| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Koge. Design, synthesis and structure-activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 11. issue 9. 2003-12-12. PMID:12670645. |
we have designed and synthesized a dual inhibitor of acetylcholinesterase (ache) and serotonin transporter (sert) as a novel class of treatment drugs for alzheimer's disease on the basis of a hypothetical model of the ache active site. |
2003-12-12 |
2023-08-12 |
mouse |
| A Menese. Role of 5-HT6 receptors in memory formation. Drug news & perspectives. vol 14. issue 7. 2003-10-22. PMID:12813582. |
nevertheless, an association between the 5-ht(6) receptor polymorphism c267t and alzheimer's disease has been reported. |
2003-10-22 |
2023-08-12 |
mouse |
| M K Lai, S W Tsang, P T Francis, M M Esiri, T Hope, O F Lai, I Spence, C P Che. [3H]GR113808 binding to serotonin 5-HT(4) receptors in the postmortem neocortex of Alzheimer disease: a clinicopathological study. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 7. 2003-10-14. PMID:12811638. |
[3h]gr113808 binding to serotonin 5-ht(4) receptors in the postmortem neocortex of alzheimer disease: a clinicopathological study. |
2003-10-14 |
2023-08-12 |
human |
| M K Lai, S W Tsang, P T Francis, M M Esiri, T Hope, O F Lai, I Spence, C P Che. [3H]GR113808 binding to serotonin 5-HT(4) receptors in the postmortem neocortex of Alzheimer disease: a clinicopathological study. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 7. 2003-10-14. PMID:12811638. |
abnormalities in neural transmission of serotonin (5-ht) may play a role in both cognitive and neuropsychiatric features of alzheimer disease (ad). |
2003-10-14 |
2023-08-12 |
human |
| Florence Leber. [Serotonin reuptake inhibitors in depression of Alzheimer's disease and other dementias]. Presse medicale (Paris, France : 1983). vol 32. issue 25. 2003-10-06. PMID:13677882. |
[serotonin reuptake inhibitors in depression of alzheimer's disease and other dementias]. |
2003-10-06 |
2023-08-12 |
Not clear |
| Shirley W Y Tsang, Mitchell K P Lai, Paul T Francis, Peter T-H Wong, Ian Spence, Margaret M Esiri, Janet Keene, Tony Hope, Christopher P L-H Che. Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients. Neuroreport. vol 14. issue 10. 2003-09-26. PMID:12876460. |
serotonin transporters are preserved in the neocortex of anxious alzheimer's disease patients. |
2003-09-26 |
2023-08-12 |
human |
| Shirley W Y Tsang, Mitchell K P Lai, Paul T Francis, Peter T-H Wong, Ian Spence, Margaret M Esiri, Janet Keene, Tony Hope, Christopher P L-H Che. Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients. Neuroreport. vol 14. issue 10. 2003-09-26. PMID:12876460. |
densities of serotonin transporters (5-htt) in the postmortem neocortex of behaviorally assessed alzheimer's disease (ad) patients and aged controls were measured by radioligand binding with [3h]citalopram. |
2003-09-26 |
2023-08-12 |
human |
| Mitchell K P Lai, Shirley W Y Tsang, Paul T Francis, Margaret M Esiri, Janet Keene, Tony Hope, Christopher P L-H Che. Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742626. |
reduced serotonin 5-ht1a receptor binding in the temporal cortex correlates with aggressive behavior in alzheimer disease. |
2003-07-22 |
2023-08-12 |
human |
| T V Davydova, O I Mikovskaya, V G Fomina, N I Voskresenskaya, O A Doronin. Induction of immune complexes and autoantibodies to serotonin and dopamine in patients with Alzheimer's disease. Bulletin of experimental biology and medicine. vol 134. issue 1. 2003-07-17. PMID:12459860. |
induction of immune complexes and autoantibodies to serotonin and dopamine in patients with alzheimer's disease. |
2003-07-17 |
2023-08-12 |
human |
| T V Davydova, O I Mikovskaya, V G Fomina, N I Voskresenskaya, O A Doronin. Induction of immune complexes and autoantibodies to serotonin and dopamine in patients with Alzheimer's disease. Bulletin of experimental biology and medicine. vol 134. issue 1. 2003-07-17. PMID:12459860. |
plasma concentration of immune complexes and antibodies to serotonin and dopamine were higher in patients with alzheimer's disease compared to mentally healthy volunteers of the same age. |
2003-07-17 |
2023-08-12 |
human |
| J Versijpt, K J Van Laere, F Dumont, Danny Decoo, Marleen Vandecapelle, Patrick Santens, Ingeborg Goethals, K Audenaert, G Slegers, Rudi A Dierckx, Jakob Kor. Imaging of the 5-HT2A system: age-, gender-, and Alzheimer's disease-related findings. Neurobiology of aging. vol 24. issue 4. 2003-06-11. PMID:12714112. |
