| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D N Middlemiss, A M Palmer, N Edel, D M Bowe. Binding of the novel serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin in normal and Alzheimer brain. Journal of neurochemistry. vol 46. issue 3. 1986-04-02. PMID:2419502. |
binding of the novel serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin in normal and alzheimer brain. |
1986-04-02 |
2023-08-11 |
human |
| B E Suranyi-Cadotte, S Gauthier, F Lafaille, S DeFlores, T V Dam, N P Nair, R Quirio. Platelet 3H-imipramine binding distinguishes depression from Alzheimer dementia. Life sciences. vol 37. issue 24. 1986-01-17. PMID:2999549. |
platelet 3h-imipramine binding and serotonin uptake were studied simultaneously in normal subjects and in depressed, parkinsonian and alzheimer's disease patients to investigate the usefulness of these variables in the diagnosis of depression in the elderly. |
1986-01-17 |
2023-08-11 |
human |
| L Volicer, P J Langlais, W R Matson, K A Mark, P H Gamach. Serotoninergic system in dementia of the Alzheimer type. Abnormal forms of 5-hydroxytryptophan and serotonin in cerebrospinal fluid. Archives of neurology. vol 42. issue 12. 1985-12-20. PMID:2415092. |
serotonin (5-ht), its precursor 5-hydroxytryptophan (5-htp), and its major metabolite 5-hydroxyindoleacetic acid (5-hiaa) were measured in the cerebrospinal fluid (csf) of 14 patients with dementia of the alzheimer type (dat) and in nine controls by high-performance liquid chromatography with a novel multisensor coulometric detection system. |
1985-12-20 |
2023-08-11 |
Not clear |
| D M Mann, P O Yates, B Marcyniuk, C R Ravindr. Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age. Journal of mental deficiency research. vol 29 ( Pt 2). 1985-09-30. PMID:2411933. |
it is calculated that in both down's syndrome and alzheimer's disease of middle age there are similar degrees of damage to cholinergic, noradrenergic and serotonin neurotransmitter systems. |
1985-09-30 |
2023-08-11 |
Not clear |
| N R Cutler, J Haxby, A D Kay, P K Narang, L J Lesko, J L Costa, M Ninos, M Linnoila, W Z Potter, J W Renfre. Evaluation of zimeldine in Alzheimer's disease. Cognitive and biochemical measures. Archives of neurology. vol 42. issue 8. 1985-08-27. PMID:2411246. |
neuropsychological and neurochemical effects of zimeldine, a relatively specific serotonin reuptake blocker, were examined in four patients with clinically diagnosed alzheimer's disease, in a double-blind, placebo-controlled, crossover study. |
1985-08-27 |
2023-08-11 |
Not clear |
| N R Cutler, J Haxby, A D Kay, P K Narang, L J Lesko, J L Costa, M Ninos, M Linnoila, W Z Potter, J W Renfre. Evaluation of zimeldine in Alzheimer's disease. Cognitive and biochemical measures. Archives of neurology. vol 42. issue 8. 1985-08-27. PMID:2411246. |
our findings indicate that alterations in central and peripheral serotoninergic function by a serotonin reuptake blocker (zimeldine) are unaccompanied by measurable changes in memory and/or reaction time in patients presumed to have alzheimer's disease. |
1985-08-27 |
2023-08-11 |
Not clear |
| L Volicer, L K Direnfeld, M Freedman, M L Albert, P J Langlias, E D Bir. Serotonin and 5-hydroxyindoleacetic acid in CSF. Difference in Parkinson's disease and dementia of the Alzheimer's type. Archives of neurology. vol 42. issue 2. 1985-04-09. PMID:2579625. |
serotonin (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) levels were measured in the sixth, 13th, and 20th milliliters of csf in patients with dementia of the alzheimer's type (dat) and parkinson's disease (pd), and in an aliquot of csf in controls. |
1985-04-09 |
2023-08-11 |
Not clear |
| D L Sparks, J T Slevi. Determination of tyrosine, tryptophan and their metabolic derivatives by liquid chromatography-electrochemical detection: application to post mortem samples from patients with Parkinson's and Alzheimer's disease. Life sciences. vol 36. issue 5. 1985-03-18. PMID:3968972. |
the levels of neurochemicals in the caudate and putamen of patients with alzheimer's disease (sdat) were also variably decreased; loss of ne was seen only in putamen and losses of da, hva and 5-ht were uniform across both caudate and putamen. |
1985-03-18 |
2023-08-11 |
human |
| W R Matson, P Langlais, L Volicer, P H Gamache, E Bird, K A Mar. n-Electrode three-dimensional liquid chromatography with electrochemical detection for determination of neurotransmitters. Clinical chemistry. vol 30. issue 9. 1984-10-09. PMID:6147209. |
cells with three to 15 electrodes have been used to measure monoamines and metabolites in brain; monoamines directly in serum filtrate; and the state of oxidation of 5-hydroxytryptamine and 5-hydroxytryptophan in cerebrospinal fluid of patients with alzheimer's disease. |
1984-10-09 |
