| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K J Rhodes, K A Meiners, D L Rosen. A novel hinge system and incubation chamber for emulsion-coated coverslip autoradiography. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 41. issue 9. 1993-09-21. PMID:8354882. |
this is demonstrated by thioflavin s staining of neuritic plaques and tangles and autoradiographic localization of serotonin 1a receptors in sections of alzheimer disease brain. |
1993-09-21 |
2023-08-12 |
human |
| G A Ricaurte, A L Markowska, G L Wenk, G Hatzidimitriou, J Wlos, D S Olto. 3,4-Methylenedioxymethamphetamine, serotonin and memory. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8102642. |
because alzheimer's disease involves impairments in acetylcholine, 5-ht and norepinephrine systems, animals with combined lesions may provide a useful model to study the mnemonic dysfunctions characteristic of this disease. |
1993-09-17 |
2023-08-12 |
rat |
| B R Grad, R Rozencwai. The role of melatonin and serotonin in aging: update. Psychoneuroendocrinology. vol 18. issue 4. 1993-07-28. PMID:8292130. |
evidence is presented for a role of melatonin and serotonin in controlling the neuroendocrine and immune networks and in inhibiting the development of ischemic heart and alzheimer's disease, tumor formation and other degenerative processes associated with aging. |
1993-07-28 |
2023-08-12 |
Not clear |
| P Koren, A Diver-Haber, A Adunsky, M Rabinowitz, M Hershkowit. Uptake of serotonin into platelets of senile dementia of the Alzheimer type patients. Journal of gerontology. vol 48. issue 3. 1993-06-01. PMID:8482811. |
uptake of serotonin into platelets of senile dementia of the alzheimer type patients. |
1993-06-01 |
2023-08-12 |
human |
| E C Azmitia, W S Griffin, D R Marshak, L J Van Eldik, P M Whitaker-Azmiti. S100 beta and serotonin: a possible astrocytic-neuronal link to neuropathology of Alzheimer's disease. Progress in brain research. vol 94. 1993-03-17. PMID:1287730. |
s100 beta and serotonin: a possible astrocytic-neuronal link to neuropathology of alzheimer's disease. |
1993-03-17 |
2023-08-11 |
Not clear |
| P T Francis, M N Pangalos, P H Stephens, J R Bartlett, P K Bridges, A L Malizia, D Neary, A W Procter, D J Thomas, D M Bowe. Antemortem measurements of neurotransmission: possible implications for pharmacotherapy of Alzheimer's disease and depression. Journal of neurology, neurosurgery, and psychiatry. vol 56. issue 1. 1993-03-10. PMID:7679142. |
the content of the serotonin metabolite alone was significantly reduced in intractable depressive illness (bipolar and major depressive disorders) compared with neurological conditions subdivided into alzheimer's disease, other dementias and other conditions. |
1993-03-10 |
2023-08-12 |
human |
| A J Nazarali, G P Reynold. Monoamine neurotransmitters and their metabolites in brain regions in Alzheimer's disease: a postmortem study. Cellular and molecular neurobiology. vol 12. issue 6. 1993-02-26. PMID:1283363. |
concentrations of the neurotransmitter amines noradrenaline (na), dopamine (da), and 5-hydroxytryptamine (5-ht) and the acid metabolites homovanillic acid (hva) and 5-hydroxyindoleacetic acid (5-hiaa) were determined in four regions of postmortem brains of demented patients with or without alzheimer's disease (ad). |
1993-02-26 |
2023-08-11 |
Not clear |
| B T Volpe, C S Hendrix, D H Park, A C Towle, H P Davi. Early post-natal administration of 5,7-dihydroxytryptamine destroys 5-HT neurons but does not affect spatial memory. Brain research. vol 589. issue 2. 1992-11-25. PMID:1393594. |
it has also been suggested that 5-ht abnormalities may mediate some aspects of the cognitive disorders associated with korsakoff syndrome and alzheimer's disease. |
1992-11-25 |
2023-08-11 |
rat |
| M Z Wrona, R N Goyal, D J Turk, C L Blank, G Dryhurs. 5,5'-Dihydroxy-4,4'-bitryptamine: a potentially aberrant, neurotoxic metabolite of serotonin. Journal of neurochemistry. vol 59. issue 4. 1992-10-26. PMID:1357095. |
previous investigators have detected unknown oxidized forms of 5-hydroxytryptamine (5-ht) in the csf of alzheimer's disease (ad) patients. |
1992-10-26 |
2023-08-11 |
mouse |
| D L Sparks, J C Hunsaker, J T Slevin, S T DeKosky, R J Kryscio, W R Markesber. Monoaminergic and cholinergic synaptic markers in the nucleus basalis of Meynert (nbM): normal age-related changes and the effect of heart disease and Alzheimer's disease. Annals of neurology. vol 31. issue 6. 1992-09-25. PMID:1355334. |
