| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Bunce, Allison A M Bielak, Kaarin J Anstey, Nicolas Cherbuin, Philip J Batterham, Simon Eastea. APOE genotype and cognitive change in young, middle-aged, and older adults living in the community. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 69. issue 4. 2014-05-06. PMID:23902936. |
the findings suggest that in the absence of clinically salient dementia pathology, apoe ε2 and ε4 alleles do not exhibit antagonistic pleiotropy in relation to cognition between the ages of 20 and 72 years. |
2014-05-06 |
2023-08-12 |
Not clear |
| Marcus Praetorius, Valgeir Thorvaldsson, Linda B Hassing, Boo Johansso. Substantial effects of apolipoprotein E ε4 on memory decline in very old age: longitudinal findings from a population-based sample. Neurobiology of aging. vol 34. issue 12. 2014-04-02. PMID:23855979. |
we examined associations between the apolipoprotein e (apoe) ε4 allele and levels of performance and rates of change in cognition in late life taking incident dementia into account. |
2014-04-02 |
2023-08-12 |
Not clear |
| Marcus Praetorius, Valgeir Thorvaldsson, Linda B Hassing, Boo Johansso. Substantial effects of apolipoprotein E ε4 on memory decline in very old age: longitudinal findings from a population-based sample. Neurobiology of aging. vol 34. issue 12. 2014-04-02. PMID:23855979. |
the effects of the apoe ε4 allele were, however, reduced to a nonsignificant level in all tests except 1 after accounting for incident dementia. |
2014-04-02 |
2023-08-12 |
Not clear |
| Marcus Praetorius, Valgeir Thorvaldsson, Linda B Hassing, Boo Johansso. Substantial effects of apolipoprotein E ε4 on memory decline in very old age: longitudinal findings from a population-based sample. Neurobiology of aging. vol 34. issue 12. 2014-04-02. PMID:23855979. |
the findings support the notion that the apoe ε4 allele is associated with substantial memory decline in very old age, but as expected, the effect is largely related to incident dementia. |
2014-04-02 |
2023-08-12 |
Not clear |
| Iwona Bojar, Mariusz Gujski, Dorota Raczkiewicz, Kasia Gustaw Rothenber. Cognitive functions, apolipoprotein E genotype and hormonal replacement therapy of postmenopausal women. Neuro endocrinology letters. vol 34. issue 7. 2014-04-01. PMID:24464001. |
the results of many studies revealed that estrogen plus progestogen therapy (ept) may modify dementia development risk in relation to the apolipoprotein e gene (apoe) polymorphisms. |
2014-04-01 |
2023-08-12 |
Not clear |
| Xiangfei Meng, Carl D'Arc. Apolipoprotein E gene, environmental risk factors, and their interactions in dementia among seniors. International journal of geriatric psychiatry. vol 28. issue 10. 2014-03-20. PMID:23255503. |
little research has been conducted to explore the joint effect of apolipoprotein e (apoe) genotypes and environmental risk factors on dementia. |
2014-03-20 |
2023-08-12 |
Not clear |
| Xiangfei Meng, Carl D'Arc. Apolipoprotein E gene, environmental risk factors, and their interactions in dementia among seniors. International journal of geriatric psychiatry. vol 28. issue 10. 2014-03-20. PMID:23255503. |
in this study, we examined the roles of apoe alleles and genotypes in dementia and cognitively impaired not demented (cind), assessed the risk of co-existing or prior health conditions (i.e. |
2014-03-20 |
2023-08-12 |
Not clear |
| Sherry A Beaudreau, J Kaci Fairchild, Adam P Spira, Laura C Lazzeroni, Ruth O'Har. Neuropsychiatric symptoms, apolipoprotein E gene, and risk of progression to cognitive impairment, no dementia and dementia: the Aging, Demographics, and Memory Study (ADAMS). International journal of geriatric psychiatry. vol 28. issue 7. 2014-01-08. PMID:22927174. |
to examine the relationship of neuropsychiatric symptoms and apolipoprotein e (apoe) ε4 allele status to dementia at baseline and progression to dementia in older adults with and without cognitive impairment, no dementia (cind). |
