| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Debashis Dutta, Malabendu Jana, Moumita Majumder, Susanta Mondal, Avik Roy, Kalipada Paha. Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo. Nature communications. vol 12. issue 1. 2021-10-14. PMID:34508096. |
pathways to control the spreading of α-synuclein (α-syn) and associated neuropathology in parkinson's disease (pd), multiple system atrophy (msa) and dementia with lewy bodies (dlb) are unclear. |
2021-10-14 |
2023-08-13 |
mouse |
| Takayuki Katayama, Jun Sawada, Kae Takahashi, Osamu Yahara, Naoyuki Haseb. Meta-analysis of cerebrospinal fluid neuron-specific enolase levels in Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-14. PMID:34610837. |
this study examined the usefulness of cerebrospinal fluid (csf) neuron-specific enolase (nse) levels as a candidate biomarker of neurodegeneration in alzheimer's disease (ad), parkinson's disease (pd), pd with dementia (pdd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2021-10-14 |
2023-08-13 |
Not clear |
| Ito Kawakami, Atsuko Motoda, Masashi Hashimoto, Aki Shimozawa, Masami Masuda-Suzukake, Reiko Ohtani, Mina Takase, Mari Kumashiro, Kazuyuki Samejima, Masato Hasegaw. Progression of phosphorylated α-synuclein in Macaca fuscata. Brain pathology (Zurich, Switzerland). vol 31. issue 5. 2021-10-13. PMID:33754430. |
prion-like spreading of abnormal proteins is proposed to occur in neurodegenerative diseases, and the progression of α-synuclein (α-syn) deposits has been reported in the brains of animal models injected with synthetic α-syn fibrils or pathological α-syn prepared from patients with parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2021-10-13 |
2023-08-13 |
human |
| John B Kwok, Clement T Loy, Carol Dobson-Stone, Glenda M Hallida. The complex relationship between genotype, pathology and phenotype in familial dementia. Neurobiology of disease. vol 145. 2021-10-12. PMID:32927063. |
causative genes involved in familial forms of dementias, including alzheimer's disease (ad), frontotemporal lobar degeneration (ftld) and dementia with lewy bodies (dlb), as well as amyotrophic lateral sclerosis and prion diseases where dementia is present as a significant clinical feature, are associated with distinct proteinopathies. |
2021-10-12 |
2023-08-13 |
Not clear |
| Nicolas Nicastro, Elijah Mak, Ajenthan Surendranathan, Timothy Rittman, James B Rowe, John T O'Brie. Altered structural connectivity networks in dementia with lewy bodies. Brain imaging and behavior. vol 15. issue 5. 2021-10-12. PMID:33511557. |
the impairment of large-scale brain networks has been observed in dementia with lewy bodies (dlb) using functional connectivity, but the potential for an analogous effect on structural covariance patterns has not been determined. |
2021-10-12 |
2023-08-13 |
human |
| Sezgi Canaslan, Matthias Schmitz, Anna Villar-Piqué, Fabian Maass, Karin Gmitterová, Daniela Varges, Paul Lingor, Franc Llorens, Peter Hermann, Inga Zer. Detection of Cerebrospinal Fluid Neurofilament Light Chain as a Marker for Alpha-Synucleinopathies. Frontiers in aging neuroscience. vol 13. 2021-10-12. PMID:34630068. |
alpha-synucleinopathies, such as parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa), are a class of neurodegenerative diseases. |
2021-10-12 |
2023-08-13 |
Not clear |
| Eoghan Donlon, Rionagh Lynch, Olwen C Murphy, Michael Farrell, Jaques Noel, Mary Keogan, Martin O'Connell, Timothy Lync. Braak's Unfinished Hypothesis: A Clinicopathological Case Report of α-Synuclein Peripheral Neuropathy Preceding Parkinsonism by 20 Years. Movement disorders clinical practice. vol 8. issue 7. 2021-10-12. PMID:34631951. |
