| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manikandan Samidurai, Karthick Chennakesavan, Souvarish Sarkar, Emir Malovic, Hai M Nguyen, Latika Singh, Anil Kumar, Alyssa Ealy, Chelva Janarthanam, Bharathi Niveditha Palanisamy, Naveen Kondru, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Anumantha Kanthasamy, Hui Zhang, Heike Wulff, Arthi Kanthasam. KCa3.1 Contributes to Neuroinflammation and Nigral Dopaminergic Neurodegeneration in Experimental models of Parkinson's Disease. bioRxiv : the preprint server for biology. 2025-04-01. PMID:40166152. |
herein, we show that kca3.1, a calcium-activated potassium channel, is robustly upregulated within microglia in multiple preclinical models of pd and, most importantly, in human pd and dementia with lewy bodies (dlb) brains. |
2025-04-01 |
2025-04-03 |
mouse |
| Kazuhiro Takeda, Hiroshige Fujishiro, Youta Torii, Hirotaka Sekiguchi, Shusei Arafuka, Chikako Habuchi, Ayako Miwa, Norio Ozaki, Mari Yoshida, Shuji Iritani, Yasushi Iwasaki, Masashi Iked. Validation of the neuropathological criteria of the fourth Consortium on dementia with Lewy Bodies in autopsy cases from psychiatric hospitals. Psychiatry and clinical neurosciences. 2025-03-31. PMID:40162542. |
the pathological criteria from the fourth consortium on dementia with lewy bodies (dlb) in psychiatric cohorts has not been validated. |
2025-03-31 |
2025-04-03 |
Not clear |
| Jennifer Zitser, Sven Forner, Katherine Wong, Jin Chengshi, John Neuhaus, Jennifer Martindale, Ben J Raudabaugh, Kendra Benisano, Kelly Goodman-O'Leary, Stacy Metcalf, Mee-Ohk Kim, Marwa Hakimi, Isabelle E Allen, Bruce L Miller, Howard J Rosen, Katherine P Rankin, Michael D Geschwin. Neuropsychiatric symptoms in sporadic Creutzfeldt-Jakob disease. Brain : a journal of neurology. 2025-03-28. PMID:40152909. |
the objective of our study was to assess prospectively the neuropsychiatric features in scjd (and their impact on caregivers) and compare them with five other neurodegenerative diseases: alzheimer's disease (ad), dementia with lewy bodies (dlb), progressive supranuclear palsy (psp), behavioral variant frontotemporal dementia (bvftd) and semantic variant primary progressive aphasia (svppa). |
2025-03-28 |
2025-03-30 |
human |
| Yasuharu Ishihara, Mai Ando, Yasuaki Goto, Sadaharu Kotani, Naoto Watanabe, Yosuke Nakatani, Satoko Ishii, Norimasa Miyamoto, Yuji Mano, Yukio Ishikaw. A novel selective phosphodiesterase 9 inhibitor, irsenontrine (E2027), enhances GluA1 phosphorylation in neurons and improves learning and memory via cyclic GMP elevation. Neuropharmacology. 2025-03-27. PMID:40147639. |
several studies have found that the no/cgmp/pkg pathway is downregulated in patients with alzheimer's disease (ad) or dementia with lewy bodies (dlb) and in older individuals. |
2025-03-27 |
2025-03-30 |
rat |
| Laura M Farr, Naomi Thorpe, Ethel M Brinda, Naser Albalushi, Mohammad Sohail, Anto P Rajkuma. Systematic Review of Differentially Abundant Proteins in People with Lewy Body Dementia. Acta neuropsychiatrica. 2025-03-27. PMID:40143552. |
dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd) are collectively called as lewy body dementia (lbd). |
2025-03-27 |
2025-03-30 |
Not clear |
| Jack Anderson, Nicholas K H Chiu, Jonathon E Pye, Maria Comas-Soberats, Aaron Lam, Ronald R Grunstein, Simon J G Lewis, Elie Mata. Rest-Activity Disturbances Correlate with Core Features in Dementia with Lewy Bodies. Movement disorders clinical practice. 2025-03-25. PMID:40130686. |
sleep-wake disturbances are a clinically important and poorly studied feature of dementia with lewy bodies (dlb) due to the challenges of in-laboratory polysomnography in this population. |
2025-03-25 |
2025-03-27 |
Not clear |
| Solji G Choi, Tyler R Tittle, Raj R Barot, Dakota J Betts, Johnie J Gallagher, Jeffrey H Kordower, Yaping Chu, Bryan A Killinge. Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson's disease. Acta neuropathologica communications. vol 13. issue 1. 2025-03-24. PMID:40122840. |
