| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuekui Li, Ling Liu, Steven W Barger, W Sue T Griffi. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 5. 2003-03-24. PMID:12629164. |
the presence of tangles of abnormally phosphorylated tau is a characteristic of alzheimer's disease (ad), and the loss of synapses correlates with the degree of dementia. |
2003-03-24 |
2023-08-12 |
Not clear |
| Benoit I Giasson, Deepak M Sampathu, Christina A Wilson, Vanessa Vogelsberg-Ragaglia, Walter E Mushynski, Virginia M-Y Le. The environmental toxin arsenite induces tau hyperphosphorylation. Biochemistry. vol 41. issue 51. 2003-02-06. PMID:12484777. |
the effects of arsenite on the phosphorylation of some tau mutations (deltakappa280, v337m, and r406w) associated with frontal-temporal dementia with parkinsonism linked to chromosome 17 was analyzed. |
2003-02-06 |
2023-08-12 |
Not clear |
| Kenneth S Kosik, Jae Ahn, Ross Stein, Li-An Ye. Discovery of compounds that will prevent tau pathology. Journal of molecular neuroscience : MN. vol 19. issue 3. 2003-02-06. PMID:12540051. |
tau is certainly a reasonable target for the development of compounds to prevent neurofibrillary pathology, particularly in the fronto-temporal dementias. |
2003-02-06 |
2023-08-12 |
Not clear |
| Henry G Tomasiewicz, Denise B Flaherty, J P Soria, John G Woo. Transgenic zebrafish model of neurodegeneration. Journal of neuroscience research. vol 70. issue 6. 2003-01-24. PMID:12444595. |
we have developed a transgenic model system to study the functional consequences and trafficking patterns in zebrafish neurons of human tau either mutated on sites associated with hereditary dementias or altered at select posttranslational modification sites. |
2003-01-24 |
2023-08-12 |
human |
| Markus Tolnay, Alphonse Probs. Frontotemporal lobar degeneration--tau as a pied piper? Neurogenetics. vol 4. issue 2. 2003-01-23. PMID:12481984. |
the underlying neuropathology can be classified into disorders with tau pathology (including pick disease, corticobasal degeneration, progressive supranuclear palsy, and familial frontotemporal dementia with parkinsonism linked to chromosome 17 - ftdp-17), and into disorders that lack tau abnormalities (including dementia lacking distinctive histology and motor neuron disease inclusion dementia). |
2003-01-23 |
2023-08-12 |
Not clear |
| Osamu Yokota, Seishi Terada, Hideki Ishizu, Kuniaki Tsuchiya, Yoshihiro Kitamura, Kenji Ikeda, Kenji Uéda, Shigetoshi Kurod. NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC). Acta neuropathologica. vol 104. issue 4. 2002-12-27. PMID:12200618. |
these findings suggest that (1) dntc shares a common pathophysiological background with parkinson's disease, dementia with lewy bodies, and multiple system atrophy in which abnormal alphas aggregation is observed, and (2) there is an interaction between alphas and tau pathology that does not involve amyloid in dntc. |
2002-12-27 |
2023-08-12 |
Not clear |
| Keisuke Ishizawa, Takashi Komori, Tomokazu Shimazu, Toshimasa Yamamoto, Tetsuyuki Kitamoto, Kunio Shimazu, Takanori Hiros. Hyperphosphorylated tau deposition parallels prion protein burden in a case of Gerstmann-Sträussler-Scheinker syndrome P102L mutation complicated with dementia. Acta neuropathologica. vol 104. issue 4. 2002-12-27. PMID:12200619. |
hyperphosphorylated tau deposition parallels prion protein burden in a case of gerstmann-sträussler-scheinker syndrome p102l mutation complicated with dementia. |
2002-12-27 |
2023-08-12 |
Not clear |
| Markus Tolnay, Nicolas Sergeant, Antoine Ghestem, Sonia Chalbot, Rob A I De Vos, Ernst N H Jansen Steur, Alphonse Probst, André Delacourt. Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms. Acta neuropathologica. vol 104. issue 4. 2002-12-27. PMID:12200631. |
agd is a late onset dementia in which pathologically aggregated tau proteins are found in limbic structures in the shape of distinct argyrophilic grains and coiled bodies. |
2002-12-27 |
2023-08-12 |
Not clear |
| Toshihisa Tanaka, Masatoshi Taked. [Tau protein abnormality and dementia: the mechanisms of neurodegeneration]. No to shinkei = Brain and nerve. vol 54. issue 9. 2002-12-19. PMID:12428364. |
[tau protein abnormality and dementia: the mechanisms of neurodegeneration]. |
2002-12-19 |
2023-08-12 |
Not clear |
| Qun Wei, Max Holzer, Martina K Brueckner, Yu Liu, Thomas Arend. Dephosphorylation of tau protein by calcineurin triturated into neural living cells. Cellular and molecular neurobiology. vol 22. issue 1. 2002-12-04. PMID:12064514. |
alzheimer disease and related dementia are characterized by the presence of hyperphosphorylated tau aggregated into filaments. |
2002-12-04 |
2023-08-12 |
Not clear |
| John G Csernansky, J Philip Miller, Daniel McKeel, John C Morri. Relationships among cerebrospinal fluid biomarkers in dementia of the Alzheimer type. Alzheimer disease and associated disorders. vol 16. issue 3. 2002-12-04. PMID:12218644. |
cerebrospinal fluid (csf) contains proteins known to be involved in the pathogenesis of alzheimer disease (ad), including amyloid-related proteins, tau protein and apolipoprotein e. while the csf concentrations of these proteins have been compared in subjects with and without dementia of the alzheimer type (dat), they have not been simultaneously assessed in carefully staged dat subjects and control subjects to examine correlations among them. |