α-synuclein aggregates in the form of lewy bodies and lewy neurites are the pathological hallmark of parkinson disease (pd) and dementia with lewy bodies (dlb). |
2021-10-12 |
2023-08-13 |
Not clear |
| Melissa J Armstrong, David J Irwin, James B Leverenz, Noheli Gamez, Angela Taylor, James E Galvi. Biomarker Use for Dementia With Lewy Body Diagnosis: Survey of US Experts. Alzheimer disease and associated disorders. vol 35. issue 1. 2021-10-06. PMID:33009039. |
dementia with lewy body (dlb) diagnostic criteria define "indicative" and "supportive" biomarkers, but clinical practice patterns are unknown. |
2021-10-06 |
2023-08-13 |
Not clear |
| Robert Espinosa, Matthew Davis, Scott Johnson, Stephanie Cline, Daniel Weintrau. A Model to Assess the Outcomes Associated With Dementia With Lewy Bodies. Alzheimer disease and associated disorders. vol 35. issue 1. 2021-10-06. PMID:33044304. |
research investigating outcomes associated with dementia with lewy bodies (dlb) disease progression is scarce. |
2021-10-06 |
2023-08-13 |
Not clear |
| Sofia Lövestam, Manuel Schweighauser, Tomoyasu Matsubara, Shigeo Murayama, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Mari Yoshida, Airi Tarutani, Masato Hasegawa, Michel Goedert, Sjors H W Schere. Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy. FEBS open bio. vol 11. issue 4. 2021-10-06. PMID:33548114. |
seeded assembly of α-synuclein into filaments is believed to underlie the prion-like spreading of protein inclusions in a number of human neurodegenerative diseases, including parkinson's disease, dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2021-10-06 |
2023-08-13 |
human |
| Sumeyya Akyol, Ali Yilmaz, Kyung Joon Oh, Zafer Ugur, Buket Aydas, Bernadette McGuinness, Peter Passmore, Patrick G Kehoe, Michael Maddens, Brian D Green, Stewart F Graha. Evidence that the Kennedy and polyamine pathways are dysregulated in human brain in cases of dementia with Lewy bodies. Brain research. vol 1743. 2021-10-04. PMID:32450077. |
disruptions of brain metabolism are considered integral to the pathogenesis of dementia, but thus far little is known of how dementia with lewy bodies (dlb) impacts the brain metabolome. |
2021-10-04 |
2023-08-13 |
human |
| Ana Gámez-Valero, Jaume Campdelacreu, Dolores Vilas, Lourdes Ispierto, Jordi Gascón-Bayarri, Ramón Reñé, Ramiro Álvarez, Maria P Armengol, Francesc E Borràs, Katrin Beye. Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer's Disease. Biomedicines. vol 9. issue 9. 2021-10-01. PMID:34572457. |
dementia with lewy bodies (dlb) is one of the most common causes of degenerative dementia, after alzheimer's disease (ad), and presents pathological and clinical overlap with both ad and parkinson's disease (pd). |
2021-10-01 |
2023-08-13 |
Not clear |
| Lars Frings, Bernhard Heimbach, Philipp T Meyer, Sabine Hellwi. Intrinsic Alertness Is Impaired in Patients with Nigrostriatal Degeneration: A Prospective Study with Reference to [123I]FP-CIT SPECT and [18F]FDG PET. Journal of Alzheimer's disease : JAD. vol 78. issue 4. 2021-09-29. PMID:33216022. |
variations in alertness and attention are common in lewy body diseases (lbd) and among the core features of dementia with lewy bodies (dlb). |
2021-09-29 |
2023-08-13 |
Not clear |
| Nicolas Nicastro, Negin Holland, George Savulich, Stephen F Carter, Elijah Mak, Young T Hong, Selena Milicevic Sephton, Tim D Fryer, Franklin I Aigbirhio, James B Rowe, John T O'Brie. European journal of hybrid imaging. vol 4. issue 1. 2021-09-24. PMID:33381679. |