synucleinopathies such as parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa) are neurodegenerative diseases with shared clinical and pathological features. |
2025-03-24 |
2025-03-26 |
Not clear |
| Marie Collin, Justine Bonnet-Chateau, Victor Gilles, Sophie Dautricourt, Thomas Gilbert, Zaza Makaroff, Marie-Hélène Coste, Virginie Dauphinot, Antoine Garnier-Crussar. Intrinsic capacity in patients with dementia with Lewy bodies compared with those with Alzheimer's disease: A cross-sectional study. The journal of nutrition, health & aging. vol 29. issue 6. 2025-03-23. PMID:40121962. |
intrinsic capacity (ic), the composite of all the physical and mental capacities of an individual, has never been studied in patients with dementia with lewy bodies (dlb). |
2025-03-23 |
2025-03-26 |
Not clear |
| Lina Gliaudelytė, Steven P Rushton, Rolando Berlinguer-Palmini, Alan J Thomas, Christopher M Morri. Dopaminergic changes in the subgenual cingulate cortex in dementia with lewy bodies associates with presence of depression. Translational psychiatry. vol 15. issue 1. 2025-03-21. PMID:40113786. |
in addition to the core clinical features of fluctuating cognition, visual hallucinations, and parkinsonism, individuals with dementia with lewy bodies (dlb) frequently experience chronic and debilitating major depression. |
2025-03-21 |
2025-03-23 |
Not clear |
| David J Koss, Olivia Todd, Hariharan Menon, Zoe Anderson, Tamsin Yang, Lucas Findlay, Ben Graham, Pawel Palmowski, Andrew Porter, Nicola Morrice, Lauren Walker, Johannes Attems, Simona S Ghanem, Omar El-Agnaf, Fiona En LeBeau, Daniel Erskine, Tiago F Outeir. A reciprocal relationship between markers of genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies. Molecular neurodegeneration. vol 20. issue 1. 2025-03-21. PMID:40114198. |
however, although nuclear asyn pathology has been observed in cortical tissue of dementia with lewy body (dlb) cases, whether such nuclear pathology coincides with the occurrence of dna damage has not previously been investigated. |
2025-03-21 |
2025-03-23 |
Not clear |
| Yueyi Yu, Jing Wang, Dan Li, Yuanyuan Lu, Lu Lu, Miao Q. Application of mini-mental state examination and Montreal Cognitive Assessment in the diagnosis of dementia with Lewy bodies and Alzheimer's disease. Applied neuropsychology. Adult. 2025-03-21. PMID:40116743. |
dementia with lewy bodies (dlb) and alzheimer's disease (ad) are two types of dementia with a relatively high incidence, and their clinical manifestations are easily confused. |
2025-03-21 |
2025-03-24 |
Not clear |
| Jingna Ye, Xuelian Dai, Canwen Zhang, Zhihui Duan, Guoqing Zhou, Juan Wan. Investigating the causal relationships between mitochondrial proteins and dementia with Lewy bodies. Journal of Alzheimer's disease : JAD. 2025-03-20. PMID:40111912. |
however, the specific role of mitochondrial proteins in the pathogenesis of dementia with lewy bodies (dlb) remains poorly understood.objectivethis study aims to investigate potential causal relationships between mitochondrial proteins and dlb risk using mendelian randomization (mr) analysis.methodscausal associations between 66 mitochondrial proteins (mps) and dlb were assessed by mr analysis, utilizing data from comprehensive genome-wide association studies (gwas), with various analytical methods, including the inverse variance weighted, mr-egger, and weighted median. |
2025-03-20 |
2025-03-23 |
Not clear |
| Hideki Kanemoto, Tetsuo Kashibayashi, Ryuichi Takahashi, Takashi Suehiro, Yuto Satake, Daiki Taomoto, Yoshihiro Chadani, Kenji Tagai, Shunichiro Shinagawa, Kazunari Ishii, Kenji Yoshiyama, Manabu Ikeda, Hiroaki Kazu. Neuroimaging of psychosis, agitation, and affective disturbance in Alzheimer's disease, dementia with Lewy bodies, and mild cognitive impairment. International psychogeriatrics. 2025-03-19. PMID:40107929. |
this study identifies neuropsychiatric syndromes and investigates their relationship with neuroimaging in alzheimer's disease dementia (ad), dementia with lewy bodies (dlb), and mild cognitive impairment (mci). |
