| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B A Lawlor, T Sunderland, A M Mellow, S E Molchan, R Martinez, D L Murph. A pilot placebo-controlled study of chronic m-CPP administration in Alzheimer's disease. Biological psychiatry. vol 30. issue 2. 1991-11-21. PMID:1912105. |
the effects of chronic m-cpp in this study contrast with the reported beneficial effects of the parent compound trazodone and selective 5-ht reuptake inhibitors in treating behavioral symptoms in alzheimer patients. |
1991-11-21 |
2023-08-11 |
Not clear |
| R C Arora, O B Emery, H Y Meltze. Serotonin uptake in the blood platelets of Alzheimer's disease patients. Neurology. vol 41. issue 8. 1991-09-06. PMID:1866025. |
serotonin uptake in the blood platelets of alzheimer's disease patients. |
1991-09-06 |
2023-08-11 |
Not clear |
| R C Arora, O B Emery, H Y Meltze. Serotonin uptake in the blood platelets of Alzheimer's disease patients. Neurology. vol 41. issue 8. 1991-09-06. PMID:1866025. |
we determined serotonin (5-ht) uptake in the blood platelets of alzheimer's disease (ad) patients and comparable age-matched normal controls. |
1991-09-06 |
2023-08-11 |
Not clear |
| B W Volge. Alternatives in the treatment of memory loss in patients with Alzheimer's disease. Clinical pharmacy. vol 10. issue 6. 1991-08-15. PMID:2065522. |
other neurotransmitters known to be compromised in patients with alzheimer's disease include norepinephrine, serotonin, dopamine, and somatostatin. |
1991-08-15 |
2023-08-11 |
Not clear |
| V K Singh, R P Warren, E A Sing. Binding of [3H]serotonin to lymphocytes in patients with neuropsychiatric disorders. Molecular and chemical neuropathology. vol 13. issue 3. 1991-08-15. PMID:2099781. |
based on recent studies of neuroimmune networks, the lymphocyte binding of serotonin neurotransmitter was studied in patients with alzheimer's disease, idiopathic mental retardation, and autism. |
1991-08-15 |
2023-08-11 |
Not clear |
| V K Singh, R P Warren, E A Sing. Binding of [3H]serotonin to lymphocytes in patients with neuropsychiatric disorders. Molecular and chemical neuropathology. vol 13. issue 3. 1991-08-15. PMID:2099781. |
the specific binding to lymphocytes of [3h]serotonin, at a single concentration of 100 nm, was significantly reduced in alzheimer's disease patients as compared to aged controls (group mean of 3.667 +/- 2.301 v 7.506 +/- 1.717 picomoles; p = 0.001), and in children with idiopathic mental retardation as compared to healthy children (group mean of 3.694 +/- 1.627 v 5.792 +/- 1.902 picomoles; p = 0.003). |
1991-08-15 |
2023-08-11 |
Not clear |
| V K Singh, R P Warren, E A Sing. Binding of [3H]serotonin to lymphocytes in patients with neuropsychiatric disorders. Molecular and chemical neuropathology. vol 13. issue 3. 1991-08-15. PMID:2099781. |
reduced lymphocyte binding of serotonin may be an indication of breakdown of an unknown neuroimmune pathway relevant to the pathophysiology of alzheimer's disease and idiopathic mental retardation. |
1991-08-15 |
2023-08-11 |
Not clear |
| K L Jansen, R L Faull, M Dragunow, B L Syne. Alzheimer's disease: changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors--an autoradiographic study. Neuroscience. vol 39. issue 3. 1991-07-23. PMID:1965859. |
alzheimer's disease: changes in hippocampal n-methyl-d-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors--an autoradiographic study. |
1991-07-23 |
2023-08-11 |
Not clear |
| K L Jansen, R L Faull, M Dragunow, B L Syne. Alzheimer's disease: changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors--an autoradiographic study. Neuroscience. vol 39. issue 3. 1991-07-23. PMID:1965859. |
the following receptors were assessed post-mortem in the hippocampi (anterior region) of eight patients with alzheimer's disease and nine age-matched controls, using autoradiography: n-methyl-d-aspartate (including glutamate, phencyclidine and glycine binding sites), quisqualate, kainic acid, adenosine a1, benzodiazepine, serotonin (1 and 2), muscarinic cholinergic, beta-adrenergic, neurotensin and opioid receptors. |
1991-07-23 |
2023-08-11 |
Not clear |
