| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B A Lawlor, T Sunderland, A M Mellow, J L Hill, S E Molchan, D L Murph. Hyperresponsivity to the serotonin agonist m-chlorophenylpiperazine in Alzheimer's disease. A controlled study. Archives of general psychiatry. vol 46. issue 6. 1989-06-30. PMID:2730278. |
the serotonin agonist m-chlorophenylpiperazine (mcpp) was administered intravenously to 12 patients with alzheimer's disease and ten age-matched controls. |
1989-06-30 |
2023-08-11 |
Not clear |
| B A Lawlor, T Sunderland, A M Mellow, J L Hill, S E Molchan, D L Murph. Hyperresponsivity to the serotonin agonist m-chlorophenylpiperazine in Alzheimer's disease. A controlled study. Archives of general psychiatry. vol 46. issue 6. 1989-06-30. PMID:2730278. |
the increased behavioral responsivity but unchanged neuroendocrine or other physiologic responsivity to mcpp may be related to damaged brain serotonin neurons or other neuronal systems that interact with serotonin neurons that have been found in postmortem and biopsy studies of patients with alzheimer's disease. |
1989-06-30 |
2023-08-11 |
Not clear |
| D L Spark. Aging and Alzheimer's disease. Altered cortical serotonergic binding. Archives of neurology. vol 46. issue 2. 1989-03-17. PMID:2916952. |
the binding of tritiated serotonin and tritiated spiperone to crude membrane preparations from human frontal poles was determined in both controls and subjects with alzheimer's disease (ad). |
1989-03-17 |
2023-08-11 |
human |
| D L Sparks, S T DeKosky, W R Markesber. Alzheimer's disease. Aminergic-cholinergic alterations in hypothalamus. Archives of neurology. vol 45. issue 9. 1988-09-29. PMID:2901257. |
to better understand the role of the hypothalamus in alzheimer's disease (ad), we have measured dopamine, norepinephrine (ne), and serotonin (5ht) levels, tritiated spiperone and tritiated serotonin blinding, and choline acetyltransferase (chat) and acetylcholinesterase activity in seven subregions of the hypothalamus from 18 normal control subjects and ten patients with ad. |
1988-09-29 |
2023-08-11 |
human |
| A M Palmer, G C Stratmann, A W Procter, D M Bowe. Possible neurotransmitter basis of behavioral changes in Alzheimer's disease. Annals of neurology. vol 23. issue 6. 1988-09-16. PMID:2457353. |
serotonin, 5-hydroxyindoleacetic acid, and homovanillic acid concentrations have been determined in 10 areas of the cerebral cortex from 17 subjects with alzheimer's disease and 18 control subjects. |
1988-09-16 |
2023-08-11 |
human |
| R P Friedland, E Koss, J V Haxby, C L Grady, J Luxenberg, M B Schapiro, J Kay. NIH conference. Alzheimer disease: clinical and biological heterogeneity. Annals of internal medicine. vol 109. issue 4. 1988-08-25. PMID:2969203. |
furthermore, patients with alzheimer disease who have extrapyramidal dysfunction or myoclonus are a distinct subgroup, with specific abnormalities of central monoamine markers of dopamine metabolism, serotonin metabolism, and the hydroxylation cofactor, biopterin. |
1988-08-25 |
2023-08-11 |
Not clear |
| A W Procter, S L Lowe, A M Palmer, P T Francis, M M Esiri, G C Stratmann, A Najlerahim, A J Patel, A Hunt, D M Bowe. Topographical distribution of neurochemical changes in Alzheimer's disease. Journal of the neurological sciences. vol 84. issue 2-3. 1988-07-18. PMID:2898011. |
biochemical indices of cortical nerve cells affected in alzheimer's disease have been proposed (excitatory dicarboxylic amino acid, edaa, sodium-dependent carrier; phosphate-activated glutaminase activity; serotonin type 2 recognition site; somatostatin-like immunoreactivity). |
1988-07-18 |
2023-08-11 |
human |
| E Koyama, A Minegishi, T Ishizak. Simultaneous determination of four monoamine metabolites and serotonin in cerebrospinal fluid by "high-performance" liquid chromatography with electrochemical detection; application for patients with Alzheimer's disease. Clinical chemistry. vol 34. issue 4. 1988-06-07. PMID:2452037. |
simultaneous determination of four monoamine metabolites and serotonin in cerebrospinal fluid by "high-performance" liquid chromatography with electrochemical detection; application for patients with alzheimer's disease. |
1988-06-07 |
2023-08-11 |
human |
| D R Thomas, E Jones, N Warner, B Harris, P Williams, P Bentle. Peripheral serotoninergic receptor sensitivity in senile dementia of the Alzheimer type. Biological psychiatry. vol 23. issue 2. 1988-02-12. PMID:3334883. |
platelet aggregation induced by 5-hydroxytryptamine (5-ht) was used as a measure of the functional responsiveness of peripheral 5-ht receptors in controls and drug-free patients suffering from senile dementia of alzheimer type (sdat). |
