| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonia M Rosso, Laura Donker Kaat, Timo Baks, Marijke Joosse, Inge de Koning, Yolande Pijnenburg, Daniëlle de Jong, Dennis Dooijes, Wouter Kamphorst, Rivka Ravid, Martinus F Niermeijer, Frans Verheij, H P Kremer, Philip Scheltens, Cornelia M van Duijn, Peter Heutink, John C van Swiete. Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study. Brain : a journal of neurology. vol 126. issue Pt 9. 2003-10-24. PMID:12876142. |
pathological findings in the 40 autopsied patients consisted of dementia lacking distinctive histology in 22%, ftd with ubiquitin-positive inclusions in 33%, pick's disease in 15% and tauopathy in the remaining 30% of patients, with tau mutations identified in more than half of the latter patients. |
2003-10-24 |
2023-08-12 |
Not clear |
| Sonia M Rosso, Laura Donker Kaat, Timo Baks, Marijke Joosse, Inge de Koning, Yolande Pijnenburg, Daniëlle de Jong, Dennis Dooijes, Wouter Kamphorst, Rivka Ravid, Martinus F Niermeijer, Frans Verheij, H P Kremer, Philip Scheltens, Cornelia M van Duijn, Peter Heutink, John C van Swiete. Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study. Brain : a journal of neurology. vol 126. issue Pt 9. 2003-10-24. PMID:12876142. |
the finding of tau mutations in 32% of patients with a positive family history for dementia justifies mutation screening in ftd patients with a positive family history, while tau mutations in non-familiar cases are rare. |
2003-10-24 |
2023-08-12 |
Not clear |
| Harald Hampel, Alexander Goernitz, Katharina Buerge. Advances in the development of biomarkers for Alzheimer's disease: from CSF total tau and Abeta(1-42) proteins to phosphorylated tau protein. Brain research bulletin. vol 61. issue 3. 2003-10-14. PMID:12909294. |
measurement of total tau (t-tau) and beta-amyloid(1-42) (abeta(1-42)) in the cerebrospinal fluid (csf) seems useful to discriminate early and incipient ad from age-associated memory-impairment, depression, and some secondary dementias. |
2003-10-14 |
2023-08-12 |
human |
| Dulal Panda, Jonathan C Samuel, Michelle Massie, Stuart C Feinstein, Leslie Wilso. Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 16. 2003-10-03. PMID:12886013. |
genetic analyses have established a cause-and-effect relationship between tau dysfunction/misregulation and neuronal cell death and dementia in frontotemporal dementia and parkinsonism associated with chromosome 17; several mutations causing this dementia lead to increased ratios of four-repeat (4r) to three-repeat (3r) wild-type tau, and an attractive hypothesis is that the abnormally high ratio of 4r to 3r tau might lead to neuronal cell death by altering normal tau functions in adult neurons. |
2003-10-03 |
2023-08-12 |
Not clear |
| N J Cairns, R A Armstron. Clustering of neuronal inclusions in "dementia with neurofilament inclusions". Acta neuropathologica. vol 106. issue 2. 2003-10-01. PMID:12732935. |
dementia with neurofilament inclusions (dni) is a new disorder characterized clinically by early-onset dementia and histologically by the presence of intraneural inclusions immunopositive for neurofilament antigens but lacking tau and alpha-synuclein reactivity. |
2003-10-01 |
2023-08-12 |
Not clear |
| Lorraine N Clark, Gilberto Levy, Ming-Xin Tang, Helen Mejia-Santana, Alejandra Ciappa, Benjamin Tycko, Lucien J Cote, Elan D Louis, Richard Mayeux, Karen Marde. The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts. Neuroscience letters. vol 347. issue 1. 2003-08-21. PMID:12865131. |
