| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Tohgi, T Abe, S Takahashi, M Saheki, M Kimur. Indoleamine concentrations in cerebrospinal fluid from patients with Alzheimer type and Binswanger type dementias before and after administration of citalopram, a synthetic serotonin uptake inhibitor. Journal of neural transmission. Parkinson's disease and dementia section. vol 9. issue 2-3. 1996-02-01. PMID:8526997. |
indoleamine concentrations in cerebrospinal fluid from patients with alzheimer type and binswanger type dementias before and after administration of citalopram, a synthetic serotonin uptake inhibitor. |
1996-02-01 |
2023-08-12 |
Not clear |
| H Tohgi, T Abe, S Takahashi, M Saheki, M Kimur. Indoleamine concentrations in cerebrospinal fluid from patients with Alzheimer type and Binswanger type dementias before and after administration of citalopram, a synthetic serotonin uptake inhibitor. Journal of neural transmission. Parkinson's disease and dementia section. vol 9. issue 2-3. 1996-02-01. PMID:8526997. |
we studied changes in the concentrations of serotonin (5-ht), kynurenine, and other indoleamines in the cerebrospinal fluid of patients with alzheimer type dementia (atd) and those with binswanger type vascular dementia (vdbt), and changes in these indoleamine concentrations 2 weeks after administration of citalopram, a 5-ht uptake inhibitor. |
1996-02-01 |
2023-08-12 |
Not clear |
| P Riekkinen, M Riekkine. Effects of tetrahydroaminoacridine and nicotine in nucleus basalis and serotonin-lesioned rats. European journal of pharmacology. vol 279. issue 1. 1995-11-21. PMID:7556384. |
the present study was designed to investigate the hypothesis that concurrent degeneration of serotonin and acetylcholine cells may decrease the therapeutic effects of cholinergic drugs on cognitive functioning in alzheimer dementia. |
1995-11-21 |
2023-08-12 |
rat |
| A M Kumar, S Sevush, M Kumar, J Ruiz, C Eisdorfe. Peripheral serotonin in Alzheimer's disease. Neuropsychobiology. vol 32. issue 1. 1995-11-07. PMID:7566524. |
peripheral serotonin in alzheimer's disease. |
1995-11-07 |
2023-08-12 |
human |
| A M Kumar, S Sevush, M Kumar, J Ruiz, C Eisdorfe. Peripheral serotonin in Alzheimer's disease. Neuropsychobiology. vol 32. issue 1. 1995-11-07. PMID:7566524. |
this investigation was carried out in order to test the hypothesis that levels of serotonin (5-ht) in the platelet will be decreased in alzheimer's disease (ad) since neurochemical studies suggest that levels of 5-ht are decreased in the brain of ad patients. |
1995-11-07 |
2023-08-12 |
human |
| B A Lawlor, T M Ryan, L M Bierer, J Schmeidler, V Haroutunian, R Mohs, K L Davi. Lack of association between clinical symptoms and postmortem indices of brain serotonin function in Alzheimer's disease. Biological psychiatry. vol 37. issue 12. 1995-10-25. PMID:7548465. |
lack of association between clinical symptoms and postmortem indices of brain serotonin function in alzheimer's disease. |
1995-10-25 |
2023-08-12 |
Not clear |
| L A McInnes, N B Freime. Mapping genes for psychiatric disorders and behavioral traits. Current opinion in genetics & development. vol 5. issue 3. 1995-10-23. PMID:7549434. |
these include the localization of a gene for circadian periodicity in the mouse, gene knockouts of serotonin receptors, and the development of a transgenic model of alzheimer's disease. |
1995-10-23 |
2023-08-12 |
mouse |
| S M Tejani-Butt, J Yang, A C Pawly. Altered serotonin transporter sites in Alzheimer's disease raphe and hippocampus. Neuroreport. vol 6. issue 8. 1995-10-10. PMID:7662909. |
altered serotonin transporter sites in alzheimer's disease raphe and hippocampus. |
1995-10-10 |
2023-08-12 |
Not clear |
| S M Tejani-Butt, J Yang, A C Pawly. Altered serotonin transporter sites in Alzheimer's disease raphe and hippocampus. Neuroreport. vol 6. issue 8. 1995-10-10. PMID:7662909. |
this study measured serotonin transporter (5-htt) sites in the dorsal raphe nucleus (drn) and hippocampus in alzheimer's disease (ad). |
1995-10-10 |
2023-08-12 |
Not clear |
| S W Tam, R Zacze. Linopirdine. A depolarization-activated releaser of transmitters for treatment of dementia. Advances in experimental medicine and biology. vol 363. 1995-08-24. PMID:7618529. |
linopirdine (dup 996, aviva), currently in phase iii clinical trial for the treatment of alzheimer's disease, is a representative of a class of novel molecules which enhances the stimulus-evoked but not basal release of several neurotransmitters including ach, da, 5-ht and glu. |