2025-03-19 |
2025-03-22 |
Not clear |
| Yu-Liang Gao, Qiu-Han X. No causal link between smoking and dementia with Lewy bodies. Parkinsonism & related disorders. 2025-03-15. PMID:40089453. |
this letter addresses the findings of goodheart and gomperts (2024), which observed an association between smoking and reduced odds of dementia with lewy bodies (dlb). |
2025-03-15 |
2025-03-18 |
Not clear |
| Cecilia Tremblay, Neha Shakir, Nan Zhang, Charles H Adler, Holly A Shill, Shyamal Mehta, Erika Driver-Dunckley, Christine M Belden, Alireza Atri, Thomas G Beach, Geidy E Serrano, Parichita Choudhur. Associations between neuropsychiatric symptoms and pathology in clinicopathologically defined Alzheimer's disease, Alzheimer's disease with Lewy bodies, and dementia with Lewy bodies. Journal of Alzheimer's disease : JAD. 2025-03-14. PMID:40084663. |
backgroundneuropsychiatric symptoms (nps) are frequent in alzheimer's disease (ad) dementia, but a higher nps burden is found in dementia with lewy bodies (dlb). |
2025-03-14 |
2025-03-16 |
Not clear |
| Emmanuel Morain, Alexandra Fayel, Philippe De Linares, Julien Dumurgier, Emmanuel Cognat, Claire Paque. Domestic violence in Lewy body dementia: A national study. Journal of Alzheimer's disease : JAD. 2025-03-14. PMID:40084665. |
a descriptive study using a transversal national online survey to evaluate the prevalence and characteristics of behavioral and psychological symptoms (bpsd) of dementia with lewy bodies (dlb), and specifically, the perpetration of violent acts against primary caregivers. |
2025-03-14 |
2025-03-16 |
Not clear |
| Fabrizia D'Antonio, Giorgio Vivacqua, Marco Serrentino, Martyna Nalepa, Aleksandra Skweres, Martina Peconi, Maria Ilenia De Bartolo, Massimiliano Panigutti, Micaela Sepe Monti, Giuseppina Talarico, Giovanni Fabbrini, Giuseppe Brun. Salivary biomarkers for the molecular diagnosis of dementia with Lewy bodies. Journal of Alzheimer's disease : JAD. 2025-03-14. PMID:40084669. |
backgrounddespite dementia with lewy bodies (dlb) being the second most common form of neurodegenerative dementia, more than 80% of dlb cases are initially misdiagnosed. |
2025-03-14 |
2025-03-16 |
human |
| Mohammed Waseequr Rahman, Preeti Sharma, Trisha Chattopadhyay, Sivaprakasam R Saroj. Distinct neuronal vulnerability and metabolic dysfunctions are characteristic features of fast-progressing Alzheimer's patients with Lewy bodies. The Journal of biological chemistry. 2025-03-12. PMID:40074078. |
we report that ad with comorbidities, such as dementia with lewy bodies (dlb) and tdp-43 pathology, progress faster than ad alone. |
2025-03-12 |
2025-03-15 |
Not clear |
| Neha Singh-Reilly, Nha Trang Thu Pham, Jonathan Graff-Radford, Mary M Machulda, Anthony J Spychalla, Matthew L Senjem, Ronald C Petersen, Val J Lowe, Bradley F Boeve, Clifford R Jack, Keith A Josephs, Kejal Kantarci, Jennifer L Whitwel. White matter hyperintensities in dementia with lewy bodies and posterior cortical atrophy. Neurobiology of aging. vol 150. 2025-03-08. PMID:40056539. |
dementia with lewy bodies (dlb) and posterior cortical atrophy (pca) are neurodegenerative disorders that can overlap clinically and in patterns of regional hypometabolism and show elevated white matter hyperintensity (wmh) burden. |
2025-03-08 |
2025-03-11 |
Not clear |
| Neha Singh-Reilly, Nha Trang Thu Pham, Jonathan Graff-Radford, Mary M Machulda, Anthony J Spychalla, Matthew L Senjem, Ronald C Petersen, Val J Lowe, Bradley F Boeve, Clifford R Jack, Keith A Josephs, Kejal Kantarci, Jennifer L Whitwel. White matter hyperintensities in dementia with lewy bodies and posterior cortical atrophy. Neurobiology of aging. vol 150. 2025-03-08. PMID:40056539. |
on comparing both dementia groups, pca showed greater subcortical wmh burden in the temporal and occipital lobes compared to dlb, while dlb showed greater wmh burden in the posterior corpus callosum compared to pca. |
2025-03-08 |
2025-03-11 |
Not clear |