serotonin (5-ht) and more specifically the 5-ht(2a) receptor is involved in cognitive and non-cognitive behavior and plays an important role in alzheimer's disease (ad). |
2003-06-11 |
2023-08-12 |
human |
| Maite Alvarez-Alvarez, Luis Galdos, Manuel Fernández-Martínez, Fernando Gómez-Busto, Victoria García-Centeno, Caridad Arias-Arias, Carmen Sánchez-Salazar, Ana Belén Rodríguez-Martínez, Juan José Zarranz, Marian M de Pancorb. 5-Hydroxytryptamine 6 receptor (5-HT(6)) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer's disease in the Basque Country. Neuroscience letters. vol 339. issue 1. 2003-05-19. PMID:12618306. |
5-hydroxytryptamine 6 receptor (5-ht(6)) receptor and apolipoprotein e (apoe) polymorphisms in patients with alzheimer's disease in the basque country. |
2003-05-19 |
2023-08-12 |
Not clear |
| Frank Lezoualc'h, Sylvain J Rober. The serotonin 5-HT4 receptor and the amyloid precursor protein processing. Experimental gerontology. vol 38. issue 1-2. 2003-05-12. PMID:12543273. |
a large body of evidence supports a major role for the serotonin 5-ht(4) receptor in learning and memory and it is suggested that 5-ht(4) agonists may be beneficial for memory disorders such as alzheimer's disease (ad). |
2003-05-12 |
2023-08-12 |
human |
| Gabor G Kovacs, Stefan Klöppel, Ingeborg Fischer, Suzanne Dorner, Elisabeth Lindeck-Pozza, Peter Birner, Ingolf C Bötefür, Peter Pilz, Benedikt Volk, Herbert Budk. Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders. Neuroreport. vol 14. issue 1. 2003-04-25. PMID:12544834. |
to evaluate the involvement of serotonergic raphe nuclei, we compared the percentage of neurons synthesizing serotonin in the nucleus centralis superior (ncs), raphe obscurus and pallidus (nrop) in alzheimer's disease (ad), progressive supranuclear palsy (psp), parkinson's disease (pd), multiple system atrophy (msa), and control brains. |
2003-04-25 |
2023-08-12 |
human |
| Ilga Misane, Sven Ove Ogre. Selective 5-HT1A antagonists WAY 100635 and NAD-299 attenuate the impairment of passive avoidance caused by scopolamine in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589378. |
these results suggest that 5-ht(1a) receptor antagonists may have a potential in the treatment of cognitive symptoms in psychopathologies characterized by reduced ach transmission such as alzheimer's disease. |
2003-04-21 |
2023-08-12 |
rat |
| Hiroshi Kogen, Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kanek. Design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease. Organic letters. vol 4. issue 20. 2002-12-27. PMID:12323018. |
design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for alzheimer's disease. |
2002-12-27 |
2023-08-12 |
Not clear |
| Anibal A Arjona, Amy M Pooler, Robert K Lee, Richard J Wurtma. Effect of a 5-HT(2C) serotonin agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in guinea pigs. Brain research. vol 951. issue 1. 2002-11-26. PMID:12231467. |
hence 5-ht(2c) receptors, which apparently are localized to the brain, may represent useful targets for the development of treatments for alzheimer's disease. |
2002-11-26 |
2023-08-12 |
Not clear |
| Krista L Lanctôt, Nathan Herrmann, Goran Eryavec, Robert van Reekum, Kenton Reed, Claudio A Naranj. Central serotonergic activity is related to the aggressive behaviors of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 4. 2002-11-19. PMID:12377401. |
the clinical correlates of reduced serotonin (5-ht) in alzheimer's disease (ad) remain unknown. |
2002-11-19 |
2023-08-12 |
human |
| Paul Newhouse, Adam Tatro, Magdalena Naylor, Kathy Quealey, Pedro Delgad. Alzheimer disease, serotonin systems, and tryptophan depletion. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 10. issue 4. 2002-08-20. PMID:12095908. |
alzheimer disease, serotonin systems, and tryptophan depletion. |
2002-08-20 |
2023-08-12 |
Not clear |
| Antonio Orlacchio, Toshitaka Kawarai, Eleonora Paciotti, Alessandro Stefani, Aldo Orlacchio, Sandro Sorbi, Peter H St George-Hyslop, Giorgio Bernard. Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease. Neuroscience letters. vol 325. issue 1. 2002-07-10. PMID:12023056. |
association study of the 5-hydroxytryptamine(6) receptor gene in alzheimer's disease. |
2002-07-10 |
2023-08-12 |
Not clear |