| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jürgen Götz, Andreas Schild, Fred Hoerndli, Luis Pennane. Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 7. 2004-12-15. PMID:15465275. |
in a related disorder termed frontotemporal dementia, which is characterized by tangles in the absence of beta-amyloid deposition, mutations have been identified in tau which also lead to neurodegeneration and dementia. |
2004-12-15 |
2023-08-12 |
mouse |
| John J Hadda. Mitogen-activated protein kinases and the evolution of Alzheimer's: a revolutionary neurogenetic axis for therapeutic intervention? Progress in neurobiology. vol 73. issue 5. 2004-11-19. PMID:15312913. |
since phosphorylation/dephosphorylation mechanisms are crucial in the regulation of tau and beta-app, a superfamily of mitogen-activated protein kinases (mapks) has recently emerged as key regulators of the formation of plagues, eventually leading to dementia and ad. |
2004-11-19 |
2023-08-12 |
Not clear |
| Michel Goeder. Tau protein and neurodegeneration. Seminars in cell & developmental biology. vol 15. issue 1. 2004-10-26. PMID:15036206. |
the identification of mutations in tau as the cause of ftdp-17 established that dysfunction or misregulation of tau protein is sufficient to cause neurodegeneration and dementia. |
2004-10-26 |
2023-08-12 |
Not clear |
| K Iqbal, I Grundke-Iqba. Inhibition of neurofibrillary degeneration: a promising approach to Alzheimer's disease and other tauopathies. Current drug targets. vol 5. issue 6. 2004-10-14. PMID:15270196. |
to date in all known tauopathics including ad, the neurofibrillary changes, whether of paired helical filaments (phf), twisted ribbons or straight filaments (sf) are made up of abnormally hyperphosphorylated tau, and the number of these lesions directly correlates to the degree of dementia in the affected individuals. |
2004-10-14 |
2023-08-12 |
Not clear |
| Kumar Sambamurti, Ann-Charlotte Granholm, Mark S Kindy, Narayan R Bhat, Nigel H Greig, Debomoy K Lahiri, Jacobo E Mintze. Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Current drug targets. vol 5. issue 6. 2004-10-14. PMID:15270198. |
alzheimer's disease (ad) is a progressive senile dementia characterized by deposition of a 4 kda peptide of 39-42 residues known as amyloid beta-peptide (abeta) in the form of senile plaques and the microtubule associated protein tau as paired helical filaments. |
2004-10-14 |
2023-08-12 |
Not clear |
| Andreas Fellgiebel, Thomas Siessmeier, Armin Scheurich, Georg Winterer, Peter Bartenstein, Lutz G Schmidt, Matthias J Mülle. Association of elevated phospho-tau levels with Alzheimer-typical 18F-fluoro-2-deoxy-D-glucose positron emission tomography findings in patients with mild cognitive impairment. Biological psychiatry. vol 56. issue 4. 2004-09-30. PMID:15312816. |
phosphorylated tau protein in cerebrospinal fluid and even more decrements of cerebral glucose metabolism in parietal, temporal, or cingulate regions have shown favorable specificity for the diagnosis of alzheimer dementia and could be useful supplementary tools to determine alzheimer pathology in early stages. |
2004-09-30 |
2023-08-12 |
Not clear |
| Jovanka Ostojic, Christina Elfgren, Ulla Passant, Karin Nilsson, Lars Gustafson, Lars Lannfelt, Susanne Froelich Fabr. The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy. Dementia and geriatric cognitive disorders. vol 17. issue 4. 2004-09-24. PMID:15178940. |
the tau r406w mutation causes progressive presenile dementia with bitemporal atrophy. |
2004-09-24 |
2023-08-12 |
Not clear |
| Jovanka Ostojic, Christina Elfgren, Ulla Passant, Karin Nilsson, Lars Gustafson, Lars Lannfelt, Susanne Froelich Fabr. The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy. Dementia and geriatric cognitive disorders. vol 17. issue 4. 2004-09-24. PMID:15178940. |
in the present study, a swedish family with presenile degenerative dementia with bitemporal atrophy was screened for mutations in the tau gene. |
2004-09-24 |
2023-08-12 |
Not clear |
| Harald Hampel, Stefan J Teipe. Total and phosphorylated tau proteins: evaluation as core biomarker candidates in frontotemporal dementia. Dementia and geriatric cognitive disorders. vol 17. issue 4. 2004-09-24. PMID:15178952. |
tau phosphorylated at threonine 231 (p-tau(231)) shows excellent differentiation between ad and ftd, whereas serine 181 (p-tau(181)) enhances accurate differentiation between ad and dementia with lewy bodies. |
2004-09-24 |
2023-08-12 |
Not clear |
| J S Snowden, D Neary, D M A Man. Autopsy proven sporadic frontotemporal dementia due to microvacuolar-type histology, with onset at 21 years of age. Journal of neurology, neurosurgery, and psychiatry. vol 75. issue 9. 2004-09-14. PMID:15314128. |
there was no family history of dementia and no mutation in the tau gene. |
2004-09-14 |
2023-08-12 |
Not clear |
| Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Gerald W Hart, Cheng-Xin Gon. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 29. 2004-08-26. PMID:15249677. |
tau pathology is critical to pathogenesis and correlates to the severity of dementia. |
2004-08-26 |
2023-08-12 |
mouse |
