| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mikio Shoji, Etsuro Matsubara, Tetsuro Murakami, Yasuhiro Manabe, Koji Abe, Mitsuyasu Kanai, Masaki Ikeda, Yasushi Tomidokoro, Masami Shizuka, Mitsunori Watanabe, Masakuni Amari, Koji Ishiguro, Takeshi Kawarabayashi, Yasuo Harigaya, Koichi Okamoto, Tsuyosi Nishimura, Yu Nakamura, Masatoshi Takeda, Katsuya Urakami, Yoshiki Adachi, Kenji Nakashima, Hiroyuki Arai, Hidetada Sasaki, Kazutomi Kanemaru, Hiroshi Yamanouchi, Yasuji Yoshida, Kunihiro Ichise, Kuniaki Tanaka, Makoto Hamamoto, Hideki Yamamoto, Takeyuki Matsubayashi, Hiroshi Yoshida, Hiromasa Toji, Shigenobu Nakamura, Shunsaku Hira. Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group. Neurobiology of aging. vol 23. issue 3. 2002-06-14. PMID:11959397. |
cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a japanese study group. |
2002-06-14 |
2023-08-12 |
human |
| Mikio Shoji, Etsuro Matsubara, Tetsuro Murakami, Yasuhiro Manabe, Koji Abe, Mitsuyasu Kanai, Masaki Ikeda, Yasushi Tomidokoro, Masami Shizuka, Mitsunori Watanabe, Masakuni Amari, Koji Ishiguro, Takeshi Kawarabayashi, Yasuo Harigaya, Koichi Okamoto, Tsuyosi Nishimura, Yu Nakamura, Masatoshi Takeda, Katsuya Urakami, Yoshiki Adachi, Kenji Nakashima, Hiroyuki Arai, Hidetada Sasaki, Kazutomi Kanemaru, Hiroshi Yamanouchi, Yasuji Yoshida, Kunihiro Ichise, Kuniaki Tanaka, Makoto Hamamoto, Hideki Yamamoto, Takeyuki Matsubayashi, Hiroshi Yoshida, Hiromasa Toji, Shigenobu Nakamura, Shunsaku Hira. Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group. Neurobiology of aging. vol 23. issue 3. 2002-06-14. PMID:11959397. |
csf samples from a total of 1,031 subjects including 366 patients with ad, 168 patients with non-alzheimer type dementia (na), 316 patients with non-dementia neurological diseases (nd) and 181 normal controls (nc) were measured using elisa for tau. |
2002-06-14 |
2023-08-12 |
human |
| Mikio Shoji, Etsuro Matsubara, Tetsuro Murakami, Yasuhiro Manabe, Koji Abe, Mitsuyasu Kanai, Masaki Ikeda, Yasushi Tomidokoro, Masami Shizuka, Mitsunori Watanabe, Masakuni Amari, Koji Ishiguro, Takeshi Kawarabayashi, Yasuo Harigaya, Koichi Okamoto, Tsuyosi Nishimura, Yu Nakamura, Masatoshi Takeda, Katsuya Urakami, Yoshiki Adachi, Kenji Nakashima, Hiroyuki Arai, Hidetada Sasaki, Kazutomi Kanemaru, Hiroshi Yamanouchi, Yasuji Yoshida, Kunihiro Ichise, Kuniaki Tanaka, Makoto Hamamoto, Hideki Yamamoto, Takeyuki Matsubayashi, Hiroshi Yoshida, Hiromasa Toji, Shigenobu Nakamura, Shunsaku Hira. Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group. Neurobiology of aging. vol 23. issue 3. 2002-06-14. PMID:11959397. |
elevation of csf tau in the non-tauopathy and tauopathy dementia groups, chronic and acute damage to the cerebrum, and meningeal disturbance were other factors that required attention for clinical practice. |
2002-06-14 |
2023-08-12 |
human |
| Kumar Sambamurti, Nigel H Greig, Debomoy K Lahir. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular medicine. vol 1. issue 1. 2002-06-14. PMID:12025813. |
alzheimer's disease (ad) is a progressive senile dementia characterized by deposition of a 4 kda peptide of 39-42 residues known as amyloid beta-peptide (abeta) in the form of senile plaques and the microtubule associated protein tau as paired helical filaments. |
2002-06-14 |
2023-08-12 |
Not clear |
| Simon Lovestone, Michael Philpot, James Connell, Peter Lantos, John Powell, Carsten Russ, Brian Anderto. Genetics, molecular biology, neuropathology and phenotype of frontal lobe dementia: a case history. The British journal of psychiatry : the journal of mental science. vol 180. 2002-06-13. PMID:11983644. |
