| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qianhua Zhao, Yunyun Xiong, Ding Ding, Qihao Guo, Zhen Hon. Synergistic effect between apolipoprotein E ε4 and diabetes mellitus for dementia: result from a population-based study in urban China. Journal of Alzheimer's disease : JAD. vol 32. issue 4. 2013-08-23. PMID:22890095. |
apoe ε4 carriers had higher prevalence of dementia and ad (diabetics: 9.2%, 7.55%, non-diabetics: 3.3%, 3.3%) than apoe ε4 non-carriers (diabetics: 6.3%, 2.3%, non-diabetics: 2.35%, 0.7%) (p < 0.05). |
2013-08-23 |
2023-08-12 |
human |
| Qianhua Zhao, Yunyun Xiong, Ding Ding, Qihao Guo, Zhen Hon. Synergistic effect between apolipoprotein E ε4 and diabetes mellitus for dementia: result from a population-based study in urban China. Journal of Alzheimer's disease : JAD. vol 32. issue 4. 2013-08-23. PMID:22890095. |
diabetics carrying the apoe ε4 allele had a 3.982-fold [95%ci, 1.418-11.184] likelihood of having dementia compared with those without these two factors. |
2013-08-23 |
2023-08-12 |
human |
| C J Brainerd, V F Reyna, R C Petersen, G E Smith, A E Kenney, C J Gross, E S Taub, B L Plassman, G G Fishe. The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study. Neuropsychology. vol 27. issue 1. 2013-08-21. PMID:23356599. |
the ε4 allele of the apolipoprotein e (apoe) genotype is the most widely accepted genetic risk factor for alzheimer's dementia (ad), but findings on whether it is a risk factor for the ad prodrome, mild cognitive impairment (mci), have been inconsistent. |
2013-08-21 |
2023-08-12 |
Not clear |
| Efrat Kravitz, James Schmeidler, Michal Schnaider Beer. Cognitive decline and dementia in the oldest-old. Rambam Maimonides medical journal. vol 3. issue 4. 2013-08-05. PMID:23908850. |
many of the risk and protective factors for dementia in the young elderly, such as apoe genotype, physical activity, and healthy lifestyle, are not relevant for the oldest-old. |
2013-08-05 |
2023-08-12 |
Not clear |
| Giancarlo Zito, Renato Polimanti, Valentina Panetta, Mariacarla Ventriglia, Carlo Salustri, Maria Cristina Siotto, Filomena Moffa, Claudia Altamura, Fabrizio Vernieri, Domenico Lupoi, Emanuele Cassetta, Paolo M Rossini, Rosanna Squitt. Antioxidant status and APOE genotype as susceptibility factors for neurodegeneration in Alzheimer's disease and vascular dementia. Rejuvenation research. vol 16. issue 1. 2013-08-01. PMID:23216585. |
antioxidant status and apoe genotype as susceptibility factors for neurodegeneration in alzheimer's disease and vascular dementia. |
2013-08-01 |
2023-08-12 |
Not clear |
| Giancarlo Zito, Renato Polimanti, Valentina Panetta, Mariacarla Ventriglia, Carlo Salustri, Maria Cristina Siotto, Filomena Moffa, Claudia Altamura, Fabrizio Vernieri, Domenico Lupoi, Emanuele Cassetta, Paolo M Rossini, Rosanna Squitt. Antioxidant status and APOE genotype as susceptibility factors for neurodegeneration in Alzheimer's disease and vascular dementia. Rejuvenation research. vol 16. issue 1. 2013-08-01. PMID:23216585. |
to address this issue, we evaluated the effects of antioxidant status and apoe genotype on neurodegeneration in patients with dementia of the alzheimer type (ad), with vascular dementia (vad), and in elderly healthy controls. |
2013-08-01 |
2023-08-12 |
Not clear |
| María M Corrada, Annlia Paganini-Hill, Daniel J Berlau, Claudia H Kawa. Apolipoprotein E genotype, dementia, and mortality in the oldest old: the 90+ Study. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 9. issue 1. 2013-07-25. PMID:23123227. |
