| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel Erskine, David Koss, Viktor I Korolchuk, Tiago F Outeiro, Johannes Attems, Ian McKeit. Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders. Acta neuropathologica. vol 141. issue 4. 2021-11-15. PMID:33515275. |
accumulation of the protein α-synuclein into insoluble intracellular deposits termed lewy bodies (lbs) is the characteristic neuropathological feature of lb diseases, such as parkinson's disease (pd), parkinson's disease dementia (pdd) and dementia with lb (dlb). |
2021-11-15 |
2023-08-13 |
Not clear |
| Arpine Sokratian, Julia Ziaee, Kaela Kelly, Allison Chang, Nicole Bryant, Shijie Wang, Enquan Xu, Joshua Y Li, Shih-Hsiu Wang, John Ervin, Sandip M Swain, Rodger A Liddle, Andrew B Wes. Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia. Acta neuropathologica. vol 141. issue 4. 2021-11-15. PMID:33641009. |
α-synuclein fibril activity in cortical brain extracts from dementia with lewy bodies (dlb) correlates with activity in matched ventricular csf. |
2021-11-15 |
2023-08-13 |
mouse |
| Giovanni Palermo, Elisabetta Belli, Luca Tommasini, Riccardo Morganti, Daniela Frosini, Valentina Nicoletti, Gloria Tognoni, Gabriele Siciliano, Ubaldo Bonuccelli, Filippo Baldacci, Roberto Ceravol. Dissecting the Interplay Between Time of Dementia and Cognitive Profiles in Lewy Body Dementias. Journal of Alzheimer's disease : JAD. vol 84. issue 2. 2021-11-15. PMID:34602466. |
dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd) are differentiated by the time of onset of cognitive and motor symptoms ('1-year rule'). |
2021-11-15 |
2023-08-13 |
human |
| Giovanni Palermo, Elisabetta Belli, Luca Tommasini, Riccardo Morganti, Daniela Frosini, Valentina Nicoletti, Gloria Tognoni, Gabriele Siciliano, Ubaldo Bonuccelli, Filippo Baldacci, Roberto Ceravol. Dissecting the Interplay Between Time of Dementia and Cognitive Profiles in Lewy Body Dementias. Journal of Alzheimer's disease : JAD. vol 84. issue 2. 2021-11-15. PMID:34602466. |
we explored the neuropsychological continuum of dlb and pdd subjects with different timing of dementia onset. |
2021-11-15 |
2023-08-13 |
human |
| Xiaobing Huang, Changliang Wang, Liang Chen, Tianjiao Zhang, Ka Lai Leung, Garry Won. Human amyloid beta and α-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 10. 2021-11-12. PMID:34146705. |
previous clinical studies uncovered aβ and α-syn co-expression in the brains of patients, which lead to lewy body dementia (lbd), a disease encompassing dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd). |
2021-11-12 |
2023-08-13 |
human |
| Changyoun Kim, Somin Kwon, Michiyo Iba, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Soo Jean Shin, Jerel A Fields, Robert A Rissman, Seung-Jae Lee, Eliezer Maslia. Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells. Experimental & molecular medicine. vol 53. issue 2. 2021-11-11. PMID:33594256. |
synucleinopathies are age-related neurological disorders characterized by the progressive deposition of α-synuclein (α-syn) aggregates and include parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2021-11-11 |
2023-08-13 |
mouse |
| Francesca Caso, Federica Agosta, Pietro G Scamarcia, Silvia Basaia, Elisa Canu, Giuseppe Magnani, Maria Antonietta Volontè, Massimo Filipp. A multiparametric MRI study of structural brain damage in dementia with lewy bodies: A comparison with Alzheimer's disease. Parkinsonism & related disorders. vol 91. 2021-11-11. PMID:34628194. |
differential diagnosis between dementia with lewy bodies (dlb) and alzheimer's disease (ad) is crucial for an adequate patients' management but might be challenging. |
2021-11-11 |
2023-08-13 |
Not clear |