mutations in tau have been found in a group of related disorders including the frontal lobe dementias. |
2002-06-13 |
2023-08-12 |
Not clear |
| Henry Brodaty, Philip Mitchell, Georgina Luscombe, John J Kwok, Renee F Badenhop, Rod McKenzie, Peter R Schofiel. Familial idiopathic basal ganglia calcification (Fahr's disease) without neurological, cognitive and psychiatric symptoms is not linked to the IBGC1 locus on chromosome 14q. Human genetics. vol 110. issue 1. 2002-05-09. PMID:11810290. |
we genotyped all family members for microsatellite markers at the ibgc1 locus and polymorphisms of the apoe, vldl, alpha1-act, bche-k, app, ps1, ps2 and tau genes and tested these for linkage to ibgc, dementia and bipolar disorder. |
2002-05-09 |
2023-08-12 |
Not clear |
| Eizo Iseki, Noriko Takayama, Wami Marui, Kenji Uéda, Kenji Kosak. Relationship in the formation process between neurofibrillary tangles and Lewy bodies in the hippocampus of dementia with Lewy bodies brains. Journal of the neurological sciences. vol 195. issue 1. 2002-05-07. PMID:11867079. |
using tau immunohistochemistry and alpha-synuclein immunohistochemistry, we quantitatively investigated the most frequent sites and the formation process of neurofibrillary tangles (nft) and lewy bodies (lb) in the hippocampus from 20 patients with dementia with lewy bodies (dlb). |
2002-05-07 |
2023-08-12 |
Not clear |
| Yuan Yuan Hu, Shan Shu He, Xiaochuan Wang, Qiu Hong Duan, Inge Grundke-Iqbal, Khalid Iqbal, Jianzhi Wan. Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay. The American journal of pathology. vol 160. issue 4. 2002-05-01. PMID:11943712. |
we found that the total tau was 215 +/- 77 pg/ml in cognitively normal control (n = 56), 234 +/- 92 pg/ml in non-ad neurological (n = 37), 304 +/- 126 pg/ml in vascular dementia (n = 46), and 486 +/- 168 pg/ml (n = 52) in ad patients, respectively. |
2002-05-01 |
2023-08-12 |
Not clear |
| Yuan Yuan Hu, Shan Shu He, Xiaochuan Wang, Qiu Hong Duan, Inge Grundke-Iqbal, Khalid Iqbal, Jianzhi Wan. Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay. The American journal of pathology. vol 160. issue 4. 2002-05-01. PMID:11943712. |
however, a remarkably elevated level in phosphorylated tau was only found in ad (187 +/- 84 pg/ml), as compared with normal controls (54 +/- 33 pg/ml), non-ad (63 +/- 34 pg/ml), and vascular dementia (72 +/- 33 pg/ml) groups. |
2002-05-01 |
2023-08-12 |
Not clear |
| Shintaro Hayashi, Yasuko Toyoshima, Masato Hasegawa, Yuri Umeda, Koichi Wakabayashi, Susumu Tokiguchi, Takeshi Iwatsubo, Hitoshi Takahash. Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Annals of neurology. vol 51. issue 4. 2002-04-18. PMID:11921059. |
thus, we consider that the arg5his mutation is an authentic tau gene abnormality responsible for the patient's tau pathology and late-onset dementia. |
2002-04-18 |
2023-08-12 |
Not clear |
| Sonia M Rosso, Esther van Herpen, Wout Deelen, Wouter Kamphorst, Lies-Anne Severijnen, Rob Willemsen, Rivka Ravid, Martinus F Niermeijer, Dennis Dooijes, Michael J Smith, Michel Goedert, Peter Heutink, John C van Swiete. A novel tau mutation, S320F, causes a tauopathy with inclusions similar to those in Pick's disease. Annals of neurology. vol 51. issue 3. 2002-03-28. PMID:11891833. |
in this article, we describe a novel missense mutation, s320f, in the tau gene in a family with presenile dementia. |
2002-03-28 |
2023-08-12 |
Not clear |
| Thomas W Mitchell, Elliott J Mufson, Julie A Schneider, Elizabeth J Cochran, Jonathan Nissanov, Li-Ying Han, Julia L Bienias, Virginia M -Y Lee, John Q Trojanowski, David A Bennett, Steven E Arnol. Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. Annals of neurology. vol 51. issue 2. 2002-03-01. PMID:11835374. |
