| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D G Muno. Stains for the differential diagnosis of degenerative dementias. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 74. issue 6. 2000-06-14. PMID:10768809. |
our understanding of the structural substrates underlying the dementia syndrome has been transformed by the introduction of the gallyas silver stain and the application of immunostains for tau, ubiquitin, and alpha-synuclein. |
2000-06-14 |
2023-08-12 |
Not clear |
| M Sjögren, L Rosengren, L Minthon, P Davidsson, K Blennow, A Walli. Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD. Neurology. vol 54. issue 10. 2000-06-06. PMID:10822437. |
to investigate the csf levels of tau and the light neurofilament protein (nfl) in patients with frontotemporal dementia (ftd) and other common dementia disorders as well as normal control subjects. |
2000-06-06 |
2023-08-12 |
human |
| F van Leuve. Single and multiple transgenic mice as models for Alzheimer's disease. Progress in neurobiology. vol 61. issue 3. 2000-05-31. PMID:10727777. |
mice overexpressing human presenilin 1, apoe 4 and protein tau to generate "multiple" transgenic mice, offer additional potential to define the pathological interactions of these genetic factors, known to be involved, directly or indirectly, in dementia of the alzheimer type. |
2000-05-31 |
2023-08-12 |
mouse |
| K Kanemaru, N Kameda, H Yamanouch. Decreased CSF amyloid beta42 and normal tau levels in dementia with Lewy bodies. Neurology. vol 54. issue 9. 2000-05-30. PMID:10802808. |
decreased csf amyloid beta42 and normal tau levels in dementia with lewy bodies. |
2000-05-30 |
2023-08-12 |
Not clear |
| D G Muño. [Neuropathology of frontotemporal dementia]. Neurologia (Barcelona, Spain). vol 15 Suppl 1. 2000-04-21. PMID:10723169. |
these processes include dementia with pick bodies, cortico-basal degeneration, dementia with itsnu (inclusions tau and synuclein negative, ubiquitinated), also known as dementia of motorneuron disease type, dementia with basophilic inclusion bodies, and dementia lacking specific histopathology, and in addition all variants linked to mutations in the tau gene, located in chromosome 17. |
2000-04-21 |
2023-08-12 |
Not clear |
| J Näslund, V Haroutunian, R Mohs, K L Davis, P Davies, P Greengard, J D Buxbau. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA. vol 283. issue 12. 2000-04-04. PMID:10735393. |
considerable controversy exists as to whether the extent of accumulation of abeta correlates with dementia and whether abeta alterations precede or follow changes in tau. |
2000-04-04 |
2023-08-12 |
Not clear |
| A Savioz, E Kövari, R Anastasiu, C Rossier, K Saini, C Bouras, G Leub. Search for a mutation in the tau gene in a Swiss family with frontotemporal dementia. Experimental neurology. vol 161. issue 1. 2000-03-23. PMID:10683298. |
thus, the existence of a yet unknown mechanism of neurodegeneration, other than via mutations near or within the microtubule-binding sites, or the exon 10 splice sites of the tau gene, has to be considered to explain dementia in this family. |
2000-03-23 |
2023-08-12 |
Not clear |
| C Duyckaerts, M A Colle, B Delatour, J J Hau. [Alzheimer's disease: lesions and their progression]. Revue neurologique. vol 155 Suppl 4. 2000-02-22. PMID:10637934. |
besides tau proteins, a beta peptide and app, several other proteins may play an important role: apolipoprotein e which could act as a chaperone protein, inducing or facilitating the formation of amyloid, presenilins 1 and 2, mutated in some cases of familial alzheimer disease, alpha-synuclein which is present in the lewy bodies found in parkinson disease and in dementia with lewy bodies. |
2000-02-22 |
2023-08-12 |
Not clear |
| H R Morris, N W Wood, A J Lee. Progressive supranuclear palsy (Steele-Richardson-Olszewski disease). Postgraduate medical journal. vol 75. issue 888. 2000-01-20. PMID:10621897. |
evidence from familial fronto-temporal dementia with parkinsonism linked to chromosome 17 suggests that tau protein deposition is a primary pathogenic event in some neurodegenerative diseases. |
2000-01-20 |
2023-08-12 |
Not clear |
| L Molina, J Touchon, M Herpé, D Lefranc, L Duplan, J P Cristol, R Sabatier, P Vermersch, B Pau, C Mourton-Gille. Tau and apo E in CSF: potential aid for discriminating Alzheimer's disease from other dementias. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619631. |
