| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Sevush, W Jy, L L Horstman, W W Mao, L Kolodny, Y S Ah. Platelet activation in Alzheimer disease. Archives of neurology. vol 55. issue 4. 1998-05-06. PMID:9561982. |
in light of recent reports of diminished platelet serotonin concentration and increased plasma serotonin levels in patients with alzheimer disease (ad), we hypothesized that a state of heightened platelet activation might be present in ad. |
1998-05-06 |
2023-08-12 |
Not clear |
| V Kumar, N B Durai, T Job. Pharmacologic management of Alzheimer's disease. Clinics in geriatric medicine. vol 14. issue 1. 1998-03-19. PMID:9456339. |
examinations of brains of alzheimer's disease patients have shown various neuropathologic and neurochemical deficits, especially decreases in acetylcholine, norepinephrine, serotonin, and some neuropeptides. |
1998-03-19 |
2023-08-12 |
Not clear |
| M T McKenna, G R Proctor, L C Young, A L Harve. Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. Journal of medicinal chemistry. vol 40. issue 22. 1997-12-11. PMID:9357518. |
novel tacrine analogues for potential use against alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-ht uptake inhibitors. |
1997-12-11 |
2023-08-12 |
Not clear |
| B J Keck, J M Lakosk. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) administration for studies of 5-HT1A receptor binding site inactivation and turnover. Brain research. Brain research protocols. vol 1. issue 4. 1997-12-10. PMID:9384817. |
alterations in the function of the neurotransmitter serotonin (5-ht) have been implicated in several neurobehavioral disorders, including depression, anxiety as well as a well-known disorder of aging, alzheimer's disease. |
1997-12-10 |
2023-08-12 |
human |
| W J Burke, V Dewan, S P Wengel, W H Roccaforte, G C Nadolny, D G Folk. The use of selective serotonin reuptake inhibitors for depression and psychosis complicating dementia. International journal of geriatric psychiatry. vol 12. issue 5. 1997-08-08. PMID:9193959. |
this retrospective chart review examines the impact of selective serotonin reuptake inhibitors on 20 patients with both depression and psychosis complicating dementia of the alzheimer type (dat) and other dementias. |
1997-08-08 |
2023-08-12 |
Not clear |
| J Levin. Controlled trials of inositol in psychiatry. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 7. issue 2. 1997-07-21. PMID:9169302. |
these results suggest that inositol has therapeutic effects in the spectrum of illness responsive to serotonin selective re-uptake inhibitors, including depression, panic and ocd, and is not beneficial in schizophrenia, alzheimer's addh, autism or ect-induced cognitive impairment. |
1997-07-21 |
2023-08-12 |
Not clear |
| T Li, C Holmes, P C Sham, H Vallada, J Birkett, G Kirov, K P Lesch, J Powell, S Lovestone, D Collie. Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease. Neuroreport. vol 8. issue 3. 1997-07-03. PMID:9106747. |
allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset alzheimer's disease. |
1997-07-03 |
2023-08-12 |
human |
| T Li, C Holmes, P C Sham, H Vallada, J Birkett, G Kirov, K P Lesch, J Powell, S Lovestone, D Collie. Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease. Neuroreport. vol 8. issue 3. 1997-07-03. PMID:9106747. |
we examined a deletion/insertion promoter polymorphism of the serotonin transporter gene, which confers an approximately 40% reduction in expression of the protein, in 196 subjects with late onset alzheimer's disease (ad) and 271 controls. |
1997-07-03 |
2023-08-12 |
human |
| K Schott, H Wormstall, M Dietrich, R Klein, A Batr. Autoantibody reactivity in serum of patients with Alzheimer's disease and other age-related dementias. Psychiatry research. vol 59. issue 3. 1997-01-02. PMID:8930031. |
serum antibodies against a series of antigens, including an organ-specific central nervous system (cns) antigen and the neurotransmitter serotonin, were investigated in 22 patients with alzheimer's disease (n=15) and other age-related dementias (n=7) by indirect immunofluorescence assay and enzyme-linked immunosorbent assay. |
1997-01-02 |
2023-08-12 |
Not clear |
| D Storga, K Vrecko, J G Birkmayer, G Reibnegge. Monoaminergic neurotransmitters, their precursors and metabolites in brains of Alzheimer patients. Neuroscience letters. vol 203. issue 1. 1996-09-26. PMID:8742039. |
the catecholamines dopamine (da), noradrenaline (na) and adrenaline (a), their aminoacid precursors tyrosine (tyr), l-3,4-dihydroxyphenylalanine (l-dopa), two of their metabolites 3,4-dihydroxyphenylacetic acid (dopac) and 4-hydroxy-3-methoxy phenyl glycol (mhpg), serotonin (5-ht) and its precursor tryptophan (trp), were measured by high pressure liquid chromatography (hplc) with electrochemical detection in seven regions (globus pallidus, putamen, nucleus amygdalae, nucleus caudatus, substantia nigra, gyrus cinguli and raphe) of postmortem brains from eight histologically verified cases with alzheimer's disease (ad) and six histologically normal controls. |
