| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lorenzo Kiferle, Roberto Ceravolo, Lucia Petrozzi, Carlo Rossi, Daniela Frosini, Anna Rocchi, Gabriele Siciliano, Ubaldo Bonuccelli, Luigi Murr. Visual hallucinations in Parkinson's disease are not influenced by polymorphisms of serotonin 5-HT2A receptor and transporter genes. Neuroscience letters. vol 422. issue 3. 2007-10-23. PMID:17614196. |
in pd there is an extensive loss of serotoninergic raphe neurons and serotonin dysfunction had been implicated in the pathogenesis of many psychiatric disorders such as depression, schizophrenia, and in psychosis of patients with alzheimer disease. |
2007-10-23 |
2023-08-12 |
Not clear |
| L Truchot, S N Costes, L Zimmer, B Laurent, D Le Bars, C Thomas-Antérion, B Croisile, B Mercier, M Hermier, A Vighetto, P Krolak-Salmo. Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment. Neurology. vol 69. issue 10. 2007-09-28. PMID:17785670. |
recent studies have suggested modifications of serotonin cerebral metabolism and of 5-ht(1a) receptors density in alzheimer disease (ad). |
2007-09-28 |
2023-08-12 |
Not clear |
| Alessandro Serretti, Antonio Drago, Diana De Ronch. HTR2A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies. Current medicinal chemistry. vol 14. issue 19. 2007-09-18. PMID:17691947. |
variants at the gene encoding for the 5-hydrosytryptamine (serotonin) receptor 2a (htr2a) have been associated with many psychiatric disorders such as schizophrenia, mood disorders, attention deficit hyperactivity disorder, suicide, anxiety disorders, obsessive-compulsive disorder, eating disorders, and alzheimer's disease. |
2007-09-18 |
2023-08-12 |
Not clear |
| Kelly Dyer, Donald P Cai. Water maze impairments after combined depletion of somatostatin and serotonin in the rat. Behavioural brain research. vol 181. issue 1. 2007-08-24. PMID:17477978. |
depletion of both somatostatin and serotonin in naïve rats produces results comparable to the spatial navigation deficits seen in some alzheimer patients and suggests that combinations of antagonist treatments may better model this disorder than single antagonist treatments do. |
2007-08-24 |
2023-08-12 |
rat |
| Yasuyoshi Watanab. [Molecular imaging for drug development]. Nihon rinsho. Japanese journal of clinical medicine. vol 65. issue 2. 2007-04-26. PMID:17302284. |
early decision of dropout substances (drug candidates) here, the examples are shown as beta-amyloid imaging for alzheimer's and mild cognitive impairment, serotonin transporter imaging for chronic fatigue, and dopaminergic components imaging for evaluation of drug for autistic spectrum disorder. |
2007-04-26 |
2023-08-12 |
Not clear |
| D Micheli, C Bonvicini, A Rocchi, R Ceravolo, M Mancuso, G Tognoni, M Gennarelli, G Siciliano, L Murr. No evidence for allelic association of serotonin 2A receptor and transporter gene polymorphisms with depression in Alzheimer disease. Journal of Alzheimer's disease : JAD. vol 10. issue 4. 2007-04-03. PMID:17183148. |
no evidence for allelic association of serotonin 2a receptor and transporter gene polymorphisms with depression in alzheimer disease. |
2007-04-03 |
2023-08-12 |
human |
| Werner J Geldenhuys, Cornelis J Van der Schy. Triquinane-based compounds as possible serotonin 5-HT(6) receptor antagonists for the treatment of Alzheimer's disease. Medical hypotheses. vol 68. issue 1. 2007-01-30. PMID:16962723. |
triquinane-based compounds as possible serotonin 5-ht(6) receptor antagonists for the treatment of alzheimer's disease. |
2007-01-30 |
2023-08-12 |
Not clear |
| Werner J Geldenhuys, Cornelis J Van der Schy. Triquinane-based compounds as possible serotonin 5-HT(6) receptor antagonists for the treatment of Alzheimer's disease. Medical hypotheses. vol 68. issue 1. 2007-01-30. PMID:16962723. |
the recently discovered serotonin 5-ht(6) receptor is a novel target for the treatment of cognitive decline associated with neurodegenerative diseases such as alzheimer's disease (ad). |
2007-01-30 |
2023-08-12 |
Not clear |
| Warren D Hirst, Tania O Stean, Derek C Rogers, David Sunter, Pippa Pugh, Stephen F Moss, Steven M Bromidge, Graham Riley, Douglas R Smith, Sarah Bartlett, Christian A Heidbreder, Alan R Atkins, Laurent P Lacroix, Lee A Dawson, Andrew G Foley, Ciaran M Regan, Neil Upto. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. European journal of pharmacology. vol 553. issue 1-3. 2007-01-24. PMID:17069795. |
these studies provide further support for the potential therapeutic utility of 5-ht(6) receptor antagonists in disorders characterised by cognitive deficits such as alzheimer's disease and schizophrenia. |
2007-01-24 |
2023-08-12 |
human |
| Jörg Holenz, Petrus J Pauwels, José Luis Díaz, Ramon Mercè, Xavier Codony, Helmut Buschman. Medicinal chemistry strategies to 5-HT(6) receptor ligands as potential cognitive enhancers and antiobesity agents. Drug discovery today. vol 11. issue 7-8. 2007-01-19. PMID:16580970. |
although the 5-hydroxytryptamine(6) (5-ht(6)) receptor was discovered only recently, its almost exclusive distribution in the brain makes it a promising, novel, target for central nervous system (cns)-mediated diseases such as alzheimer's disease (cognitive function), schizophrenia, anxiety and obesity. |