we also observed a trend in non-hispanic white pdd cases with the sth 'qq' (tau h1/h1) genotype increased (76%) compared to pd cases without dementia (61.7%) and controls (56.6%); however, this difference was not statistically significant (pdd vs. controls or 2.1; 95% ci: 0.8-5.8, p=0.2). |
2003-08-21 |
2023-08-12 |
Not clear |
| G Benitez-King, I Túnez, A Bellon, G G Ortíz, F Antón-Ta. Melatonin prevents cytoskeletal alterations and oxidative stress induced by okadaic acid in N1E-115 cells. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821385. |
okadaic acid (oa) causes oxidative stress, tau hyperphosphorylation, and altered cytoskeletal organization similar to those observed in neurons of patients with dementia. |
2003-08-06 |
2023-08-12 |
Not clear |
| Katsuya Urakami, Kenji Nakashim. [Corticobasal degeneration and progressive supranuclear palsy--biochemical marker]. Rinsho shinkeigaku = Clinical neurology. vol 42. issue 11. 2003-07-09. PMID:12784694. |
the diagnostic significance of tau proteins in cerebrospinal fluids (csf) has been described in many cases of dementia of alzheimer type (ad). |
2003-07-09 |
2023-08-12 |
human |
| R Rademakers, M Cruts, B Dermaut, K Sleegers, S M Rosso, M Van den Broeck, H Backhovens, J van Swieten, C M van Duijn, C Van Broeckhove. Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval. Molecular psychiatry. vol 7. issue 10. 2003-07-08. PMID:12476321. |
tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cm interval. |
2003-07-08 |
2023-08-12 |
Not clear |
| Victoria Zhukareva, Sonali Sundarraj, David Mann, Magnus Sjogren, Kaj Blenow, Christopher M Clark, Daniel W McKeel, Alison Goate, Carol F Lippa, Jean-Paul Vonsattel, John H Growdon, John Q Trojanowski, Virginia M-Y Le. Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study. Acta neuropathologica. vol 105. issue 5. 2003-06-06. PMID:12677447. |
recently, biochemical criteria were proposed to complement histological criteria for the diagnosis of dementia lacking distinctive histopathology (dldh), the most common pathological variant of frontotemporal dementias (ftds), based on evidence of a selective reduction of soluble tau proteins in brains from a large cohort of sporadic dldh and hereditary ftd (hddd2 family) patients. |
2003-06-06 |
2023-08-12 |
Not clear |
| Takashi Ishizawa, Petri Mattila, Peter Davies, Dengshun Wang, Dennis W Dickso. Colocalization of tau and alpha-synuclein epitopes in Lewy bodies. Journal of neuropathology and experimental neurology. vol 62. issue 4. 2003-05-21. PMID:12722831. |
the major protein constituent of lewy bodies (lbs), the pathological hallmark of parkinson disease and dementia with lewy bodies, is considered to be alpha-synuclein, but other proteins, in particular the microtubule-associated protein tau, have been implicated in the pathogenesis of lbs. |
2003-05-21 |
2023-08-12 |
rabbit |
| Eizo Iseki, Takashi Togo, Kyoko Suzuki, Omi Katsuse, Wami Marui, Rohan de Silva, Andrews Lees, Takayuki Yamamoto, Kenji Kosak. Dementia with Lewy bodies from the perspective of tauopathy. Acta neuropathologica. vol 105. issue 3. 2003-04-23. PMID:12557014. |
we immunohistochemically investigated the prevalence and pattern of phosphorylated tau accumulation in neurons and glia in 46 cases of dementia with lewy bodies (dlb). |
2003-04-23 |
2023-08-12 |
Not clear |
| E Kapaki, G P Paraskevas, I Zalonis, C Zourna. CSF tau protein and beta-amyloid (1-42) in Alzheimer's disease diagnosis: discrimination from normal ageing and other dementias in the Greek population. European journal of neurology. vol 10. issue 2. 2003-04-23. PMID:12603286. |
