| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Goedert, M G Spillantin. Tau gene mutations and neurodegeneration. Biochemical Society symposium. issue 67. 2001-12-14. PMID:11447840. |
the new work has shown that dysfunction of tau protein can cause neurodegeneration and dementia. |
2001-12-14 |
2023-08-12 |
Not clear |
| M L Schmidt, V Zhukareva, K L Newell, V M Lee, J Q Trojanowsk. Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease. Acta neuropathologica. vol 101. issue 5. 2001-12-13. PMID:11484824. |
tau isoform profile and phosphorylation state in dementia pugilistica recapitulate alzheimer's disease. |
2001-12-13 |
2023-08-12 |
Not clear |
| L Parnetti, A Lanari, S Amici, V Gallai, E Vanmechelen, F Hulstaer. CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies. Phospho-Tau International Study Group. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 22. issue 1. 2001-12-13. PMID:11487210. |
csf phosphorylated tau is a possible marker for discriminating alzheimer's disease from dementia with lewy bodies. |
2001-12-13 |
2023-08-12 |
Not clear |
| F García-Sierra, C M Wischik, C R Harrington, J Luna-Muñoz, R Men. Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease. Journal of chemical neuroanatomy. vol 22. issue 1-2. 2001-11-01. PMID:11470555. |
our findings, therefore, suggest that the perforant pathway may be substantially affected by the accumulation of truncated tau protein in ad and that this represents a neuropathological predictor for the clinical severity of dementia. |
2001-11-01 |
2023-08-12 |
Not clear |
| F García-Sierra, C M Wischik, C R Harrington, J Luna-Muñoz, R Men. Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease. Journal of chemical neuroanatomy. vol 22. issue 1-2. 2001-11-01. PMID:11470555. |
the different stages may represent a sequence of conformational changes that tau proteins undergo during tangle formation in the allocortex during the early development of dementia in ad. |
2001-11-01 |
2023-08-12 |
Not clear |
| S J Baloyannis, S L Manolidis, L S Manolidi. The acoustic cortex in frontal dementia. Acta oto-laryngologica. vol 121. issue 2. 2001-10-18. PMID:11349798. |
hyperphosphorylation of the isoforms of tau protein, a microtubule-associated protein, which plays an important role in the pathogenetic mechanisms of alzheimer's disease, is mainly involved in the pathogenesis of frontal dementia. |
2001-10-18 |
2023-08-12 |
Not clear |
| N Rösler, I Wichart, K A Jellinge. Clinical significance of neurobiochemical profiles in the lumbar cerebrospinal fluid of Alzheimer's disease patients. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 2. 2001-08-30. PMID:11314776. |
immunoreactivities of total apolipoprotein e (apoe-ir), amyloid beta peptide(1-42) (abeta42-ir), interleukin-6 (il-6-ir), substance p (spir) and total tau protein (ttir) were measured in lumbar cerebrospinal fluid samples of patients with alzheimer's disease (ad), non-alzheimer's dementias (nad), neurological disorders without cognitive impairment (ond) and controls without central nervous system disease using sensitive and specific enzyme immunoassay methods. |
2001-08-30 |
2023-08-12 |
Not clear |
| J Göt. Tau and transgenic animal models. Brain research. Brain research reviews. vol 35. issue 3. 2001-08-30. PMID:11423157. |
the identification of mutations in the tau gene which are linked to ftdp-17 established that dysfunction of tau can, as well as abeta formation, lead to neurodegeneration and dementia. |
2001-08-30 |
2023-08-12 |
mouse |
| M Tsolaki, V Sakka, G Gerasimou, N Dimacopoulos, O Chatzizisi, K N Fountoulakis, G Kyriazis, J Papanastasiou, A Kazi. Correlation of rCBF (SPECT), CSF tau, and cognitive function in patients with dementia of the Alzheimer's type, other types of dementia, and control subjects. American journal of Alzheimer's disease and other dementias. vol 16. issue 1. 2001-07-19. PMID:11416945. |
correlation of rcbf (spect), csf tau, and cognitive function in patients with dementia of the alzheimer's type, other types of dementia, and control subjects. |
2001-07-19 |
2023-08-12 |
human |
| M M Mesula. Primary progressive aphasia. Annals of neurology. vol 49. issue 4. 2001-05-31. PMID:11310619. |
recent advances in chromosome 17-linked dementias justify a rigorous search for tau polymorphisms and tauopathy in sporadic ppa. |
2001-05-31 |
2023-08-12 |
Not clear |
| A C Ludolph, A Sperfeld, B M Collatz, A Storc. [Tauopathies--a new class of neurodegenerative diseases]. Der Nervenarzt. vol 72. issue 2. 2001-05-03. PMID:11256158. |