tau and apo e in csf: potential aid for discriminating alzheimer's disease from other dementias. |
2000-01-19 |
2023-08-12 |
Not clear |
| L Molina, J Touchon, M Herpé, D Lefranc, L Duplan, J P Cristol, R Sabatier, P Vermersch, B Pau, C Mourton-Gille. Tau and apo E in CSF: potential aid for discriminating Alzheimer's disease from other dementias. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619631. |
to evaluate the usefulness of tau proteins as biological markers in the diagnosis of dementia of the alzheimer type (dat), we analyzed the concentration of tau proteins in 253 cerebrospinal fluid (csf) samples from patients with or without neurological disorders. |
2000-01-19 |
2023-08-12 |
Not clear |
| M G Spillantini, M Tolnay, S Love, M Goeder. Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia. Acta neuropathologica. vol 97. issue 6. 2000-01-14. PMID:10378377. |
microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia. |
2000-01-14 |
2023-08-12 |
Not clear |
| M Ingelson, M Blomberg, E Benedikz, L O Wahlund, E Karlsson, E Vanmechelen, L Lannfel. Tau immunoreactivity detected in human plasma, but no obvious increase in dementia. Dementia and geriatric cognitive disorders. vol 10. issue 6. 2000-01-11. PMID:10559557. |
tau immunoreactivity detected in human plasma, but no obvious increase in dementia. |
2000-01-11 |
2023-08-12 |
human |
| M Ingelson, M Blomberg, E Benedikz, L O Wahlund, E Karlsson, E Vanmechelen, L Lannfel. Tau immunoreactivity detected in human plasma, but no obvious increase in dementia. Dementia and geriatric cognitive disorders. vol 10. issue 6. 2000-01-11. PMID:10559557. |
in this study, we investigated the presence of tau in plasma from subjects with alzheimer's disease (n = 16), frontotemporal dementia (n = 10), vascular dementia (n = 16) and from healthy controls (n = 15). |
2000-01-11 |
2023-08-12 |
human |
| M Ingelson, M Blomberg, E Benedikz, L O Wahlund, E Karlsson, E Vanmechelen, L Lannfel. Tau immunoreactivity detected in human plasma, but no obvious increase in dementia. Dementia and geriatric cognitive disorders. vol 10. issue 6. 2000-01-11. PMID:10559557. |
we conclude that measurements of tau in plasma cannot be utilized diagnostically for alzheimer's disease or for the other dementias investigated. |
2000-01-11 |
2023-08-12 |
human |
| S Yen, C Easson, P Nacharaju, M Hutton, S H Ye. FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion. FEBS letters. vol 461. issue 1-2. 1999-12-14. PMID:10561502. |
frontal temporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) is caused by splice site and missense mutations in the tau gene, and characterized by the accumulation of filamentous tau in cerebral neurons and glia. |
1999-12-14 |
2023-08-12 |
Not clear |
| M Kanai, M Shizuka, K Urakami, E Matsubara, Y Harigaya, K Okamoto, M Shoj. Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer's disease. Neuroscience letters. vol 267. issue 1. 1999-12-06. PMID:10400250. |
apolipoprotein e4 accelerates dementia and increases cerebrospinal fluid tau levels in alzheimer's disease. |
1999-12-06 |
2023-08-12 |
Not clear |
| M Kanai, M Shizuka, K Urakami, E Matsubara, Y Harigaya, K Okamoto, M Shoj. Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer's disease. Neuroscience letters. vol 267. issue 1. 1999-12-06. PMID:10400250. |
the apoe epsilon4 allele accelerates the progression of dementia and increases the levels of csf tau in ad patients. |
1999-12-06 |
2023-08-12 |
Not clear |
| L Buée, A Delacourt. Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease. Brain pathology (Zurich, Switzerland). vol 9. issue 4. 1999-11-16. PMID:10517507. |
finally, recent findings provide a direct link between a genetic defect in tau and its abnormal aggregation into filaments in fronto-temporal dementia with parkinsonism linked to chromosome 17, demonstrating that tau aggregation is sufficient for nerve cell degeneration. |
1999-11-16 |
2023-08-12 |
human |
| D A Grimes, C B Bergeron, A E Lan. Motor neuron disease-inclusion dementia presenting as cortical-basal ganglionic degeneration. Movement disorders : official journal of the Movement Disorder Society. vol 14. issue 4. 1999-11-02. PMID:10435507. |
the motor neuron disease-inclusion dementia (mndid) subtype is characterized by the accumulation of specific intraneuronal ubiquitin-immunoreactive inclusions with the complete absence of tau immunoreactivity. |
1999-11-02 |
2023-08-12 |
Not clear |