2014-01-08 |
2023-08-12 |
Not clear |
| Vivian P Lara, Paulo Caramelli, Antônio L Teixeira, Maira T Barbosa, Karoline C Carmona, Maria G Carvalho, Ana P Fernandes, Karina B Gome. High cortisol levels are associated with cognitive impairment no-dementia (CIND) and dementia. Clinica chimica acta; international journal of clinical chemistry. vol 423. 2014-01-07. PMID:23611893. |
this study aimed to compare serum cortisol concentrations in cognitively healthy elderly and in subjects with cognitive impairment no dementia (cind) and dementia, besides to evaluate these concentrations according to apolipoprotein e genotype (apoe). |
2014-01-07 |
2023-08-12 |
human |
| Niels D Prins, Wiesje M van der Flier, H Robert Brashear, Dirk L Knol, Laura A van de Pol, Frederik Barkhof, Philip Schelten. Predictors of progression from mild cognitive impairment to dementia in the placebo-arm of a clinical trial population. Journal of Alzheimer's disease : JAD. vol 36. issue 1. 2013-12-09. PMID:23563246. |
we studied the predictive value of cognitive performance, vascular risk factors, apolipoprotein e (apoe) genotype, and structural brain changes on mri, on progression to dementia in post hoc analyses of 426 placebo patients (mean age 71 years; 55% women) with mild cognitive impairment (mci) who participated in a previously published large multi-center clinical trial (gal-int-11). |
2013-12-09 |
2023-08-12 |
Not clear |
| Niels D Prins, Wiesje M van der Flier, H Robert Brashear, Dirk L Knol, Laura A van de Pol, Frederik Barkhof, Philip Schelten. Predictors of progression from mild cognitive impairment to dementia in the placebo-arm of a clinical trial population. Journal of Alzheimer's disease : JAD. vol 36. issue 1. 2013-12-09. PMID:23563246. |
results of cox proportional-hazards regression analysis showed that higher age, worse cognitive test performance, presence of an apoe ε4 allele, and higher mta scores on mri increased the risk of progression to dementia in univariate analyses. |
2013-12-09 |
2023-08-12 |
Not clear |
| Ma Fei, Wang Jianhu. Apolipoprotein ε4-allele as a significant risk factor for conversion from mild cognitive impairment to Alzheimer's disease: a meta-analysis of prospective studies. Journal of molecular neuroscience : MN. vol 50. issue 2. 2013-12-05. PMID:23242623. |
to estimate the risk posed by apoe ε4-allele for developing ad in mci subjects using meta-analysis and identify possible sources of heterogeneity between studies, we reviewed longitudinal epidemiological studies of the presence of apoe ε4-allele on risk for progression to dementia in mci subjects, and conducted meta-analyses of the results from these studies. |
2013-12-05 |
2023-08-12 |
human |
| Ma Fei, Wang Jianhu. Apolipoprotein ε4-allele as a significant risk factor for conversion from mild cognitive impairment to Alzheimer's disease: a meta-analysis of prospective studies. Journal of molecular neuroscience : MN. vol 50. issue 2. 2013-12-05. PMID:23242623. |
apoe ε4-allele conferred increased risk for progression to dementia in mci subjects. |
2013-12-05 |
2023-08-12 |
human |
| F Coria, I Rubio, C Bayón, N Cuadrado, N Santaengracia, F Rodriguez-Artalej. Apolipoprotein E allelic variants predict dementia in elderly patients with memory impairment. European journal of neurology. vol 2. issue 3. 2013-12-03. PMID:24283637. |
we now report that: (1) this allelic variant is more frequent among patients with age-associated memory impairment (aami) than among healthy control subjects; (2) after a 3 year follow-up, those aami patients who developed dementia had apoeɛ4 more frequently than those who did not; (3) apoe allele distribution did not differ significantly between demented aami and late-onset ad patients. |
2013-12-03 |
2023-08-12 |
human |