recently it was shown by several research groups that mutations in the gene encoding for the tau protein associated with microtubuli on chromosome 17 caused a distinct form of dementia named frontotemporal dementia and parkinsonism (ftdp-17). |
2001-05-03 |
2023-08-12 |
Not clear |
| E W Nagiec, K E Sampson, I Abraha. Mutated tau binds less avidly to microtubules than wildtype tau in living cells. Journal of neuroscience research. vol 63. issue 3. 2001-04-26. PMID:11170176. |
because the mutations (v337m, p301l) are associated with genetic tauopathies, these results suggest that a factor in disease etiology of genetic tauopathies and other dementias with altered tau is a greater abundance of tau in the cytoplasm due to decreased binding to microtubules. |
2001-04-26 |
2023-08-12 |
human |
| H Kim, H Xia, L Li, J Gewi. Attenuation of neurodegeneration-relevant modifications of brain proteins by dietary soy. BioFactors (Oxford, England). vol 12. issue 1-4. 2001-04-19. PMID:11216492. |
a hallmark of several human dementias including ad and fronto temporal dementia with parkinsonism on chromosome 17 (ftdp-17) is the hyperphosphorylation of the microtubule-associated protein tau. |
2001-04-19 |
2023-08-12 |
human |
| E H Bigio, A M Lipton, S H Yen, M L Hutton, M Baker, P Nacharaju, C L White, P Davies, W Lin, D W Dickso. Frontal lobe dementia with novel tauopathy: sporadic multiple system tauopathy with dementia. Journal of neuropathology and experimental neurology. vol 60. issue 4. 2001-04-19. PMID:11305868. |
the unique cortical tau pathology in this case of sporadic multiple system tauopathy with dementia adds a new pathologic profile to the spectrum of tauopathies. |
2001-04-19 |
2023-08-12 |
Not clear |
| K Oyanagi, K Tsuchiya, M Yamazaki, K Iked. Substantia nigra in progressive supranuclear palsy, corticobasal degeneration, and parkinsonism-dementia complex of Guam: specific pathological features. Journal of neuropathology and experimental neurology. vol 60. issue 4. 2001-04-19. PMID:11305875. |
disease-specific findings in the substantia nigra were examined in cases of progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and parkinsonism-dementia complex of guam (pdc); diseases in which the patients exhibit dementia and parkinsonism, with neurofibrillary tangles (nfts) and glial tangles composed of hyperphosphorylated tau. |
2001-04-19 |
2023-08-12 |
Not clear |
| H J Tschampa, W Schulz-Schaeffer, J Wiltfang, S Poser, M Otto, M Neumann, H A Kretzschma. Decreased CSF amyloid beta42 and normal tau levels in dementia with Lewy bodies. Neurology. vol 56. issue 4. 2001-04-05. PMID:11222819. |
decreased csf amyloid beta42 and normal tau levels in dementia with lewy bodies. |
2001-04-05 |
2023-08-12 |
Not clear |
| P Poorkaj, M Grossman, E Steinbart, H Payami, A Sadovnick, D Nochlin, T Tabira, J Q Trojanowski, S Borson, D Galasko, S Reich, B Quinn, G Schellenberg, T D Bir. Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. Archives of neurology. vol 58. issue 3. 2001-04-05. PMID:11255441. |
frequency of tau gene mutations in familial and sporadic cases of non-alzheimer dementia. |
2001-04-05 |
2023-08-12 |
Not clear |
| B Paradowski, M Szczepaniak, T Dobosz, M Sasiade. [Apolipoprotein E(ApoE)and tau protein in Alzheimer type dementia]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 9. issue 53. 2001-03-08. PMID:11204323. |
[apolipoprotein e(apoe)and tau protein in alzheimer type dementia]. |
2001-03-08 |
2023-08-12 |
Not clear |
| U Finckh, T Müller-Thomsen, U Mann, C Eggers, J Marksteiner, W Meins, G Binetti, A Alberici, P Sonderegger, C Hock, R M Nitsch, A Ga. High frequency of mutations in four different disease genes in early-onset dementia. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193137. |
heterozygous mutations in the genes for amyloid precursor protein (app), the presenilins (ps1, ps2), prion protein (prp), neuroserpin, and tau are associated with early-onset dementia (eod) with or without neurological signs in the early disease stage. |
2001-02-08 |
2023-08-12 |
Not clear |
| B Ghetti, J R Murrell, P Zolo, M G Spillantini, M Goeder. Progress in hereditary tauopathies: a mutation in the Tau gene (G389R) causes a Pick disease-like syndrome. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193177. |
the present findings indicate that the g389r mutation in tau can cause a dementia similar to that in pick's disease. |
2001-02-08 |
2023-08-12 |
Not clear |