| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manabu Fuchikami, Shigeru Morinobu, Masahiro Segawa, Yasumasa Okamoto, Shigeto Yamawaki, Norio Ozaki, Takeshi Inoue, Ichiro Kusumi, Tsukasa Koyama, Kounosuke Tsuchiyama, Takeshi Tera. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PloS one. vol 6. issue 8. 2011-12-23. PMID:21912609. |
dna methylation profiles of the brain-derived neurotrophic factor (bdnf) gene as a potent diagnostic biomarker in major depression. |
2011-12-23 |
2023-08-12 |
human |
| Manabu Fuchikami, Shigeru Morinobu, Masahiro Segawa, Yasumasa Okamoto, Shigeto Yamawaki, Norio Ozaki, Takeshi Inoue, Ichiro Kusumi, Tsukasa Koyama, Kounosuke Tsuchiyama, Takeshi Tera. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PloS one. vol 6. issue 8. 2011-12-23. PMID:21912609. |
we examined the methylation profile of 2 cpg islands (i and iv) at the promoters of the brain-derived neurotrophic factor (bdnf) gene, which is well known to be involved in the pathophysiology of depression. |
2011-12-23 |
2023-08-12 |
human |
| Manabu Fuchikami, Shigeru Morinobu, Masahiro Segawa, Yasumasa Okamoto, Shigeto Yamawaki, Norio Ozaki, Takeshi Inoue, Ichiro Kusumi, Tsukasa Koyama, Kounosuke Tsuchiyama, Takeshi Tera. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PloS one. vol 6. issue 8. 2011-12-23. PMID:21912609. |
despite the small number of subjects, our results indicate that classification based on the dna methylation profiles of cpg i of the bdnf gene may be a valuable diagnostic biomarker for major depression. |
2011-12-23 |
2023-08-12 |
human |
| Brisa Simões Fernandes, Clarissa Severino Gama, Keila Maria Ceresér, Lakshmi N Yatham, Gabriel Rodrigo Fries, Gabriela Colpo, David de Lucena, Mauricio Kunz, Fabiano Alves Gomes, Flavio Kapczinsk. Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis. Journal of psychiatric research. vol 45. issue 8. 2011-11-29. PMID:21550050. |
the bdnf levels were decreased in both mania and depression when compared to controls (es -0.81, 95% ci -1.11 to -0.52, p < 0.0001 and es -0.97, 95% ci -1.79 to -0.51, p = 0.02, respectively). |
2011-11-29 |
2023-08-12 |
human |
| André Tadić, Stefanie Wagner, Konrad Friedrich Schlicht, Dirk Peetz, Liudmyla Borysenko, Nadine Dreimüller, Christoph Hiemke, Klaus Lie. The early non-increase of serum BDNF predicts failure of antidepressant treatment in patients with major depression: a pilot study. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 2. 2011-11-22. PMID:20732374. |
the early non-increase of serum bdnf predicts failure of antidepressant treatment in patients with major depression: a pilot study. |
2011-11-22 |
2023-08-12 |
Not clear |
| Kimihiko Watanabe, Eri Hashimoto, Wataru Ukai, Takao Ishii, Toshihiro Yoshinaga, Takafumi Ono, Masaru Tateno, Ippei Watanabe, Tomohiro Shirasaka, Satoshi Saito, Toshikazu Sait. Effect of antidepressants on brain-derived neurotrophic factor (BDNF) release from platelets in the rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 8. 2011-11-14. PMID:20708057. |
a single report suggests that decreased serum bdnf in major depression is related to mechanisms of platelet bdnf release; however, the mechanisms of changes in bdnf blood levels are still poorly understood. |
2011-11-14 |
2023-08-12 |
human |
| Kai-Ren Luo, Chen-Jee Hong, Ying-Jay Liou, Sheue-Jane Hou, Yn-Ho Huang, Shih-Jen Tsa. Differential regulation of neurotrophin S100B and BDNF in two rat models of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 8. 2011-11-14. PMID:20728493. |
differential regulation of neurotrophin s100b and bdnf in two rat models of depression. |
2011-11-14 |
2023-08-12 |
rat |
