| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen-Geng Liu, Jing Song, Yue-Qi Zhang, Pei-Chang Wan. MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease. Molecular medicine reports. vol 10. issue 5. 2015-06-09. PMID:25119742. |
the levels of mir‑193b, exosomal mir‑193b, aβ, tau, p‑tau, hcy and apoe in samples from app/ps1 double‑transgenic mice, mild cognitive impairment (mci) and dementia of alzheimer‑type (dat) patients, were measured. |
2015-06-09 |
2023-08-13 |
mouse |
| Claire Paquet, Jay Amin, François Mouton-Liger, Mariam Nasser, Seth Love, Françoise Gray, Ruth M Pickering, James A R Nicoll, Clive Holmes, Jacques Hugon, Delphine Boch. Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease. The Journal of pathology. vol 235. issue 5. 2015-05-07. PMID:25430817. |
data were corrected for age, gender, duration of dementia and apoe genotype and also assessed in relation to aβ42 and tau pathology and key features of ad. |
2015-05-07 |
2023-08-13 |
human |
| Orwa Aboud, Paul A Parcon, K Mark DeWall, Ling Liu, Robert E Mrak, W Sue T Griffi. Aging, Alzheimer's, and APOE genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-P50. Frontiers in cellular neuroscience. vol 9. 2015-04-10. PMID:25859183. |
however, few studies address these issues in human brain from those who either age without dementia and overt neuropathology, or succumb to alzheimer's; especially as such propensity may be influenced by apoe genotype. |
2015-04-10 |
2023-08-13 |
human |
| T Luck, S G Riedel-Heller, M Luppa, B Wiese, M Köhler, F Jessen, H Bickel, S Weyerer, M Pentzek, H-H König, J Prokein, A Ernst, M Wagner, E Mösch, J Werle, A Fuchs, C Brettschneider, M Scherer, W Maie. Apolipoprotein E epsilon 4 genotype and a physically active lifestyle in late life: analysis of gene-environment interaction for the risk of dementia and Alzheimer's disease dementia. Psychological medicine. vol 44. issue 6. 2015-03-31. PMID:23883793. |
as physical activity may modify the effect of the apolipoprotein e (apoe) ε4 allele on the risk of dementia and alzheimer's disease (ad) dementia, we tested for such a gene-environment interaction in a sample of general practice patients aged ⩾75 years. |
2015-03-31 |
2023-08-12 |
Not clear |
| Katrine L Rasmussen, Anne Tybjaerg-Hansen, Børge G Nordestgaard, Ruth Frikke-Schmid. Plasma levels of apolipoprotein E and risk of dementia in the general population. Annals of neurology. vol 77. issue 2. 2015-03-20. PMID:25469919. |
the apolipoprotein e (apoe) ε4 allele is a major genetic risk factor for alzheimer disease and dementia. |
2015-03-20 |
2023-08-13 |
Not clear |
| André Karch, Henrike Manthey, Claudia Ponto, Peter Hermann, Uta Heinemann, Christian Schmidt, Inga Zer. Investigating the association of ApoE genotypes with blood-brain barrier dysfunction measured by cerebrospinal fluid-serum albumin ratio in a cohort of patients with different types of dementia. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386372. |
investigating the association of apoe genotypes with blood-brain barrier dysfunction measured by cerebrospinal fluid-serum albumin ratio in a cohort of patients with different types of dementia. |
2015-02-23 |
2023-08-12 |
Not clear |
| André Karch, Henrike Manthey, Claudia Ponto, Peter Hermann, Uta Heinemann, Christian Schmidt, Inga Zer. Investigating the association of ApoE genotypes with blood-brain barrier dysfunction measured by cerebrospinal fluid-serum albumin ratio in a cohort of patients with different types of dementia. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386372. |
in the present study we addressed the question if apoe genotypes might be associated with bbb function measured by albumin ratio (qalb) in a large cohort of patients with different types of dementia. |
