| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Zhou, Samuel Daniels, Vijay Singh, Marissa Menard, Martha L Escobar Galvis, Hong-Yuan Ch. α-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice. Neurobiology of disease. 2024-10-15. PMID:39406290. |
abnormal accumulation of insoluble α-synuclein (α-syn) inclusions in neurons, neurites, and glial cells is the defining neuropathology of synucleinopathies, including parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy. |
2024-10-15 |
2024-10-18 |
mouse |
| Kathryn A Wyman-Chick, Tanis J Ferman, Daniel Weintraub, Melissa J Armstrong, Bradley F Boeve, Ece Bayram, Ella Chrenka, Matthew J Barret. Distinguishing Prodromal Dementia With Lewy Bodies From Prodromal Alzheimer Disease: A Longitudinal Study. Neurology. Clinical practice. vol 15. issue 1. 2024-10-14. PMID:39399551. |
it can be clinically challenging to differentiate dementia with lewy bodies (dlb) and alzheimer disease (ad). |
2024-10-14 |
2024-10-16 |
Not clear |
| Junyun Wu, Jia Nan Wu, Tao Chen, Jing Cai, Reng Re. Protein Aggregation and its Affecting Mechanisms in Neurodegenerative Diseases. Neurochemistry international. 2024-10-13. PMID:39396709. |
protein aggregation serves as a critical pathological marker in a spectrum of neurodegenerative diseases (nds), including the formation of amyloid β (aβ) and tau neurofibrillary tangles in alzheimer's disease, as well as α-synuclein (α-syn) aggregates in parkinson's disease, parkinson's disease-related dementia (pdd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2024-10-13 |
2024-10-16 |
Not clear |
| Xi Li, Linwei Yu, Xikai Liu, Tianyi Shi, Yu Zhang, Yushuo Xiao, Chen Wang, Liangliang Song, Ning Li, Xinran Liu, Yuchen Chen, Robert B Petersen, Xiang Cheng, Weikang Xue, Yanxun V Yu, Li Xu, Ling Zheng, Hong Chen, Kun Huan. β-synuclein regulates the phase transitions and amyloid conversion of α-synuclein. Nature communications. vol 15. issue 1. 2024-10-10. PMID:39384788. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are neurodegenerative disorders characterized by the accumulation of α-synuclein aggregates. |
2024-10-10 |
2024-10-12 |
caenorhabditis_elegans |
| Vincent Couture, Jean-François Carmel, Katerine Rousseau, Geneviève Létourneau, Doris Clerc, Philippe Huot, Marie-France Forget, Quoc Dinh Nguyen, Richard Camicioli, Philippe Desmarai. Sex Differences in Neuropsychiatric Symptoms in Alpha-Synucleinopathies: A Systematic Review and Meta-Analysis. Movement disorders clinical practice. 2024-10-10. PMID:39385552. |
alpha-synucleinopathies, such as parkinson's disease (pd), parkinson's disease dementia (pdd), and dementia with lewy bodies (dlb), demonstrate sex differences with regard to prevalence, age of onset, and motor manifestations. |
2024-10-10 |
2024-10-12 |
Not clear |
| Deepmala Nandanwar, Daniel D Truon. Multiple system atrophy: Diagnostic challenges and a proposed diagnostic algorithm. Clinical parkinsonism & related disorders. vol 11. 2024-10-09. PMID:39381077. |
it shares a common pathological origin with parkinson's disease (pd) and lewy body dementia (dlb) and they are collectively grouped as "synucleinopathies." |
2024-10-09 |
2024-10-11 |
Not clear |
| Liam Horan-Portelance, Michiyo Iba, Dominic J Acri, J Raphael Gibbs, Eliezer Masliah, Mark R Cookso. Single-cell spatial transcriptomics reveals molecular patterns of selective neuronal vulnerability to α-synuclein pathology in a transgenic mouse model of Lewy body disease. bioRxiv : the preprint server for biology. 2024-10-07. PMID:39372781. |
one of the unifying pathological hallmarks of parkinson's disease (pd) and dementia with lewy bodies (dlb) is the presence of misfolded, aggregated, and often phosphorylated forms of the protein α-synuclein in neurons. |
2024-10-07 |
2024-10-09 |
mouse |
| Alice Chen-Plotkin, George Kannarkat, Rebecca Zack, R Tyler Skrinak, James Morley, Roseanne Davila-Rivera, Sanaz Arezoumandan, Kelvin Luk, David Wolk, Daniel Weintraub, Thomas Tropea, Edward Lee, Sharon Xie, Ganesh Chandrasekaran, Virginia Lee, David Irwin, Rizwan Akhtar, Katherine Dorfma. Alpha-Synuclein Conformations in Plasma Distinguish Parkinson's Disease from Dementia with Lewy Bodies. Research square. 2024-10-07. PMID:39372921. |
aggregation of misfolded alpha-synuclein (asyn) within the brain is the pathologic hallmark of lewy body diseases (lbd), including parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2024-10-07 |
2024-10-09 |
human |
| Ryuji Yajima, Yasuharu Saito, Takeshi Sato, Akiko Suzuki, Satoshi Narus. Cognitive Impairment Caused by Isolated Adrenocorticotropic Hormone Deficiency Mimicking Dementia with Lewy Bodies. Internal medicine (Tokyo, Japan). 2024-10-06. PMID:39370251. |
a 73-year-old man who presented with nonspecific general symptoms and cognitive impairment was initially diagnosed with mild cognitive impairment due to dementia with lewy bodies (dlb) based on a reduced blood flow in the parietal and occipital lobes on single-photon emission computed tomography (spect) imaging. |
2024-10-06 |
2024-10-09 |
Not clear |