2007-01-19 |
2023-08-12 |
Not clear |
| Barbara K Martin, Constantine E Frangakis, Paul B Rosenberg, Jacobo E Mintzer, Ira R Katz, Anton P Porsteinsson, Lon S Schneider, Peter V Rabins, Cynthia A Munro, Curtis L Meinert, George Niederehe, Constantine G Lyketso. Design of Depression in Alzheimer's Disease Study-2. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 14. issue 11. 2006-12-15. PMID:17068314. |
to address these issues, the authors present the design of the depression in alzheimer's disease study-2 (diads-2), a randomized, placebo-controlled multicenter trial to evaluate the efficacy and safety of the selective serotonin reuptake inhibitor sertraline for the treatment of depression in people with alzheimer disease. |
2006-12-15 |
2023-08-12 |
Not clear |
| Katsuyoshi Mizukami, Yoshiro Tanaka, Takashi Asad. Efficacy of milnacipran on the depressive state in patients with Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 7. 2006-10-31. PMID:16603301. |
an open-labeled study was conducted to examine the efficacy of selective serotonin and noradrenaline reuptake inhibitor (snri), milnacipran in treating depression in alzheimer's disease (ad) patients. |
2006-10-31 |
2023-08-12 |
Not clear |
| Dietrich E Lorke, Gang Lu, Eric Cho, David T Ye. Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients. BMC neuroscience. vol 7. 2006-08-23. PMID:16640790. |
serotonin 5-ht2a and 5-ht6 receptors in the prefrontal cortex of alzheimer and normal aging patients. |
2006-08-23 |
2023-08-12 |
Not clear |
| J A J Schmitt, M Wingen, J G Ramaekers, E A T Evers, W J Riede. Serotonin and human cognitive performance. Current pharmaceutical design. vol 12. issue 20. 2006-08-10. PMID:16842171. |
given the mounting evidence for a role of 5-ht in human cognition, reduced 5-ht function could be directly linked to cognitive disturbances in certain conditions, such as in depression and alzheimer's disease (ad). |
2006-08-10 |
2023-08-12 |
human |
| A J Thomas, M Hendriksen, M Piggott, I N Ferrier, E Perry, P Ince, J T O'Brie. A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression. Neuropathology and applied neurobiology. vol 32. issue 3. 2006-07-05. PMID:16640648. |
a study of the serotonin transporter in the prefrontal cortex in late-life depression and alzheimer's disease with and without depression. |
2006-07-05 |
2023-08-12 |
human |
| Armando Mansilla-Olivare. [Signal transduction, pillar of the neurobiological integration of memory. An alternative view to the cholinergic hypothesis]. Gaceta medica de Mexico. vol 141. issue 6. 2006-05-02. PMID:16381507. |
despite the widespread dissemination of the cholinergic hypothesis in alzheimer's disease, memory build up rather than involving acetylcholine essentially depends on the participation of other neurotransmitters such as 5-ht and glutamate, which have not been adequately considered in the treatment of this disease. |
2006-05-02 |
2023-08-12 |
Not clear |
| Nather Madjid, Elin Elvander Tottie, Maria Lüttgen, Björn Meister, Johan Sandin, Alexander Kuzmin, Oliver Stiedl, Sven Ove Ogre. 5-Hydroxytryptamine 1A receptor blockade facilitates aversive learning in mice: interactions with cholinergic and glutamatergic mechanisms. The Journal of pharmacology and experimental therapeutics. vol 316. issue 2. 2006-04-04. PMID:16223872. |
selective 5-ht(1a) receptor antagonists may be useful in the treatment of cognitive deficits such as alzheimer's disease. |
2006-04-04 |
2023-08-12 |
mouse |
| Vladimir Kepe, Jorge R Barrio, Sung-Cheng Huang, Linda Ercoli, Prabha Siddarth, Kooresh Shoghi-Jadid, Gregory M Cole, Nagichettiar Satyamurthy, Jeffrey L Cummings, Gary W Small, Michael E Phelp. Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 3. 2006-02-28. PMID:16407119. |
serotonin 1a receptors in the living brain of alzheimer's disease patients. |
2006-02-28 |
2023-08-12 |
human |
| Vladimir Kepe, Jorge R Barrio, Sung-Cheng Huang, Linda Ercoli, Prabha Siddarth, Kooresh Shoghi-Jadid, Gregory M Cole, Nagichettiar Satyamurthy, Jeffrey L Cummings, Gary W Small, Michael E Phelp. Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 3. 2006-02-28. PMID:16407119. |
4-[f-18]fluoro-n-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-n-(2-pyridinyl)benzamide, a selective serotonin 1a (5-ht(1a)) molecular imaging probe, was used in conjunction with positron emission tomography (pet) for quantification of 5-ht(1a) receptor densities in the living brains of alzheimer's disease patients (ads) (n = 8), subjects with mild cognitive impairment (n = 6), and controls (n = 5). |
2006-02-28 |
2023-08-12 |
human |
| Tae Min Ha, Deuk Man Cho, Sung Woo Park, Myung Jin Joo, Bong Ju Lee, Bo Geum Kong, Jae Min Kim, Jin Sang Yoon, Young Hoon Ki. Evaluating associations between 5-HTTLPR polymorphism and Alzheimer's disease for Korean patients. Dementia and geriatric cognitive disorders. vol 20. issue 1. 2005-10-11. PMID:15832033. |
there has been growing evidence that the serotonin (5-ht) system is important in the regulation of memory and thus might be associated with alzheimer's disease (ad), while research results on this issue have been inconsistent. |
2005-10-11 |
2023-08-12 |
Not clear |