |
| Paul David Sigalas, Himanshu Garg, Stuart Watson, Richard Hamish McAllister-Williams, I Nicol Ferrie. Metyrapone in treatment-resistant depression. Therapeutic advances in psychopharmacology. vol 2. issue 4. 2013-08-28. PMID:23983967. |
the most robust evidence for its antidepressant efficacy in depression comes from a double-blind, randomized, placebo-controlled study of augmentation of serotonergic antidepressants with metyrapone. |
2013-08-28 |
2023-08-12 |
Not clear |
| Paul David Sigalas, Himanshu Garg, Stuart Watson, Richard Hamish McAllister-Williams, I Nicol Ferrie. Metyrapone in treatment-resistant depression. Therapeutic advances in psychopharmacology. vol 2. issue 4. 2013-08-28. PMID:23983967. |
a 3-week augmentation of serotonergic antidepressants with 1 g metyrapone daily was shown to be superior to placebo in reducing the montgomery-asberg depression rating scale by 50%, 5 weeks following initiation of treatment. |
2013-08-28 |
2023-08-12 |
Not clear |
| Richard B Thorpe, Sara L Stockman, James M Williams, Thomas M Lincoln, William J Pearc. Hypoxic depression of PKG-mediated inhibition of serotonergic contraction in ovine carotid arteries. American journal of physiology. Regulatory, integrative and comparative physiology. vol 304. issue 9. 2013-08-26. PMID:23447135. |
hypoxic depression of pkg-mediated inhibition of serotonergic contraction in ovine carotid arteries. |
2013-08-26 |
2023-08-12 |
Not clear |
| Laura Saenz del Burgo, Roser Cortés, Guadalupe Mengod, Mario Montaña, Gontzal García del Caño, Joan Sallé. Chronic effects of corticosterone on GIRK1-3 subunits and 5-HT1A receptor expression in rat brain and their reversal by concurrent fluoxetine treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 3. 2013-08-19. PMID:22591911. |
dysregulation of the serotonergic system and abnormalities of the hypothalamic-pituitary-adrenal axis have been demonstrated in major depression. |
2013-08-19 |
2023-08-12 |
rat |
| Moritz Lebe, Monika I Hasenbring, Kirsten Schmieder, Kathleen Jetschke, Albrecht Harders, Jörg T Epplen, Sabine Hoffjan, Judith Köttin. Association of serotonin-1A and -2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6 months after lumbar disc surgery. Pain. vol 154. issue 3. 2013-08-15. PMID:23318131. |
single nucleotide polymorphisms (snps) in the serotonergic (5ht) system seem to have modulatory effects on depression and physical function. |
2013-08-15 |
2023-08-12 |
Not clear |
| Laura Mandelli, Niki Antypa, Finiki A Nearchou, Chrysostomos Vaiopoulos, Costas N Stefanis, Alessandro Serretti, Nikos C Stefani. The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism. Journal of affective disorders. vol 142. issue 1-3. 2013-08-13. PMID:22868061. |
several genes of the serotonergic neurotransmission have been related to depression phenotypes, however results are inconsistent, possibly due to the oversight of the role of environmental stress. |
2013-08-13 |
2023-08-12 |
Not clear |
| Agnieszka Wąsik, Edyta Możdżeń, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michalu. Antidepressant-like activity of the endogenous amine, 1-methyl-1,2,3,4-tetrahydroisoquinoline in the behavioral despair test in the rat, and its neurochemical correlates: a comparison with the classical antidepressant, imipramine. European journal of pharmacology. vol 700. issue 1-3. 2013-08-05. PMID:23246532. |
disturbances in noradrenergic and serotonergic transmissions have been postulated to form neurochemical background of depression. |
2013-08-05 |
2023-08-12 |
rat |
| Gabriel Manjarrez-Gutiérrez, Rodolfo Ramírez-Campillo, Gabriela Borrayo-Sánchez, Jorge Hernández-Rodrígue. Disturbance of serotonergic neurotransmission in patients with postmyocardial infarction and depression. Metabolic brain disease. vol 28. issue 1. 2013-08-02. PMID:23129293. |
disturbance of serotonergic neurotransmission in patients with postmyocardial infarction and depression. |
2013-08-02 |
2023-08-12 |
Not clear |
| Gabriel Manjarrez-Gutiérrez, Rodolfo Ramírez-Campillo, Gabriela Borrayo-Sánchez, Jorge Hernández-Rodrígue. Disturbance of serotonergic neurotransmission in patients with postmyocardial infarction and depression. Metabolic brain disease. vol 28. issue 1. 2013-08-02. PMID:23129293. |
the objective of this study was to assess the hypothesis that patients who develop depression after myocardial infarction (mi) have a lower level of brain serotonergic neurotransmission through measurement of plasma free fraction of l-tryptophan and intensity-dependence auditory-evoked potentials (idaeps). |
2013-08-02 |
2023-08-12 |
Not clear |
| Gabriel Manjarrez-Gutiérrez, Rodolfo Ramírez-Campillo, Gabriela Borrayo-Sánchez, Jorge Hernández-Rodrígue. Disturbance of serotonergic neurotransmission in patients with postmyocardial infarction and depression. Metabolic brain disease. vol 28. issue 1. 2013-08-02. PMID:23129293. |
these findings suggest an important deterioration of brain serotonergic activity as a pathophysiological mechanism in post-mi patients for the development of clinical depression. |
2013-08-02 |
2023-08-12 |
Not clear |
| Pilar A Saiz, Sara Martínez-Barrondo, María P García-Portilla, Paul Corcoran, Blanca Morales, María-Teresa Bascaran, Begoña Paredes, Victoria Alvarez, Eliecer Coto, Juan M Fernández, Manuel Bousoño, Julio Bobe. Role of serotonergic polymorphisms in the clinical severity of the panic disorder. Revista de psiquiatria y salud mental. vol 2. issue 1. 2013-07-25. PMID:23034196. |
to investigate the association between three serotonergic polymorphisms (a-1438g [rs6311] of the htr2a gene, stin2 vntr and 5-httlpr of the slc6a4 gene) and the severity of panic and depression symptomatology among mental health outpatients with diagnosis of panic disorder (pd). |
2013-07-25 |
2023-08-12 |
Not clear |