| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramón Cacabelos, Rocío Martínez, Lucía Fernández-Novoa, Juan C Carril, Valter Lombardi, Iván Carrera, Lola Corzo, Iván Tellado, Jerzy Leszek, Adam McKay, Masatoshi Taked. Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22482072. |
the ε4 variant of the apoe gene seems to be a major risk factor for both degenerative and vascular dementia. |
2012-08-23 |
2023-08-12 |
Not clear |
| Yan-Wei Yin, Jing-Cheng Li, Jing-Zhou Wang, Bing-Hu Li, Yan Pi, Qing-Wu Yang, Chuan-Qin Fang, Chang-Yue Gao, Li-Li Zhan. Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: a meta-analysis. Neuroscience letters. vol 514. issue 1. 2012-08-20. PMID:22381401. |
it remains controversial regarding the association between apolipoprotein e (apoe) gene polymorphism and the risk of vascular dementia (vad). |
2012-08-20 |
2023-08-12 |
Not clear |
| James F Morley, Sharon X Xie, Howard I Hurtig, Matthew B Stern, Amy Colcher, Stacy Horn, Nabila Dahodwala, John E Duda, Daniel Weintraub, Alice S Chen-Plotkin, Vivianna Van Deerlin, Dana Falcone, Andrew Siderow. Genetic influences on cognitive decline in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 4. 2012-08-08. PMID:22344634. |
carrying at least one apoe ε4 allele is associated with more rapid cognitive decline in pd, supporting the idea of a component of shared etiology between pd dementia and alzheimer's disease. |
2012-08-08 |
2023-08-12 |
Not clear |
| Ineke A van Rossum, Pieter Jelle Visser, Dirk L Knol, Wiesje M van der Flier, Charlotte E Teunissen, Frederik Barkhof, Marinus A Blankenstein, Philip Schelten. Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 29. issue 2. 2012-07-26. PMID:22233766. |
csf aβ1-42, apoe status, age, gender, and educational level were not associated with time to dementia. |
2012-07-26 |
2023-08-12 |
human |
| Joel Kowalewski, Claire Murph. Olfactory ERPs in an odor/visual congruency task differentiate ApoE ε4 carriers from non-carriers. Brain research. vol 1442. 2012-07-25. PMID:22305338. |
apoe ε4 carriers and non-carriers were screened for anosmia, severe hyposmia, and dementia. |
2012-07-25 |
2023-08-12 |
Not clear |
| Xu Liu, Lei Li, Fang Liu, Shuming Deng, Ruixia Zhu, Qu Li, Zhiyi H. ApoE gene polymorphism and vascular dementia in Chinese population: a meta-analysis. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 3. 2012-07-23. PMID:21984189. |
apoe gene polymorphism and vascular dementia in chinese population: a meta-analysis. |
2012-07-23 |
2023-08-12 |
human |
| Xu Liu, Lei Li, Fang Liu, Shuming Deng, Ruixia Zhu, Qu Li, Zhiyi H. ApoE gene polymorphism and vascular dementia in Chinese population: a meta-analysis. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 3. 2012-07-23. PMID:21984189. |
the apolipoprotein e (apoe) gene polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remains inconclusive even in chinese population. |
2012-07-23 |
2023-08-12 |
human |
| Xu Liu, Lei Li, Fang Liu, Shuming Deng, Ruixia Zhu, Qu Li, Zhiyi H. ApoE gene polymorphism and vascular dementia in Chinese population: a meta-analysis. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 3. 2012-07-23. PMID:21984189. |
therefore, we performed this meta-analysis in order to evaluate the relationship between apoe gene polymorphism and susceptibility to vascular dementia in chinese population by pooling data from all relevant case-control studies published domestically and abroad from january 1990 to may 2011. |
2012-07-23 |
2023-08-12 |
human |
| Xu Liu, Lei Li, Fang Liu, Shuming Deng, Ruixia Zhu, Qu Li, Zhiyi H. ApoE gene polymorphism and vascular dementia in Chinese population: a meta-analysis. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 3. 2012-07-23. PMID:21984189. |
these results suggest that apoe polymorphism is significantly associated with susceptibility to vascular dementia in chinese population. |
2012-07-23 |
2023-08-12 |
human |
| Elizabeth A Murphy, John Cooper Roddey, Linda K McEvoy, Dominic Holland, D J Hagler, Anders M Dale, James B Brewe. CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer's disease risk in an APOE-dependent manner. Brain imaging and behavior. vol 6. issue 1. 2012-06-12. PMID:21892657. |
conversely, in apoe ε4 non-carriers, the i allele, which increases cetp and decreases hdl, associated with greater baseline thickness, less atrophy and lower risk of dementia. |
2012-06-12 |
2023-08-12 |
human |
| D Domenger, D Dea, L Theroux, L Moquin, A Gratton, J Poirie. The MPTP neurotoxic lesion model of Parkinson's disease activates the apolipoprotein E cascade in the mouse brain. Experimental neurology. vol 233. issue 1. 2012-03-25. PMID:22155743. |
apoe associations studies with parkinson's disease (pd), the second most prevalent neurodegenerative disease, have generated contradictory results but associations with age at onset and dementia in pd stand out. |