2002-12-04 |
2023-08-12 |
human |
| John G Csernansky, J Philip Miller, Daniel McKeel, John C Morri. Relationships among cerebrospinal fluid biomarkers in dementia of the Alzheimer type. Alzheimer disease and associated disorders. vol 16. issue 3. 2002-12-04. PMID:12218644. |
moreover, increased severity of dementia was correlated with increased csf tau concentrations and decreased sapp and abeta concentrations. |
2002-12-04 |
2023-08-12 |
human |
| Donald R Royall, Raymond Palmer, Amy R Mulroy, Marsha J Polk, Gustavo C Román, Jean-Phillippe David, André Delacourt. Pathological determinants of the transition to clinical dementia in Alzheimer's disease. Experimental aging research. vol 28. issue 2. 2002-10-11. PMID:11928525. |
the authors developed multivariate models to examine the association between clinical dementia rating (cdr) scale scores and the spatial distribution of paired helical filament tau (phf-tau) pathology. |
2002-10-11 |
2023-08-12 |
Not clear |
| Luc Buée, Malika Hamdane, Patrice Delobel, Anne-Véronique Sambo, Séverine Bégard, Antoine Ghestem, Nicolas Sergeant, André Delacourt. [Tau story: from frontotemporal dementia to other tauopathies]. Journal de la Societe de biologie. vol 196. issue 1. 2002-08-23. PMID:12134624. |
finally, the recent discovery of tau gene mutations in fronto-temporal dementia with parkinsonism linked to chromosome 17 has reinforced the direct role attributed to tau proteins in the pathogenesis of neurodegenerative disorders, and underlined the fact that distinct sets of tau isoforms expressed in different neuronal populations could lead to different pathologies. |
2002-08-23 |
2023-08-12 |
human |
| François Torreilles, Jacques Toucho. Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease. Progress in neurobiology. vol 66. issue 3. 2002-08-12. PMID:11943451. |
alzheimer's disease (ad) is an age-dependent dementia characterized by progressive loss of cognitive functions and by characteristic pathological changes in the brain: the formation of aggregates extracellularly by beta-amyloid (abeta) peptide and intracellularly by tau proteins. |
2002-08-12 |
2023-08-12 |
Not clear |
| Lysia S Forno, J William Langston, Maie K Herrick, Jon D Wilson, Shigeo Murayam. Ubiquitin-positive neuronal and tau 2-positive glial inclusions in frontotemporal dementia of motor neuron type. Acta neuropathologica. vol 103. issue 6. 2002-08-07. PMID:12012092. |
in addition to the presence of ubiquitin-reactive, but tau-and silver impregnation-negative neuronal inclusions, all cases demonstrated tau 2-positive glial inclusions, similar to those recently reported in three motor neuron disease cases with dementia. |
2002-08-07 |
2023-08-12 |
Not clear |
| K Blennow, E Vanmechelen, H Hampe. CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease. Molecular neurobiology. vol 24. issue 1-3. 2002-07-24. PMID:11831556. |
in particular, two biochemical markers, csf total tau (t-tau) protein and the 42 amino acid form of beta-amyloid (abeta42), perform satisfactorily enough to achieve a role in the clinical diagnostic settings of patients with dementia together with the cumulative information from basic clinical work-up, genetic screening, and brain imaging. |
2002-07-24 |
2023-08-12 |
Not clear |
| J Neil Henderson, Richard Crook, Julia Crook, John Hardy, Luisa Onstead, Linda Carson-Henderson, Pat Mayer, Bea Parker, Ronald Petersen, Birdie William. Apolipoprotein E4 and tau allele frequencies among Choctaw Indians. Neuroscience letters. vol 324. issue 1. 2002-07-12. PMID:11983299. |
apolipoprotein genotyping and tau haplotyping were carried out on a series of cases with dementia and controls from the choctaw nation of oklahoma. |
2002-07-12 |
2023-08-12 |
Not clear |
| J Neil Henderson, Richard Crook, Julia Crook, John Hardy, Luisa Onstead, Linda Carson-Henderson, Pat Mayer, Bea Parker, Ronald Petersen, Birdie William. Apolipoprotein E4 and tau allele frequencies among Choctaw Indians. Neuroscience letters. vol 324. issue 1. 2002-07-12. PMID:11983299. |
both the apolipoprotein e4 allele frequency and the tau h2 haplotype frequency were low in the choctaw compared with caucasians and there was the possibility that the association between dementia and the e4 allele was weaker than in caucasians. |
2002-07-12 |
2023-08-12 |
Not clear |
| Yoshio Tsuboi, Ryan J Uitti, Marie-Bernadette Delisle, Joaquim J Ferreira, Christine Brefel-Courbon, Olivier Rascol, Bernardino Ghetti, Jill R Murrell, Michael Hutton, Matthew Baker, Zbigniew K Wszole. Clinical features and disease haplotypes of individuals with the N279K tau gene mutation: a comparison of the pallidopontonigral degeneration kindred and a French family. Archives of neurology. vol 59. issue 6. 2002-07-01. PMID:12056930. |
an n279k missense mutation in exon 10 of the tau gene reported in an american family with pallidopontonigral degeneration (ppnd family) was recently found in members of a french kindred with dementia and supranuclear palsy. |
2002-07-01 |
2023-08-12 |
Not clear |