1988-02-12 |
2023-08-11 |
human |
| b' G Ebinger, M Bruyland, J J Martin, P Herregodts, P Cras, Y Michotte, L Gomm\\xc3\\xa. Distribution of biogenic amines and their catabolites in brains from patients with Alzheimer\'s disease. Journal of the neurological sciences. vol 77. issue 2-3. 1987-04-08. PMID:3819769.' |
norepinephrine, epinephrine, dopamine, serotonin and their major catabolites were measured in 17 regions of the left hemisphere of two brains obtained from two brothers with alzheimer's disease with very early onset. |
1987-04-08 |
2023-08-11 |
Not clear |
| b' G Ebinger, M Bruyland, J J Martin, P Herregodts, P Cras, Y Michotte, L Gomm\\xc3\\xa. Distribution of biogenic amines and their catabolites in brains from patients with Alzheimer\'s disease. Journal of the neurological sciences. vol 77. issue 2-3. 1987-04-08. PMID:3819769.' |
the serotonin deficiency sheds light on possible mechanisms of myoclonus in alzheimer's disease. |
1987-04-08 |
2023-08-11 |
Not clear |
| C Bouras, S de St Hilaire-Kafi, J Constantinidi. Neuropeptides in Alzheimer's disease: a review and morphological results. Progress in neuro-psychopharmacology & biological psychiatry. vol 10. issue 3-5. 1987-02-06. PMID:2432629. |
na, da, 5ht, ach and gaba in the post-mortem autopsied brain of alzheimer's disease (ad) has been reviewed. |
1987-02-06 |
2023-08-11 |
Not clear |
| C G Gottfries, T Bartfai, A Carlsson, S Eckernäs, L Svennerhol. Multiple biochemical deficits in both gray and white matter of Alzheimer brains. Progress in neuro-psychopharmacology & biological psychiatry. vol 10. issue 3-5. 1987-02-06. PMID:3797685. |
in the brains from the alzheimer patients a disturbance was found in the 5-ht system in the form of reduced levels of 5-ht and 5-hydroxyindolacetic acid (5-hiaa). |
1987-02-06 |
2023-08-11 |
cat |
| G M Whitfor. Alzheimer's disease and serotonin: a review. Neuropsychobiology. vol 15. issue 3-4. 1987-01-15. PMID:3785643. |
alzheimer's disease and serotonin: a review. |
1987-01-15 |
2023-08-11 |
Not clear |
| G M Whitfor. Alzheimer's disease and serotonin: a review. Neuropsychobiology. vol 15. issue 3-4. 1987-01-15. PMID:3785643. |
data from post-mortem brain, cerebrospinal fluid and serotonin (5-ht) synapse studies indicate serious impairment of the serotoninergic system in patients with alzheimer's disease. |
1987-01-15 |
2023-08-11 |
Not clear |
| D L Sparks, W R Markesbery, J T Slevi. Alzheimer's disease: monoamines and spiperone binding reduced in nucleus basalis. Annals of neurology. vol 19. issue 6. 1986-08-13. PMID:2425718. |
levels of dopamine and serotonin, and of their precursors and metabolites, were measured in the nucleus basalis of meynert (nbm) of patients with alzheimer's disease and control patients. |
1986-08-13 |
2023-08-11 |
Not clear |
| D L Sparks, W R Markesbery, J T Slevi. Alzheimer's disease: monoamines and spiperone binding reduced in nucleus basalis. Annals of neurology. vol 19. issue 6. 1986-08-13. PMID:2425718. |
the nbm from patients with alzheimer's disease showed significant decreases in both spiperone binding and in the levels of dopamine and serotonin but no decrease in either tyrosine or tryptophan levels. |
1986-08-13 |
2023-08-11 |
Not clear |
| C M Yates, J Simpson, A Gordo. Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease. Neuroscience letters. vol 65. issue 2. 1986-07-01. PMID:2940479. |
regional brain 5-hydroxytryptamine levels are reduced in senile down's syndrome as in alzheimer's disease. |
1986-07-01 |
2023-08-11 |
Not clear |
| C M Yates, J Simpson, A Gordo. Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease. Neuroscience letters. vol 65. issue 2. 1986-07-01. PMID:2940479. |
5-hydroxytryptamine (5-ht) and choline acetyltransferase (chat) were assayed in amygdala, cingulate cortex and caudate nucleus of post-mortem brains from 7 cases of down's syndrome (6 with the neuropathological features of alzheimer's disease and one with no such features), 9 cases of alzheimer's disease and 12 controls. |
1986-07-01 |
2023-08-11 |
Not clear |
| C M Yates, J Simpson, A Gordo. Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease. Neuroscience letters. vol 65. issue 2. 1986-07-01. PMID:2940479. |
5-ht was markedly reduced in all 3 areas of the pathologically affected down brains, unaltered in the down brain with no alzheimer pathology and reduced in the amygdala and cingulate cortex of the alzheimer brains. |
1986-07-01 |
2023-08-11 |
Not clear |