| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christoph Laske, Sabine Banschbach, Elke Stransky, Sabine Bosch, Guido Straten, Jürgen Machann, Andreas Fritsche, Arno Hipp, Andreas Niess, Gerhard W Eschweile. Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression. The international journal of neuropsychopharmacology. vol 13. issue 5. 2011-01-25. PMID:20067661. |
major depression (md) has been associated with decreased brain-derived neurotrophic factor (bdnf) serum levels, while antidepressant drugs were found to increase these decreased bdnf levels. |
2011-01-25 |
2023-08-12 |
Not clear |
| Reiji Yoshimura, Atsuko Ikenouchi-Sugita, Hikaru Hori, Wakako Umene-Nakano, Kenji Hayashi, Asuka Katsuki, Nobuhisa Ueda, Jun Nakamur. [Blood levels of brain-derived neurotrophic factor (BDNF) in major depressive disorder]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 112. issue 10. 2011-01-25. PMID:21179660. |
bdnf has been most extensively studied in relation to depression. |
2011-01-25 |
2023-08-12 |
Not clear |
| Reiji Yoshimura, Atsuko Ikenouchi-Sugita, Hikaru Hori, Wakako Umene-Nakano, Kenji Hayashi, Asuka Katsuki, Nobuhisa Ueda, Jun Nakamur. [Blood levels of brain-derived neurotrophic factor (BDNF) in major depressive disorder]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 112. issue 10. 2011-01-25. PMID:21179660. |
in conclusion, blood bdnf levels partially reflect those in the brain, and there is also strong and consistent evidence indicating that these levels normalize following the biological intervention for depression. |
2011-01-25 |
2023-08-12 |
Not clear |
| Shigeru Morinobu, Manabu Fuchikami, Yosuke Yamawaki, Shigeto Yamamoto, Akiko Kurata, Shigeto Yamawak. [Epigenetic mechanism of depression]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 112. issue 10. 2011-01-25. PMID:21179661. |
preclinical and clinical studies demonstrate that changes in levels of various genes in the brain including bdnf, play a role in the pathophysiology of depression. |
2011-01-25 |
2023-08-12 |
rat |
| Shigeru Morinobu, Manabu Fuchikami, Yosuke Yamawaki, Shigeto Yamamoto, Akiko Kurata, Shigeto Yamawak. [Epigenetic mechanism of depression]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 112. issue 10. 2011-01-25. PMID:21179661. |
based on these findings, it is postulated that epigenetic regulation of the bdnf gene by stress and antidepressants may be involved in the pathophysiology of depression. |
2011-01-25 |
2023-08-12 |
rat |
| Hiroshi Kunugi, Hiroaki Hori, Naoki Adachi, Tadahiro Numakaw. Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression. Psychiatry and clinical neurosciences. vol 64. issue 5. 2011-01-21. PMID:20923424. |
several lines of evidence from postmortem studies, animal studies, blood levels, and genetic studies have suggested that bdnf is involved in the pathogenesis of depression and in the mechanism of action of biological treatments for depression. |
2011-01-21 |
2023-08-12 |
Not clear |
| Marianne H Larsen, Jens D Mikkelsen, Anders Hay-Schmidt, Carmen Sand. Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment. Journal of psychiatric research. vol 44. issue 13. 2011-01-12. PMID:20172535. |
present evidence suggests a role for brain-derived neurotrophic factor (bdnf) in depression. |
2011-01-12 |
2023-08-12 |
rat |
| Jennifer Y F Lau, David Goldman, Beata Buzas, Colin Hodgkinson, Ellen Leibenluft, Eric Nelson, Lindsey Sankin, Daniel S Pine, Monique Erns. BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:19931400. |
these data are first to demonstrate the contribution of bdnf gene variants to the neural correlates of adolescent anxiety and depression. |
2011-01-03 |
2023-08-12 |
human |
| Bun-Hee Lee, Yong-Ku Ki. BDNF mRNA expression of peripheral blood mononuclear cells was decreased in depressive patients who had or had not recently attempted suicide. Journal of affective disorders. vol 125. issue 1-3. 2010-12-30. PMID:20207421. |
recent reports have suggested a pathophysiological role for brain-derived neurotrophic factor (bdnf) in major depression and suicide. |
2010-12-30 |
2023-08-12 |
Not clear |
| Bun-Hee Lee, Yong-Ku Ki. BDNF mRNA expression of peripheral blood mononuclear cells was decreased in depressive patients who had or had not recently attempted suicide. Journal of affective disorders. vol 125. issue 1-3. 2010-12-30. PMID:20207421. |
we evaluate bdnf mrna in peripheral blood mononuclear cells (pbmcs) of patients with major depression who had or had not recently attempted suicide. |
2010-12-30 |
2023-08-12 |
Not clear |
| Catharina Lavebratt, Elin Aberg, Louise K Sjöholm, Yvonne Forsel. Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort. Journal of affective disorders. vol 125. issue 1-3. 2010-12-30. PMID:20226536. |