| Ana Espinosa, Montserrat Alegret, Sergi Valero, Georgina Vinyes-Junqué, Isabel Hernández, Ana Mauleón, Maitée Rosende-Roca, Agustín Ruiz, Oscar López, Lluís Tárraga, Mercè Boad. A longitudinal follow-up of 550 mild cognitive impairment patients: evidence for large conversion to dementia rates and detection of major risk factors involved. Journal of Alzheimer's disease : JAD. vol 34. issue 3. 2013-12-02. PMID:23271318. |
the aim of this study was to determine which neuropsychological test performances, including episodic memory profiles, and genetic risk factors (apoe ε4) better predict early conversion to dementia among the four mci subtypes. |
2013-12-02 |
2023-08-12 |
Not clear |
| Simon Evans, Marcus A Gray, Nicholas G Dowell, Naji Tabet, Paul S Tofts, Sarah L King, Jennifer M Ruste. APOE E4 Carriers show prospective memory enhancement under nicotine, and evidence for specialisation within medial BA10. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 4. 2013-10-29. PMID:23232444. |
there is evidence to suggest that the apoe ɛ4 allele (which confers an increased risk of developing dementia) might be associated with cognitive advantages earlier in life. |
2013-10-29 |
2023-08-12 |
human |
| Erika J Laukka, Martin Lövdén, Agneta Herlitz, Sari Karlsson, Beata Ferencz, Alexandra Pantzar, Lina Keller, Caroline Graff, Laura Fratiglioni, Lars Bäckma. Genetic effects on old-age cognitive functioning: a population-based study. Psychology and aging. vol 28. issue 1. 2013-10-18. PMID:23276211. |
similarly, excluding future dementia cases attenuated the effects of apoe on episodic memory and global cognition, suggesting that part of the effects of apoe on old-age cognitive performance may be driven by dementia-related processes. |
2013-10-18 |
2023-08-12 |
Not clear |
| Angelique P A Vermeiren, Hans Bosma, Pieter-Jelle Visser, Maurice P Zeegers, Caroline Graff, Michael Ewers, Giovanni B Frisoni, Lutz Frölich, Harald Hampel, Roy W Jones, Patrick G Kehoe, Hermine Lenoir, Lennart Minthon, Flavio M Nobili, Marcel Olde Rikkert, Anne-Sophie Rigaud, Philip Scheltens, Hilkka Soininen, Luiza Spiru, Magda Tsolaki, Lars-Olof Wahlund, Bruno Vellas, Gordon Wilcock, Lyzel S Elias-Sonnenschein, Frans R J Verhe. The association between APOE ε4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA Study. Journal of Alzheimer's disease : JAD. vol 35. issue 2. 2013-10-17. PMID:23380990. |
the association between apoe ε4 and alzheimer-type dementia among memory clinic patients is confined to those with a higher education. |
2013-10-17 |
2023-08-12 |
human |
| Angelique P A Vermeiren, Hans Bosma, Pieter-Jelle Visser, Maurice P Zeegers, Caroline Graff, Michael Ewers, Giovanni B Frisoni, Lutz Frölich, Harald Hampel, Roy W Jones, Patrick G Kehoe, Hermine Lenoir, Lennart Minthon, Flavio M Nobili, Marcel Olde Rikkert, Anne-Sophie Rigaud, Philip Scheltens, Hilkka Soininen, Luiza Spiru, Magda Tsolaki, Lars-Olof Wahlund, Bruno Vellas, Gordon Wilcock, Lyzel S Elias-Sonnenschein, Frans R J Verhe. The association between APOE ε4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA Study. Journal of Alzheimer's disease : JAD. vol 35. issue 2. 2013-10-17. PMID:23380990. |
apoe ε4 predicted the onset of ad-type dementia in middle (hr 3.45 95% ci 1.79-6.65, n = 222) and high (hr 3.67 95% ci 1.36-9.89, n = 139) but not in low educated subjects (hr 0.81, 95% ci 0.38-1.72, n = 183). |
2013-10-17 |
2023-08-12 |
human |
| Qianhua Zhao, Yunyun Xiong, Ding Ding, Qihao Guo, Zhen Hon. Synergistic effect between apolipoprotein E ε4 and diabetes mellitus for dementia: result from a population-based study in urban China. Journal of Alzheimer's disease : JAD. vol 32. issue 4. 2013-08-23. PMID:22890095. |
we aim to determine the prevalence of dementia in chinese diabetics and non-diabetic individuals, and assess the effect of the apoe genotype. |
2013-08-23 |
2023-08-12 |
human |