1995-08-24 |
2023-08-12 |
Not clear |
| H Hörtnag. AF64A-induced brain damage and its relation to dementia. Journal of neural transmission. Supplementum. vol 44. 1995-04-27. PMID:7897396. |
the af64a-induced withdrawal of cholinergic function in the rat hippocampus was associated with reversible functional changes in other neurotransmitters, including noradrenaline, serotonin, somatostatin and glutamate, thereby mimicking changes in alzheimer's disease. |
1995-04-27 |
2023-08-12 |
rat |
| J L Yau, P A Kelly, J R Seck. Increased glucocorticoid receptor gene expression in the rat hippocampus following combined serotonergic and medial septal cholinergic lesions. Brain research. Molecular brain research. vol 27. issue 1. 1995-04-06. PMID:7877448. |
degeneration of both cholinergic and serotonergic (5-ht) hippocampal afferents is prominent in aged rats and alzheimer's disease. |
1995-04-06 |
2023-08-12 |
rat |
| F Lebert, F Pasquier, H Peti. Behavioral effects of trazodone in Alzheimer's disease. The Journal of clinical psychiatry. vol 55. issue 12. 1995-02-07. PMID:7814348. |
central serotonin depletion may contribute to the anxiety, restlessness, irritability, and affective disturbance seen in a variety of psychiatric conditions, particularly dementia of the alzheimer's type (dat) in which brain concentrations of both 5-hydroxytryptamine (5-ht) and its 5-hydroxyindoleacetic acid (5-hiaa) metabolite are reduced. |
1995-02-07 |
2023-08-12 |
Not clear |
| D M McLoughlin, J V Lucey, T G Dina. Central serotonergic hyperresponsivity in late-onset Alzheimer's disease. The American journal of psychiatry. vol 151. issue 11. 1994-11-15. PMID:7943465. |
this finding suggests that central serotonin responsivity is greater in alzheimer's disease. |
1994-11-15 |
2023-08-12 |
Not clear |
| E K Perry, E Marshall, P Thompson, I G McKeith, D Collerton, A F Fairbairn, I N Ferrier, D Irving, R H Perr. Monoaminergic activities in Lewy body dementia: relation to hallucinosis and extrapyramidal features. Journal of neural transmission. Parkinson's disease and dementia section. vol 6. issue 3. 1994-04-12. PMID:8123190. |
serotonergic (5-ht) and dopaminergic activities have been examined in lewy body dementia (lbd) and compared with parkinson's disease (pd) and alzheimer's disease (ad). |
1994-04-12 |
2023-08-12 |
Not clear |
| M J Owens, C B Nemerof. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clinical chemistry. vol 40. issue 2. 1994-03-24. PMID:7508830. |
in our studies, this reduction in platelet 5-ht transporter binding is not due to prior antidepressant treatment of hypercortisolemia and is not observed in mania, alzheimer disease, schizophrenia, panic disorder, fibromyalgia, or atypical depression. |
1994-03-24 |
2023-08-12 |
Not clear |
| N C Inestrosa, R Alarcón, J Arriagada, A Donoso, J Alvare. Platelet of Alzheimer patients: increased counts and subnormal uptake and accumulation of [14C]5-hydroxytryptamine. Neuroscience letters. vol 163. issue 1. 1994-03-02. PMID:8295739. |
platelet of alzheimer patients: increased counts and subnormal uptake and accumulation of [14c]5-hydroxytryptamine. |
1994-03-02 |
2023-08-12 |
Not clear |
| T A Milner, E Veznedarogl. Serotonin-containing terminals synapse on septohippocampal neurons in the rat. Journal of neuroscience research. vol 36. issue 3. 1994-01-31. PMID:7505834. |
these findings suggest that serotonin may affect learning and memory through modulation of septal efferents to the hippocampal formation and may have direct relevance to the neuropathological basis for alzheimer's disease. |
1994-01-31 |
2023-08-12 |
rat |
| K S Wong, R N Goyal, M Z Wrona, C L Blank, G Dryhurs. 7-S-glutathionyl-tryptamine-4,5-dione: a possible aberrant metabolite of serotonin. Biochemical pharmacology. vol 46. issue 9. 1993-12-16. PMID:8240421. |
recent evidence has suggested that aberrant oxidations of 5-ht occur in the central nervous system of individuals with alzheimer's disease (ad). |
1993-12-16 |
2023-08-12 |
mouse |
| K S Wong, R N Goyal, M Z Wrona, C L Blank, G Dryhurs. 7-S-glutathionyl-tryptamine-4,5-dione: a possible aberrant metabolite of serotonin. Biochemical pharmacology. vol 46. issue 9. 1993-12-16. PMID:8240421. |
it is conceivable that one or more of these conjugates might serve as analytical markers in a search for evidence in support of the hypothesis that aberrant oxidations of 5-ht occur in the alzheimer brain. |
1993-12-16 |
2023-08-12 |
mouse |