2015-02-23 |
2023-08-12 |
Not clear |
| David S Knopman, Clifford R Jack, Heather J Wiste, Emily S Lundt, Stephen D Weigand, Prashanthi Vemuri, Val J Lowe, Kejal Kantarci, Jeffrey L Gunter, Matthew L Senjem, Michelle M Mielke, Rosebud O Roberts, Bradley F Boeve, Ronald C Peterse. 18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons. Neurobiology of aging. vol 35. issue 9. 2015-02-12. PMID:24702820. |
in age- and sex-matched cn participants the magnitude of the difference in partial volume corrected fdg ratio in the ad-signature meta-roi for apoe ε4 carriers compared with noncarriers was about 4 times smaller than the magnitude of the difference between age- and sex-matched elderly apoe ε4 carrier cn compared with ad dementia participants. |
2015-02-12 |
2023-08-13 |
human |
| Giovanna Viticchi, Lorenzo Falsetti, Fabrizio Vernieri, Claudia Altamura, Riccardo Altavilla, Simona Luzzi, Marco Bartolini, Leandro Provinciali, Mauro Silvestrin. Apolipoprotein E genotype and cerebrovascular alterations can influence conversion to dementia in patients with mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 41. issue 2. 2015-02-09. PMID:24625799. |
moreover, we explored whether the possible correlation between apoe genotype and cerebrovascular parameters influences the risk of conversion from mci to dementia. |
2015-02-09 |
2023-08-12 |
Not clear |
| Giovanna Viticchi, Lorenzo Falsetti, Fabrizio Vernieri, Claudia Altamura, Riccardo Altavilla, Simona Luzzi, Marco Bartolini, Leandro Provinciali, Mauro Silvestrin. Apolipoprotein E genotype and cerebrovascular alterations can influence conversion to dementia in patients with mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 41. issue 2. 2015-02-09. PMID:24625799. |
the risk of conversion to dementia was significantly higher in apoe ε4+ patients than in apoe ε4- ones (or: 6.818; 95% ci:1.894-24.545, p = 0.003). |
2015-02-09 |
2023-08-12 |
Not clear |
| Giovanna Viticchi, Lorenzo Falsetti, Fabrizio Vernieri, Claudia Altamura, Riccardo Altavilla, Simona Luzzi, Marco Bartolini, Leandro Provinciali, Mauro Silvestrin. Apolipoprotein E genotype and cerebrovascular alterations can influence conversion to dementia in patients with mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 41. issue 2. 2015-02-09. PMID:24625799. |
a path-analysis model showed that apoe genotype influences the progression to dementia directly and indirectly by increasing the risk of pathologic values of imt or bhi. |
2015-02-09 |
2023-08-12 |
Not clear |
| Joshua D Rizak, Yuanye Ma, Xintian H. Is formaldehyde the missing link in AD pathology? The differential aggregation of amyloid-beta with APOE isoforms in vitro. Current Alzheimer research. vol 11. issue 5. 2015-02-02. PMID:24766729. |
apolipoprotein e (apoe) genetic variation and aging are the two most noted risk factors associated with the development of alzheimer's disease (ad) related dementia. |
2015-02-02 |
2023-08-13 |
Not clear |
| Guro Berge, Sigrid B Sando, Arvid Rongve, Dag Aarsland, Linda R Whit. Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort. Journal of neurology, neurosurgery, and psychiatry. vol 85. issue 11. 2015-01-26. PMID:24639435. |
results conflict concerning the relevance of apoe alleles on the development of dementia with lewy bodies (dlb), though they are well established in connection with alzheimer's disease (ad). |
2015-01-26 |
2023-08-12 |
Not clear |
| Ruediger Zimmermann, Ellen Huber, Christine Schamber, Natalia Lelental, Barbara Mroczko, Sebastian Brandner, Juan Manuel Maler, Timo Oberstein, Maciej Szmitkowski, Manfred Rauh, Johannes Kornhuber, Piotr Lewczu. Plasma concentrations of the amyloid-β peptides in young volunteers: the influence of the APOE genotype. Journal of Alzheimer's disease : JAD. vol 40. issue 4. 2015-01-06. PMID:24577473. |