| Andreas Mershin, Elias Pavlopoulos, Olivia Fitch, Brittany C Braden, Dimitri V Nanopoulos, Efthimios M C Skoulaki. Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 11. issue 3. 2004-08-25. PMID:15169857. |
mutations in the neuronal-specific microtubule-binding protein tau are associated with several dementias and neurodegenerative diseases. |
2004-08-25 |
2023-08-12 |
drosophila_melanogaster |
| Q Tian, Z-Q Lin, X-C Wang, J Chen, Q Wang, C-X Gong, J-Z Wan. Injection of okadaic acid into the meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit. Neuroscience. vol 126. issue 2. 2004-08-24. PMID:15207345. |
abnormal hyperphosphorylation of tau and cholinergic deficit occur in the early stage of alzheimer's disease (ad) and relate to the dementia symptom. |
2004-08-24 |
2023-08-12 |
rat |
| Janel Johnson, Jovanka Ostojic, Lars Lannfelt, Anna Glaser, Hans Basun, Ekaterina Rogaeva, Toshitaka Kawarai, Amalia Bruni, Peter H St George Hyslop, Alison Goate, Pau Pastor, Sumi Chakraverty, Joanne Norton, John C Morris, John Hardy, Andrew Singleto. No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found. Neuroscience letters. vol 363. issue 2. 2004-08-04. PMID:15172093. |
no evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found. |
2004-08-04 |
2023-08-12 |
Not clear |
| Janel Johnson, Jovanka Ostojic, Lars Lannfelt, Anna Glaser, Hans Basun, Ekaterina Rogaeva, Toshitaka Kawarai, Amalia Bruni, Peter H St George Hyslop, Alison Goate, Pau Pastor, Sumi Chakraverty, Joanne Norton, John C Morris, John Hardy, Andrew Singleto. No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found. Neuroscience letters. vol 363. issue 2. 2004-08-04. PMID:15172093. |
given the remarkable similarities between the genetics of tau diseases and the genetics of alpha-synuclein diseases, and given the fact that we have recently found a triplication of the alpha-synuclein locus in a family in which we had shown linkage to the alpha-synuclein locus, we determined to test whether some of the several families with autosomal dominant frontal temporal dementia which show genetic linkage to the tau locus but in which tau mutations have not been found could be caused by similar structural mutations. |
2004-08-04 |
2023-08-12 |
Not clear |
| Dennis W Dickso. Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? The Journal of clinical investigation. vol 114. issue 1. 2004-08-02. PMID:15232608. |
proteolysis of tau may be critical to neurofibrillary degeneration, which correlates with dementia. |
2004-08-02 |
2023-08-12 |
Not clear |
| Piotr Lewczuk, Hermann Esselmann, Markus Otto, Juan Manuel Maler, Andreas Wolfram Henkel, Maria Kerstin Henkel, Oliver Eikenberg, Christof Antz, Wolf-Rainer Krause, Udo Reulbach, Johannes Kornhuber, Jens Wiltfan. Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau. Neurobiology of aging. vol 25. issue 3. 2004-07-15. PMID:15123331. |
neurochemical diagnosis of alzheimer's dementia by csf abeta42, abeta42/abeta40 ratio and total tau. |
2004-07-15 |
2023-08-12 |
human |
| Piotr Lewczuk, Hermann Esselmann, Markus Otto, Juan Manuel Maler, Andreas Wolfram Henkel, Maria Kerstin Henkel, Oliver Eikenberg, Christof Antz, Wolf-Rainer Krause, Udo Reulbach, Johannes Kornhuber, Jens Wiltfan. Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau. Neurobiology of aging. vol 25. issue 3. 2004-07-15. PMID:15123331. |
cerebrospinal fluid (csf) concentrations of amyloid beta peptides ending at positions 42 and 40 (abeta42 and abeta40, respectively), and total tau (ttau) protein were measured by elisa in order to compare their accuracy in discriminating patients with alzheimer's disease (ad, n = 22), non-alzheimer dementia (nad, n = 11) and control subjects (con, n=35). |
2004-07-15 |
2023-08-12 |
human |
| Craig E Hou, Danielle Carlin, Bruce L Mille. Non-Alzheimer's disease dementias: anatomic, clinical, and molecular correlates. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 49. issue 3. 2004-07-07. PMID:15101498. |
to review the clinical and molecular features of non-alzheimer's disease (non-ad) dementias, focusing on disorders associated with tau pathology (that is, frontotemporal lobar degeneration [ftld], corticobasal ganglionic degeneration [cbd], and progressive supranuclear palsy [psp]) or on disorders with synuclein pathology (that is, dementia with lewy bodies [dlb] and multisystem atrophy [msa]). |
2004-07-07 |
2023-08-12 |
Not clear |
| H Lins, I Wichart, C Bancher, C-W Wallesch, K A Jellinger, N Rösle. Immunoreactivities of amyloid beta peptide((1-42)) and total tau protein in lumbar cerebrospinal fluid of patients with normal pressure hydrocephalus. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 3. 2004-06-01. PMID:14991454. |
immunoreactivities of amyloid beta peptide((1-42)) (abeta42-ir) and total tau protein (ttir) were measured in lumbar cerebrospinal fluid of 48 patients (12 patients in each group) with normal pressure hydrocephalus (nph), vascular dementia (vd), alzheimer's disease (ad), parkinson's disease without dementia (pd) and 24 controls (con) using sensitive and specific enzyme immunoassays. |
2004-06-01 |
2023-08-12 |
Not clear |