1996-09-26 |
2023-08-12 |
Not clear |
| A M Kumar, M Kumar, S Sevush, J Ruiz, C Eisdorfe. Serotonin uptake and its kinetics in platelets of women with Alzheimer's disease. Psychiatry research. vol 59. issue 1-2. 1996-09-26. PMID:8771229. |
serotonin uptake and its kinetics in platelets of women with alzheimer's disease. |
1996-09-26 |
2023-08-12 |
Not clear |
| A M Kumar, M Kumar, S Sevush, J Ruiz, C Eisdorfe. Serotonin uptake and its kinetics in platelets of women with Alzheimer's disease. Psychiatry research. vol 59. issue 1-2. 1996-09-26. PMID:8771229. |
the uptake of serotonin (14c-5-hydroxytryptamine, 5ht) in platelets and its kinetic characteristics were investigated in a group of women (n = 20) with probable alzheimer's disease (mean age = 76.0, years, sd = 8.27, range = 63-88) and in healthy normal women (n = 18, mean age = 72.6 years, sd = 7.24, range = 61-84). |
1996-09-26 |
2023-08-12 |
Not clear |
| A M Kumar, M Kumar, S Sevush, J Ruiz, C Eisdorfe. Serotonin uptake and its kinetics in platelets of women with Alzheimer's disease. Psychiatry research. vol 59. issue 1-2. 1996-09-26. PMID:8771229. |
both the apparent affinity of binding of 5ht to the platelet membrane (km) and the maximum velocity (vmax) of the rate of transport of 14c-5ht into platelets were significantly higher in the alzheimer's disease group than in the normal comparison group. |
1996-09-26 |
2023-08-12 |
Not clear |
| C P Chen, J T Alder, D M Bowen, M M Esiri, B McDonald, T Hope, K A Jobst, P T Franci. Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication. Journal of neurochemistry. vol 66. issue 4. 1996-06-25. PMID:8627315. |
presynaptic serotonergic markers, serotonin uptake sites, and concentrations of serotonin and 5-hydroxyindoleacetic acid were studied in the frontal and temporal cortex of 20 community-acquired cases of alzheimer's disease and 16 controls matched for age, sex, postmortem delay, and storage. |
1996-06-25 |
2023-08-12 |
human |
| C P Chen, J T Alder, D M Bowen, M M Esiri, B McDonald, T Hope, K A Jobst, P T Franci. Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication. Journal of neurochemistry. vol 66. issue 4. 1996-06-25. PMID:8627315. |
there was significant reduction in the number of serotonin uptake sites in alzheimer cases in temporal but not frontal cortex. |
1996-06-25 |
2023-08-12 |
human |
| C P Chen, J T Alder, D M Bowen, M M Esiri, B McDonald, T Hope, K A Jobst, P T Franci. Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication. Journal of neurochemistry. vol 66. issue 4. 1996-06-25. PMID:8627315. |
alzheimer patients who had persistent depressive symptoms during life had significantly fewer serotonin uptake sites in both cortical areas compared with alzheimer patients without these symptoms. |
1996-06-25 |
2023-08-12 |
human |
| C P Chen, J T Alder, D M Bowen, M M Esiri, B McDonald, T Hope, K A Jobst, P T Franci. Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication. Journal of neurochemistry. vol 66. issue 4. 1996-06-25. PMID:8627315. |
in addition, alzheimer patients who were receiving chronic neuroleptic medication had significantly lower concentrations of serotonin in frontal cortex and 5-hydroxyindoleacetic acid in temporal cortex than those patients not receiving such treatment. |
1996-06-25 |
2023-08-12 |
human |
| R M Nitsch, M Deng, J H Growdon, R J Wurtma. Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion. The Journal of biological chemistry. vol 271. issue 8. 1996-06-21. PMID:8626761. |
inasmuch as generation of apps precludes the formation of amyloidogenic derivatives, serotonin receptors provide a novel pharmacological target to reduce these derivatives in alzheimer's disease. |
1996-06-21 |
2023-08-12 |
Not clear |
| L A Mamounas, M E Blue, J A Siuciak, C A Alta. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 12. 1996-06-06. PMID:8613731. |
a pathology of brain serotonergic (5-ht) systems has been found in psychiatric disturbances, normal aging and in neurodegenerative disorders including alzheimer's and parkinson's disease. |
1996-06-06 |
2023-08-12 |
rat |
| C F Reynolds, E Frank, J M Perel, S Mazumdar, D J Kupfe. Maintenance therapies for late-life recurrent major depression: research and review circa 1995. International psychogeriatrics. vol 7 Suppl. 1996-03-15. PMID:8580390. |
finally, we suggest that maintenance therapy trials should be extended in several directions: (a) long-term treatment of bipolar and delusional subtypes in the elderly, as well as depression associated with progressive neurodegenerative disorders such as alzheimer's dementia; (b) assessment of the benefits and risks of long-term therapy with other than tricyclic and monoamine oxidase inhibitor antidepressant agents, such as selective serotonin reuptake inhibitors; and (c) development of models of long-term course, including the interaction of treatments with medical and psychosocial variables that can have a profound impact on illness onset and offset. |
1996-03-15 |
2023-08-12 |
Not clear |