therefore, we studied the plasma concentrations of aβ peptides (aβ1-42, aβ1-40, aβx-42, and aβx-40), and the apoe genotype in 173 young volunteers (average age, 28 ± 7.6 years) without memory deficits, in order to see whether the non-demented group of subjects at risk already characterize with aβ changes three-to-four decades before the age at which dementia usually occurs. |
2015-01-06 |
2023-08-12 |
human |
| Che-Sheng Chu, Ti Lu, Shih-Jen Tsai, Cheng-Jee Hong, Heng-Liang Yeh, Albert C Yang, Mu-En Li. APOE ɛ4 polymorphism and cognitive deficit among the very old Chinese veteran men without dementia. Neuroscience letters. vol 576. 2015-01-05. PMID:24887584. |
apoe ɛ4 polymorphism and cognitive deficit among the very old chinese veteran men without dementia. |
2015-01-05 |
2023-08-13 |
human |
| Che-Sheng Chu, Ti Lu, Shih-Jen Tsai, Cheng-Jee Hong, Heng-Liang Yeh, Albert C Yang, Mu-En Li. APOE ɛ4 polymorphism and cognitive deficit among the very old Chinese veteran men without dementia. Neuroscience letters. vol 576. 2015-01-05. PMID:24887584. |
four hundred and twenty-five aged chinese veteran men without dementia were enrolled for apoe genotyping and neuropsychological tests including mini-mental status examination (mmse), digit span forward and backward, and cognitive ability screening instrument chinese language version (casi c-2.0) were evaluated in these subjects. |
2015-01-05 |
2023-08-13 |
human |
| Che-Sheng Chu, Ti Lu, Shih-Jen Tsai, Cheng-Jee Hong, Heng-Liang Yeh, Albert C Yang, Mu-En Li. APOE ɛ4 polymorphism and cognitive deficit among the very old Chinese veteran men without dementia. Neuroscience letters. vol 576. 2015-01-05. PMID:24887584. |
this study suggests that the apoe ɛ4 alleles contributed detrimental effects on cognitive function in the very old veterans who do not have dementia. |
2015-01-05 |
2023-08-13 |
human |
| Hugh C Hendrie, Jill Murrell, Olusegun Baiyewu, Kathleen A Lane, Christianna Purnell, Adesola Ogunniyi, Frederick W Unverzagt, Kathleen Hall, Christopher M Callahan, Andrew J Saykin, Oye Gureje, Ann Hake, Tatiana Foroud, Sujuan Ga. APOE ε4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba. International psychogeriatrics. vol 26. issue 6. 2014-12-22. PMID:24565289. |
in previous analyses from the indianapolis-ibadan dementia project, we have reported that apoe ε4 increased the risk for alzheimer's disease (ad) in african americans but not in yoruba. |
2014-12-22 |
2023-08-12 |
Not clear |
| Brit Mollenhauer, Lynn Rochester, Alice Chen-Plotkin, David Brook. What can biomarkers tell us about cognition in Parkinson's disease? Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 5. 2014-12-19. PMID:24757111. |
in addition, genetic variation in the apolipoprotein e (apoe), catechol-o-methyltransferase (comt), microtubule-associated protein tau (mapt), and glucocerebrosidase (gba) genes may confer risk for cognitive impairment in pd; and gait disturbance may also indicate an increased risk for dementia. |
2014-12-19 |
2023-08-13 |
Not clear |
| Richard E Kennedy, Gary R Cutter, Lon S Schneide. Effect of APOE genotype status on targeted clinical trials outcomes and efficiency in dementia and mild cognitive impairment resulting from Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 3. 2014-12-10. PMID:23712001. |
effect of apoe genotype status on targeted clinical trials outcomes and efficiency in dementia and mild cognitive impairment resulting from alzheimer's disease. |
2014-12-10 |
2023-08-12 |
Not clear |