| Samantha L Strickland, Hélène Morel, Christian Prusinski, Mariet Allen, Tulsi A Patel, Minerva M Carrasquillo, Olivia J Conway, Sarah J Lincoln, Joseph S Reddy, Thuy Nguyen, Kimberly G Malphrus, Alexandra I Soto, Ronald L Walton, Julia E Crook, Melissa E Murray, Bradley F Boeve, Ronald C Petersen, John A Lucas, Tanis J Ferman, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Neill R Graff-Radford, Dennis W Dickson, Nilüfer Ertekin-Tane. Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy. Acta neuropathologica communications. vol 8. issue 1. 2021-11-10. PMID:33092647. |
lbd-np patients were further categorized as high, intermediate and low likelihood of clinical dementia with lewy bodies (dlb-cl) based on dlb consortium criteria. |
2021-11-10 |
2023-08-13 |
Not clear |
| Connor Bargar, Wen Wang, Steven A Gunzler, Alexandra LeFevre, Zerui Wang, Alan J Lerner, Neena Singh, Curtis Tatsuoka, Brian Appleby, Xiongwei Zhu, Rong Xu, Vahram Haroutunian, Wen-Quan Zou, Jiyan Ma, Shu G Che. Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 9. issue 1. 2021-11-10. PMID:33827706. |
definitive diagnosis of parkinson's disease (pd) and dementia with lewy bodies (dlb) relies on postmortem finding of disease-associated alpha-synuclein (αsyn |
2021-11-10 |
2023-08-13 |
Not clear |
| James E Galvin, Stephanie Chrisphonte, Iris Cohen, Keri K Greenfield, Michael J Kleiman, Claudia Moore, Mary Lou Riccio, Amie Rosenfeld, Niurka Shkolnik, Marcia Walker, Lun-Ching Chang, Magdalena I Tole. Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD-MOD). Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 10. 2021-11-09. PMID:33793069. |
characterization of dementia with lewy bodies (dlb) and mild cognitive impairment using the lewy body dementia module (lbd-mod). |
2021-11-09 |
2023-08-13 |
Not clear |
| James E Galvin, Stephanie Chrisphonte, Iris Cohen, Keri K Greenfield, Michael J Kleiman, Claudia Moore, Mary Lou Riccio, Amie Rosenfeld, Niurka Shkolnik, Marcia Walker, Lun-Ching Chang, Magdalena I Tole. Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD-MOD). Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 10. 2021-11-09. PMID:33793069. |
the national institute on aging alzheimer's disease research center program added the lewy body dementia module (lbd-mod) to the uniform data set to facilitate lbd characterization and distinguish dementia with lewy bodies (dlb) from alzheimer's disease (ad). |
2021-11-09 |
2023-08-13 |
Not clear |
| D Hansen, H Ling, T Lashley, J A Foley, C Strand, T M Eid, J L Holton, T T Warne. Novel clinicopathological characteristics differentiate dementia with Lewy bodies from Parkinson's disease dementia. Neuropathology and applied neurobiology. vol 47. issue 1. 2021-11-08. PMID:32720329. |
dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd) known as lewy body dementias have overlapping clinical and neuropathological features. |
2021-11-08 |
2023-08-13 |
Not clear |
| Maryna Psol, Sofia Guerin Darvas, Kristian Leite, Sameehan U Mahajani, Mathias Bähr, Sebastian Kügle. Dementia with Lewy bodies-associated ß-synuclein mutations V70M and P123H cause mutation-specific neuropathological lesions. Human molecular genetics. vol 30. issue 3-4. 2021-11-08. PMID:33760043. |
here, we demonstrate that ß-syn mutants v70m, detected in a sporadic case of dementia with lewy bodies (dlb), and p123h, detected in a familial case of dlb, robustly aggravate the neurotoxic potential of ß-syn. |
2021-11-08 |
2023-08-13 |
Not clear |
| Surabhi Mehra, Laxmikant Gadhe, Riya Bera, Ajay Singh Sawner, Samir K Maj. Structural and Functional Insights into α-Synuclein Fibril Polymorphism. Biomolecules. vol 11. issue 10. 2021-11-08. PMID:34680054. |
