| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Renata Suchanek, Aleksander Owczarek, Małgorzata Kowalczyk, Krzysztof Kucia, Jan Kowalsk. Association between C-281A and val66met functional polymorphisms of BDNF gene and risk of recurrent major depressive disorder in Polish population. Journal of molecular neuroscience : MN. vol 43. issue 3. 2011-07-21. PMID:21103954. |
according to neurotrophic hypothesis, brain-derived neurotrophic factor (bdnf) is the potential candidate involved in the pathogenesis of depression. |
2011-07-21 |
2023-08-12 |
human |
| O Malkesman, T Asaf, L Shbiro, A Goldstein, R Maayan, A Weizman, N Kinor, E Okun, B Sredni, G Yadid, A Welle. Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression-An Animal Model Study. Advances in pharmacological sciences. vol 2009. 2011-07-14. PMID:21152205. |
the results imply that dhea(s) and bdnf may be involved in the pathophysiology and pharmacotherapy of childhood depression. |
2011-07-14 |
2023-08-12 |
rat |
| Bun-Hee Lee, Yong-Ku Ki. The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry investigation. vol 7. issue 4. 2011-07-14. PMID:21253405. |
the roles of bdnf in the pathophysiology of major depression and in antidepressant treatment. |
2011-07-14 |
2023-08-12 |
human |
| Bun-Hee Lee, Yong-Ku Ki. The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry investigation. vol 7. issue 4. 2011-07-14. PMID:21253405. |
a similar change in bdnf activity occurs in the brain of patients with major depression disorder (mdd). |
2011-07-14 |
2023-08-12 |
human |
| Bun-Hee Lee, Yong-Ku Ki. The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry investigation. vol 7. issue 4. 2011-07-14. PMID:21253405. |
bdnf levels can therefore be useful markers for clinical response or improvement of depressive symptoms, but they are not diagnostic markers of major depression. |
2011-07-14 |
2023-08-12 |
human |
| Shih-Jen Tsai, Chen-Jee Hong, Ying-Jay Lio. Effects of BDNF polymorphisms on antidepressant action. Psychiatry investigation. vol 7. issue 4. 2011-07-14. PMID:21253406. |
evidence suggests that the down-regulation of the signaling pathway involving brain-derived neurotrophic factor (bdnf), a molecular element known to regulate neuronal plasticity and survival, plays an important role in the pathogenesis of major depression. |
2011-07-14 |
2023-08-12 |
human |
| Maxime Cazorla, Joël Prémont, Andre Mann, Nicolas Girard, Christoph Kellendonk, Didier Rogna. Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. The Journal of clinical investigation. vol 121. issue 5. 2011-07-12. PMID:21505263. |
the neurotrophin brain-derived neurotrophic factor (bdnf) and its receptor tropomyosin-related kinase b (trkb) have emerged as key mediators in the pathophysiology of several mood disorders, including anxiety and depression. |
2011-07-12 |
2023-08-12 |
mouse |
| W D Taylor, D R McQuoid, A Ashley-Koch, J R MacFall, J Bridgers, R R Krishnan, D C Steffen. BDNF Val66Met genotype and 6-month remission rates in late-life depression. The pharmacogenomics journal. vol 11. issue 2. 2011-07-08. PMID:20195291. |
bdnf val66met genotype and 6-month remission rates in late-life depression. |
2011-07-08 |
2023-08-12 |
human |
| Gaelle Naert, Guy Ixart, Tangui Maurice, Lucia Tapia-Arancibia, Laurent Givaloi. Brain-derived neurotrophic factor and hypothalamic-pituitary-adrenal axis adaptation processes in a depressive-like state induced by chronic restraint stress. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:20708081. |
recent findings suggest that all depression treatments may boost the neurotrophin production especially brain-derived neurotrophic factor (bdnf). |
2011-07-05 |
2023-08-12 |
rat |
| Francesco Angelucci, Nicoletta Croce, Gianfranco Spalletta, Vincenzo Dinallo, Paolo Gravina, Paola Bossù, Giorgio Federici, Carlo Caltagirone, Sergio Bernardin. Paroxetine rapidly modulates the expression of brain-derived neurotrophic factor mRNA and protein in a human glioblastoma-astrocytoma cell line. Pharmacology. vol 87. issue 1-2. 2011-06-20. PMID:21178384. |
