| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B L Goode, M Chau, P E Denis, S C Feinstei. Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease. The Journal of biological chemistry. vol 275. issue 49. 2001-01-18. PMID:10984497. |
consistent with this hypothesis, regulatory mutations in the human tau gene that disrupt the normal balance between 3-repeat and 4-repeat tau isoform expression lead to a collection of neurodegenerative diseases known as ftdp-17 (fronto-temporal dementias and parkinsonism linked to chromosome 17), which are characterized by the formation of pathological tau filaments and neuronal cell death. |
2001-01-18 |
2023-08-12 |
human |
| T Tapiola, T Pirttilä, P D Mehta, I Alafuzofff, M Lehtovirta, H Soinine. Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease. Neurobiology of aging. vol 21. issue 5. 2001-01-18. PMID:11016543. |
combination of abeta42 and tau resulted a sensitivity of 50.4% for ad and specificities of 94.8% for controls and 85.2% for other dementias. |
2001-01-18 |
2023-08-12 |
Not clear |
| M G Spillantini, H Yoshida, C Rizzini, P L Lantos, N Khan, M N Rossor, M Goedert, J Brow. A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies. Annals of neurology. vol 48. issue 6. 2001-01-11. PMID:11117553. |
a novel tau mutation (n296n) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies. |
2001-01-11 |
2023-08-12 |
Not clear |
| M G Spillantini, H Yoshida, C Rizzini, P L Lantos, N Khan, M N Rossor, M Goedert, J Brow. A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies. Annals of neurology. vol 48. issue 6. 2001-01-11. PMID:11117553. |
here we describe a novel silent mutation in exon 10 of tau (n296n) in this familial dementia. |
2001-01-11 |
2023-08-12 |
Not clear |
| M G Spillantini, J C Van Swieten, M Goeder. Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Neurogenetics. vol 2. issue 4. 2001-01-09. PMID:10983715. |
taken together, the new work has shown that dysfunction of tau protein causes neurodegeneration and dementia. |
2001-01-09 |
2023-08-12 |
human |
| C Andersen, S Froelich Fabre, P Ostberg, L Lannfelt, L Wahlun. Tau protein in cerebrospinal fluid from semantic dementia patients. Neuroscience letters. vol 294. issue 3. 2000-12-27. PMID:11072138. |
tau protein in cerebrospinal fluid from semantic dementia patients. |
2000-12-27 |
2023-08-12 |
human |
| C Andersen, S Froelich Fabre, P Ostberg, L Lannfelt, L Wahlun. Tau protein in cerebrospinal fluid from semantic dementia patients. Neuroscience letters. vol 294. issue 3. 2000-12-27. PMID:11072138. |
these results indicate that semantic dementia is a rather uncommon but clinically distinct condition which shows a moderate increase of csf tau protein levels and for which the epsilon4 allele is a risk factor. |
2000-12-27 |
2023-08-12 |
human |
| K Arima, T Mizutani, M A Alim, H Tonozuka-Uehara, Y Izumiyama, S Hirai, K Uéd. NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies. Acta neuropathologica. vol 100. issue 2. 2000-12-22. PMID:10963357. |
nacp/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with lewy bodies: double-immunolabeling fluorescence and electron microscopic studies. |
2000-12-22 |
2023-08-12 |
Not clear |
| K Arima, T Mizutani, M A Alim, H Tonozuka-Uehara, Y Izumiyama, S Hirai, K Uéd. NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies. Acta neuropathologica. vol 100. issue 2. 2000-12-22. PMID:10963357. |
the co-localization of nacp/alpha-synuclein and tau epitopes was examined in the brain stem and hippocampal formation in two patients from a family of autosomal dominant parkinsonism and dementia with lewy bodies (lbs) without two reported missense mutations in the nacp gene. |
2000-12-22 |
2023-08-12 |
Not clear |
| R Vidal, M Calero, P Piccardo, M R Farlow, F W Unverzagt, E Méndez, A Jiménez-Huete, R Beavis, G Gallo, E Gomez-Tortosa, J Ghiso, B T Hyman, B Frangione, B Ghett. Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele. Acta neuropathologica. vol 100. issue 1. 2000-12-07. PMID:10912914. |
senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the apoe-epsilon4 allele. |
2000-12-07 |
2023-08-12 |
human |
| R Vidal, M Calero, P Piccardo, M R Farlow, F W Unverzagt, E Méndez, A Jiménez-Huete, R Beavis, G Gallo, E Gomez-Tortosa, J Ghiso, B T Hyman, B Frangione, B Ghett. Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele. Acta neuropathologica. vol 100. issue 1. 2000-12-07. PMID:10912914. |
we report clinical, pathological and biochemical studies on two apoe-epsilon4 homozygous subjects, who had senile dementia and whose main neuropathological feature was a severe and diffuse amyloid angiopathy associated with perivascular tau neurofibrillary pathology. |