2023-08-12 |
Not clear |
| L K Direnfeld, M L Albert, L Volicer, P J Langlais, J Marquis, E Kapla. Parkinson's disease. The possible relationship of laterality to dementia and neurochemical findings. Archives of neurology. vol 41. issue 9. 1984-09-25. PMID:6477229. |
we tested patients with pd, patients with alzheimer's type of senile dementia, and a control group neuropsychologically, and we determined their csf levels of homovanillic acid, 3,4-dihydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindolacetic acid, serotonin, and acetylcholinesterase. |
1984-09-25 |
2023-08-12 |
Not clear |
| G K Wilcoc. The temporal lobe in dementia of Alzheimer's type. Gerontology. vol 29. issue 5. 1983-11-23. PMID:6618185. |
together with evidence from studies of cerebral atrophy, 5-ht levels, and clinical findings, this indicates that changes in the temporal lobe may play a prominent role in alzheimer's disease, especially in elderly patients. |
1983-11-23 |
2023-08-12 |
Not clear |
| I Bergman, G Bråne, C G Gottfries, K G Jostell, I Karlsson, L Svennerhol. Alaproclate: a pharmacokinetic and biochemical study in patients with dementia of Alzheimer type. Psychopharmacology. vol 80. issue 3. 1983-10-08. PMID:6412274. |
alaproclate, a specific inhibitor of neuronal serotonin re-uptake, was given to 12 patients with dementia of alzheimer type. |
1983-10-08 |
2023-08-12 |
Not clear |
| D M Bowen, S J Allen, J S Benton, M J Goodhardt, E A Haan, A M Palmer, N R Sims, C C Smith, J A Spillane, M M Esiri, D Neary, J S Snowdon, G K Wilcock, A N Daviso. Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease. Journal of neurochemistry. vol 41. issue 1. 1983-08-11. PMID:6306169. |
markers of serotonin synapses in entire temporal lobe and frontal and temporal neocortex were examined for changes in alzheimer's disease by use of both neurosurgical and autopsy samples. |
1983-08-11 |
2023-08-12 |
Not clear |
| D M Bowen, S J Allen, J S Benton, M J Goodhardt, E A Haan, A M Palmer, N R Sims, C C Smith, J A Spillane, M M Esiri, D Neary, J S Snowdon, G K Wilcock, A N Daviso. Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease. Journal of neurochemistry. vol 41. issue 1. 1983-08-11. PMID:6306169. |
when the alzheimer's samples were subdivided according to age, the reduction in [3h]serotonin binding was a feature of only autopsy samples from younger patients. |
1983-08-11 |
2023-08-12 |
Not clear |
| D M Mann, P O Yate. Serotonin nerve cells in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 46. issue 1. 1983-06-23. PMID:6842210. |
serotonin nerve cells in alzheimer's disease. |
1983-06-23 |
2023-08-12 |
Not clear |
| H Soininen, E MacDonald, M Rekonen, P J Riekkine. Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with senile dementia of Alzheimer type. Acta neurologica Scandinavica. vol 64. issue 2. 1982-03-13. PMID:6172950. |
the possibility of disturbed dopamine and serotonin metabolism in senile dementia of alzheimer type was studied. |
1982-03-13 |
2023-08-12 |
Not clear |
| H Soininen, E MacDonald, M Rekonen, P J Riekkine. Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with senile dementia of Alzheimer type. Acta neurologica Scandinavica. vol 64. issue 2. 1982-03-13. PMID:6172950. |
it is concluded that in severe forms of senile dementia of alzheimer type, there is a decrease in the levels of hva and 5-hiaa in csf which may reflect a decreased turnover of dopamine and serotonin. |
1982-03-13 |
2023-08-12 |
Not clear |
| E Tukiainen, J Wikström, H Kilpeläine. Uptake of 5-hydroxytryptamine by blood platelets in Huntington's chorea and Alzheimer type of presenile dementia. Medical biology. vol 59. issue 2. 1982-02-22. PMID:6458746. |
uptake of 5-hydroxytryptamine by blood platelets in huntington's chorea and alzheimer type of presenile dementia. |
1982-02-22 |
2023-08-12 |
Not clear |
| E Tukiainen, J Wikström, H Kilpeläine. Uptake of 5-hydroxytryptamine by blood platelets in Huntington's chorea and Alzheimer type of presenile dementia. Medical biology. vol 59. issue 2. 1982-02-22. PMID:6458746. |
kinetics of 5-ht uptake by blood platelets was studied om eleven patients with huntington's chorea and in ten patients with presenile dementia of alzheimer type. |
1982-02-22 |
2023-08-12 |
Not clear |
| V Argentiero, B Tavolat. Dopamine (DA) and serotonin metabolic levels in the cerebrospinal fluid (CSF) in Alzheimer's presenile dementia under basic conditions and after stimulation with cerebral cortex phospholipids (BC-PL). Journal of neurology. vol 224. issue 1. 1980-11-24. PMID:6157799. |
dopamine (da) and serotonin metabolic levels in the cerebrospinal fluid (csf) in alzheimer's presenile dementia under basic conditions and after stimulation with cerebral cortex phospholipids (bc-pl). |
1980-11-24 |
2023-08-12 |
Not clear |