| W J Burke, D H Park, H D Chung, G L Marshall, J H Haring, T H Jo. Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease. Brain research. vol 537. issue 1-2. 1991-05-23. PMID:1707735. |
these neurons are affected in alzheimer's disease (ad) in several ways: serotonin is decreased in axon terminals, serotonin neurons accumulate neurofibrillary protein, and these neurons are lost in ad brains. |
1991-05-23 |
2023-08-11 |
Not clear |
| W J Burke, D H Park, H D Chung, G L Marshall, J H Haring, T H Jo. Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease. Brain research. vol 537. issue 1-2. 1991-05-23. PMID:1707735. |
to determine whether there is a defect in axonal transport in serotonin neurons in ad we measured tph activity, serotonin and its oxidative metabolite 5-hydroxyindoleacetic acid (5-hiaa) in dorsal raphe cell bodies from alzheimer and control cases. |
1991-05-23 |
2023-08-11 |
Not clear |
| W J Burke, D H Park, H D Chung, G L Marshall, J H Haring, T H Jo. Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease. Brain research. vol 537. issue 1-2. 1991-05-23. PMID:1707735. |
serotonin and 5-hiaa are increased by 4.0- and 2.0-fold, respectively in alzheimer compared to control raphe cell bodies. |
1991-05-23 |
2023-08-11 |
Not clear |
| C G Gottfrie. Neurochemical aspects on aging and diseases with cognitive impairment. Journal of neuroscience research. vol 27. issue 4. 1991-04-26. PMID:2079715. |
in patients with alzheimer's disease (ad/sdat), multiple changes indicate disturbed metabolism in the acetylcholine (ach), da, noradrenaline (na), and 5-hydroxytryptamine (5-ht) systems. |
1991-04-26 |
2023-08-11 |
cat |
| C G Gottfrie. Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer's dementia. Journal of neural transmission. Supplementum. vol 30. 1990-10-04. PMID:2202785. |
disturbance of the 5-hydroxytryptamine metabolism in brains from patients with alzheimer's dementia. |
1990-10-04 |
2023-08-11 |
human |
| C G Gottfrie. Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer's dementia. Journal of neural transmission. Supplementum. vol 30. 1990-10-04. PMID:2202785. |
in dementia of the alzheimer type (ad/sdat), there are significantly reduced concentrations of 5-ht and 5-hydroxyindoleacetic acid (5-hiaa). |
1990-10-04 |
2023-08-11 |
human |
| A Wallin, C G Gottfrie. Biochemical substrates in normal aging and Alzheimer's disease. Pharmacopsychiatry. vol 23 Suppl 2. 1990-06-12. PMID:1970889. |
postmortem investigations of hypothalamus from alzheimer brains have shown reduced concentrations of 5-hydroxytryptamine. |
1990-06-12 |
2023-08-11 |
Not clear |
| L Volicer, J C Chen, P B Crino, B A Vogt, J Fishman, J Rubins, P W Schenepper, N Wolf. Neurotoxic properties of a serotonin oxidation product: possible role in Alzheimer's disease. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2481322. |
neurotoxic properties of a serotonin oxidation product: possible role in alzheimer's disease. |
1990-01-31 |
2023-08-11 |
rat |
| G B Baker, G P Reynold. Biogenic amines and their metabolites in Alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. Neuroscience letters. vol 100. issue 1-3. 1989-09-15. PMID:2474777. |
biogenic amines and their metabolites in alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. |
1989-09-15 |
2023-08-11 |
human |
| G B Baker, G P Reynold. Biogenic amines and their metabolites in Alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. Neuroscience letters. vol 100. issue 1-3. 1989-09-15. PMID:2474777. |
the following monoamine transmitters and related neurochemicals were analyzed in hippocampus and substantia innominata from postmortem brain tissue of subjects with senile dementia of the alzheimer's type (sdat): tryptophan (tp), 5-hydroxytryptamine (5-ht), 5-hydroxyindole-3-acetic acid (5-hiaa), noradrenaline (na), dopamine (da) and homovanillic acid (hva). |
1989-09-15 |
2023-08-11 |
human |
| B A Lawlor, T Sunderland, A M Mellow, J L Hill, S E Molchan, D L Murph. Hyperresponsivity to the serotonin agonist m-chlorophenylpiperazine in Alzheimer's disease. A controlled study. Archives of general psychiatry. vol 46. issue 6. 1989-06-30. PMID:2730278. |
hyperresponsivity to the serotonin agonist m-chlorophenylpiperazine in alzheimer's disease. |
1989-06-30 |
2023-08-11 |
Not clear |