| Fuyuki Kametani, Marina Tahira, Masaki Takao, Tomoyasu Matsubara, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Masato Hasegaw. Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies. Scientific reports. vol 14. issue 1. 2024-10-02. PMID:39358446. |
our previous cryogenic electron microscopy (cryoem) analysis showed that the core structures of α-synuclein filaments accumulated in brains of patients diagnosed with dementia with lewy bodies (dlb) and multiple system atrophy (msa) patients are different. |
2024-10-02 |
2024-10-05 |
Not clear |
| S G Choi, T Tittle, R Barot, D Betts, J Gallagher, J H Kordower, Y Chu, B A Killinge. Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson's disease reveals unique and shared pathological features. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345456. |
primary synucleinopathies, such as parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa), are neurodegenerative disorders with some shared clinical and pathological features. |
2024-09-30 |
2024-10-02 |
Not clear |
| Shannon D Donofry, Claire E O'Hanlo. Measuring Cognition in Clinical Trials in Parkinson's Disease, Dementia with Lewy Bodies, and Related Disorders: Roundtable Proceedings and Roadmap for Research. Rand health quarterly. vol 11. issue 4. 2024-09-30. PMID:39346105. |
emerging research suggests that parkinson's disease (pd) and dementia with lewy bodies (dlb) share underlying pathology and may represent a single, biologically defined disease spectrum. |
2024-09-30 |
2024-10-02 |
Not clear |
| Lucy L Gibson, Christoph Mueller, Robert Stewart, Dag Aarslan. Characteristics associated with progression to probable dementia with Lewy bodies in a cohort with very late-onset psychosis. Psychological medicine. 2024-09-26. PMID:39324394. |
very late-onset psychosis (vlop) is associated with higher rates of dementia but the proportion who develop dementia with lewy bodies (dlb) is unknown. |
2024-09-26 |
2024-09-28 |
Not clear |
| Lucy L Gibson, Christoph Mueller, Robert Stewart, Dag Aarslan. Characteristics associated with progression to probable dementia with Lewy bodies in a cohort with very late-onset psychosis. Psychological medicine. 2024-09-26. PMID:39324394. |
we aimed to identify individuals with vlop who develop dementia and dlb and characterize the risk factors for progression. |
2024-09-26 |
2024-09-28 |
Not clear |
| Kazuki Miyaue, Hiroki Ison. A Case Report of Probable Dementia With Lewy Bodies Diagnosed Through Repeated Episodes of Depressed Consciousness. Cureus. vol 16. issue 8. 2024-09-24. PMID:39310588. |
this case report details the diagnostic challenges of an 84-year-old male with unrecognized dementia with lewy bodies (dlb) who presented to the emergency department (ed) with episodes of unresponsiveness and depressed consciousness. |
2024-09-24 |
2024-09-26 |
Not clear |
| Kazuki Miyaue, Hiroki Ison. A Case Report of Probable Dementia With Lewy Bodies Diagnosed Through Repeated Episodes of Depressed Consciousness. Cureus. vol 16. issue 8. 2024-09-24. PMID:39310588. |
this case underscores the importance of considering dlb in patients with unexplained recurrent depressed consciousness and highlights the importance of clarifying the etiologies of dementia. |
2024-09-24 |
2024-09-26 |
Not clear |
| Shunji Toya, Mamoru Hashimoto, Yuta Manabe, Hajime Yamakage, Manabu Iked. Factors Associated with Increased Burden of Caregivers of People with Dementia with Lewy Bodies. Geriatrics (Basel, Switzerland). vol 9. issue 5. 2024-09-23. PMID:39311240. |
the burden of caregivers of people with dementia with lewy bodies (dlb) is high; however, factors related to their caregiving burden are not fully clarified. |
2024-09-23 |
2024-09-26 |
Not clear |
| Miho Ota, Hiroyuki Maki, Yuji Takahashi, Yoko Shigemoto, Yukio Kimura, Hiroshi Matsuda, Noriko Sat. Relationships between neuroimaging biomarkers and glymphatic-system activity in dementia with Lewy bodies. Neuroscience letters. vol 842. 2024-09-23. PMID:39307177. |
alpha-synuclein deposits in the brain have been suspected to cause parkinson's disease and dementia with lewy bodies (dlb). |
2024-09-23 |
2024-09-26 |
human |
| Estelle Schueller, Iris Grgurina, Brigitte Cosquer, Elodie Panzer, Noémie Penaud, Anne Pereira, Aline Stéphan, Karine Merienne, Jean-Christophe Cassel, Chantal Mathis, Frédéric Blanc, Olivier Bousiges, Anne-Laurence Boutillie. A novel mouse model reproducing frontal alterations related to the prodromal stage of dementia with LEWY bodies. Neurobiology of disease. 2024-09-22. PMID:39307398. |
dementia with lewy bodies (dlb) is the second most common age-related neurocognitive pathology after alzheimer's disease. |
2024-09-22 |
2024-09-26 |
mouse |
| Carmelo Luca Smeralda, Siddhartha Pandit, Sonia Turrini, Julianne Reilly, Annalisa Palmisano, Giulia Sprugnoli, Harald Hampel, Alberto Benussi, Barbara Borroni, Daniel Press, Alexander Rotenberg, Georges El Fakhri, Giacomo Koch, Simone Rossi, Emiliano Santarnecch. The role of parvalbumin interneuron dysfunction across neurodegenerative dementias. Ageing research reviews. 2024-09-21. PMID:39306248. |
recent evidence indicates that pv+ cells are also impaired in frontotemporal dementia (ftd) and dementia with lewy bodies (dlb). |
2024-09-21 |
2024-09-24 |
Not clear |