several european studies suggest that the effect of the apoe ε4 allele on dementia and mortality disappears in very old age. |
2013-07-25 |
2023-08-12 |
human |
| Stéphanie Paillard-Borg, Laura Fratiglioni, Weili Xu, Bengt Winblad, Hui-Xin Wan. An active lifestyle postpones dementia onset by more than one year in very old adults. Journal of Alzheimer's disease : JAD. vol 31. issue 4. 2013-07-08. PMID:22751170. |
age at onset of dementia was significantly older in persons who had higher levels of participation in mental, physical, or social activity (β: 0.18, 0.29 and 0.23 respectively, p < 0.001 for all the activities) independent of education, medical condition, functional status, and other confounders including apoe. |
2013-07-08 |
2023-08-12 |
Not clear |
| J M Rusted, S L Evans, S L King, N Dowell, N Tabet, P S Toft. APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures. NeuroImage. vol 65. 2013-06-28. PMID:23063453. |
the apoe e4 allele, which confers an increased risk of developing dementia in older adulthood, has been associated with enhanced cognitive performance in younger adults. |
2013-06-28 |
2023-08-12 |
Not clear |
| Carlos Cruchaga, John S K Kauwe, Petra Nowotny, Kelly Bales, Eve H Pickering, Kevin Mayo, Sarah Bertelsen, Anthony Hinrichs, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goat. Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease. Human molecular genetics. vol 21. issue 20. 2013-06-21. PMID:22821396. |
we used mendelian randomization and genetic variants as instrumental variables to confirm that the association of csf apoe with csf aβ(42) levels and clinical dementia rating (cdr) is not because of a reverse causation or confounding effect. |
2013-06-21 |
2023-08-12 |
Not clear |
| Wei-Li Xu, Barbara Caracciolo, Hui-Xin Wang, Giola Santoni, Bengt Winblad, Laura Fratiglion. Accelerated progression from mild cognitive impairment to dementia among APOE ε4ε4 carriers. Journal of Alzheimer's disease : JAD. vol 33. issue 2. 2013-05-28. PMID:23247007. |
accelerated progression from mild cognitive impairment to dementia among apoe ε4ε4 carriers. |
2013-05-28 |
2023-08-12 |
human |
| Wei-Li Xu, Barbara Caracciolo, Hui-Xin Wang, Giola Santoni, Bengt Winblad, Laura Fratiglion. Accelerated progression from mild cognitive impairment to dementia among APOE ε4ε4 carriers. Journal of Alzheimer's disease : JAD. vol 33. issue 2. 2013-05-28. PMID:23247007. |
the impact of apoe ε4 on mild cognitive impairment (mci) and its progression to dementia remain controversial. |
2013-05-28 |
2023-08-12 |
human |
| Wei-Li Xu, Barbara Caracciolo, Hui-Xin Wang, Giola Santoni, Bengt Winblad, Laura Fratiglion. Accelerated progression from mild cognitive impairment to dementia among APOE ε4ε4 carriers. Journal of Alzheimer's disease : JAD. vol 33. issue 2. 2013-05-28. PMID:23247007. |
we aimed to examine the association of apoe ε4 with mci, and to verify the hypothesis that ε4 accelerates progression from mci to dementia. |
2013-05-28 |
2023-08-12 |
human |
| Wei-Li Xu, Barbara Caracciolo, Hui-Xin Wang, Giola Santoni, Bengt Winblad, Laura Fratiglion. Accelerated progression from mild cognitive impairment to dementia among APOE ε4ε4 carriers. Journal of Alzheimer's disease : JAD. vol 33. issue 2. 2013-05-28. PMID:23247007. |
compared with apoe ε3ε3, the hazard ratios (hrs) (95% cis) of ε2ε4/ε3ε4 were 2.24 (1.10-4.57) for amci and 1.78 (1.15-2.75) for ocind, while the ε4ε4 was related to dementia with a hr of 4.35 (1.97-9.63) in the cognitively healthy cohort. |