variations in fkbp5 and bdnf genes are suggestively associated with depression in a swedish population-based cohort. |
2010-12-30 |
2023-08-12 |
Not clear |
| Catharina Lavebratt, Elin Aberg, Louise K Sjöholm, Yvonne Forsel. Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort. Journal of affective disorders. vol 125. issue 1-3. 2010-12-30. PMID:20226536. |
genetic variations in fkbp5, bdnf, p2rx7 and cacna1 are current candidates for involvement in depression. |
2010-12-30 |
2023-08-12 |
Not clear |
| George S Alexopoulos, Charles E Glatt, Matthew J Hoptman, Dora Kanellopoulos, Christopher F Murphy, Robert E Kelly, Sarah S Morimoto, Kelvin O Lim, Faith M Gunnin. BDNF val66met polymorphism, white matter abnormalities and remission of geriatric depression. Journal of affective disorders. vol 125. issue 1-3. 2010-12-30. PMID:20346518. |
bdnf val66met polymorphism, white matter abnormalities and remission of geriatric depression. |
2010-12-30 |
2023-08-12 |
Not clear |
| George S Alexopoulos, Charles E Glatt, Matthew J Hoptman, Dora Kanellopoulos, Christopher F Murphy, Robert E Kelly, Sarah S Morimoto, Kelvin O Lim, Faith M Gunnin. BDNF val66met polymorphism, white matter abnormalities and remission of geriatric depression. Journal of affective disorders. vol 125. issue 1-3. 2010-12-30. PMID:20346518. |
our objectives were: 1) to test the hypothesis that bdnf(val/met) status influences the remission rate of geriatric depression; 2) to explore whether the relationship between bdnf allelic status to remission is influenced by the presence of microstructural white matter abnormalities. |
2010-12-30 |
2023-08-12 |
Not clear |
| William Berger, Akhil Mehra, Maryann Lenoci, Thomas J Metzler, Christian Otte, Gary Tarasovsky, Synthia H Mellon, Owen M Wolkowitz, Charles R Marmar, Thomas C Neyla. Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 7. 2010-12-29. PMID:20643177. |
some studies have found that antidepressants increase serum brain-derived neurotrophic factor (bdnf) levels in patients with major depression and the expression of bdnf mrna in limbic structures of rats. |
2010-12-29 |
2023-08-12 |
rat |
| Silvia Alboni, Cristina Benatti, Giacomo Capone, Daniela Corsini, Federica Caggia, Fabio Tascedda, Julien Mendlewicz, Nicoletta Brunell. Time-dependent effects of escitalopram on brain derived neurotrophic factor (BDNF) and neuroplasticity related targets in the central nervous system of rats. European journal of pharmacology. vol 643. issue 2-3. 2010-12-28. PMID:20599917. |
escitalopram, known to be already effective in preclinical models of depression after 7 days, allowed us to investigate whether two effective treatment regimens (7 and 21 days) may contribute to synaptic plasticity by acting on bdnf signalling. |
2010-12-28 |
2023-08-12 |
rat |
| Siddheshwar Utge, Pia Soronen, Timo Partonen, Anu Loukola, Erkki Kronholm, Sami Pirkola, Emma Nyman, Tarja Porkka-Heiskanen, Tiina Pauni. A population-based association study of candidate genes for depression and sleep disturbance. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 2. 2010-12-20. PMID:19548263. |
we also found suggestive associations in women for gad1, gria3, and bdnf with depression accompanied by fatigue, and for crhr1 with depression accompanied by early morning awakenings. |
2010-12-20 |
2023-08-12 |
Not clear |
| Luisella Bocchio-Chiavetto, Vincenzo Bagnardi, Roberta Zanardini, Raffaella Molteni, Maria Gabriela Nielsen, Anna Placentino, Caterina Giovannini, Luciana Rillosi, Mariacarla Ventriglia, Marco A Riva, Massimo Gennarell. Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 11. issue 6. 2010-12-06. PMID:20334574. |
serum and plasma bdnf levels in major depression: a replication study and meta-analyses. |
2010-12-06 |
2023-08-12 |
Not clear |
| Luisella Bocchio-Chiavetto, Vincenzo Bagnardi, Roberta Zanardini, Raffaella Molteni, Maria Gabriela Nielsen, Anna Placentino, Caterina Giovannini, Luciana Rillosi, Mariacarla Ventriglia, Marco A Riva, Massimo Gennarell. Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 11. issue 6. 2010-12-06. PMID:20334574. |
alterations of bdnf signalling in major depression (md) are supported by studies demonstrating decreased levels of the neurotrophin serum and plasma content in md patients. |
2010-12-06 |
2023-08-12 |
Not clear |
| M Toriya, F Maekawa, Y Maejima, T Onaka, K Fujiwara, T Nakagawa, M Nakata, T Yad. Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotrophin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus. Journal of neuroendocrinology. vol 22. issue 9. 2010-12-06. PMID:20561155. |
brain-derived neurotrophic factor (bdnf) has been implicated in learning, depression and energy metabolism. |
2010-12-06 |
2023-08-12 |
Not clear |