| Kai-Ren Luo, Chen-Jee Hong, Ying-Jay Liou, Sheue-Jane Hou, Yn-Ho Huang, Shih-Jen Tsa. Differential regulation of neurotrophin S100B and BDNF in two rat models of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 8. 2011-11-14. PMID:20728493. |
several clinical studies have demonstrated that serum brain-derived neurotrophic factor (bdnf) levels are decreased and serum s100b levels are increased in patients with major depression. |
2011-11-14 |
2023-08-12 |
rat |
| b' Montserrat Serra-Mill\\xc3\\xa0s, Irene L\\xc3\\xb3pez-V\\xc3\\xadlchez, V\\xc3\\xadctor Navarro, Ana-Mar\\xc3\\xada Gal\\xc3\\xa1n, Gin\\xc3\\xa9s Escolar, Rafael Penad\\xc3\\xa9s, Rosa Catal\\xc3\\xa1n, Lourdes Fa\\xc3\\xb1an\\xc3\\xa1s, B\\xc3\\xa1rbara Arias, Crist\\xc3\\xb3bal Gast\\xc3\\xb. Changes in plasma and platelet BDNF levels induced by S-citalopram in major depression. Psychopharmacology. vol 216. issue 1. 2011-11-08. PMID:21308467.' |
changes in plasma and platelet bdnf levels induced by s-citalopram in major depression. |
2011-11-08 |
2023-08-12 |
Not clear |
| Charles S Carver, Sheri L Johnson, Jutta Joormann, Joelle Lemoult, Michael L Cuccar. Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis. Journal of affective disorders. vol 132. issue 1-2. 2011-11-01. PMID:21420735. |
childhood adversity interacts separately with 5-httlpr and bdnf to predict lifetime depression diagnosis. |
2011-11-01 |
2023-08-12 |
Not clear |
| Charles S Carver, Sheri L Johnson, Jutta Joormann, Joelle Lemoult, Michael L Cuccar. Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis. Journal of affective disorders. vol 132. issue 1-2. 2011-11-01. PMID:21420735. |
the serotonin transporter polymorphism (5-httlpr) and the brain-derived neurotrophic factor (bdnf) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (mdd) in interaction with adversity; there have also been failures to find the effects. |
2011-11-01 |
2023-08-12 |
Not clear |
| Aurélie Blugeot, Cyril Rivat, Elodie Bouvier, Jenny Molet, Amandine Mouchard, Brigitte Zeau, Christophe Bernard, Jean-Jacques Benoliel, Chrystel Becke. Vulnerability to depression: from brain neuroplasticity to identification of biomarkers. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 36. 2011-10-31. PMID:21900567. |
in contrast, 42% of animals displayed persistent decreased serum and hippocampus bdnf concentrations, reduced hippocampal volume and neurogenesis, ca3 dendritic retraction and decrease in spine density, as well as amygdala neuron hypertrophy, constituting latent vulnerability traits to depression. |
2011-10-31 |
2023-08-12 |
Not clear |
| Aurélie Blugeot, Cyril Rivat, Elodie Bouvier, Jenny Molet, Amandine Mouchard, Brigitte Zeau, Christophe Bernard, Jean-Jacques Benoliel, Chrystel Becke. Vulnerability to depression: from brain neuroplasticity to identification of biomarkers. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 36. 2011-10-31. PMID:21900567. |
our results thus characterize the presence of latent vulnerability traits that underlie the emergence of depression and identify the association of low bdnf with normal corticosterone serum concentrations as a predictive biomarker of vulnerability to depression. |
2011-10-31 |
2023-08-12 |
Not clear |
| Josep Tomàs, Manel M Santafé, Maria A Lanuza, Neus García, Nuria Besalduch, Marta Tomà. Silent synapses in neuromuscular junction development. Journal of neuroscience research. vol 89. issue 1. 2011-09-26. PMID:20857511. |
in addition, tropomyosin-related tyrosine kinase b (trkb) receptor-mediated brain-derived neurotrophic factor (bdnf) activity may oppose the pkc-mediated ach release depression. |
2011-09-26 |
2023-08-12 |
Not clear |