neurotransmitter markers for acetylcholine, serotonin (5-ht), and dopamine (da) were measured in autopsied human nucleus basalis of meynert (nbm) from nondemented individuals without heart disease (non-hd) (age range, 4-84 years; n = 77), nondemented individuals with heart disease (hd) (age range, 57-92 years; n = 23), and individuals with alzheimer's disease (ad) (age range, 59-92 years; n = 22). |
1992-09-25 |
2023-08-11 |
human |
| H Tohgi, T Abe, S Takahashi, M Kimura, J Takahashi, T Kikuch. Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia. Neuroscience letters. vol 141. issue 1. 1992-09-22. PMID:1508406. |
concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with alzheimer type dementia. |
1992-09-22 |
2023-08-11 |
Not clear |
| H Tohgi, T Abe, S Takahashi, M Kimura, J Takahashi, T Kikuch. Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia. Neuroscience letters. vol 141. issue 1. 1992-09-22. PMID:1508406. |
we studied concentrations of free and total serotonin (5-hydroxytryptamine, 5-ht) and its related substances in the cerebrospinal fluid from patients with alzheimer type dementia (atd) compared with controls. |
1992-09-22 |
2023-08-11 |
Not clear |
| J K Cooper, D Munga. Serotonin response in sweet-food craving Alzheimer's disease subjects. Aging (Milan, Italy). vol 4. issue 2. 1992-09-18. PMID:1504133. |
serotonin response in sweet-food craving alzheimer's disease subjects. |
1992-09-18 |
2023-08-11 |
human |
| J H Eubanks, M Altherr, C Wagner-McPherson, J D McPherson, J J Wasmuth, G A Evan. Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus. Genomics. vol 12. issue 3. 1992-05-14. PMID:1532789. |
genes encoding g-protein-coupled receptors, including dopamine, serotonin, muscarinic cholinergic, and adrenergic receptors, play an important role in neurotransmission and may be involved in the pathophysiology of diseases such as alzheimer's disease, parkinson's disease, or huntington's disease (hd). |
1992-05-14 |
2023-08-11 |
human |
| A Andersson, R Adolfsson, K Eriksson, J Marcusso. Platelet [3H]paroxetine binding to 5-HT uptake sites in Alzheimer's disease. Neurobiology of aging. vol 12. issue 5. 1992-02-21. PMID:1837595. |
platelet [3h]paroxetine binding to 5-ht uptake sites in alzheimer's disease. |
1992-02-21 |
2023-08-11 |
Not clear |
| A Andersson, R Adolfsson, K Eriksson, J Marcusso. Platelet [3H]paroxetine binding to 5-HT uptake sites in Alzheimer's disease. Neurobiology of aging. vol 12. issue 5. 1992-02-21. PMID:1837595. |
platelet serotonin (5-hydroxytryptamine, 5-ht) uptake sites were studied in a control group (n = 30) and an alzheimer group (n = 40) using [3h]paroxetine as radioligand. |
1992-02-21 |
2023-08-11 |
Not clear |
| A Andersson, R Adolfsson, K Eriksson, J Marcusso. Platelet [3H]paroxetine binding to 5-HT uptake sites in Alzheimer's disease. Neurobiology of aging. vol 12. issue 5. 1992-02-21. PMID:1837595. |
thus even though several previous studies have demonstrated marked atrophy of 5-ht containing neurites and 5-ht uptake sites in alzheimer's disease, these findings are not found in the periphery on platelets. |
1992-02-21 |
2023-08-11 |
Not clear |
| A Andersson, R Adolfsson, K Eriksson, J Marcusso. Platelet [3H]paroxetine binding to 5-HT uptake sites in Alzheimer's disease. Neurobiology of aging. vol 12. issue 5. 1992-02-21. PMID:1837595. |
the platelet 5-ht uptake site cannot be used as a peripheral marker of alzheimer's disease. |
1992-02-21 |
2023-08-11 |
Not clear |
| E C Azmitia, P M Whitaker-Azmiti. Awakening the sleeping giant: anatomy and plasticity of the brain serotonergic system. The Journal of clinical psychiatry. vol 52 Suppl. 1992-01-30. PMID:1752858. |
the developmental role of 5-ht appears to become dormant as the brain matures, and during aging and alzheimer's disease, 5-ht receptors are significantly depressed. |
1992-01-30 |
2023-08-11 |
Not clear |
| B A Lawlor, T Sunderland, A M Mellow, S E Molchan, R Martinez, D L Murph. A pilot placebo-controlled study of chronic m-CPP administration in Alzheimer's disease. Biological psychiatry. vol 30. issue 2. 1991-11-21. PMID:1912105. |
meta-chlorophenylpiperazine (m-cpp), a serotonin agonist and metabolite of the anti-depressant trazodone, was administered chronically to eight moderate to severely affected alzheimer patients to determine whether it would produce improvement in behavioral symptoms complicating this illness. |
1991-11-21 |
2023-08-11 |
Not clear |