glial cells are able to store and release bdnf, and it has been hypothesized that glial dysfunction may contribute to the etiopathogenesis of depression. |
2011-06-20 |
2023-08-12 |
human |
| Sabine Chourbaji, Christiane Brandwein, Peter Gas. Altering BDNF expression by genetics and/or environment: impact for emotional and depression-like behaviour in laboratory mice. Neuroscience and biobehavioral reviews. vol 35. issue 3. 2011-06-01. PMID:20621121. |
according to the "neurotrophin hypothesis", brain-derived neurotrophic factor (bdnf) is an important candidate gene in depression. |
2011-06-01 |
2023-08-12 |
mouse |
| Zhiming Zhou, Tingting Lu, Gelin Xu, Xuanye Yue, Wusheng Zhu, Minmin Ma, Wenhua Liu, Shuanggen Zhu, Xinfeng Li. Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism. Clinical chemistry and laboratory medicine. vol 49. issue 2. 2011-05-27. PMID:21143020. |
decreased serum brain-derived neurotrophic factor (bdnf) is associated with post-stroke depression but not with bdnf gene val66met polymorphism. |
2011-05-27 |
2023-08-12 |
Not clear |
| Zhiming Zhou, Tingting Lu, Gelin Xu, Xuanye Yue, Wusheng Zhu, Minmin Ma, Wenhua Liu, Shuanggen Zhu, Xinfeng Li. Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism. Clinical chemistry and laboratory medicine. vol 49. issue 2. 2011-05-27. PMID:21143020. |
decreased brain-derived neurotrophic factor (bdnf) has been demonstrated in animal models and patients with depression. |
2011-05-27 |
2023-08-12 |
Not clear |
| Zhiming Zhou, Tingting Lu, Gelin Xu, Xuanye Yue, Wusheng Zhu, Minmin Ma, Wenhua Liu, Shuanggen Zhu, Xinfeng Li. Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism. Clinical chemistry and laboratory medicine. vol 49. issue 2. 2011-05-27. PMID:21143020. |
however, little is known about changes in bdnf in post-stroke depression (psd). |
2011-05-27 |
2023-08-12 |
Not clear |
| Dekel Taliaz, Assaf Loya, Roman Gersner, Sharon Haramati, Alon Chen, Abraham Zange. Resilience to chronic stress is mediated by hippocampal brain-derived neurotrophic factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 12. 2011-05-27. PMID:21430148. |
alterations in secretion of stress hormones and levels of brain-derived neurotrophic factor (bdnf) in the hippocampus were implicated in depression and the effects of antidepressant medications. |
2011-05-27 |
2023-08-12 |
rat |
| Reiji Yoshimura, Koshiro Tsuji, Nobuhisa Ueda, Jun Nakamur. Increase of plasma brain-derived neurotrophic factor levels in two psychotic depressed patients responding to lithium addition to paroxetine treatment. Neuropsychiatric disease and treatment. vol 3. issue 5. 2011-05-17. PMID:19300599. |
these results suggest that the increases in plasma bdnf levels reflect recovery from depressive symptoms in psychotic depression. |
2011-05-17 |
2023-08-12 |
Not clear |
| R F Sun, Y S Zhu, W J Kuang, Y Liu, S B L. The G-712A polymorphism of brain-derived neurotrophic factor is associated with major depression but not schizophrenia. Neuroscience letters. vol 489. issue 1. 2011-05-02. PMID:21129438. |
bdnf is implicated in major depression (md), and to a lesser extent, in schizophrenia. |
2011-05-02 |
2023-08-12 |
Not clear |
| Yogesh Dwived. Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatric disease and treatment. vol 5. 2011-04-26. PMID:19721723. |
increasing evidence demonstrates that suicidal behavior is also associated with lower expression of bdnf, which may be independent from depression. |
2011-04-26 |
2023-08-12 |
Not clear |
| Yogesh Dwived. Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatric disease and treatment. vol 5. 2011-04-26. PMID:19721723. |
overall, these studies suggest the possibility that bdnf and its mediated signaling may participate in the pathophysiology of depression and suicidal behavior. |
2011-04-26 |
2023-08-12 |
Not clear |
| Yogesh Dwived. Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatric disease and treatment. vol 5. 2011-04-26. PMID:19721723. |
this review focuses on the critical evidence demonstrating the involvement of bdnf in depression and suicide. |
2011-04-26 |
2023-08-12 |
Not clear |