| Mariska Bot, François Pouwer, Johanna Assies, Eugène H J M Jansen, Aartjan T F Beekman, Peter de Jong. Supplementation with eicosapentaenoic omega-3 fatty acid does not influence serum brain-derived neurotrophic factor in diabetes mellitus patients with major depression: a randomized controlled pilot study. Neuropsychobiology. vol 63. issue 4. 2011-09-13. PMID:21422768. |
in this exploratory randomized double-blind placebo-controlled study in diabetes patients with major depression, we tested whether (a) omega- 3 ethyl-eicosapentaenoic acid (e-epa) leads to increased serum bdnf levels and (b) whether changes in bdnf levels are associated with corresponding changes in depression. |
2011-09-13 |
2023-08-12 |
Not clear |
| Gunter Kenis, Jos Prickaerts, Jim van Os, Ger H Koek, Geert Robaeys, Harry W M Steinbusch, Marieke Wicher. Depressive symptoms following interferon-α therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor? The international journal of neuropsychopharmacology. vol 14. issue 2. 2011-09-02. PMID:20667172. |
these findings suggest that the effect of ifn-α-induced immune activation on depression may be explained in part by alterations in neuroprotective capacity, reflected by decreases in serum bdnf following ifn-α treatment. |
2011-09-02 |
2023-08-12 |
Not clear |
| Ryo Isomura, Ken Kitajima, Chihiro Sat. Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia. The Journal of biological chemistry. vol 286. issue 24. 2011-08-30. PMID:21464126. |
taken together, impairment of the amount and quality of polysia may be involved in psychiatric disorders through impaired binding to bdnf and da, which are deeply involved in schizophrenia and other psychiatric disorders, such as depression and bipolar disorder. |
2011-08-30 |
2023-08-12 |
Not clear |
| Reiji Yoshimura, Wakako Umene-Nakano, Tsutomu Hoshuyama, Atsuko Ikenouchi-Sugita, Hikaru Hori, Asuka Katsuki, Kenji Hayashi, Kiyokazu Atake, Jun Nakamur. Plasma levels of brain-derived neurotrophic factor and interleukin-6 in patients with dysthymic disorder: comparison with age- and sex-matched major depressed patients and healthy controls. Human psychopharmacology. vol 25. issue 7-8. 2011-08-25. PMID:21312291. |
these results suggest that the pathophysiology of dysthymic disorder and major depression might be similar in terms of the blood levels of bdnf and il-6. |
2011-08-25 |
2023-08-12 |
human |
| Mia Thompson Ray, Cynthia Shannon Weickert, Eugene Wyatt, Maree J Webste. Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. Journal of psychiatry & neuroscience : JPN. vol 36. issue 3. 2011-08-15. PMID:21223646. |
to determine whether this reduction extends to other brain regions, we measured the expression levels of bdnf, trkb-tk+ and gad67 mrna in regions of the hippocampus, including the dentate gyrus (dg), cornu ammonis subfields (ca1-4), subiculum and entorhinal cortex (ec) of individuals with schizophrenia, bipolar disorder, major depression and unaffected controls. |
2011-08-15 |
2023-08-12 |
Not clear |
| Gabriella Juhasz, Jason S Dunham, Shane McKie, Emma Thomas, Darragh Downey, Diana Chase, Kathryn Lloyd-Williams, Zoltan G Toth, Hazel Platt, Krisztina Mekli, Antony Payton, Rebecca Elliott, Steve R Williams, Ian M Anderson, J F William Deaki. The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Biological psychiatry. vol 69. issue 8. 2011-08-08. PMID:21215389. |
the neuroplastic pathway, which includes cyclic adenosine monophosphate response element-binding protein 1 (creb1), brain-derived neurotrophic factor (bdnf), and its receptor (neurotrophic tyrosine kinase receptor, type 2 [ntrk2]), plays a crucial role in the adaptation of brain to stress, and thus variations of these genes are plausible risk factors for depression. |
2011-08-08 |
2023-08-12 |
Not clear |