csf tau protein and beta-amyloid (1-42) in alzheimer's disease diagnosis: discrimination from normal ageing and other dementias in the greek population. |
2003-04-23 |
2023-08-12 |
human |
| E Kapaki, G P Paraskevas, I Zalonis, C Zourna. CSF tau protein and beta-amyloid (1-42) in Alzheimer's disease diagnosis: discrimination from normal ageing and other dementias in the Greek population. European journal of neurology. vol 10. issue 2. 2003-04-23. PMID:12603286. |
in order to evaluate their diagnostic potential in clinical practice, we measured tau and abeta42 levels in the csf of 49 ad patients, 15 patients with non-ad neurodegenerative dementias (nand), six patients with vascular dementia (vd) and 49 elderly controls. |
2003-04-23 |
2023-08-12 |
human |
| E Kapaki, G P Paraskevas, I Zalonis, C Zourna. CSF tau protein and beta-amyloid (1-42) in Alzheimer's disease diagnosis: discrimination from normal ageing and other dementias in the Greek population. European journal of neurology. vol 10. issue 2. 2003-04-23. PMID:12603286. |
thus, the combined use of csf tau and abeta42 in the form of the tau/abeta42 ratio is a simple, safe and useful adjuvant to clinical criteria for dementia diagnosis. |
2003-04-23 |
2023-08-12 |
human |
| C Mulder, S N M Schoonenboom, L-O Wahlund, Ph Scheltens, G J van Kamp, R Veerhuis, C E Hack, M Blomberg, R B H Schutgens, P Eikelenboo. CSF markers related to pathogenetic mechanisms in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 12. 2003-04-18. PMID:12486489. |
the objective of the present study was to compare the levels of abeta(1-42), tau, c1q and sap in csf of a well characterized group of ad patients and controls, and to assess the association with dementia severity. |
2003-04-18 |
2023-08-12 |
Not clear |
| Katarina Nägga, Johan Gottfries, Kaj Blennow, Jan Marcusso. Cerebrospinal fluid phospho-tau, total tau and beta-amyloid(1-42) in the differentiation between Alzheimer's disease and vascular dementia. Dementia and geriatric cognitive disorders. vol 14. issue 4. 2003-03-28. PMID:12411760. |
cerebrospinal fluid phospho-tau, total tau and beta-amyloid(1-42) in the differentiation between alzheimer's disease and vascular dementia. |
2003-03-28 |
2023-08-12 |
Not clear |
| Katarina Nägga, Johan Gottfries, Kaj Blennow, Jan Marcusso. Cerebrospinal fluid phospho-tau, total tau and beta-amyloid(1-42) in the differentiation between Alzheimer's disease and vascular dementia. Dementia and geriatric cognitive disorders. vol 14. issue 4. 2003-03-28. PMID:12411760. |
the two most frequently examined biomarkers in the diagnosis of dementia are cerebrospinal fluid (csf) tau and beta-amyloid(1-42) (abeta(1-42)). |
2003-03-28 |
2023-08-12 |
Not clear |
| Katarina Nägga, Johan Gottfries, Kaj Blennow, Jan Marcusso. Cerebrospinal fluid phospho-tau, total tau and beta-amyloid(1-42) in the differentiation between Alzheimer's disease and vascular dementia. Dementia and geriatric cognitive disorders. vol 14. issue 4. 2003-03-28. PMID:12411760. |
from the results of the present study, it is concluded that neither measurement of phospho-tau, tau nor abeta(1-42) in csf can discriminate entirely between dementia and cognitively non-disturbed controls or between dementia of different aetiologies in the clinical diagnostic procedure. |
2003-03-28 |
2023-08-12 |
Not clear |
| Anne K Vehmas, Claudia H Kawas, Walter F Stewart, Juan C Troncos. Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease. Neurobiology of aging. vol 24. issue 2. 2003-03-26. PMID:12498966. |
tau immunoreactivity appears as the strongest morphological correlate of dementia. |
2003-03-26 |
2023-08-12 |
human |