abnormal accumulation of aggregated α-synuclein (α-syn) is seen in a variety of neurodegenerative diseases, including parkinson's disease (pd), multiple system atrophy (msa), dementia with lewy body (dlb), parkinson's disease dementia (pdd), and even subsets of alzheimer's disease (ad) showing lewy-body-like pathology. |
2021-11-08 |
2023-08-13 |
Not clear |
| Kathrin Brockmann, Corinne Quadalti, Stefanie Lerche, Marcello Rossi, Isabel Wurster, Simone Baiardi, Benjamin Roeben, Angela Mammana, Milan Zimmermann, Ann-Kathrin Hauser, Christian Deuschle, Claudia Schulte, Katharina Waniek, Ingolf Lachmann, Simon Sjödin, Ann Brinkmalm, Kaj Blennow, Henrik Zetterberg, Thomas Gasser, Piero Parch. Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34717775. |
real-time quaking-induced conversion (rt-quic) analysis of csf has recently shown high sensitivity and specificity for the detection of misfolded α-syn in patients with parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2021-11-05 |
2023-08-13 |
Not clear |
| Adriana P Hermida, Evelina Sterina, P Parker Schwab, Cody Michael Browning, Hannah M Chapman, Ana P Marques Pinheiro, Neil Mor. Ultrabrief Right Unilateral Electroconvulsive Therapy for the Treatment of the Neuropsychiatric Symptoms of Dementia with Lewy Bodies. The journal of ECT. 2021-11-05. PMID:34739421. |
dementia with lewy bodies (dlb) is a debilitating disorder associated with a number of distressing neuropsychiatric symptoms. |
2021-11-05 |
2023-08-13 |
Not clear |
| Babak Tousi, James B Leveren. The Application of Zonisamide to Patients Suffering from Dementia with Lewy Bodies: Emerging Clinical Data. Drug design, development and therapy. vol 15. 2021-11-04. PMID:33976533. |
given that dementia with lewy bodies (dlb) and pd are considered subtypes of a lewy body disease spectrum, zonisamide was investigated for the treatment of parkinsonism in dlb. |
2021-11-04 |
2023-08-13 |
human |
| Rodrigo San-Martin, Francisco J Fraga, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Flavio Nobili, Dario Arnaldi, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, John Paul Taylor, Ian McKeith, Fabrizio Stocchi, Raffaele Ferri, Marco Onofrj, Susanna Lopez, Laura Bonanni, Claudio Babilon. Classification of Patients with Alzheimer's Disease and Dementia with Lewy Bodies using Resting EEG Selected Features at Sensor and Source Levels: A proof-of-concept study. Current Alzheimer research. 2021-11-03. PMID:34711165. |
early differentiation between alzheimer's disease (ad) and dementia with lewy bodies (dlb) is important for accurate prognosis, as dlb patients typically show faster disease progression. |
2021-11-03 |
2023-08-13 |
human |
| Kurt Segers, Florence Benoit, Jean-Marie Meyts, Gérald Glibert, Sophie Levy, Murielle Surqui. Dementia with Lewy bodies in first-generation immigrants in a European memory clinic. Acta neurologica Belgica. vol 121. issue 1. 2021-11-02. PMID:32931000. |
we wanted to explore possible differences in disease presentation, frequency, and age of onset of dementia with lewy bodies (dlb) between first-generation immigrants (fgi) and patients born in belgium (pbib). |
2021-11-02 |
2023-08-13 |
Not clear |
| Mariana Moscovich, Sebastian Heinzel, Ronald B Postuma, Ralf Reilmann, Thomas Klockgether, Heike Jacobi, Günter Höglinger, Daniela Ber. How specific are non-motor symptoms in the prodrome of Parkinson's disease compared to other movement disorders? Parkinsonism & related disorders. vol 81. 2021-11-01. PMID:33039276. |
we here aim to give a first insight into the published evidence of prodromal non-motor symptoms in pd, dementia with lewy bodies (dlb), multiple system atrophy (msa), huntington's disease (hd), progressive supranuclear palsy (psp) and spinocerebellar ataxia (sca). |
2021-11-01 |
2023-08-13 |
Not clear |