2000-12-07 |
2023-08-12 |
human |
| H Arai, K Ishiguro, H Ohno, M Moriyama, N Itoh, N Okamura, T Matsui, Y Morikawa, E Horikawa, H Kohno, H Sasaki, K Imahor. CSF phosphorylated tau protein and mild cognitive impairment: a prospective study. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031097. |
although either a total-tau, phospho-tau measurement or a combination of these can help in predicting if mci will develop ad, our results suggest that the pathogenic steps of ad may be at the stage that finally leads to an accumulation of abnormally phosphorylated tau and neuron death, at least in some brain areas, when mci patients present with the earliest detectable clinical symptoms of dementia. |
2000-12-07 |
2023-08-12 |
Not clear |
| M Sjögren, L Minthon, P Davidsson, Granérus A-K, A Clarberg, H Vanderstichele, E Vanmechelen, A Wallin, K Blenno. CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 5. 2000-11-30. PMID:11072752. |
csf levels of tau, beta-amyloid(1-42) and gap-43 in frontotemporal dementia, other types of dementia and normal aging. |
2000-11-30 |
2023-08-12 |
Not clear |
| M Sjögren, L Minthon, P Davidsson, Granérus A-K, A Clarberg, H Vanderstichele, E Vanmechelen, A Wallin, K Blenno. CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 5. 2000-11-30. PMID:11072752. |
cerebrospinal fluid (csf) levels of tau, beta-amyloid(1-42) and growth-associated protein 43 (gap-43) were studied in patients with frontotemporal dementia (ftd; n = 17), alzheimer's disease (ad; n = 60), subcortical white-matter dementia (swd; n = 24), parkinson's disease (pd; n = 23) and dysthymia (n = 19) and in age-matched controls (n = 32). |
2000-11-30 |
2023-08-12 |
Not clear |
| T Iwatsub. [Alzheimer's disease: basic aspects]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 37. issue 3. 2000-10-04. PMID:10879068. |
in addition, the pathogenic role of tau in neuronal death is highlighted based on the identification of mutations in tau gene in a dominantly-inherited neurodegenerative dementia ftdp-17. |
2000-10-04 |
2023-08-12 |
Not clear |
| M Tolnay, M Grazia Spillantini, C Rizzini, D Eccles, J Lowe, D Elliso. A new case of frontotemporal dementia and parkinsonism resulting from an intron 10 +3-splice site mutation in the tau gene: clinical and pathological features. Neuropathology and applied neurobiology. vol 26. issue 4. 2000-09-19. PMID:10931371. |
for the index case only, sequencing of intronic sequences flanking exon 10 of the tau gene identified a g to a transition at position +3 of the splice-donor site downstream of exon 10, identical to that reported in multiple system tauopathy with presenile dementia (mstd). |
2000-09-19 |
2023-08-12 |
Not clear |
| K Iked. Neuropathological discrepancy between Japanese Pick's disease without Pick bodies and frontal lobe degeneration type of frontotemporal dementia proposed by Lund and Manchester Group. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 20. issue 1. 2000-09-06. PMID:10935442. |
there is a possibility that japanese, british, and swedish neuropathologists deal with heterogeneous groups of dementia characterized as ftd without tau or ubiquitin pathology. |
2000-09-06 |
2023-08-12 |
Not clear |
| R Kohnken, K Buerger, R Zinkowski, C Miller, D Kerkman, J DeBernardis, J Shen, H J Möller, P Davies, H Hampe. Detection of tau phosphorylated at threonine 231 in cerebrospinal fluid of Alzheimer's disease patients. Neuroscience letters. vol 287. issue 3. 2000-09-01. PMID:10863026. |
a new sandwich elisa is described which shows specificity for tau phosphorylated at threonine 231 and preferentially reacts with alzheimer's disease (ad) brain extracts relative to other dementias. |
2000-09-01 |
2023-08-12 |
Not clear |
| S Kropp, J Schlimme, S Bleich, J Wiltfang, D E Dietrich, H M Emric. [Diagnostic steps in Alzheimer dementia before treatment with new antidimentives]. Fortschritte der Neurologie-Psychiatrie. vol 68. issue 6. 2000-08-29. PMID:10923250. |
in case of a typical clinical constellation, the exclusion of a primarily vascular dementia as well as the proof of decreased a beta 1-42 peptides and an increased tau protein in csf we recommend the new drugs for dat as meaningful and justified therapeutics to yield optimal treatment. |
2000-08-29 |
2023-08-12 |
Not clear |
| Z Jiang, J Cote, J M Kwon, A M Goate, J Y W. Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17. Molecular and cellular biology. vol 20. issue 11. 2000-07-06. PMID:10805746. |
aberrant splicing of tau pre-mrna caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17. |
2000-07-06 |
2023-08-12 |
human |