dementia with lewy bodies (dlb) is a common cause of dementia, but atrophy is mild compared to alzheimer's disease. |
2021-09-24 |
2023-08-13 |
Not clear |
| Ahmad Salman, Itshak Lapidot, Elad Shufan, Adam H Agbaria, Bat-Sheva Porat Katz, Shaul Mordecha. Potential of infrared microscopy to differentiate between dementia with Lewy bodies and Alzheimer's diseases using peripheral blood samples and machine learning algorithms. Journal of biomedical optics. vol 25. issue 4. 2021-09-24. PMID:32329265. |
accurate and objective identification of alzheimer's disease (ad) and dementia with lewy bodies (dlb) is of major clinical importance due to the current lack of low-cost and noninvasive diagnostic tools to differentiate between the two. |
2021-09-24 |
2023-08-13 |
Not clear |
| Ahmad Salman, Itshak Lapidot, Elad Shufan, Adam H Agbaria, Bat-Sheva Porat Katz, Shaul Mordecha. Potential of infrared microscopy to differentiate between dementia with Lewy bodies and Alzheimer's diseases using peripheral blood samples and machine learning algorithms. Journal of biomedical optics. vol 25. issue 4. 2021-09-24. PMID:32329265. |
the problem is especially acute because these two dementias have some common symptoms and characteristics, which can lead to misdiagnosis of dlb as ad and vice versa, mainly at their early stages. |
2021-09-24 |
2023-08-13 |
Not clear |
| Ilaria Poggiolini, Daniel Erskine, Nishant N Vaikath, Janarthanan Ponraj, Said Mansour, Christopher M Morris, Omar M A El-Agna. RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies. Biomolecules. vol 11. issue 6. 2021-09-23. PMID:34072869. |
aggregated α-synuclein (αsyn) protein is a core pathological feature of parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2021-09-23 |
2023-08-13 |
Not clear |
| Stefania Pezzoli, Annachiara Cagnin, Cinzia Bussè, Giovanni Zorzi, Federica Fragiacomo, Oliver Bandmann, Annalena Venner. Cognitive correlates and baseline predictors of future development of visual hallucinations in dementia with Lewy bodies. Cortex; a journal devoted to the study of the nervous system and behavior. vol 142. 2021-09-21. PMID:34217015. |
visual hallucinations (vh) are common in dementia with lewy bodies (dlb), and are among the core symptoms for its clinical diagnosis. |
2021-09-21 |
2023-08-13 |
Not clear |
| Fabrizia D'Antonio, Joseph P M Kane, Agustin Ibañez, Simon J G Lewis, Richard Camicioli, Huali Wang, Yueyi Yu, Jing Zhang, Yong Ji, Miguel Germán Borda, Rukmini Mridula Kandadai, Claudio Babiloni, Laura Bonanni, Manabu Ikeda, Bradley F Boeve, James B Leverenz, Dag Aarslan. Dementia with Lewy bodies research consortia: A global perspective from the ISTAART Lewy Body Dementias Professional Interest Area working group. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-09-21. PMID:34541289. |
dementia with lewy bodies (dlb) research has seen a significant growth in international collaboration over the last three decades. |
2021-09-21 |
2023-08-13 |
Not clear |
| Elie Matar, Simon R White, John-Paul Taylor, Alan Thomas, Ian G McKeith, Joseph P M Kane, Ajenthan Surendranathan, Glenda M Halliday, Simon J G Lewis, John T O'Brie. Progression of Clinical Features in Lewy Body Dementia Can Be Detected Over 6 Months. Neurology. vol 97. issue 10. 2021-09-20. PMID:34404743. |
this study aimed to quantify the trajectory and magnitude of change of the key clinical features and corresponding symptom domains of dementia with lewy bodies (dlb) and parkinson disease dementia (pdd), including global cognition, parkinsonism, recurrent visual hallucinations, cognitive fluctuations, and sleep disturbance. |
2021-09-20 |
2023-08-13 |
Not clear |