2013-05-28 |
2023-08-12 |
human |
| Ingmar Skoog, Pernille J Olesen, Kaj Blennow, Bo Palmertz, Sterling C Johnson, Erin D Bigle. Head size may modify the impact of white matter lesions on dementia. Neurobiology of aging. vol 33. issue 7. 2013-05-27. PMID:21420196. |
we aimed to examine whether total intracranial volume (ticv), a marker of premorbid brain size, modified the impact of the apolipoprotein e (apoe) e4 phenotype and ischemic white matter lesions (wmls) on odds for dementia. |
2013-05-27 |
2023-08-12 |
human |
| Lawrence J Whalley, Roger T Staff, Alison D Murray, Ian J Deary, John M Star. Genetic and environmental factors in late onset dementia: possible role for early parental death. International journal of geriatric psychiatry. vol 28. issue 1. 2013-05-14. PMID:22821632. |
we tested a multivariate model of risk factors for late onset dementia that included established (female sex, a family history of dementia, apoe ε4) and putative influences (vascular risk factors, years of full-time education, parental ages at death, and childhood iq) on dementia risk. |
2013-05-14 |
2023-08-12 |
Not clear |
| Stephanie J B Vos, Ineke A van Rossum, Frans Verhey, Dirk L Knol, Hilkka Soininen, Lars-Olof Wahlund, Harald Hampel, Magda Tsolaki, Lennart Minthon, Giovanni B Frisoni, Lutz Froelich, Flavio Nobili, Wiesje van der Flier, Kaj Blennow, Robin Wolz, Philip Scheltens, Pieter Jelle Visse. Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI. Neurology. vol 80. issue 12. 2013-05-14. PMID:23446677. |
to compare the predictive accuracy of β-amyloid (aβ)1-42 and total tau in csf, hippocampal volume (hcv), and apoe genotype for alzheimer disease (ad)-type dementia in subjects with amnestic mild cognitive impairment (amci) and nonamnestic mild cognitive impairment (namci). |
2013-05-14 |
2023-08-12 |
human |
| Camilla Ferrari, Wei-Li Xu, Hui-Xin Wang, Bengt Winblad, Sandro Sorbi, Chengxuan Qiu, Laura Fratiglion. How can elderly apolipoprotein E ε4 carriers remain free from dementia? Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22503000. |
apolipoprotein e (apoe) ε4 is a major risk factor for alzheimer's disease (ad) and dementia, but not all ε4 carriers develop dementia. |
2013-04-23 |
2023-08-12 |
human |
| Camilla Ferrari, Wei-Li Xu, Hui-Xin Wang, Bengt Winblad, Sandro Sorbi, Chengxuan Qiu, Laura Fratiglion. How can elderly apolipoprotein E ε4 carriers remain free from dementia? Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22503000. |
high education, active leisure activities, or maintaining vascular health seems to reduce the risk of dementia related to apoe ε4. |
2013-04-23 |
2023-08-12 |
human |
| Debby Tsuang, James B Leverenz, Oscar L Lopez, Ronald L Hamilton, David A Bennett, Julie A Schneider, Aron S Buchman, Eric B Larson, Paul K Crane, Jeffrey A Kaye, Patricia Kramer, Randy Woltjer, John Q Trojanowski, Daniel Weintraub, Alice S Chen-Plotkin, David J Irwin, Jacqueline Rick, Gerard D Schellenberg, G Stennis Watson, Walter Kukull, Peter T Nelson, Gregory A Jicha, Janna H Neltner, Doug Galasko, Eliezer Masliah, Joseph F Quinn, Kathryn A Chung, Dora Yearout, Ignacio F Mata, Jia Y Wan, Karen L Edwards, Thomas J Montine, Cyrus P Zabetia. APOE ε4 increases risk for dementia in pure synucleinopathies. JAMA neurology. vol 70. issue 2. 2013-04-16. PMID:23407718. |
apoe ε4 increases risk for dementia in pure synucleinopathies. |
2013-04-16 |
2023-08-12 |
Not clear |