these data indicate that phosphorylated tau pathology in the ventromedial temporal lobe develop prior to the onset of clinical dementia and their presence is associated with cognitive impairment, particularly impairment of episodic memory. |
2002-03-01 |
2023-08-12 |
human |
| Amritpal Mudher, Simon Loveston. Alzheimer's disease-do tauists and baptists finally shake hands? Trends in neurosciences. vol 25. issue 1. 2002-02-27. PMID:11801334. |
the finding of tau mutations in other dementias has added weight to the hypothesis as it suggests that tau-pathology is a downstream but essential part of the dementing process. |
2002-02-27 |
2023-08-12 |
mouse |
| Heather L Scott, David V Pow, Anthony E G Tannenberg, Peter R Dod. Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 3. 2002-02-27. PMID:11826152. |
these findings suggest that eaat1 changes are related to tau expression (and hence neurofibrillary tangle formation) in dementia cases showing alzheimer-type pathology. |
2002-02-27 |
2023-08-12 |
Not clear |
| H Ren, Q Ji, Y Liu, B R. Different protective roles in vitro of alpha- and beta-domains of growth inhibitory factor (GIF) on neuron injuries caused by oxygen free radicals. Biochimica et biophysica acta. vol 1568. issue 2. 2002-01-31. PMID:11750760. |
it was well known that beta-amyloid (abeta) and tau protein play an important role in pathological procedure of alzheimer's disease (ad), a senile dementia. |
2002-01-31 |
2023-08-12 |
Not clear |
| A Wallin, M Sjögre. Cerebrospinal fluid cytoskeleton proteins in patients with subcortical white-matter dementia. Mechanisms of ageing and development. vol 122. issue 16. 2001-12-31. PMID:11589912. |
the cerebrospinal fluid (csf) levels of two cytoskeleton proteins, tau and the light subunit of neurofilament protein (nfl), both considered to reflect cerebral white-matter components, were investigated in a group of patients with a subtype of vascular dementia called 'subcortical white-matter dementia' (swd). |
2001-12-31 |
2023-08-12 |
Not clear |
| E Vanmechelen, H Vanderstichele, F Hulstaert, N Andreasen, L Minthon, B Winblad, P Davidsson, K Blenno. Cerebrospinal fluid tau and beta-amyloid(1-42) in dementia disorders. Mechanisms of ageing and development. vol 122. issue 16. 2001-12-31. PMID:11589918. |
cerebrospinal fluid tau and beta-amyloid(1-42) in dementia disorders. |
2001-12-31 |
2023-08-12 |
Not clear |
| E Adamec, H T Chang, E G Stopa, J C Hedreen, J P Vonsatte. Tau protein expression in frontotemporal dementias. Neuroscience letters. vol 315. issue 1-2. 2001-12-26. PMID:11711205. |
the expression of the microtubule-associated protein tau was studied in postmortem samples of frontal cortex of 19 cases (12 pick's disease a, b, c; 4 dementia lacking distinct histology; 3 motor neuron disease type) by western blotting with a phosphorylation-independent anti-tau antibody. |
2001-12-26 |
2023-08-12 |
Not clear |
| E Adamec, H T Chang, E G Stopa, J C Hedreen, J P Vonsatte. Tau protein expression in frontotemporal dementias. Neuroscience letters. vol 315. issue 1-2. 2001-12-26. PMID:11711205. |
the presence of tau protein was detected in all cases evaluated, including the 11 brains classified as frontotemporal lobe degeneration (diagnostic categories pick's disease b, c and dementia lacking distinct histology). |
2001-12-26 |
2023-08-12 |
Not clear |
| M Goedert, M G Spillantin. Tau gene mutations and neurodegeneration. Biochemical Society symposium. issue 67. 2001-12-14. PMID:11447840. |
however, until recently, there was no genetic evidence linking dysfunction of tau protein to neurodegeneration and dementia. |
2001-12-14 |
2023-08-12 |
Not clear |