2012-03-25 |
2023-08-12 |
mouse |
| Charles J Brainerd, Valerie F Reyna, Ronald C Petersen, Glenn E Smith, Emily S Tau. Is the apolipoprotein e genotype a biomarker for mild cognitive impairment? Findings from a nationally representative study. Neuropsychology. vol 25. issue 6. 2012-02-29. PMID:21728427. |
although the ε4 allele of the apolipoprotein e (apoe) genotype is a known risk factor for alzheimer's dementia (ad), prior findings on whether it is also a risk factor for mild cognitive impairment (mci) have been inconsistent. |
2012-02-29 |
2023-08-12 |
Not clear |
| D F Tate, E S Neeley, M C Norton, J T Tschanz, M J Miller, L Wolfson, C Hulette, C Leslie, K A Welsh-Bohmer, B Plassman, Erin D Bigle. Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis. Brain research. vol 1385. 2012-02-14. PMID:21172323. |
parametrically, no main effect was found for ticv when predicting a dementia diagnosis; however, the cart analysis did reveal important ticv subgroups, including a sex differential wherein ε4 apoe allele presence in males and low ticv predicted ad classification. |
2012-02-14 |
2023-08-12 |
human |
| Juliana Fagion Lucatelli, Alessandra Chielle Barros, Vanessa Kappel da Silva, Fernanda da Silva Machado, Pâmela Camini Constantin, Ana Amélia Cipriani Dias, Mara Helena Hutz, Fabiana Michelsen de Andrad. Genetic influences on Alzheimer's disease: evidence of interactions between the genes APOE, APOC1 and ACE in a sample population from the South of Brazil. Neurochemical research. vol 36. issue 8. 2012-02-01. PMID:21533863. |
the objective of this study was to investigate the association of ace and apoc1 gene polymorphisms with susceptibility to alzheimer's disease and dementia in general, both alone and combined with the apoe gene. |
2012-02-01 |
2023-08-12 |
Not clear |
| Michelle M Mielke, Jeannie-Marie Leoutsakos, JoAnn T Tschanz, Robert C Green, Yorghos Tripodis, Chris D Corcoran, Maria C Norton, Constantine G Lyketso. Interaction between vascular factors and the APOE ε4 allele in predicting rate of progression in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 26. issue 1. 2012-01-10. PMID:21593560. |
linear mixed effects models tested interactions between the vascular factors, apoe ε4, and time as predictors of clinical progression on the mini-mental state exam (mmse) and clinical dementia rating-sum of boxes (cdr-sb). |
2012-01-10 |
2023-08-12 |
human |
| Friederike Fritze, Uwe Ehrt, Hogne Sønnesyn, Martin Kurz, Tibor Hortobágyi, Sabine Piepenstock Nore, Clive Ballard, Dag Aarslan. Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features. International journal of geriatric psychiatry. vol 26. issue 10. 2011-12-21. PMID:21905099. |
depression in mild dementia: associations with diagnosis, apoe genotype and clinical features. |
2011-12-21 |
2023-08-12 |
Not clear |
| Lina Keller, Weili Xu, Hui-Xin Wang, Bengt Winblad, Laura Fratiglioni, Caroline Graf. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. Journal of Alzheimer's disease : JAD. vol 23. issue 3. 2011-12-20. PMID:21098976. |
cox-regression models were used to assess the relative risks of developing ad and dementia (dsm-iii-r criteria) according to fto genotypes (rs9939609), taking into account apoe, physical inactivity, bmi, diabetes, and cardiovascular disease (cvd). |
2011-12-20 |
2023-08-12 |
human |
| Lina Keller, Weili Xu, Hui-Xin Wang, Bengt Winblad, Laura Fratiglioni, Caroline Graf. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. Journal of Alzheimer's disease : JAD. vol 23. issue 3. 2011-12-20. PMID:21098976. |
compared to carriers of the fto tt-genotype, aa-carriers had a higher risk for ad (rr 1.58, 95% ci: 1.11-2.24) and for dementia (rr 1.48, 95% ci: 1.09-2.02) after adjustment for age, gender, education, and apoe genotype. |
2011-12-20 |
2023-08-12 |
human |
| Lina Keller, Weili Xu, Hui-Xin Wang, Bengt Winblad, Laura Fratiglioni, Caroline Graf. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. Journal of Alzheimer's disease : JAD. vol 23. issue 3. 2011-12-20. PMID:21098976. |
an interaction between fto and apoe was found, with increased risk for dementia for those carrying both fto aa and apoe ϵ4. |
2011-12-20 |
2023-08-12 |
human |
| Elizabeth Head, Eric Doran, Mihaela Nistor, MaryAnn Hill, Frederick A Schmitt, Richard J Haier, Ira T Lot. Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. Journal of Alzheimer's disease : JAD. vol 23. issue 3. 2011-12-20. PMID:21116050. |
a larger second group included demented and nondemented adults with ds, in order to test the hypothesis that plasma aβ may vary as a function of dementia and apolipoprotein e (apoe) genotype. |
2011-12-20 |
2023-08-12 |
human |